Aspects Of Health Research Articles

Discover the Factors of Longevity by Causal Discovery with PC Algorithm and Neural Networks

The study title has been to study the multilayered factors that govern a human prospect of living through the application of the PC Algorithm (Graph-Based Algorithm), logistic regression analysis, and the neural networks in combination. To realign the research purpose, a vast array of data can be used, which included socioeconomic status information alongside health and environmental aspects carefully chosen for their likely influence on how long people can live. This article will explain the longevity determinants by examining not only the conditions but also the environmental and health indicators and their combinatory effects. The PC algorithm can produce a directed acyclic graph (DAG) to see how elements like healthcare spending, education, and CO2 emissions are correlated with human longevity and how they influence each other. Moreover, the research takes other examples by analysis: researchers can examine hypothetical events. Neural networks were employed to depict the interrelationship among these variables which subsequently provided a user-appropriate understanding of their sudden joint influence. Consequently, a hypothesize was purposed that the potential interventions for the elongation of human life. Policy-making researchers can gain a better representation of the situation of health inequality and the new recommended solutions to tackle this problem and increase life expectancy by implementing complex analysis tools to blows away the criminal aspects of human longevity.

The Effect Of Good Dairy Farming Implementation On The Income Level And Efficiency Of Dairy Cows Farmers Businesses In West Malang Regency

The research aims to identify the implementation of Good Dairy Farming Practice, measure the income and efficiency of livestock business. The research was conducted in West Malang Regency from November 2021 to February 2022 in three sub-districts namely Pujon, Ngantang and Kasembon. Samples were taken as many as 100 using purposive sampling method. Data analysis was descriptive quantitative to identify the Good Dairy Farming Practice score, analysis of business efficiency with Cobb Douglass Production Function Regression, analysis of business income and influential factors with Multiple Linear Regression. The results showed that the application of GDFP with sufficient score categories is health aspects (2.84), milking hygiene aspects (2.76), feed nutrition and drinking water aspects (2.43), animal welfare aspects (2.87), environmental aspects (2.64), and unfavorable score category is socio-economic aspects (1.37). The average income of dairy farmers is IDR 70,959,024 per year. The results of income regression analysis showed that the variables of health and nutrition aspects had a very significant effect, the milking hygiene aspect had a significant effect, and the environmental aspect had a less significant effect. The results of the efficiency of the use of factors of milk production with a value of 1.215 showed increasing returns to scale. All aspects of GDFP are in the sufficient category and the socio-economic aspects are in the unfavorable category. This makes the farmer's income less than optimal.

A lifestyle program for socially vulnerable community-dwelling elderly

Abstract Problem Socially vulnerable older adults often face lower health literacy and limited access to health care. Description of the problem Current lifestyle programs are often insufficiently adapted to this socially vulnerable target group. As a result, these older adults are underrepresented in lifestyle programs. From a public health perspective, lifestyle programs that improve the poorer physical and mental health of these older adults, should be made more accessible by involving the expertise, participation and needs of this group. The aim of this study was to develop and implement a lifestyle program adapted to the expectations and needs of socially vulnerable older adults. Results Both the target group and the local community (health) centers were involved during the co-creative phase of development. A neighborhood analysis was used to identify and reach out to the target group. Motivators and barriers for a healthy lifestyle were identified through focus groups. The developed program consisted of 10 weekly group sessions. Various health aspects were integrated, including exercise, nutrition, stress, sleep, positive psychology, meaningful living, and motivation. Nine centers for community dwelling older adults in Flanders and Brussels were included. In total, 93 older adults were recruited out of which 76 completed the full program. In the final phase, the program was evaluated by means of objective and subjective measuring methods. Finally, the local community (health) centers are currently involved in the program’s sustainability through a trainers’ program. Lessons The belongingness, the catering, the empowering attitude of the trainer and the ‘fun’ factor turned out to be success factors for the adherence to the program. The participating centres experienced an increase in numbers of older adults that were attracted to their activities that are focused on healthy lifestyle behaviors. The continuity of the program is currently being examined. Key messages • A neighbourhood analysis in collaboration with local partners helped to reach the target group. • The program was made attractive by the involvement of the older adults, the fun-factor and the small groups.

