Aspects Of Infant Research Articles

Impact of Infant and Young Child Feeding Practices on the Nutritional Status of Children in Northern Bangladesh

Background: Proper feeding practices are essential for attaining and maintaining optimum nutrition, health, and development of infants and children. Exclusive breastfeeding during the first six months of life and continued breastfeeding for two years, together with age-appropriate, nutritionally adequate complementary feeding initiated after six months of age, are optimum Infant and Young Child Feeding (IYCF) practices. However, often many aspects of infant and young child feeding practices are not optimum, with serious consequences for the child.
 Objective: To determine the impact of Infant and Young Child Feeding (IYCF) practices on the nutritional status of children. Materials and Method: This Cross-sectional descriptive type of study was conducted among 314 children from 6 months to 24 months of age at the Pediatric Outpatient Department and EPI center of Rajshahi Medical College Hospital during the period of January 2017 to December 2018. Collected data were analyzed by using 'SPSS version 16.
 Result: Among 314 children exclusive breastfeeding (EBF) rate was 68.2% for the first six months, and timely started complementary feeding was 58.5% of cases. In 214 exclusive breastfed infants, only 4.7% and 1.4% of children were moderate to severely wasted and stunted, respectively. On the other hand, among 97 infants who were not exclusively breastfed, the percentage of moderate to severe wasting and stunting was 11.4% and 13.4%, respectively. Among the 175 timely started complementary feeding children, only 12% and 6% were moderate to severely underweight and wasted, respectively, no one was stunted, but among the inappropriately started complementary children, 20.2%, 12.5%, and 12.8% were moderately to severely underweight, wasted and stunted respectively.
 Conclusion: Most of the children who were given exclusive breastfeeding in the first six months and started complementary food at an appropriate time after six months had normal nutritional status. Both moderate to severe stunting and wasting were common in those children who were non-exclusively breastfed and started complementary feeding either early or late.
 TAJ 2022; 35: No-2: 83-91

Breastfeeding and humanitarian emergencies: the experiences of pregnant and lactating women during the earthquake in Abruzzo, Italy

BackgroundEmergencies have a great impact on infant and young child feeding. Despite the evidence, the recommended feeding practices are often not implemented in the emergency response, undermining infant and maternal health. The aim of this study was to explore the experiences of pregnant and lactating women during the earthquake emergency that occurred in L’Aquila on 6 April 2009.MethodsThe study design was qualitative descriptive. Data were collected by individual semi-structured interviews, investigating the mother’s experiences of pregnancy, childbirth, breastfeeding, infant formula or complementary feeding during the emergency and the post emergency phase. Data analysis was categorical and was performed by using N-Vivo software.ResultsSix women who were pregnant at the time of the earthquake were interviewed in January 2010. In addition to the essential needs of pregnant and lactating women, such as those related to the emergency shelters conditions, the main findings emerged from this study were: the reconfiguration of relationships and the central role of partners and family support; the need of spaces for sharing experiences and practices with other mothers; the lack of breastfeeding support after the hospital discharge; the inappropriate donations and distribution of Breast Milk Substitutes.ConclusionsDuring and after L’Aquila earthquake, several aspects of infant and young child feeding did not comply with standard practices and recommendations. The response system appeared not always able to address the specific needs of pregnant and lactating women. It is urgent to develop management plans, policies and procedures and provide communication, sensitization, and training on infant and young child feeding at all levels and sectors of the emergency response.

Prenatal Metal Exposures and Infants' Developmental Outcomes in a Navajo Population.

Early-life exposure to environmental toxicants can have detrimental effects on children’s neurodevelopment. In the current study, we employed a causal modeling framework to examine the direct effect of specific maternal prenatal exposures on infants’ neurodevelopment in the context of co-occurring metals. Maternal metal exposure and select micronutrients’ concentrations were assessed using samples collected at the time of delivery from mothers living across Navajo Nation with community exposure to metal mixtures originating from abandoned uranium mines. Infants’ development across five domains was measured at ages 10 to 13 months using the Ages and Stages Questionnaire Inventory (ASQ:I), an early developmental screener. After adjusting for effects of other confounding metals and demographic variables, prenatal exposure to lead, arsenic, antimony, barium, copper, and molybdenum predicted deficits in at least one of the ASQ:I domain scores. Strontium, tungsten, and thallium were positively associated with several aspects of infants’ development. Mothers with lower socioeconomic status (SES) had higher lead, cesium, and thallium exposures compared to mothers from high SES backgrounds. These mothers also had infants with lower scores across various developmental domains. The current study has many strengths including its focus on neurodevelopmental outcomes during infancy, an understudied developmental period, and the use of a novel analytical method to control for the effects of co-occurring metals while examining the effect of each metal on neurodevelopmental outcomes. Yet, future examination of how the effects of prenatal exposure on neurodevelopmental outcomes unfold over time while considering all potential interactions among metals and micronutrients is warranted.

