Northern Asia Research Articles

Complementary activity of Trifludimoxazin and Saflufenacil when used in combination for postemergence and residual weed control

Abstract Trifludimoxazin is a new herbicide that inhibits protoporphyrinogen oxidase and is targeted for commercial market introduction in North America, South America, and Asia. It will be available both as a standalone product and in a 1:2 mixture with saflufenacil. The herbicide is intended for use in preplant burndown (PPBD) and preemergence applications in cereal, corn (Zea mays L.), soybean [Glycine max (L.) Merr.], and pulse crops to control a variety of annual broadleaf and grass weed species. Additionally, it is planned to be used in tree crops, oil-palm (Elaeis quineensis Jacq.), and non-crop areas. In this study, we meticulously evaluated the performance and effectiveness of both the standalone herbicide and the innovative mixture concept in combating prevalent weeds commonly encountered in corn and soybean fields. Our findings revealed that both products exhibited exceptional efficacy, significantly reducing the presence of these troublesome weeds. Furthermore, the mixture concept not only demonstrated commendable soil mobility but also showcased impressive residual activity, positioning it as a powerful tool for sustainable weed control. These promising effects are further substantiated by our comprehensive ADME (Adsorption-Distribution-Metabolism-Extraction) studies, which provide insight into the behavior and longevity of the herbicides in the agricultural ecosystem.

Real‐world use of androgen‐deprivation therapy intensification for metastatic hormone‐sensitive prostate cancer: a systematic review

ObjectiveTo conduct a systematic literature review of real‐world data (RWD) studies to summarise treatment patterns among men with metastatic hormone‐sensitive prostate cancer (mHSPC). While androgen‐deprivation therapy (ADT) is a primary treatment strategy for mHSPC, ADT intensification with androgen receptor pathway inhibitors (ARPIs) and/or chemotherapy is recommended by current guidelines and has improved clinical outcomes in the last decade.MethodsWe searched electronic databases (PubMed; Excerpta Medica dataBASE [EMBASE]) for eligible studies (retrospective or prospective observational RWD studies examining mHSPC treatment patterns) between database inception and July 2023, and manually screened the past 2 years of relevant conference proceedings.ResultsOf 2336 retrieved citations, 29 studies met the inclusion criteria, covering North America (United States, n = 21; Canada, n = 2), Europe (n = 8), and Asia (n = 6). Most studies utilised retrospective cohorts (n = 26) and included men with a median age of ≥70 years (n = 20). ADT monotherapy was predominantly used across geographies, followed by ADT + ARPI and ADT + docetaxel in the United States and Europe but not in Asia, where use of each combination remained low. Studies with recent electronic medical record data from cancer centres/registries showed >40% use of ADT + ARPI in the United States and Europe. Abiraterone was the most frequently used ARPI, followed by enzalutamide. Quantitative factors associated with ADT intensification were high disease burden, younger age, Eastern Cooperative Oncology Group performance status score of 0 to 1, fewer comorbidities, and oncologist physician specialty; qualitative factors were patient preference, unsatisfactory response to ADT, ability to tolerate adverse events, and absence of cost barriers.ConclusionWhile there was an increasing trend in ADT intensification for mHSPC over the study period across geographies, use remained suboptimal considering the high proportion of patients who were still receiving ADT monotherapy only. These findings highlight the need for interventions to further optimise current mHSPC therapies with high guideline concordance.

