AbstractValue‐added products such as biofuels, chemicals, enzymes, and many others can be prepared from lignocellulosic biomass (LCB). To achieve high yields of these value‐added products, powerful tools such as artificial neural networks (ANN) and adaptive neuro‐fuzzy inference systems (ANFIS) can be utilized during process development. In this article, we have therefore reviewed the recent application of ANN and ANFIS in modeling LCB valorization processes. Studies have shown the high predictive capability of both ANN and ANFIS for a range of different processes such as pre‐treatment processes (microwave‐assisted, organosolv‐, ultrasound‐assisted pre‐treatment and many others), thermal processes (pyrolysis and gasification), enzymatic hydrolysis, and fermentation processes. These tools have also shown outstanding accuracy in predicting elemental composition and thermal characteristics of biomass by using only the proximate composition of LCB as the input information. In combination with evolutionary algorithms like genetic algorithm, particle swarm optimization or ant colony optimization, the ANN and ANFIS tools have shown excellent results in obtaining operational conditions for the efficient production of bioethanol, biogas, organic acids, lignin, and enzymes. However, there are only limited reports of the application of ANN and ANFIS in enzyme, organic acid and lignin production. Further research is therefore required to assess the suitability of using these tools in process development for the production of lignin, enzymes, and organic acids. © 2022 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
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