The effect of brain-derived neurotrophic factor on motor development and its relation to the pattern of feeding in early infancy

Background Infant feeding is a modifiable health behavior that has long-term effect on various aspects of infant's neurodevelopmental achievement. Neurotrophins are a family of proteins, especially nerve growth factor and brain-derived neurotrophic factor (BDNF), that play a major role in the development, nutrition, growth, and maintenance of the neurons. Moreover, BDNF has a major role in axonal guidance, promoting growth of dendrites and dendritic spines, and in the pathogenesis of neurodegenerative, cardiometabolic, and autoimmune diseases. Aim This study aimed to evaluate the effect of feeding pattern in the first 6 months of life on BDNF serum level and motor development in early infancy. Patients and methods This cross-sectional study included 60 clinically healthy infants aged 6–12 months who were categorized according to their feeding pattern in the first 6 months of life into 30 breastfed and 30 formula-fed infants. BDNF serum levels were measured by enzyme-linked immunosorbent assay, and Denver developmental screening tests were assessed in relation to the feeding pattern. Results Infants with delayed achievement of motor milestones had significant lower level of BDNF than those with appropriate development. Breastfed infants had higher BDNF level (3.45±1.6 ng/ml) than formula-fed infants (1.98±1.30 ng/ml) (P<0.0001). Achievement of motor developmental milestone was significantly delayed in artificially fed than breastfed infant (43.3 vs. 16.7%) (P=0.02). Regression analysis demonstrated that BDNF is an independent predictor of motor development in early infancy. Conclusion BDNF is an important regulator of motor development in early infancy. Serum level of BDNF was higher; achievement of motor milestones was earlier in breastfed than formula-fed infants. Health programs encouraging exclusive breastfeeding in the first 6 months of life should be established. Efforts should be done to follow-up the motor development of artificially fed infant for early detection of any delay.

Knowledge, Attitudes and Practices of Caregivers of Children 0 - 23 Months in Eastern and Central Uganda

Introduction: Appropriate feeding and consequently good nutritional status of young children largely depends on their caregivers. Aim: The current study aimed at assessing maternal/caregivers’ current knowledge, attitudes, practices, and beliefs regarding different aspects of infant and young child feeding in Eastern and Central Uganda. Methodology: A cross-sectional survey design with mixed methods employing both qualitative and quantitative methods was used for data collection. Results: The study participants included 556 caregivers and 572 children. Results indicate that most caregivers (77%) were knowledgeable about key infant and young child feeding practices such as breastfeeding, complementary feeding and meal frequency. However, culture and economic hardships were a major barrier to the applicability of this knowledge. Nearly all (98%) children were ever breastfed with 41% having been initiated on breast milk in the first hour after birth and 68% of all the children below 6 months exclusively breastfed. Three percent of the children aged 6 - 23 months were classified as having either Moderate (2%) or Severe (1%) Acute malnutrition. The median birth weight was 3.2 Kgs with nine percent of the children classified as underweight at birth. The majority (78%) of the children consumed foods from at least four food groups however only 44% consumed heme-rich animal flesh food such as meat, poultry, organ meats and fish, 29% consumed milk and milk products while only 11% consumed eggs. The barriers to improved nutritional status and health-seeking behaviour in children from both regions were largely similar. Some of these included cultural practices which prohibit children from eating certain foods and lack of drugs in the health facilities. Lack of male involvement was a key barrier to health-seeking behaviour and the nutritional well-being of children. Males were, however, more knowledgeable about the key childcare practices that are critical to positive outcomes because they listen to radios, have access to social media and usually congregate at bars where this information is disseminated and exchanged. Conclusion: There should be continuous sensitization of mothers on the benefits of breastfeeding with special focus on early initiation and exclusive breastfeeding as well as child feeding practices during illness. To increase protein intake in children 6 - 23 months, interventions aimed at increasing consumption of these vital nutrients such as promotion of nutrition-sensitive agricultural enterprises like rearing of small livestock and chickens should be emphasized. Consumption of these foods is critical, especially during pregnancy and infancy. Finally, male involvement in maternal and child feeding should be encouraged.