QLTI-03. REAL-WORLD PARADIGM FOR TREATMENT OF PRIMARY CNS LYMPHOMA PATIENTS IN CLINICAL PRACTICE

Abstract Although high-dose methotrexate (HD-MTX) is the foundation of induction therapy for primary CNS lymphoma (PCNSL), a gold-standard regimen has yet to be established. A 10-case-based survey, to assess the practice patterns at key decision-points in adult PCNSL management outside of clinical trials, was distributed through IPCG, HOVON, and AAN Neuro-Oncology Section. Eighty-five responses were collected from North American (N=42), European (N=33), Asian (N=7), and other countries (N=3) from neurologist neurooncologists (N=35), hem-onc neurooncologists (N=24), hematologist-oncologists (N=18), neurosurgeons (N=5), radiation-oncologist (N=2), and hematopathologist (N=1). The most common first-line induction regimen was R-MP+/-V: rituximab, HD-MTX, procarbazine, +/-vincristine (N=28) followed by MATRix: HD-MTX, cytarabine, thiotepa, rituximab (N=23), then R-MT: rituximab, HD-MTX, temozolomide (N=19). For elderly patients, R-MP+/-V remained most common (N=32). The majority preferred to omit intra-CSF chemotherapy (N=50). The most preferred consolidation after complete response was high-dose chemotherapy and autologous stem-cell transplantation (HDC-ASCT, N=57), or high-dose cytarabine (N=17) in elderly patients. In cases of partial response, the most common approach was still HDC-ASCT (N=24). For stable disease, participants would move to various salvage chemotherapy (N=33), continue additional induction (N=39), or to move to radiotherapy (N=10). If early progression was noted, the most preferred approach was non-methotrexate chemotherapy (N=31). For recurrences after previous complete response and HDC-ASCT consolidation, the majority preferred to try chemotherapy before moving to radiotherapy in scenarios < 1 year (N=64) or > 1 year from consolidation (N=68), and even if the performance status was poor (N=57). Close to half (N=34) participants felt there is a role for stereotactic radiosurgery in various clinical settings. This survey noted clear consensus to use multi-drug MD-MTX based chemotherapy, and common induction regimens, however, highlighted a great variety of treatment preferences after first-line therapy even amongst disease experts through clinical consortiums, suggesting likely wider range of treatments and disease response in larger community settings.

Trends and innovations in mycorrhizal biofertilizers: a technological prospecting study

Exponential population growth, combined with the reduction of arable land, has created a need for increased agricultural production within a smaller physical space and with limited water and nutrient resources. In this context, biofertilizers have emerged as an environmentally friendly alternative to meet the demand for technologies and products that enhance productivity. The objective of this study was to map the production of technological knowledge and identify the main characteristics of innovation assets developed in the field of biofertilizers, with a particular focus on mycorrhizal biofertilizers, during the first decades of the 21st century. To achieve this, data was collected from international databases, including the European Patent Office (EPO) and the World Intellectual Property Organization (WIPO), as well as from the national database of the National Institute of Industrial Property (INPI) in Brazil. The search was conducted using simple and combined queries with the keywords "Mycorrhiza" and "Biofertilizer," followed by quantitative and qualitative analyses. The results indicated that the primary patent applicants in this field are companies and universities, predominantly located in North America and Asia. The highest concentration of patent publications occurred between 2010 and 2021, particularly in relation to new biofertilizer compositions and the optimization of production processes for these compounds. Although new technologies in the field of mycorrhizal biofertilizers can be observed, there are still unexplored avenues, and new initiatives will be important for the emergence of innovative solutions.

Global Incidence and Prevalence of Chronic Rhinosinusitis: A Systematic Review.

Data on the global prevalence of chronic rhinosinusitis (CRS) is significantly varied and limited across countries and over time. Therefore, we aimed to conduct a comprehensive investigation into the global, regional, and national burden of CRS from the years 1980 to 2021, as well as identify those factors that influence levels of such burden. We conducted a systematic review and meta-analysis of general population-based observational studies focusing on CRS. We calculated pooled estimates of CRS prevalence and incidence with 95% confidence intervals (CIs). Subgroup analyses were conducted stratifying by sex, age cohorts, geographic regions, smoking status, obesity, and comorbid conditions. PubMed/MEDLINE, EMBASE, CINAHL, Google Scholar, and Cochrane databases. We included general population-based observational studies on CRS published from database inception through October 20, 2023. A total of 28 eligible studies, encompassing more than 237 million participants and 11,342,923 patients with CRS from 20 countries across four continents, were included in the analysis. Global pooled prevalence of CRS and CRS with nasal polyps (CRSwNP) was found to be 8.71% (95% CI, 6.69-11.33; number of studies, 20) and 0.65% (95% CI, 0.56-0.75; number of studies, 4), respectively. The prevalence of CRS was greater in Europe compared with North America, South America, and Asia; adults compared with children; smokers compared with never-smoker; those with obesity compared with normal weight; and those with comorbidities such as asthma, diabetes mellitus, eczema, and nasal septal deviation. Pooled prevalence of CRS increased from 1980 to 2020 (1980-2000: 4.72%; 95% CI, 2.12-10.49; 2014-2020: 19.40%; 95% CI, 12.12-31.07). Similar patterns were observed in CRS incidence. Our study provides valuable insights into CRS prevalence and incidence across diverse demographic and clinical factors, highlighting its increasing global burden. The reported prevalence of CRS varies internationally, and may be increasing over time. To enhance data quality and comparability, standardization of reporting methodologies is imperative. PROSPERO (registration no. CRD42024527805).

Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives

Aging is closely linked to various health challenges, including cardiovascular disease, metabolic disorders, and neurodegenerative conditions. This study emphasizes the critical role of bioactive compounds derived from marine sources, such as antioxidants, omega-3 fatty acids, vitamins, minerals, and polysaccharides, in addressing oxidative stress, inflammation, and metabolic disorders closely related to aging. Incorporating these materials into functional foods not only provides essential nutrients but also delivers therapeutic effects, thereby promoting healthy aging and mitigating age-related diseases. The growth of the global anti-aging market, particularly in North America, Europe, and Asia, underscores the significance of this study. This review systematically analyzes the current research, identifying key bioactive compounds, their mechanisms of action, and their potential health benefits, thus highlighting the broad applicability of marine-derived bioactive compounds to enhancing healthy aging and improving the quality of life of aging populations.

Ionic composition of snow cover on the territory of Siberia and the Far East

Long-term (from 2007 to 2022) observations of the dynamics of acidity, mineralization and ionic composition of snow cover in remote mountainous and lowland landscapes of Northern Asia were carried out. As a result, spatiotemporal changes in the molar concentration of basic (Ca2+, Mg2+, HCO3-, Cl- and SO42-) and nitrogen-containing (NH4+, NO3- and NO2-) ions were analyzed. It turned out that during the entire observation period, bicarbonate ions prevailed in all monitoring regions, even near the sea coasts, where there is an intensive intake of sulfate and chloride ions into the atmosphere. Until 2012, the molar concentration of these three anions was characterized by higher values, which decreased 3–8 times in subsequent years, this is especially noticeable for bicarbonate ions and to a lesser extent for chloride ions. The molar concentration of nitrogen-containing ions in the snow cover of Northern Asia was at a low level (especially nitrite ions). Ammonium ions were predominant throughout the observation period (especially in mountainous landscapes) and only in some years – nitrate ions.

Towards cleaner desalination systems utilizing waste heat: a bibliometric analysis

Water scarcity is a global issue facing the coming generations. Desalination is a dependable, nonconventional freshwater method. However, desalination is an energy-intensive water treatment method. The primary energy source used to power various desalination processes for thermal and electrical energy consumption is fossil fuels, such as coal, oil, and gas. The widespread use of fossil fuels has been linked to climate change and global warming, leading to numerous demands to reduce their usage and energy utilization. Waste heat has an excellent potential for energy recovery that can reduce the consumption of fossil fuels. This research study has been conducted to evaluate related waste heat desalination literature with data analysis, bibliometric, and clustering methods. Based on articles published between 2013 and 2023, the current study analyzed existing trends, distribution of publication subjects, journals' performances, countries' collaborations, affiliations' performances, most cited publications, authors' contributions, keyword analysis, and future perspectives on waste heat desalination systems. The findings showed that the most active journal in this field is Desalination, with 133 publications and 6332 citations. China led in publications with 242, while the United States topped the list of citations with 3598. Also, King Abdullah University of Science and Technology in Saudi Arabia published 50 documents. The top 10 institutions in this field of research are in the Middle East and North Africa (MENA) region and Asia, particularly in Saudi Arabia, China, Iran, Egypt, and Singapore. Moreover, the most frequently used terms are analyzed and clustered into three main topics. The top 3 clusters are solar-powered desalination technologies, membrane-powered desalination technologies, and power cycles driving desalination technologies.

