Aspects Of Integration Research Articles

Deciphering the Role of the Nucleus Accumbens Shell Area on Spatial Memory Deficits Induced by Neuropathic Pain in Rats

The nucleus accumbens shell (NAcSh) is a major structure associated with distinct aspects of reward and mnemonic information encoding, relying on spatial data to define optimal behavioral strategies. Chronic pain-derived striatal plasticity is considered one underpinning cause of working memory (WM) impairments. However, it is unclear how the NAcSh is involved in these spatial deficits. To address this, we evaluated the impact of unilateral local NAcSh electrical lesions during the execution of a food-reinforced eight-shaped spatial alternation WM task. Behavioral performance was assessed in rats after the onset of the neuropathic pain model—spared nerve injury (SNI). Our findings indicate that the induction of SNI and/or NAcSh lesions did not significantly impact the animals’ performance accuracy or motor activity during the execution of the behavioral task, but altered their response latency patterns. In addition, these manipulations did not induce significant antinociceptive effects. Collectively, these results suggest that the NAcSh may participate in specific aspects of spatial information integration and processing under neuropathic pain conditions.

Emotional Distress Symptoms, Coping Efficacy, and Social Support: A Network Analysis of Distress and Resources in Persons With Cancer.

The study's main aim was to analyze the structure and configuration of distress symptoms and resource factors. Common methods of assessing distress symptoms in cancer patients (i) do not capture the configuration of individual distress symptoms and (ii) do not take into account resource factors (e.g., social support, coping, caring health professionals). Network analysis focuses on the configuration and relationships among symptoms that can result in tailored interventions for distress. Network analysis was used to derive a symptom-level view of distress and resource factors. Nine hundred and ninety-two cancer patients (mixed diagnoses) completed an abridged Distress Screening Schedule that included 24 items describing symptoms related to distress (depression, anxiety) and resource factors (social support, coping, caring health professionals). In network analysis, the centrality strength index (CSI) is the degree to which an item is connected to all other items, thus constituting an important focal point in the network. A depression symptom had the highest CSI value: felt lonely/isolated (CSI = 1.30). In addition, resource factors related to coping efficacy (CSI = 1.20), actively seeking support (CSI = 1.10), perceiving one's doctor as caring (CSI = 1.10), and receiving social support (CSI = 1.10) also all had very high CSI scores. These results emphasize the integral importance of the social symptoms of loneliness/isolation in distress. Thus, distress symptoms (loneliness) and resource factors (coping efficacy, seeking social support, and perceiving medical professionals as caring) should be integral aspects of distress management and incorporated into assessment tools and interventions to reduce distress.

Isotretinoin‐associated intracranial hypertension: A concise report

AbstractWe present a case of a 24‐year‐old preobese female undergoing isotretinoin treatment for acne vulgaris, who experienced drug‐induced intracranial hypertension (DIIH). Recognizing and addressing this potentially serious adverse effect is essential to prevent severe outcomes, particularly irreversible vision impairment. When suspected, immediate discontinuation of isotretinoin, neuroradiological imaging and urgent ophthalmologic evaluation to rule out papilloedema is imperative. Formulation of alternative treatment strategies, caution while prescribing DIIH‐causing drugs in future patient treatments and proactive reporting of adverse events are integral aspects of its comprehensive management.

APPLICATION OF ARTIFICIAL INTELLIGENCE IN THE EDUCATIONAL PROCESS: PREPARATION OF FUTURE EDUCATORS FOR THE USE OF AI IN TEACHING PRACTICE

This study analyzes the application of artificial intelligence (AI) in the educational process with an emphasis on preparing future teachers to use it effectively in educational practice. The paper considers various aspects of AI integration in education, including personalization of learning, adaptive assessment, and the development of AI-supported educational platforms. Particular attention is paid to the analysis of current pedagogical practices and identification of the main benefits and challenges associated with the implementation of AI in the educational process. In addition, the study suggests for preparing future teachers to use AI to ensure inclusiveness and accessibility of education for all students. The results of the study provide valuable scientific and practical findings that can be used to develop training programs and courses on the integration of AI in educational activities.

