Land degradation is a global environmental problem that affects the livelihoods of communities. Understanding the extent and causative factors of this phenomenon is important to design the cause-targeted strategies to cope with this problem. This study aimed to assess the effects of biophysical and socio-economic factors on the occurrence of land productivity degradation at the territorial level in Eastern DR Congo, using the Kalehe territory as a case study. The land productivity dynamics were determined based on the trend analysis of Landsat-based NDVI annual composites over the 1987-2020 period. Additionally, a binary logistic regression model was developed to identify the determinant factors and to map the susceptibility of this degradation at the territorial level. The results revealed that 31.25% (1303.175 km2) of the territory had experienced a decrease in land productivity, with 10.8% (453.83 km2) characterized by a significant decrease at the confidence level of 90%, representing the hotspots area of land productivity degradation where conservation actions should be prioritized. This decrease in land productivity is location-specific as it depends on the land cover types and health zones. It is likely to occur at high altitudes, in areas close to artisanal mining sites, rivers, and administrative centers. These results imply that policy interventions to cope with the problem of land productivity degradation should be developed following the heterogeneity of the landscape, and sustainable land management practices that take into account both the biophysical and socio-economic drivers of land degradation should be implemented in this region to achieve the land degradation neutrality by 2030.