A rapid and parallel Late Pleistocene/Holocene morphological radiation in a predaceous planktonic water flea: the case of Bythotrephes (Cladocera: Cercopagididae)

Abstract The predatory cladoceran Bythotrephes is one of North America’s most successful and impactive invasive species in freshwater plankton communities. The taxonomic status of the genus Bythotrephes Leydig, 1860 (Crustacea: Cladocera: Cercopagididae) has remained unclear and a subject of intensive debate for over 150 years. We applied an integrative taxonomy approach with multi-gene analysis (mitochondrial COI and 12S genes, and nuclear 18S and 28S genes) on 80 individuals (representing at least four morphospecies) from various regions spanning the genus distribution (North America, Europe, and Asia) to resolve the taxonomic status of species within Bythotrephes. The results of our study strongly support the hypothesis of a single species—Bythotrephes longimanus Leydig, 1860, and ecological morphs should be accepted as junior synonyms. Our work also elucidates the very recent radiation of Bythotrephes, which may have begun rapidly and parallel during the Late Pleistocene, or even after the last glaciation. Finally, we provide a comprehensive biogeographic reconstruction of Bythotrephes dispersal within the Holarctic realm. Europe likely served as a dispersal centre for Bythotrephes from where they spread relatively recently (possibly, less than 10 kyr) and we distinguish five possible dispersal events in its evolutionary history.

Resilience in Oral Health Professional Education: A Scoping Review.

Resilience is defined as an individual's capacity to effectively adapt in the face of challenges without detrimental effects on their health and well-being. This scoping review identifies and rationalises the published concepts that underpin resilience in oral health professional (OHP) education. It provides recommendations for the development of evidence-based strategies for promoting resilience in OHP education. The PRISMA and Arksey and O'Malley methodological frameworks for scoping reviews were used to determine the methodology and answer the question 'What concepts contribute to resilience in OHP Education?'. The search strategy included published literature searches and internet searches. In total, 744 articles on resilience and coping were identified, and 59 were included after excluding irrelevant records. Most studies used surveys as their study design and focused on undergraduate dental students in North America and Asia. Three main themes were identified: factors that contribute to resilience, measurement tools and scales and enhancing resilience. This review highlights a positive correlation between increased resilience and improved outcomes for dental students. Resilience and its related factors are not well understood. There is insufficient evidence to support interventions for building resilience due to inconsistent measuring methods and limited research validating resilience scales in OHP education. Investigators should accurately understand the terminology for clarity and consistency. Validated outcome measures and student feedback should be used to determine the effectiveness of interventions. It is important to teach students coping strategies to manage stressors, and digital applications for building resilience should be developed and tested in OHP student populations.

Insights into genomic sequence diversity of the SAG surface antigen superfamily in geographically diverse Eimeria tenella isolates

Eimeria tenella is among the protozoan parasites that cause the infectious disease coccidiosis in chickens, incurring huge economic losses to the global poultry industry. Surface antigens (EtSAGs) involved in host-parasite interaction are potential targets for control strategies. However, the occurrence of genetic diversity for EtSAGs in field populations is unknown, as is the risk of such diversity to the efficacy of EtSAG-based control approaches. Here, the extent of EtSAG genetic diversity and its implications on protein structure and function is assessed. Eighty-seven full-length EtSAG genomic sequences were identified from E. tenella genome assemblies of isolates sampled from continents including North America (United States), Europe (United Kingdom), Asia (Malaysia and Japan) and Africa (Nigeria). Limited diversity was observed in the EtSAG sequences. However, distinctive patterns of polymorphism were identified between EtSAG subfamilies, suggesting functional differences among these antigen families. Polymorphisms were sparsely distributed across isolates, with a small number of variants exclusive to specific geographical regions. These findings enhance our understanding of EtSAGs, particularly in elucidating functional differences among the antigens that could inform the development of more effective and long-lasting anticoccidial control strategies.