Evidence-based decision-making in a climate of political expediency: insights from local government

Aims: Local authorities in England are responsible for public health and health promotion. This article sought to explore how research and decision-making co-exist in a local authority in England. Methods: An Embedded Researcher was based within the local authority and used qualitative methodology to address the research aim. Interviews and focus groups were employed to ascertain a range of stakeholder views in the local authority. All transcripts were coded on NVivo 12 by the Embedded Researcher and two members of the research team cross-checked a sample for coding accuracy. Data were analysed using framework analysis. Results: The data suggest several barriers to using research to inform decision-making in health promotion and public health. The study shows that research is valued in local authorities, but not always privileged – this is due to cultural factors and practical political reasons which often means that decisions need to be made expediently. Participants outlined a juxtaposition between academic credibility; timeliness to complete the research and the financial cost associated with it; against the independence and credibility that independent academics could bring. Conclusion: Policy formulation and delivery is an integral aspect of health promotion and critical to achieving improved population health and reductions in health inequalities. However, there exists tensions between gathering research evidence and making research-informed decisions. The article concludes by advocating the use of Embedded Researchers to fully understand how research is gathered and used to support public health and health promotion policymaking.

“Trying to write a story together”: general practitioners’ perspectives on culturally sensitive care

BackgroundCulturally sensitive care is integral to effective and equitable healthcare delivery, necessitating an understanding and acknowledgment of patients’ cultural needs, preferences, and expectations. This study investigates the perceptions of cultural sensitivity among general practitioners (GPs), focusing on their intentions, willingness and perceived responsibilities in providing care tailored to cultural needs.MethodsIn-depth interviews were conducted with 21 Flemish GPs to explore their perspectives on culturally sensitive care. Data analysis followed a conventional qualitative content analysis approach within a constructivist framework. A coding scheme was developed to identify recurring themes and patterns in the GPs’ responses.ResultsFindings reveal that culturally sensitive care provision is perceived as a multifaceted process, initiated by an exploration phase where GPs inquire about patients’ cultural needs and preferences. Two pivotal factors shaping culturally sensitive care emerged: patients’ specific cultural expectations and GPs’ perceived responsibilities. These factors guided the process of culturally sensitive care towards three distinct outcomes, ranging from complete adaptation to patients’ cultural requirements driven by a high sense of responsibility, through negotiation and compromise, to a paternalistic approach where GPs expect patients to conform to GPs’ values and expectations. Three typologies of GPs in providing culturally sensitive care were identified: genuinely culturally sensitive, surface-level culturally sensitive, and those perceiving diversity as a threat. Stereotyping and othering persist in healthcare, underscoring the importance of critical consciousness and cultural reflexivity in providing patient-centered and equitable care.ConclusionsThis study emphasizes the significance of empathy and underscores the necessity for GPs to embrace the exploration and acknowledgement of patients’ preferences and cultural needs as integral aspects of their professional role. It highlights the importance of shared decision-making, critical consciousness, cultural desire and empathy. Understanding these nuances is essential for enhancing culturally sensitive care and mitigating healthcare disparities.

The conserved σD envelope stress response monitors multiple aspects of envelope integrity in corynebacteria.

The cell envelope fortifies bacterial cells against antibiotics and other insults. Species in the Mycobacteriales order have a complex envelope that includes an outer layer of mycolic acids called the mycomembrane (MM) and a cell wall composed of peptidoglycan and arabinogalactan. This envelope architecture is unique among bacteria and contributes significantly to the virulence of pathogenic Mycobacteriales like Mycobacterium tuberculosis. Characterization of pathways that govern envelope biogenesis in these organisms is therefore critical in understanding their biology and for identifying new antibiotic targets. To better understand MM biogenesis, we developed a cell sorting-based screen for mutants defective in the surface exposure of a porin normally embedded in the MM of the model organism Corynebacterium glutamicum. The results revealed a requirement for the conserved σD envelope stress response in porin export and identified MarP as the site-1 protease, respectively, that activate the response by cleaving the membrane-embedded anti-sigma factor. A reporter system revealed that the σD pathway responds to defects in mycolic acid and arabinogalactan biosynthesis, suggesting that the stress response has the unusual property of being induced by activating signals that arise from defects in the assembly of two distinct envelope layers. Our results thus provide new insights into how C. glutamicum and related bacteria monitor envelope integrity and suggest a potential role for members of the σD regulon in protein export to the MM.