Possible effects of shipping routes on coral reef degradation and diversity in Karimunjawa Marine National Park, Java Sea

The Karimunjawa Marine National Park, situated in the Java Sea, Indonesia, is renowned for its rich biodiversity and lively coral reefs. However, amidst the backdrop of this natural beauty, concerns have been raised regarding the potential impacts of shipping activities on the health and diversity of these fragile ecosystems. The increase in maritime traffic, including commercial vessels, tourist boats, and fishing vessels, traversing through the Karimunjawa Marine National Park, raises significant environmental concerns. The movement of these vessels, especially along specific shipping routes, has the potential to disturb and damage coral reefs through various mechanisms. Hence, this study aimed to investigate the possible impacts of shipping routes on the coral abundance and diversity and the coral health in the Karimunjawa Islands, Java Sea, Indonesia. This study categorized ship routes into West Route, East Route, and Non-Route and assessed coral health and diversity across 15 islands. Key metrics analyzed included coral disease prevalence, coral cover, diversity index, species richness, relative abundance, and evenness, using 15 × 2 m belt transects at 3 and 8 m depths with three repetitions each. Statistical analysis revealed significant differences in coral abundance and species richness among ship-route groups, but no significant depth-related differences. These results suggest that while shipping routes affect certain aspects of coral health and diversity, other factors may be more influential in shaping coral disease prevalence and overall diversity in Karimunjawa reefs.

Developing a structured framework to address vaccination barriers for Newly Arrived Migrants in EU/EEA

Abstract Background Access to vaccination is a critical aspect of public health, particularly for newly arrived migrants (NAMs) in European Union/European Economic Area (EU/EEA) countries. Despite this, significant barriers exist, necessitating urgent attention. This study addresses the pressing need to improve vaccination coverage for NAMs by developing a General Conceptual Framework (GCF) to understand and overcome system barriers and analyzing possible strategies. Methods starting from a theoretical conceptualization, the study employed a mixed-method approach, incorporating literature review and qualitative research. The GCF was formulated based on key components of the vaccination process. Barriers and solutions were identified through a non-systematic literature review and qualitative investigation. The GCF served as a guide for study activities, facilitating data integration. Results The study outlines a structured GCF comprising five interconnected steps in the vaccination process: entitlement, reachability, adherence, achievement, and evaluation of vaccination. Barriers and solutions identified through literature review and qualitative research are presented. Strategies to enhance professional knowledge, accessibility, adherence, coverage, and intervention evaluation are proposed. Recommendations include proximity strategies, provider training, migrant-sensitive approaches, and robust data collection. Conclusions Equitable access to vaccination is paramount for public health, particularly for vulnerable populations like NAMs in EU/EEA countries. The development of the GCF represents a crucial step towards understanding and addressing barriers to vaccination access. Implementation of recommended strategies can significantly improve vaccination outcomes for NAMs, ultimately contributing to the overall health and well-being of these communities.

Leveraging Social Marketing to Increase Vaccination Rates: A Systematic Review

Abstract Introduction Vaccinations are crucial for protecting individuals from preventable diseases, serving as a cornerstone of public health, safeguarding entire populations. Low vaccination rates can have devastating consequences, leading to outbreaks of preventable diseases. Social marketing has had an increasing role to play in public health. This systematic review seeks to investigate social marketing effectiveness in boosting vaccination adherence. Methods A literature search was conducted in PubMed, Scopus and Cochrane Library, using keywords “social marketing”, ‘campaigns”, “vaccination”, “vaccination uptake”. The search was limited to English-language studies, including studies discussing social marketing campaigns and its impact on vaccination uptake. Prior to inclusion, the studies were evaluated for relevance and applicability to the research question. Included studies were analysed for methodology, sample size, data collection methods, and key findings. Results Of 198 articles identified, 26 studies met inclusion criteria. All studies reported demonstrable improvement in vaccination adherence and hence higher vaccination rates with the use of social marketing campaigns. Targeted messaging on social media allows communication to be tailored to specific demographics and address their unique concerns. Community engagement combats vaccine hesitancy by dismantling misinformation and rebuilding trust. Additionally, these campaigns leverage social influence and mobilise communities to cultivate pro-vaccine attitudes. By addressing personal choice, knowledge gaps, and hesitancy, social marketing paves the way for greater vaccination uptake. Conclusions Social marketing has been proven to be an effective tool in promoting vaccination adherence in public health. As vaccination remains a critical aspect of public health, the continued use of social marketing interventions is essential for improving vaccination rates and ultimately enhancing overall population health. Key messages • Social marketing campaigns lead to higher vaccination rates across various populations. • By addressing vaccine hesitancy, social marketing paves the way for increased vaccination uptake.