Mitogenomic analysis of the position of the Azygiidae and constituent genera, with a new species of Azygia

The Azygiidae Looss, 1899 is a family of digeneans with a Holarctic distribution in which members of some genera mature in marine elasmobranchs while others occur only in freshwater teleosts. Some have questioned whether the marine genus Otodistomum Stafford, 1904 indeed belongs to the same family as the freshwater azygiid genera, namely Azygia Looss, 1899, Proterometra Horsfall, 1933, and Leuceruthrus Marshall and Gilbert, 1905. We present phylogenetic analyses based on mitochondrial genomes, rDNA operons, and partial Cox1 cytochrome c oxidase I sequences from North American and Asian species that support the monophyly of Azygiidae, and placement of Azygioidea in the suborder Hemiurata, in contrast to recently published mitochondrial genome phylogenies. All phylogenies indicate that Azygia includes Leuceruthrus, which we therefore propose to be a junior synonym, together with suppression of the Leuceruthrinae. The status of Proterometra was equivocal, with support in some but not all analyses of 28S, but not in other markers. We describe a new species of Azygia from northeastern North America. Our results confirm the morphological variability of adults in Azygia, with worm size positively correlated with host size in Azygia angusticauda. Phylogenies suggest a marine origin for the Azygiidae, and a Palearctic origin for freshwater azygiids, with a single trans-Atlantic radiation to the Nearctic.

The genomic natural history of the aurochs.

Now extinct, the aurochs (Bos primigenius) was a keystone species in prehistoric Eurasian and North African ecosystems, and the progenitor of cattle (Bos taurus), domesticates that have provided people with food and labour for millennia1. Here we analysed 38 ancient genomes and found 4 distinct population ancestries in the aurochs-European, Southwest Asian, North Asian and South Asian-each of which has dynamic trajectories that have responded to changes in climate and human influence. Similarly to Homo heidelbergensis, aurochsen first entered Europe around 650 thousand years ago2, but early populations left only trace ancestry, with both North Asian and European B. primigenius genomes coalescing during the most recent glaciation. North Asian and European populations then appear separated until mixing after the climate amelioration of the early Holocene. European aurochsen endured the more severe bottleneck during the Last Glacial Maximum, retreating to southern refugia before recolonizing from Iberia. Domestication involved the capture of a small number of individuals from the Southwest Asian aurochs population, followed by early and pervasive male-mediated admixture involving each ancestral strain of aurochs after domestic stocks dispersed beyond their cradle of origin.

Indian summer monsoon’s role in shaping variability in Arctic sea ice

The impacts of Arctic sea ice loss on summertime weather in the Northern Hemisphere have garnered considerable attention. Despite the extensive focus on this relationship, the influence of tropical systems on Arctic regions has been relatively underexplored, with only a limited number of existing studies concentrating exclusively on either dynamic or thermodynamic effects. This study aims to address this gap by examining a barotropic anomalous circulation over the Arctic region associated with Indian Summer Monsoon (ISM) rainfall. The observed anomalous circulation exhibits a distinct zonally dipole pattern, characterized by anomalous high pressure over Northern Canada and Asia, coupled with anomalous low pressure located east of Greenland. Verification through model experiments demonstrates that the diabatic heating of ISM rainfall contribute to the formation of the observed ISM-related circulation. The modulation of surface clear sky downwelling longwave radiation (DLRclear sky\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{DLR}}_{{clear\\; sky}}$$\\end{document}) by the circulation anomalies over the Arctic modified surface thermal conditions, thereby influencing subsequent variations in sea ice thickness and concentration. Under anomalous high pressure, DLRclear sky\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{DLR}}_{{clear\\; sky}}$$\\end{document} increases, leading to a decline in sea ice thickness, and vice versa. Additionally, from a dynamic standpoint, low-level wind-driven sea ice drift helps shape the spatial distribution and extent of sea ice cover. Besides, the impacts of ISM on Arctic sea ice are largely independent of contemporary ENSO. These findings present fresh perspectives on the role of extrapolar phenomena, such as the ISM, in driving variability in Arctic sea ice during the summer months. This enhanced comprehension holds promise for enhancing predictions of changes in summertime Arctic sea ice extent.