COVID-19 Illness: Mother–Baby Separation, Viruses, and Breastfeeding

ObjectivesSome hospitals have instituted separation of mothers and their newborn(s) when SARS-CoV-2 is suspected or confirmed in the mother. Limited data are available for SARS-CoV-2 vertical transmission, including studies on breast milk. This article looks at SARS CoV-2 case studies and data to date as well as prior pertinent research.MethodsInformal searches of PUBMED, CINAHL and Ovid Emcare were used to identify early reports of vertical transmissions of the novel Coronavirus, case reports, and population based reports of early evolving protocols and their outcomes. As this is a novel virus the authors used previously identified anti-infectivity and antiviral mechanisms of human milk on other similar viruses to guide analysis. Further this article reviewed the well established literature regarding the risks of undue infant separation which negatively affect nearly every aspect of infant and maternal health.ResultsInformal searches conducted in the spring and early summer of 2020 identified 14 early reports attempting to analyze the initial and evolving global response to SARS-CoV-2 and the effects of the virus on the maternal-infant dyad.ConclusionThe feasibility of single-family rooms and support for breastfeeding as an alternative approach that addresses many of the risks favorably and reduces economic cost, both in lifetime disease burden and direct care are discussed. Initial reports seem to indicate that immediate separation of the mother from her newborn is likely to increase the risk to both mother and infant.

How does adolescent motherhood affect mother–infant/toddler relationship and emotional availability

Background The present study examined the different aspects of infant–mother relationships in adolescent mothers and compared them in adult mothers. Methods Children aged 18–40 months who were referred to our outpatient Infant Mental Health Department were analysed retrospectively. Sociodemographic data, Parent–Infant Relationship Global Assessment Scale (PIR-GAS) scores, and Emotional Availability (EA) Scales scores were analysed. Twenty-nine adolescent mothers being younger than 20 years at the beginning of pregnancy and thirty mothers who were aged at least 25 years were enrolled the same data as adult mother group. Results In the adolescent mothers group, the education years of the mothers, the ratio of mothers having professions were significantly lower (p < 0.001); the spousal age gap was significantly higher than among the adult mothers (p < 0.001). It was also found that an underinvolved relationship pattern was seen more frequently among the mother–infant dyads in the adolescent mothers’ group than in the adult mothers group (p = 0.002). Conclusions Although there were not found many problems in terms of the relationship of adolescent mothers with their infants/toddlers in the current study this may have been due to a small sample, we would like to emphasise that the problems should be detected and appropriate interventions should be made for adolescent mothers. Key points Our main aim for this study was assesment of the effect of adolescent motherhood in terms of infant\ oddler–mother relationship Our findings showed that lower education level and being unemployed were higher in adolescent mothers group. Higher age gap between spouses was found to be associated with adolescent motherhood. Underinvolved relationship was highly prevalent among adolescent mothers Our findings suggest that early motherhood is a risk factor for mother–infant\ oddler–relationship and parenthood. Intervention and education programs during and after pregnancy for adolescent girls may help them to prepare for motherhood more consciously and form established relationships with their infants.

Infants’ intentionally communicative vocalizations elicit responses from caregivers and are the best predictors of the transition to language: A longitudinal investigation of infants’ vocalizations, gestures and word production

What aspects of infants' prelinguistic communication are most valuable for learning to speak, and why? We test whether early vocalizations and gestures drive the transition to word use because, in addition to indicating motoric readiness, they (a) are early instances of intentional communication and (b) elicit verbal responses from caregivers. In study 1, 11 month olds(N=134) were observed to coordinate vocalizations and gestures with gaze to their caregiver's face at above chance rates, indicating that they are plausibly intentionally communicative. Study 2 tested whether those infant communicative acts that were gaze-coordinated best predicted later expressive vocabulary. We report a novel procedure for predicting vocabulary via multi-model inference over a comprehensive set of infant behaviours produced at 11 and 12 months (n=58). This makes it possible to establish the relative predictive value of different behaviours that are hierarchically organized by level of granularity. Gaze-coordinated vocalizations were the most valuable predictors of expressive vocabulary size up to 24months. Study 3 established that caregivers were more likely to respond to gaze-coordinated behaviours. Moreover, the dyadic combination of infant gaze-coordinated vocalization and caregiver response was by far the best predictor of later vocabulary size. We conclude that practice with prelinguistic intentional communication facilitates the leap to symbol use. Learning is optimized when caregivers respond to intentional vocalizations with appropriate language.