Factors associated with major adverse cardiovascular events among Arabs and Jews in Israel: a population-based cohort study

Abstract Introduction Arabs in Israel are at higher risk of cardiovascular mortality; however, there are no data on factors associated with disparities in major adverse cardiovascular events (MACE) incidence among Arabs and Jews. Purpose To study factors associated with MACE incidence among Arabs and Jews in Israel. Materials and Methods This is a cohort study carried out in urban localities of Hadera District in Israel. The study sample included 1,100 participants, stratified in equal numbers by ethnicity (Arab and Jewish), sex, and five 10-year age group (mean age: 51 years, range: 26-77). Data collected via in-person interviews conducted between 2001-2006 included socio-demographic characteristics and health-related behaviors (smoking, physical activity, and diet). Data on baseline diabetes, hypertension, dyslipidemia, and cardiovascular disease were collected from interviews and participants' health records. Information on MACE occurring during follow-up was determined based on hospital discharge diagnoses, recorded in the Israel Ministry of Health hospital admission database. MACE was defined as an acute coronary, cerebrovascular or peripheral artery event, or invasive procedure for its treatment. Factors associated with the time to first MACE were tested in Cox proportional hazards models. Sensitivity analysis included death from any cause as a competing risk, using Fine and Gray’s model. Results During a median follow-up period of 20 years, there were 221 first MACE during follow-up; 91 among Jewish participants and 130 among Arab participants, hazard ratio (HR) Arab vs. Jewish: 1.59; 95% confidence interval (CI) 1.22, 2.09, adjusted for age and sex. Arab ethnicity was no longer significantly associated with MACE, following further adjustment for years of education; HR: 1.32; 95%CI 0.95, 1.84. The HR (95%CI) associated with ethnicity after additional adjustment for health-related behaviors, body weight and baseline chronic morbidity was 1.02 (95%CI: 0.73, 1.42). A subgroup analysis among 950 participants, who did not have a baseline diagnosis of cardiovascular disease, produced similar results. These participants experience 147 first MACE during follow-up. The age and sex-adjusted HR (95%CI) associated with Arab ethnicity was 1.72 (1.23, 2.40), compared to 1.08 (0.72, 1.64) in a fully adjusted model. Competing risk analysis did not materially change these results. Conclusions Arabs in Israel are at higher risk for MACE. Lower socioeconomic position and higher prevalence of unhealthy lifestyle and cardiovascular risk factors may explain the excess risk of MACE among Arabs. Improving cardiovascular health among Arabs should consider social determinants of health and cultural aspects.

The Association between Social Capital, Food Security, and Type 2 Diabetes Management

Abstract Background Given nutrition’s key role in treating diabetes, food insecurity may seriously affect the standard management of the disease. A patient’s social environment or community plays an important role in managing the disease. This study explores how food security and social capital are associated with the management of type 2 diabetes. Methods A cross-sectional telephone survey of 381 Israelis Jewish and Arab with type 2 diabetes was conducted. Data was collected on food security, social capital, disease management factors, and socioeconomic status. Moreover, medical records provided information about HbA1c, age, and disease diagnosis date for each respondent. Results Blood glucose balance (HbA1c ≤7mmol/mol) was associated with employment, while unemployed respondents had a better balance. Food security is correlated with health perception - the better the food security, the better the health perception. Food security is related to social and family support, as well as to neighborhood help and connections. The social capital index increases as food security increases. A higher disease management index score, as well as a higher trust index score, indicates a more balanced patient. In light of the fact that food security is associated with social aspects of health, it may act as a mediator between social capital and perceived health. Conclusions Social factors directly affect the balance of the disease. Subjective health and gender were associated with food security. Social capital and support are linked to subjective health reporting through food security, so this variable is a mediator. It can be concluded that social factors and food security play a role in subjective health assessment in diabetics. Diabetes management and balancing depend not only on behavioral factors but also on environmental and social factors. Key messages • Food security is a necessary factor in balancing blood glucose levels, as well as a mediator factor between social capital and perceived health among diabetics. • A balanced diabetes requires social support, such as a supportive social environment and must consider the individual’s character.