Privacy, confidentiality and ethical concerns in audio ai assistants: A comparative study of North American, European, and Asian Markets

This study examines the ethical, privacy, and confidentiality issues with audio AI assistants in the markets of North America, Europe, and Asia. Understanding the ramifications of data collecting, storage, and usage is crucial as the use of technologies like Google Assistant and Amazon Alexa grows. The study highlights significant regulatory differences between the areas; North America offers a fragmented landscape, and many Asian nations are still developing their data protection legislation, while Europe leads with strong frameworks like the General Data Protection Regulation (GDPR). Key challenges identified include a lack of user awareness regarding privacy rights, extensive data collection practices, unauthorized listening, data breaches, and cultural differences influencing attitudes toward data protection. The findings reveal that these challenges impact user trust and hinder the responsible innovation of AI technologies. Recommendations for improvement include establishing global regulations to promote consistency in data protection, adopting best practices such as privacy-by-design principles, and enhancing user education initiatives. Additionally, the study identifies critical areas for future research, particularly the role of AI assistants in sensitive sectors like healthcare and education, where privacy concerns may differ significantly. Overall, this comparative analysis provides a foundational understanding of audio AI assistants' ethical landscape and underscores the importance of addressing these issues to foster a secure and trustworthy digital environment.

Rural-Urban Disparities in Mortality of Patients with Acute Myocardial Infarction and Heart Failure: A Systematic Review and Meta-Analysis.

Patients with cardiac disease living in rural areas may face significant challenges in accessing care and studies suggest that living in rural areas may be associated with worse outcomes. However, it is unclear whether rural-urban disparities have an impact on mortality in patients presenting with acute myocardial infarction (AMI) and heart failure (HF). This meta-analysis aimed to assess differences in mortality between rural and urban patients presenting with AMI and HF. A systematic search of the literature was performed using PubMed, Embase, MEDLINE and CENTRAL for all studies published until January 16, 2024. A grey literature search was also performed using a manual web search. The following inclusion criteria were applied: (i) studies must compare rural patients to urban patients presenting to hospital with AMI or HF; and (ii) studies must report on mortality. The primary outcome was all-cause mortality. Comprehensive data were extracted including study design, patient characteristics (sex, age and comorbidities), sample size, follow-up period and outcomes. Odds ratios (ORs) were pooled with random-effects model. A subgroup analysis was performed to investigate causes for heterogeneity in which studies were separated based on in-hospital mortality, post-discharge mortality, and region of origin including North America, Europe, Asia and Australia. In total, 37 studies were included (29 retrospective studies, 4 cross-sectional studies and 4 prospective cohort studies) in our meta-analysis; 24 studies for AMI, 11 studies for HF and 2 studies for both AMI and HF. This included a total of 21,107,886 patients with AMI (2,230,264 of which were in rural regions) and 18,434,270 patients with HF (2,655,469 of which were in rural regions). Rural patients with AMI had similar age (mean age 69.8 +/- 5.7; vs 67.5 +/- 5.1) and were more likely to be female (43.2% vs 38.5%) compared to urban patients. Rural patients with HF had similar age (mean age 77.1 +/- 4.4 vs 76.5 +/- 4.2) and were more likely to be female (56.4% vs 49.5%) compared to urban patients. The range of follow-up for the AMI cohort was 0 days to 24 months and the range of follow-up for the HF cohort was 0 days to 24 months. Compared with urban patients, rural patients with AMI had higher mortality rate at follow-up (15.5% vs 13.4%; OR 1.18, 95% CI, 1.13-1.24; I2 = 97%). Compared with urban patients, rural patients with HF had higher mortality rate at follow-up (12.3% vs 11.6%; OR 1.11, 95% CI, 1.11-1.12; I2 = 98%). To our knowledge, this is the first systematic review and meta-analysis assessing mortality differences between rural and urban patients presenting with AMI and HF. We found that patients living in rural areas had an increased risk of mortality when compared to patients in urban areas. Clinical and policy efforts are required to reduce these disparities.

