Artificial Intelligence (AI) has grown extensively in recent times and already encroaches into our lives, for example, with smart cars and smart homes. AI current and future trends in areas such as smart cars, face recognition, robotic surgeries, or automatic disease classification, focus on hybridization to improve the performance of smart expert systems. Despite the huge growth of various AI and machine learning techniques, such as decision trees, data mining, or deep convergence learning, there are still many challenges and threats which limit the performance of these smart expert systems. This special issue focuses on new directions in hybrid AI and machine learning methodologies to address current research problems. It focuses on bringing together leading-edge articles on hybrid AI techniques for smart expert systems for various applications. From about 25 articles submitted, 4 papers were selected based on the review process. Each paper was reviewed by at least two independent reviewers and undertook at least one round of review. Their contributions are summarized below. Raghavendra et al. (2019) has proposed a research work on accurate and early detection of breast cancer using effective imaging modalities with medical image analysis. The research results have shown that two-dimensional synthesized mammogram imaging and conventional full-field digital mammography (FFDM) are two important imaging modalities which can be used for screening breast cancer. The developed method achieved an average performance of 92.9% accuracy using a probabilistic neural network classifier for FFDM images with tenfold cross validation. The obtained results can be used as a distinct system in rural hospitals. Gupta et al. (2020) has done their research studies on to detect infected leaves using machine learning techniques. An improved artificial plant optimization (IAPO) algorithm using machine learning has been introduced that identifies the plant diseases and categorize the leaves into healthy and infected on a private data set of 236 images. The degree of infection is eventually computed, and the leaves with infection greater than a certain calculated threshold are classified as infected leaves. The results show that IAPO can be used for the classification of infected and healthy leaves and this algorithm can be generalized to solve problems in other domains as well. Hammad et al. (2020) has found a new authentication approach based on biometric modalities such as heartbeat pattern obtained from electrocardiogram (ECG) signals. This work shows two novel deep neural network (DNN) models (convolutional neural network (CNN) and ResNet-Attention) using ECG signals for human authentication and the proposed CNN algorithm achieved an accuracy of 98.59% and 99.72% using PTB and CYBHi, respectively. The results obtained by the developed model proved that the performance is better than existing algorithms and can be used in real-time authentication systems after the validation with more diverse ECG data. Teles et al. (2020) has devised a decision support system on credit operations which can provide different estimations of expected recovery based on the same data sets. This research work classifies credit by the formulation of a rule that describes the values of a categorical variable according to some specified definition. Results reveal that while linear regression can be used for the prediction of a continuous variable in the credit process using collateral, it is not suitable for categorical data. Out of linear and logistic regressions, linear regression is more applicable in determining groups of variables that can significantly predict an outcome. We would like to take this opportunity to thank Dr. Jon G. Hall, Editor-in-Chief of Expert Systems, The Journal of Knowledge Engineering, for the privilege to edit this special issue. Gustavo Ramírez González is a professor at department of telematics engineering in Universidad del Cauca, Colombia. His research interests include image processing, secure communication, and machine learning. He has published several research papers in reputed journals and served as a Guest Editor for several Special Issues at many journals.