Association Between Dysphagia and Depressive Symptoms: Propensity Score Matching Approaches.

The co-occurrence of depression and dysphagia is obvious to clinicians and has been the focus of several research investigations. Dysphagia not only leads to physical complications but also exerts a negative emotional impact, resulting in a decline in quality of life. The purpose of the study was to investigate the association between dysphagia and depressive symptoms at the population level while accounting for various demographics and health conditions. This study was a cross-sectional design using the 2022 National Health Interview Survey. The study subjects were American adults who completed the survey questionnaires about depressive symptoms, swallowing problems, and health conditions. Regression models and three different propensity score matching approaches were utilized to estimate associations between dysphagia and depressive symptom. Data analyzed in the study showed that among 25,651 U.S. adults, 1,664 (6.48%) reported dysphagia. Among patients with dysphagia, 976 (58.65%) were women, and the average age was 55.48 years. The differences in demographics and health conditions between individuals with and without dysphagia were balanced by three propensity score matching approaches (p >.05). After adjustments using population-weighted multivariable logistic regression, the inverse probability of treatment weighting (IPTW) with both normalized weights, IPTW with stabilized weights, and Greedy algorithms with 1:1 matching method, the risks of having depressive symptom in those with dysphagia were significantly higher than those without dysphagia (odds ratios ranged from 1.763 to 2.402, p <.0001). The study supports that dysphagia and depressive symptoms frequently co-occur in U.S. adults, highlighting the need for comprehensive care that addresses both physical and mental health aspects of swallowing impairments.

Toothbrushing habits are associated with self perceived stress

Abstract Background Personal self-care is one of the most important factors in maintaining and improving oral health. Public health guidelines are recommending tooth brushing at least twice daily, once before bed time and at least on one occasion. On the other hand, our regular routines and caring for our own health is influenced by different factors including stress. We wanted to research how much does daily stress influencing tooth brushing habits. Methods We analyzed data from 2020 CINDI nationwide cross-sectional survey in Slovenia. Tooth brushing once a day or less was assessed as inadequate. Stress was assessed with question &amp;gt;&amp;gt;How often in the last 14 days have you felt tense, stressed or under a lot of pressure? &amp;lt;&amp;lt; Participants who chose often or always as an answer were assessed as persons under stress. Method of binary logistic regression was used for statistical analysis of association between tooth brushing frequency and self-perceived stress, modified for some socioeconomic factors. Results Prevalence of inadequate frequency of tooth brushing was present in 31,6 % of sample, 31,5% in participants who were not feeling tense and 31,8% in participants who often felt tense or stressed. At first it seemed stress is not associated with tooth brushing habits. We adjusted this association for gender, education level and age and this association became clearer. Participants who felt stress and/or under pressure had higher odds for poor tooth brushing habits, their odds ratio was 1,283 (p &amp;lt; 0,001; 95% CI 1,124; 1,464) when adjusted for aforementioned factors. Conclusions Oral health is integral part of general health. Association between oral and mental health is often overlooked even though psycho-social aspects are part of modern oral health definition. As personal self-care is cornerstone of maintaining and improving oral health, implementation of mental health aspects should be incorporated in public health advises and programmes for promoting oral health. Key messages • Self-perceived stress is associated with toothbrushing habits. • People who are under stress less regularly brush their teeth.