The Relationship between Political Image and Voting Behavior in First-time Voters: Demographics of Generation Z Voters in the 2024 Election in Indonesia

Purpose: This research aims to determine the relationship between voting behavior and political image as well as the demographic characteristics of the voting behavior tendencies of Generation Z in the 2024 Election in Indonesia. Methods: Data collection uses a questionnaire that has good validity and reliability, the questionnaire contains a measurement scale for voting behavior and political image. The measurement of voting behavior variables uses a scale that includes aspects of knowledge, attitudes and actions. Meanwhile, the measurement of the political image variable uses a scale that includes aspects of competence, benevolence, integrity, fairness and reliability. Respondents are given alternative answers to choose one of the four answers provided starting from the options Strongly Agree to Strongly Disagree. Scoring for each answer choice for each variable is 1-4. Apart from that, the questionnaire also contains descriptive questions regarding respondents’ voting tendencies. The number of samples that met the criteria for first-time voter respondents was 453 respondents taken using a purposive sampling technique. The data analysis technique uses the Pearson Product Moment Correlation Test (r) which aims to determine the level of closeness of the relationship between variables which is expressed by the correlation coefficient (r). Results: The research results show a significant positive correlation between political image and voting behavior. The findings also show that the categorization of respondents’ political image is medium and the categorization of voting behavior is in the high category. The majority of respondents chose candidates based on their track record, ethnicity and religion, having a nationalist and religious image, and looking cool and trendy. Conclusion: The political image and voting behavior of Generation Z can be concluded to be correlated with each other. This research also shows how the candidate’s political image is desired by first-time voters.

Contradictions of the Marginal Utility Theory of Value? Identifying Some Logical Errors

This article engages in an exploration and identification of potential internal contradictions such as logical errors in the marginal utility theory of value. Specifi-cally, it explores and attempts to identify possible logical contradictions between certain integral elements and aspects of this theory. It first investigates and ana-lyzes potential logical contradictions between the ‘law of satiable wants' and the ‘law' of diminishing marginal utility within the marginal utility theory of value fo-cusing on its early formulations and later elaborations. It then explores and ana-lyzes possible logical contradictions between the status of marginal utility theory as a subjective or individualistic and as a psychological theory of value. It con-cludes that the marginal utility theory of value manifests certain internal contra-dictions in the form of logical errors.

Water Intrusion: An Analysis of Water Sources, Categories, and the Degradation Science of Building Materials

Water intrusion into a building envelope describes the unwanted movement of water or vapor into a building, where it causes damage. Various factors dictate water intrusion category determination and classification. These factors include, but are not limited to, the type and degree of water intrusion, the source and route of the contamination, and exposure time, as well as geographical environmental conditions. This comprehensive research paper looked at the literature and the science to explore the bases for indoor environmental professional (IEP) classification and category determination, but also the science behind the effects of water intrusion on building materials (BM). The efficacy of building materials once degradation has occurred and any accelerating effects impacting the efficiency of building materials and their loss of integrity were closely examined in terms of material microstructural and compositional changes. The damaging effects of moisture and heat on building materials are called hygrothermal damage, which compromises the properties and use of materials. Both aspects of building integrity, i.e., water intrusion and structural deterioration, should be of concern when mitigating and remediating the intrusion of moisture. Previous research on the clarification of water categories for water intrusions is lacking. Past approaches to water classification have lacked universal scientific clarity and understanding. In addition to a need to understand the effects that water category might have on building materials and their corresponding degree of degradation, more science and reviews are needed. The need for proper class and category determination for the remediation of water intrusion within buildings is the first step toward achieving correct mitigation to ensure human health and safety. The possible adverse health effects of water intrusion need focus and cohesion for the determination of categories. We know that the final determination of water categories differs according to the degree of contamination over time and the degree of a given class of water intrusion; however, what role do the route and initial water contamination play in the determination of the category? The following paper aims to provide not only a review of the science but also an elaboration of the category determination process and the degradation effects on building materials which should be considered, as well as possible avenues of scientific research.