Early Life Predictors of Socio-Emotional Development in a Sample of Egyptian Infants.

IntroductionEmotional problems are amongst the most critical concerns to be intentionally handled to enhance the wellbeing and development of children.ObjectiveTo determine the predictors of socio-emotional development of Egyptian infants related to infant feeding practices, aspects of infant and maternal health and socioeconomic status.Subjects and MethodsA cross-sectional comparative study included 322 breast fed, 240 bottle fed and 93 mixed fed infants, from 6–24 months of age, who were enrolled in the Well–Baby Clinic of the National Research Centre and from pediatric outpatient facilities in urban Cairo. Assessment of socio-emotional development was performed using Bayley Scales of Infant and Toddler Development (Bayley III). Detailed maternal and infant history was recorded. Levels of serum zinc, copper, iron, vitamin B12 and complete blood count (CBC) were assessed in a subsample of 193 infants.ResultsThe risk of having below average socio-emotional composite score was nearly two and half times among formula-fed infants than among breast-fed infants. By binary logistical regression analysis, predictors of below average socio-emotional score were a lower serum zinc value, being formula fed during the first half-year and introduction of complementary food before the age of six months (p< 0.05).ConclusionExclusive breastfeeding and to a lesser extent mixed feeding during the first half year is correlated with above average socio-emotional development. Maternal education and zinc status were also determinants of better infant mental health. Our endeavors ought to be directed towards integrated interventions addressing multiple risks to children’s development.

The Quality of Spontaneous Movements of Preterm Infants: Associations with the Quality of Mother–Infant Interaction

The assessment of the quality of infants’ spontaneous movements is a diagnostic tool for the young nervous system. We examined whether it relates to the quality of the interactions between infants born preterm and their mothers. Thirty‐nine healthy infants born preterm (Mage in weeks = 14.59, SD = 2.21; 38.46% female) and their mothers participated in the study. Infants’ quality of spontaneous movements was assessed using the General Movement Assessment according to Prechtl (Prechtl, Early Human Development 1990, 23, 151). A new measurement was employed to evaluate the following aspects of the mother–infant interaction: maternal sensitivity in the motor modality (i.e., when touching, picking up, holding, and putting down the infant), maternal sensitivity in the modalities of vocalization and eye contact, and infants’ positive engagement. Several aspects of infants’ quality of movements were associated with maternal sensitivity in the motor modality and infants’ positive engagement, but not with maternal sensitivity in the modalities of vocalization and eye contact. These findings suggest that the quality of infants’ spontaneous movements may explain some of the variability in the interactions between infants born preterm and their mothers. The results also highlight the importance of differentiating between the modalities of mothers’ behavior when assessing their sensitivity. Implications for research and practice with families of preterm infants are discussed.

Influência do estado comportamental nos padrões de sucção de recém-nascidos pré-termo

Objetivo Verificar a influência do estado comportamental na sucção não nutritiva, na sucção nutritiva e na performance alimentar de recém-nascidos pré-termo, no momento da liberação da via oral. Métodos Participaram 32 recém-nascidos pré-termo, clinicamente estáveis, internados em uma unidade de terapia intensiva neonatal. Foram realizadas, por um fonoaudiólogo, as avaliações do estado comportamental, padrão postural, reflexos orais, características dos órgãos fonoarticulatórios, sucção não nutritiva e nutritiva, número de suções por bloco de sucção, taxa de transferência e desempenho alimentar, após a liberação médica para início da alimentação por via oral. Resultados Não foi possível verificar associação do estado comportamental com a sucção não nutritiva. Na sucção nutritiva, verificou-se influência do estado comportamental sobre o número de sucções nos três primeiros blocos, ou seja, o estado de alerta, ao iniciar a mamada, possibilitou aos recém-nascidos apresentarem maior número de sucções, quando comparados aos recém-nascidos em estado de sono. Isto se refletiu na performance alimentar, por meio da maior taxa de transferência e melhor desempenho, embora não tenha sido observada significância estatística quanto a esses aspectos. Conclusão Os achados mostram que o estado comportamental não influenciou os aspectos de sucção não nutritiva, considerados, entretanto, na sucção nutritiva. O estado de alerta apresentou associação com maior número de sucções por bloco, em relação ao estado de sono.