Extreme Saharan dust events expand northward over the Atlantic and Europe, prompting record-breaking PM10 and PM2.5 episodes

Abstract. Unprecedented extreme Saharan dust (duxt) events have recently expanded northward from subtropical NW Africa to the Atlantic and Europe, with severe impacts on the Canary Islands, mainland Spain and continental Portugal. These six historic duxt episodes occurred on 3–5 and 22–29 February 2020, 15–21 February 2021, 14–17 January 2022, 29 January–1 February 2022, and 14–20 March 2022. We analyzed data of 341 governmental air quality monitoring stations (AQMSs) in Spain (330) and Portugal (11), where PM10 and PM2.5 are measured with European norm (EN) standards, and found that during duxt events PM10 concentrations are underestimated due to technical limitations of some PM10 monitors meaning that they can not properly measure extremely high concentrations. We assessed the consistency of PM10 and PM2.5 data and reconstructed 1690 PM10 (1 h average) data points of 48 and 7 AQMSs in Spain and Portugal, respectively, by using our novel “duxt-r” method. During duxt events, 1 h average PM10 and PM2.5 concentrations were within the range 1000–6000 µg m−3 and 400–1200 µg m−3, respectively. The intense winds leading to massive dust plumes occurred within meteorological dipoles formed by a blocking anticyclone over western Europe and a cutoff low located to the southwest, near the Canary Islands and Cape Verde, or into the Sahara. These cyclones reached this region via two main paths: by deviating southward from the Atlantic mid-latitude westerly circulation or northward from the tropical belt. The analysis of the 2000–2022 PM10 and PM2.5 time series shows that these events have no precedent in this region. The 22–29 February 2020 event led to (24 h average) PM10 and PM2.5 concentrations within the range 600–1840 and 200–404 µg m−3, respectively, being the most intense dust episode ever recorded on the Canary Islands. The 14–20 March 2022 event led to (24 h average) PM10 and PM2.5 values within the range 500–3070 and 100–690 µg m−3 in southeastern Spain, 200–1000 and 60–260 µg m−3 in central Spain, 150–500 and 75–130 µg m−3 in the northern regions of mainland Spain, and within the ranges 200–650 and 30–70 µg m−3 in continental Portugal, respectively, being the most intense dust episode ever recorded in these regions. All duxt events occurred during meteorological anomalies in the Northern Hemisphere characterized by subtropical anticyclones shifting to higher latitudes, anomalous low pressure expanding beyond the tropical belt and amplified mid-latitude Rossby waves. New studies have reported on recent record-breaking PM10 and PM2.5 episodes linked to dipole-induced extreme dust events from North Africa and Asia in a paradoxical context of a multidecadal decrease in dust emissions, a topic that requires further investigation.

Risk of long COVID and associated symptoms after acute SARS-COV-2 infection in ethnic minorities: a Danish nationwide cohort study

Abstract Background and aim Ethnic minorities living in high-income countries have been disproportionately affected by COVID-19 in terms of infection rates, hospitalisations, and deaths; however, less is known about long COVID in these populations. Our aim was to examine the risk of long COVID and associated symptoms among ethnic minorities. Methods We used Danish nationwide register-based cohort data on individuals diagnosed with COVID-19 aged ≥18 years (n = 2 334 271) between January 2020 and August 2022. We calculated the risk of long COVID diagnosis and long COVID symptoms among ethnic minorities compared with native Danes using multivariable Cox proportional hazard regression and logistic regression, respectively. Results Of the diagnosed COVID-19 cases, 1 973 998 (84.6%) were native Danes and 360 273 (15.4%) were ethnic minorities. After adjustment for age, sex, civil status, education, family income, and Charlson comorbidity index, ethnic minorities from North Africa (adjusted hazard ratio [aHR] 1.41, 95% CI [1.12,1.79]), Middle East (aHR 1.38, 95% CI [1.24,1.55]), Eastern Europe (aHR 1.35, 95% CI [1.22,1.49]), and Asia (aHR 1.23, 95% CI [1.09,1.40]), had significantly greater risk of long COVID diagnosis than native Danes. In the analysis by largest countries of origin, the greater risks of long COVID diagnosis were found in Iraqis (aHR 1.56, 95% CI [1.30,1.88]), Turks (aHR 1.42, 95% CI [1.24,1.63]), and Somalis (aHR 1.42, 95% CI [1.07,1.91]). A significant factor associated with an increased risk of long COVID diagnosis was COVID-19 hospitalisation. Conclusions Migrants and ethnic minorities had higher risk of long-COVID compared to native Danes.