Genesis of economic integration of Ukraine into the EU

The paper examines the genesis of economic integration of Ukraine to the EU. The purpose of the paper is to investigate the genesis of economic integration of Ukraine to the EU and develop recommendations for their development. The result of bilateral trade integration following the implementation of the consolidated and all-inclusive free trade zone was the modernization of Ukraine's trade policy. The primary dominants may include: the increase in trade turnover between the countries and the increase in the share of European countries in the structure of foreign trade of Ukraine; changes in import duties; improved access to the market; harmonization of legislation; establishment of tariff quotas; а further reduction in non-tariff barriers to trade; home ownership of the region is one hundred percent improved robotic work; harmonization of the technical regulation system; systems of standardization, metrology, conformity assessment and market visibility; sanitary and phytosanitary visits; Strengthening the protection of intellectual rights. The genesis of economic integration of Ukraine to the EU was investigated. An analysis of the Vikonanny Ugodi about association for 2022 and 2023 was carried out. We have analyzed the strengths and weaknesses, the emerging opportunities and threats to the integration of Ukraine into the EU. Directly from further scientific research, it is important to look at the most important aspects of the economic integration of Ukraine, since the most important payments will ensure the formation of the revenue side of the budget from further It is re-divided into different socio-economic goals of the state.

Deep learning-assisted structural health monitoring: acoustic emission analysis and domain adaptation with intelligent fiber optic signal processing

Structural health monitoring aims to detect damage progression in materials. This study focuses on categorizing crack stages, a critical aspect of monitoring structural integrity. By leveraging acoustic emission (AE) monitoring, cracks can be analyzed in a data-driven manner. However, applying AE analysis poses several challenges, including discrepancies between simulated AE data from models and experimental data from the field, as well as class imbalance in crack progression data, with a scarcity of late-stage data. To bridge the gap between theory and experiments, our approach employs domain adaptation to synchronize simulated and actual AE data. The model learns robust domain-invariant features through meticulous experimentation across training epochs. Quantitative analysis of the model’s performance provides key insights. F1 scores vary with feature counts, and domain adaptation outperforms by 20% on highly imbalanced datasets. This emphasizes the model’s adaptability for precise crack classification, even with underrepresented damage classes. In summary, this study advances structural health monitoring by offering a solid AE analysis approach. Core contributions include reconciling simulated and experimental data discrepancies, tackling class imbalance, optimizing feature extraction, and demonstrating robust crack stage categorization. The insights gained highlight the merits of domain adaptation and data-driven AE analysis for predicting crack progression.

The Main Directions of Supranational Regulation of the Digital Space in the EAEU at the Present Stage

Introduction. The study of the main directions of supranational regulation of the digital space is an important task in the context of the constant complication and expansion of social relations in the digital sphere. The creation of effective and progressive regulation in the relevant area can become the basis for increasing the competitiveness of the EAEU on the world stage. At the same time, the corresponding issues have been practically not studied in the domestic academic literature. Within the framework of this article, an attempt has been made to comprehensively assess the system of supranational regulation of the digital space in the EAEU, to identify its strengths and weaknesses.Materials and methods. The methodological basis of the study was made up of general scientific and special scientific methods. General scientific methods are presented: analysis, synthesis, inductive-deductive method, systematic method. Special scientific methods include: the method of systemic analysis of law, the comparative legal method, the formal legal method. The research materials are presented by supranational acts of the EAEU (primarily the Treaty on the EAEU and its protocols), official documents and statements, as well as doctrinal concepts and approaches.Results of the study. The article analyzes and evaluates the key areas of supranational regulation of the digital space in the EAEU at the present stage. The conceptual and legal foundations of the relevant regulation are identified (including in comparison with the EU approach to supranational regulation of the digital space) and their role and significance for the development of supranational regulation of the digital space in the EAEU is analyzed. Changes in the customs legislation of the EAEU in terms of supranational regulation of external (with the participation of residents of third countries) electronic trade are involved in scientific circulation.Discussion and conclusion. Based on the results of the study, it was concluded that currently the system of supranational regulation of the digital space in the EAEU is at the stage of its formation and extends only to four main areas: the circulation of non-personal data, public procurement, intellectual property protection and external electronic commerce. At the same time, recent initiatives in the field of supranational regulation of external electronic commerce represent an important step towards a new stage in the development of digital aspects of Eurasian integration.