The relationship between sleep quality, depression, and smartphone addiction in pregnant women: a mediation analysis

ABSTRACT In recent years, the prevalence of smartphone addiction has significantly increased. This situation has raised concerns about its potential impact on health aspects, such as sleep quality and mental health, particularly among vulnerable populations like pregnant women. This study aimed to identify the factors that determine sleep quality in pregnant women and examine the relationship between smartphone addiction, depression, and sleep quality. This descriptive correlational study included 257 pregnant women in their second and third trimesters who were registered at six family health centers between September 2022 and March 2023. Data were collected using a sociodemographic questionnaire, the Smartphone Addiction Scale Short Form, Edinburgh Postnatal Depression Scale, and Pittsburgh Sleep Quality Index. Regression and mediation analyses were performed for the data. Of the participants, 44.4 percent had poor sleep quality. Depression and third trimester were significant determinants of sleep quality. The bootstrapping results revealed that smartphone addiction led to an increase in the level of depression (β = 0.145; p < .001). Depression worsened sleep quality (β = 0.262; p < .001). The smartphone addiction did not significantly affect sleep quality (β = 0.020; p = .279). Depression mediates the relationship between sleep quality and smartphone addiction (β = 0.038; 95 percent CI [0.018: 0.062]). The study highlights that while smartphone addiction does not directly impact sleep quality in pregnant women, it is associated with increased depression levels, which subsequently worsen sleep quality. It is recommended that healthcare providers monitor smartphone usage and mental health in pregnant women to mitigate the risk of sleep disturbances and improve overall well-being.

Employee’s Security and Health Augmentation in the Hotel Sector

The vibrant and quick-paced environment that defines the hotel sector is defined by a strong emphasis on employee welfare. This study examines the various aspects of worker health and safety in the context of the hospitality sector with the goal of identifying problems, prevalent behaviors, and appropriate remedial measures. The study uses a mixed-methods approach, combining quantitative analysis of safety event data with qualitative interviews with important industry players. In-depth interviews with hotel managers, staff members, and safety specialists are conducted as part of the qualitative component to elucidate the myriad difficulties faced by hotel staff in upholding their health and safety. The effects of irregular work schedules and sleep patterns, workplace stress, and ergonomic considerations all emerge as major themes. The study also examines how well the current training and safety practices work, looking for flaws and potential improvement areas. The study examines historical safety event data from a wide range of hotels on the quantitative front. The goal of this analysis is to spot trends, prevalent accident causes, and geographic regions with a higher prevalence of safety concerns. The results offer a data-driven framework for creating focused interventions and preventive actions. The research also examines how technology can support initiatives to increase employee safety in hotels. We investigate the possibilities for real-time monitoring systems, wearable technology, and enhanced training simulations to improve safety awareness and reactivity. A series of suggestions for enhancing employee health and safety in the hotel business are provided as part of the study's conclusion. The incorporation of technical solutions, specialized training programs, and changes to policy are all included in these suggestions. The hotel business may cultivate a safer and healthier work environment by resolving the issues mentioned, enhancing overall employee well-being and assisting in the industry's long-term success.

Juridical Analysis Of Criminal Law Enforcement In The Crime Of Organ Trafficking

This study aims to analyze criminal law enforcement related to organ trafficking cases. This research includes examining the conformity between existing legal regulations and practices in the field, identifying obstacles in law enforcement, and evaluating the effectiveness of measures that have been taken to deal with organ trafficking. The research method used is empirical. The results show that the main obstacles in handling this case include recovery and rehabilitation services for victims from health and social aspects that are appropriate to the needs of victims. This research concludes that legal regulations related to Organ Trafficking Crime are still incomplete. In addition, handling victims is not only the responsibility of the Police but also the Government and community institutions. It is suggested that the prevention and handling of Organ Trafficking should be optimized and integrated through synergistic cooperation between the community, Government, and community institutions in combating this crime.

Vitamin C supplementation improves placental function and alters placental gene expression in smokers

Maternal smoking during pregnancy (MSDP), driven by nicotine crossing the placenta, causes lifelong decreases in offspring pulmonary function and vitamin C supplementation during pregnancy prevents some of those changes. We have also shown in animal models of prenatal nicotine exposure that vitamin C supplementation during pregnancy improves placental function. In this study we examined whether vitamin C supplementation mitigates the effects of MSDP on placental structure, function, and gene expression in pregnant human smokers. Doppler ultrasound was performed in a subset of 55 pregnant smokers participating in the “Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function” (VCSIP) randomized clinical trial (NCT01723696) and in 33 pregnant nonsmokers. Doppler ultrasound measurements showed decreased umbilical vein Doppler velocity (Vmax) in placebo-treated smokers that was significantly improved in smokers randomized to vitamin C, restoring to levels comparable to nonsmokers. RNA-sequencing demonstrated that vitamin C supplementation to pregnant smokers was associated with changes in mRNA expression in genes highly relevant to vascular and cardiac development, suggesting a potential mechanism for vitamin C supplementation in pregnant smokers to improve some aspects of offspring health.