Multiple Acquisitions of XopJ2 Effectors in Populations of Xanthomonas perforans.

Type III effectors (T3Es) are major determinants of Xanthomonas virulence and targets for resistance breeding. XopJ2 (synonym AvrBsT) is a highly conserved YopJ-family T3E acquired by X. perforans, the pathogen responsible for bacterial spot disease of tomato. In this study, we characterized a new variant (XopJ2b) of XopJ2, which is predicted to have a similar three-dimensional (3D) structure as the canonical XopJ2 (XopJ2a) despite sharing only 70% sequence identity. XopJ2b carries an acetyltransferase domain and the critical residues required for its activity, and the positions of these residues are predicted to be conserved in the 3D structure of the proteins. We demonstrated that XopJ2b is a functional T3E and triggers a hypersensitive response (HR) when translocated into pepper cells. Like XopJ2a, XopJ2b triggers HR in Arabidopsis that is suppressed by the deacetylase, SOBER1. We found xopJ2b in genome sequences of X. euvesicatoria, X. citri, X. guizotiae, and X. vasicola strains, suggesting widespread horizontal transfer. In X. perforans, xopJ2b was present in strains collected in North America, Africa, Asia, Australia, and Europe, whereas xopJ2a had a narrower geographic distribution. This study expands the Xanthomonas T3E repertoire, demonstrates functional conservation in T3E evolution, and further supports the importance of XopJ2 in X. perforans fitness on tomato. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.

Stakeholder perspectives on supplemental milk for infants under six months with growth faltering

Abstract Background Growth faltering is a significant public health issue among infants aged <6 months (m). Supplemental milk is commonly used for infants with growth faltering, with variations in type and duration. We synthesized qualitative evidence on stakeholder perspectives about equity, feasibility, and acceptability of the type and duration of supplemental milk for infants aged <6m with growth faltering. Methods We conducted a comprehensive search of six electronic databases in addition to manual searches to identify all qualitative studies published during January 2000-June 2022. Identified articles were screened in two stages against an inclusion criteria with titles and abstract screened first followed by full-text screening. Included studies were quality appraised using the Critical Appraisal Skills Programme checklist. The primary outcome was equity, feasibility, and acceptability of various supplemental milk for infants <6mwith growth faltering. Results Eighteen studies, reporting perspectives of mothers, fathers, grandmothers and healthcare providers were included. Studies were conducted in North America (9), Africa (5) and Asia (3) and South Australia (1). Donor human milk (DHM) (13) and infant formula(9) were the main supplementary milk reported followed by cow/goat milk (2). Key sub-themes derived were: education/awareness, socio-economic status (SES), race and religion, practicality, availability of resources, sustainability, cost, affective attitude, perceived effectiveness and ethicality. Maternal/caregiver SES was a key sub-theme across all three supplemental milk feeds, acting either as a barrier or facilitator for uptake. Conclusions DHM and infant formula were the most commonly reported supplemental feed for infants aged <6m with growth faltering. Maternal/care giver factors were perceived as key to ensure equity, feasibility, and acceptability with respect to type and duration of supplemental milk for infants aged <6m with growth faltering. Key messages • Stakeholders perceived donor human milk and infant formula as main supplemental milk for infants aged <6 months with growth faltering. • Maternal/care giver factors are key to ensure equity, feasibility, and acceptability of supplemental milk for infants aged <6 months with growth faltering.