Music Education in China and the Philippines: The Exploration of Tradition and Integration

As two countries with characteristics, China and the Philippines both carry rich cultural heritage and historical background, especially in the field of music education have formed a unique tradition. In China, as an ancient civilization with a long history, its music education is deeply influenced by traditional culture. The inherited classical music, national Musical Instruments and music education concepts all highlight the extensive and profound Chinese culture. In the Philippines, as a country with diverse cultures, its music education integrates a variety of foreign cultures and local characteristics, showing a diversified, inclusive and innovative educational style. With the wave of building a community with a shared future for mankind sweeping the world, and culture as the spiritual embodiment of a community with a shared future for mankind, China and the Philippines have also begun to break regional boundaries and conduct frequent exchanges and cooperation. In the aspect of music education, this exchange and integration is not only reflected in the mutual reference of music education concepts, but also includes the sharing and innovation of teaching methods and teaching materials, as well as the exchange of visits and exchanges between teachers and students. In this process, the music education of the two countries is constantly absorbing each other's advantages and making up for their own shortcomings, so as to explore a music education model more in line with the development needs of The Times. This paper traces the origin of music education in the two countries from a historical perspective, deeply analyzes the uniqueness of their respective education systems, and compares the similarities and differences of teaching methods in detail. At the same time, this paper also focuses on the integration phenomenon of Sino-Philippine music education in the background of globalization, which is not only the exchange of technology and methods, but also the deep collision and integration at the cultural level.

CORPORATE SOCIAL RESPONSIBILITY OF JOHNSON AND JOHNSON

Corporate Social Responsibility (CSR) has become an integral aspect of modern business operations, reflecting a company's commitment to sustainable development and ethical practices. Johnson & Johnson, a global healthcare giant, exemplifies a robust CSR framework. This abstract outlines Johnson & Johnson's CSR initiatives, focusing on key areas such as community engagement, environmental sustainability, and ethical business practices. Johnson & Johnson's CSR strategy prioritizes community welfare through various philanthropic programs and partnerships. Their commitment to environmental sustainability is demonstrated through initiatives to reduce carbon footprint, water usage, and waste generation across their operations. Furthermore, the company emphasizes ethical business conduct by adhering to stringent standards of integrity and transparency in their dealings. Keywords: Johnson & Johnson, Corporate Social Responsibility, CSR initiatives, community engagement, environmental sustainability, ethical business practices.

Teori Psikodinamika : Perspektif Multikultural Dalam Trend Pendekatan Psikodinamika

The psychodynamic approach includes a deep understanding of the complex interactions between culture and individual psychological aspects. This approach combines elements of psychodynamics, such as unconscious conflict and psychosexual development, with sensitivity to the role of culture in shaping a person's identity and thought patterns. The aim of this research is to understand in depth the multicultural view in the psychodynamic approach. By using literature study research methods which involve collecting, reviewing, and synthesizing information from relevant text sources to answer research questions or develop arguments. This study supports the aspect of cultural integration in psychodynamic practice to understand mental dynamics in a multicultural context. Psychodynamics in multiculturalism tends to emphasize the importance of understanding the complexity of individuals by considering their cultural background. These conclusions indicate the need to integrate multicultural aspects in psychodynamic practice to understand and respond to the diversity of human experience more holistically

