Background: Dentures are removably inserted dental prosthetics that fill up tooth gaps. There are many types of dentures, including complete, partial and implant-supported dentures. As long-term supports for tooth replacements, dental implants have significantly changed the treatment philosophies of conventional prosthodontics. However, the success and durability of these prosthetic devices may be impacted if a person seeking denture implants has diabetes. Diabetes affects the body in many ways, including the mouth's oral health. Immediate dentures have many benefits, including better oral functions, preservation of lower facial height, preservation of tooth sockets, improvement of aesthetics, and replication of natural teeth's shape, form, and location by artificial teeth. Diabetes mellitus has been reported to be associated strongly with the oral health. The higher glucose microenvironment prolongs healing of tooth extraction sockets. Thus, encouraging the healing of tooth extraction sockets is crucial from a therapeutic perspective for people with diabetes mellitus. Methods: An electronic search of English peer-reviewed dental literature on PubMed, Science Direct and Google Scholar was conducted to identify all publications reporting on how diabetes affect dentures until August 2023. Overall, 977 publications were found through an electronic and manual search, out of which 130 articles were selected after screening based on title and abstract. A total of 52 publications passed the second review phase after assessment for eligibility, from which 24 studies were excluded after full-text screening. Finally, a total of 28 studies were selected. A total of 10 articles were found to match our eligibility criteria to the full and were included in the final systematic review. Conclusion: Diabetes negatively impacts implanted dentures' success and longevity, leading to complications like Candida infection, poor bone integration, peri-implantitis, and compromised healing. Larger clinical trials are needed to understand diabetes's impact on implant therapy outcomes. Clinicians should assess patients' overall health, monitor glycemic control, maintain oral hygiene, and perform regular maintenance for optimal outcomes.