Overview and trends in electrochemical sensors, biosensors and cellular antioxidant assays for oxidant and antioxidant determination in food

Screening and quantifying antioxidants from food samples, their antioxidant activity, as well as the assessment of food oxidation is critical, not only for ensuring food quality and safety, but also to understand and relate these parameters to the shelf life, sensory attributes, and health aspects of food products. For this purpose, several methods have been developed and used for decades, which regardless of their effectiveness, present a certain number of drawbacks mainly related to extensive sample preparation and technical complexity, time requirements, and the use of hazardous chemicals. Electrochemical sensors and biosensors are gaining popularity in food analysis due to their high sensitivity, specificity, rapid response times, and potential for miniaturisation and portability. Furthermore, other modern methods using whole living cells such as the cellular antioxidant activity assay, the antioxidant power 1 assay, and the catalase-like assays, may interpret more realistic antioxidant results rather than just reporting the ability to scavenge free radicals in isolated systems with extrapolation to reality. This paper provides an overview of electrochemical sensors, biosensors, and cellular antioxidant assays, and reviews the latest advancements and emerging trends in these techniques for determining oxidants and antioxidants in complex food matrices. The performances of different strategies are described for each of these approaches to provide insights into the extent to which these methods can be exploited in the field and inspire new research to fill the current gaps.

Caffeine and Vision: Effects on the Eye.

Caffeine, commonly found in coffee and tea, affects various aspects of eye health as it blocks adenosine receptors, impacting tear production, intraocular pressure, macular perfusion, and choroidal thickness. However, its connection with eye conditions like glaucoma and cataracts remains uncertain due to conflicting research findings. Some studies suggest potential benefits for cataracts, while others warn against frequent caffeine intake in glaucoma and surgical scenarios due to possible increases in intraocular pressure. Conflicting evidence also exists regarding its effects on dry eye, macular degeneration, myopia/hyperopia, diabetic retinopathy, retinopathy of prematurity, and central serous retinopathy. Caffeine does not seem to be a risk factor for dry eye, although studies have shown that caffeine may offer protection against wet age-related macular degeneration, and the metabolite 7-methylxanthine could be a more promising treatment for myopia. Moreover, caffeine can potentially cause tremors and might hinder surgical performance, especially in less experienced surgeons. Recommendations from experts vary, highlighting the need for further research to fully understand how caffeine affects the eye. Individuals genetically predisposed to glaucoma should be cautious due to the possibility of clinically significant elevations in intraocular pressure with caffeine consumption. For delicate procedures like microsurgery, where tremors can be detrimental, caution should be exercised with caffeine. This review underscores the importance of additional studies to provide clearer insights and prudent recommendations regarding caffeine's impact on eye health.

Measuring Students' Understanding of Concepts, Law, and the Impact of Bullying

This study aims to find out how well students understand the meaning of bullying, the laws, bullying and the impact that occurs on bullying victims. The design of the mix method was used to reveal students' understanding of bullying. Tests and questionnaires are used to collect data. SPSS was used as a tool to process data. The results of the study are as follows: Most of the students generally have a fairly good understanding of the concept of bullying. good understanding of the law of bullying, although there are variations in their understanding, good understanding of the impact of bullying, although there is little variation in their assessment of some aspects of mental health. In general, this study shows that students have an excellent understanding of bullying in terms of concepts, laws, and impacts. These results indicate that students actually do not have problems in terms of theory about bullying, but it is necessary to find out why there are still students who do bullying. For this reason, it is necessary to study from the other side related to why students are still bullying.

Parental awareness and dental health behavior of children with congenital heart disease, with diabetes mellitus, or undergoing anti-cancer treatment, compared to healthy children.