Establishing Faith – The Close Relationships, the Early Influences and the Aspect of Integrity and Trust

Abstract This study examines the establishment of Christian faith amongst Norwegians aged 30–40, with focus on the impact and nature of early religious influences. Employing an explanatory sequential mixed-methods design, the research synthesizes quantitative data from 585 participants, complemented by qualitative follow-ups with 10 respondents from the initial cohort. The tripartite investigation probes into the dynamics of Christian faith formation in this demographic. It particularly scrutinizes the synergy between personal relationships and engagement in Christian practices. The findings suggest a composite of activities that collectively underscore their significance. While youth ministry and parental influence during adolescence play notable roles, the qualities embodied in personal relationships – characterized by warmth, trustworthiness, and integrity – may be more crucial than the structural aspects of the relationships themselves. These insights contest conventional views of predominant influences on faith formation and religious acculturation, underscoring the salience of authentic interpersonal connections in navigating one’s spiritual trajectory.

How to Complete Supply Chain Integration and Improve Supply Chain Performance Through Relationship Governance in the Digital Age

In the process of manufacturing supply chain development, because appropriate governance mechanisms are lacking, manufacturing supply chain stability, integration and other aspects face many challenges. Such as opportunism, “free riding” and data leakage affect supply chain development. Thus, many manufacturing firms are adopting supply chain relationship governance (SCRG) as a strategic to enhance performance. Using data collected from a survey of 295 manufacturing firms, this paper confirms the influence of SCRG on supply chain performance (SCP). The mediating effect of supply chain integration (SCI) and the moderating effect of digital capabilities (DCs) are explored. The results show that SCRG has a beneficial effect on SCP. SCI plays a partial mediating role in SCRG and SCP. DCs positively moderate the relationship between SCRG and SCI. This study is one of the first to explore the role of DCs in the relationship between supply chain partners and the impact on performance. It provides fresh perspectives and real-world evidence for determining the importance of SCRG strategies.

WuMKG: a Chinese painting and calligraphy multimodal knowledge graph

Chinese Painting and Calligraphy (ChP&C) holds significant cultural value, representing integral aspects of both Chinese culture and global art. A considerable amount of ChP&C works are dispersed worldwide. With the emergence of digital humanities, a vast collection of cultural artifacts data is now available online. However, the online databases of these artifacts remain decentralized and diverse, posing significant challenges to their effective organization and utilization. Addressing this, our paper focuses on the Wu Men School of Painting and proposes a framework for constructing a multimodal knowledge graph for the ChP&C domain. We construct the domain ontology by analyzing the ChP&C knowledge schema. Then, we acquire knowledge from diverse data sources, including textual and visual information. To enhance data collection around collecting historical context and subject matter, we propose methods for seal extraction and subject extraction specific to ChP&C. We validate the effectiveness of these methods on the constructed dataset. Finally, we construct the Wu Men Multimodal Knowledge Graph (WuMKG) and implement applications such as cross-modal retrieval, knowledge-based question-answering and visualization.

Understanding and Managing Job Stress in the Service Sector: A Literature Review

Job stress is an integral aspect of human resource development dynamics within organizations. This literature review investigates job stress, highlighting its prevalence as a critical issue for employees in various service sectors, such as healthcare, hospitality, banking, consumer, and courier services. The study sets out to accomplish two primary goals: firstly, to delineate the factors that contribute to job stress, and secondly, to evaluate the repercussions of job stress on employees. By examining insights from ten prior studies, we identify a comprehensive array of internal and external factors that intensify job stress. We further explore the influence of these stressors on vital outcomes, including turnover intentions, employee performance, and burnout. Our findings reveal that job stress significantly impacts employees' intentions to leave. Nonetheless, effectively managing job stress can foster positive outcomes for organizations. These insights underscore the critical need for management in the service sector to grasp the complex origins of job stress fully. Armed with this understanding, they can devise and implement strategies to reduce turnover intentions, bolstering overall organizational performance