The phonological forms and perceived functions of janyarrp, the Gurindji ‘baby talk’ register

Baby talk is an aspect of infant- or child-directed speech where caregivers imitate children's immature productions in stylized form. Within non-generativist approaches to language acquisition, children's language acquisition is often viewed an emergent response to a highly patterned linguistic environment, at least some of which is tailored by caregivers to children's cognitive and social needs. Some cross-cultural research, however, has disputed whether caregivers modify speech to children in all cultures, and whether or to what extent special infant- or child-directed speech is necessary for successful language acquisition. In this paper we present new cross-linguistic and cross-cultural data on baby talk or janyarrp among Gurindji people. Using a corpus of naturalistic family interactions and interviews with Gurindji people of northern Australia we describe the phonological modifications and specific lexicon of baby talk and investigate its possible functions. Several phonological reductions were found which are familiar from baby talk and child speech in other languages, including rhotic replacement and cluster reduction. More unusually, baby talk neutralizes the three-way coronal contrast in Gurindji Kriol, the language which Gurindji children learn at home. The functions of baby talk for Gurindji people likewise seem to comprise familiar baby talk functions like holding attention as well as less familiar functions, such facilitating children's imitations in production.

226 Prenatal blood lead level and childhood neurobehavioral deficit

ObjectivesLead is one of the oldest known toxic metals. For decades, its effects on child development has been remained a topic of concern with an increased interest in ‘what prenatal...

Maternal pre-pregnancy body mass index is not associated with infant and young child feeding in low-income Mexican children 1-24 months old

Pre-pregnancy overweight and obesity is associated with shorter breastfeeding (BF) duration. Whether pre-pregnancy overweight and obesity is associated with other aspects of infant and young child feeding (IYCF) has not been investigated. We used data from 370 children born January 1999-September 2001 in a semi-urban community in Morelos, Mexico, where information on how they were fed was available at 1, 3, 6, 9, 12, 18 and 24 months of age. We modified the World Health Organization's dietary diversity indicator to assess the quality of the complementary foods. An index that included BF, quality of complementary foods and other behaviours was constructed to measure IYCF. We used survival analysis to examine the association of pre-pregnancy body mass index (pBMI) category and BF duration and mixed models for quality of complementary food and IYCF index. Mean maternal pBMI was 24.4 ± 4.1; 31% were overweight, and 9% were obese. pBMI was not associated with BF duration. Quality of complementary food improved over time (6 months, 1.3 ± 1.3; 24 months, 3.8 ± 1.04). Compared with normal-weight women, overweight and obese women were more likely to feed from more food groups (0.24 ± 0.11 point, P=0.03), but this did not improve diet diversity from 6 to 24 months. IYCF index decreased throughout follow-up (1 month, 7.8 ± 2.4; 24 months, 5.5 ± 1.8), and pBMI was not associated with IYCF (-0.11 ± 0.13 point, P=0.4). We conclude that heavier women were not engaging in IYCF behaviours that were distinct from those of normal-weight women from 1 to 24 months post-partum.

Child-Related Interparental Conflict in Infancy Predicts Child Cognitive Functioning in a Nationally Representative Sample

While associations between exposure to marital conflict and child development have been documented extensively in middle childhood and adolescence, few studies have examined the developmental consequences of conflict exposure in infancy. Moreover, those that have examined marital conflict in infancy tended to focus on consequences of conflict exposure on infants’ attachment security, and various aspects of infants’ physiological and emotion regulation. Virtually nothing is known about the longitudinal links between exposure to interparental conflict in infancy and later cognitive development. Using longitudinal data on a subsample of infants (N = 6,019) and their parents who participated in the Early Childhood Longitudinal Study, Birth Cohort (ECLS-B), this study examined links between the frequency of interparental conflict at 9 months and child cognitive development 15 months later. Combining data from parent interviews, birth certificates, in-home assessments of child cognitive development, and videotaped parent–child interactions, results showed significant negative associations between the frequency of child-related interparental conflict at 9 months of age and child cognitive ability at 24 months. The negative association reflects a direct effect that was not mediated by parental support or child attachment security measured at 24 months. Associations were calculated while considering children’s prior cognitive functioning (at 9 months), and a wide range of child, parent and household characteristics.

