Arylation Of Benzoxazoles Research Articles

Room temperature ionic liquid promoted regioselective synthesis of 2-aryl benzimidazoles, benzoxazoles and benzthiazoles under ambient conditions

A regioselective one-pot synthesis of 2-aryl benzimidazoles, benzoxazoles and benzthiazoles has been achieved in excellent isolated yields under ambient conditions using the ionic liquids, 1-butylimidazolium tetraflouroborate ([Hbim]BF4) and 1,3-di-n-butylimidazolium tetrafluoroborate ([bbim]BF4) as reaction media and promoters. There was no need for the use of an additional catalyst normally employed in the methodologies reported so far.

Search for physiologically active compounds

2-aryl benzoxazoles have been prepared in good yield by the condensation of o-amino phenol with aromatic aldehydes in nitrobenzene medium. Starting from 4-nitro, 4-chloro and 5-nitro o-amino phenols, 5 and 6 substituted 2-aryl benzoxazoles have also been synthesised.