Children with chronic diseases tend to experience a considerably higher burden of oral disease compared to their healthy peers. Low awareness of the impact of systemic diseases on oral health, lack of motivation, and discomfort may render the maintenance of good oral hygiene challenging. We conducted a study of four groups of parents: of children with congenital heart disease (CHD), with diabetes mellitus type 1 (DM), and undergoing anti-cancer treatment (ACT); and a control group of healthy children (C). We aimed to compare between the groups, parental attitudes and knowledge of their children's oral health, and their reports of their children's dental habits. Parents who arrived with their children for routine check-ups at three main clinics: cardiology, endocrinology, and hematology-oncology were asked to respond to a questionnaire regarding their children's oral and dental health. A total of 287 questionnaires were collected from 76 parents of children with CHD, 100 parents of children with DM, 50 parents of children undergoing ACT, and 61 parents who comprised group C. Compared to the CHD and DM groups, the ACT group demonstrated significantly more awareness of the importance of maintaining oral and dental health following diagnosis of their children's medical condition. Mothers' education was found to correlate with dental health knowledge. Most children in the DM and C groups had previous dental examinations, compared to only half in the CHD and ACT groups. A higher proportion of the children in the C than the other groups brushed teeth twice daily. The groups were similar in their consumption of sugary drinks, and of sweets and snacks. The children's specialist physicians were the main source of information on oral health, especially in the ACT group. Although most of the parents reported awareness to the oral health aspects of their children's disease, only part of them reported that their children visited dentists, and brushed their teeth twice daily. For the parents of children with CHD, DM, and ACT, their children's treating specialists were the primary source of information regarding oral health. This highlights the importance of clear and continuous communication between pediatric specialists and dentists.

Insights into the Phytochemical Profile and Therapeutical Potential of Withania Somnifera (L.) Dunal

Abstract: Withania somnifera (L.) Dunal (W. somnifera) is an herb commonly known by its English name Winter Cherry, and Ashwagandha in Hindi. It has been used as a traditional Rasayana herb for a long time. It is a rich reservoir of bioactive compounds known as withanolides, namely, withaferin-A and withanolide-D. Its current research covers many aspects of human health, which include anti-stress, anti-tumor, 9immuno-modulatory, hypocholesterolemic, hepatoprotective, hypoglycemic, diuretic, anti-convulsant, neurotropic, adaptogenic, and cardioprotective properties. This overview W. somnifera traditional uses, phytochemical, and pharmacological activities. However, in-depth studies are needed on the clinical use of W. somnifera against human diseases. Besides, detailed toxicological analysis is also to be performed for its safe and efficacious use in preclinical and clinical studies and as a health-promoting herb.

Strength in Numbers - Identifying a Significant Association Between High Serum Ferritin Levels and Newly diagnosed Malignancy in a Large Health Organization Cohort.

Ferritin, an iron storage protein and acute phase reactant, has been implicated in various aspects of human health and disease, including cancer. Previous studies have identified elevated serum ferritin (SF) levels in several cancer types, but a comprehensive examination across different malignancies remains lacking. This study aims to fill this gap by utilizing anonymized data from Maccabi Health Services (MHS), one of Israel's largest health organizations, to explore the association between elevated SF levels and the diagnosis of different malignancies. An extensive dataset from MHS, comprising 2.7 million members, including 1.3 million individuals who underwent SF level testing, was analyzed. Odds Ratios (OR) and 95% confidence intervals (CI) were calculated to assess the association between high SF levels and cancer diagnosis. Subgroup analysis was conducted to investigate variations across different malignancies. The analysis revealed a significant association between elevated SF levels and cancer diagnosis among MHS members, with an OR of 1.9 (95% CI 1.71-2.15). Sub- group analysis unveiled differences in the association across malignancy types, with hematological, hepatobiliary and respiratory malignancies more strongly associated with high SF levels. This study provides further support for the link between elevated SF levels and malignancy, leveraging a vast dataset from MHS, underscoring potential utilities of elevated SF levels as a potential indicator for cancer with a variable role among different malignancy types. The identification of elevated SF levels as a potential indicator for underlying malignancy for seemingly-healthy individuals.