With the advancement of technology, various denture base materials have been developed with enhanced mechanical and physical properties. Because the mechanical properties of the denture base play a significant role in its clinical lifespan, this systematic review aims to examine the effects of various additives added to polymethyl methacrylate (PMMA) denture base materials on the physical (surface properties, water sorption) and mechanical (flexural strength, impact strength, thermal conductivity) properties of the denture base and can then be used to produce artificial palates. An electronic database search of peer-reviewed published papers in English was conducted using relevant keywords between the 23rd of August 2016 and the 24th of August 2022. The database yielded 1048 relevant published articles. However, 21 articles were qualified for this study after considering the inclusion and exclusion criteria. A substantial body of literature demonstrates that zirconium ZrO2 is widely used as an additive in the modification of PMMA. Meanwhile, flexural strength is the most conducted test based on the literature.