Say It Like You Mean It: Mothers’ Use of Prosody to Convey Word Meaning

Prosody plays a variety of roles in infants' communicative development, aiding in attention modulation, speech segmentation, and syntax acquisition. This study investigates the extent to which parents also spontaneously modulate prosodic aspects of infant directed speech in ways that distinguish semantic aspects of language. Fourteen mothers of two-year-old children read a picture book to their children in which they labeled pictures using dimensional adjectives (e.g., big, small, hot, cold). Recordings of the mothers' input to their children were analyzed acoustically and antonyms within each dimension were compared. Mothers modulated aspects of their prosody including amplitude and duration of target words and sentences to distinguish dimensional adjectives. Mothers appear to recruit prosody in the service of word learning.

Urinary excretion ofin vivo13C-labelled milk oligosaccharides in breastfed infants

Recent observations indicate that human milk oligosaccharides (HMO) are involved in a variety of physiological processes in infants. Their metabolic fate, however, is virtually unknown. We investigated metabolic aspects in infants after endogenous 13C-labelling of HMO. An oral bolus of natural and 13C-labelled galactose (Gal; 23 g Gal+4 g 13C-Gal) was given to ten lactating women. Aliquots of milk at each nursing as well as breath samples from the mothers and urine from their infants were collected over 36 h. The 13C-enrichment of HMO and their renal excretion was determined by isotope ratio-MS; characterisation was achieved by fast atom bombardment-MS. After the Gal bolus was given, an immediate 13C-enrichment in milk and in infants' urine was observed which lasted 36 h. Mass spectrometric analysis of 13C-enriched urinary fractions confirmed the excretion of a variety of neutral and acidic HMO without metabolic modification of their structures. Components with glucose split off at the reducing end were also detectable. Quantitative data regarding the infants' intake of lacto-N-tetraose and its monofucosylated derivative lacto-N-fucopentaose II ranged from 50 to 160 mg with each suckling, respectively; renal excretion of both components varied between 1 and 3 mg/d. Since the intake of individual HMO by the infants was in the range of several hundred mg per suckling, i.e. several g/d, and some of these components were excreted in mg amounts as intact HMO with the infants' urine, not only local but also systemic effects might be expected.

Neurological disorders affecting the lower limb in children

Changes in foot and ankle posture are a normal aspect of infant and child development but may also reflect neurological conditions affecting the brain, spinal cord, peripheral nerves or muscles. Development of cavus or planus foot deformities often reflects underlying neurologic disorders and may predate development of more overt neurological signs. This session will concentrate upon signs and symptoms suggestive of occult neurologic problems in children presenting with positional or developmental abnormalities of the lower limbs.

How Well are Australian Infants and Children Aged 4 to 5 Years Doing?

This report presents an analysis of the data from the first wave of the Longitudinal Study of Australian Children (LSAC) to explore the wellbeing of over 10,000 Australian infants and children. This report presents an analysis of the data from the first wave of the Longitudinal Study of Australian Children (LSAC) to explore the wellbeing of 5,107 children in the infant cohort of the study and the 4,983 children, aged 4 to 5 years, in the child cohort. Wave 1 of LSAC includes measures of multiple aspects of children's early development. These developmental measures are summarised in the LSAC Outcome Index, a composite measure which includes an overall index as well as three separate domain scores, tapping physical development, social and emotional functioning, and learning and cognitive development. This report explores five specific aspects of infants' and children's experiences, exposures and environments in relation to their Outcome Index scores: * key sociodemographic characteristics covering the child, mother, family and neighbourhood * non-parental care experiences * child health—prenatal and postnatal experiences and exposures * maternal physical and mental health * the early educational experiences of the child cohort in the home and out-of-home contexts. This paper is by Melissa Wake, Ann Sanson, Donna Berthelsen, Pollyanna Hardy, Sebastian Misson, Katherine Smith, Judy Ungerer and the LSAC Research Consortium.

Cardiac aspects in infants with Pompe disease: Antenatal diagnosis by fetal echocardiography improves outcome

Cardiac aspects in infants with Pompe disease: Antenatal diagnosis by fetal echocardiography improves outcome