This paper presents methods based on chemometrics analysis to select the optimal model for variety discrimination of ginkgo (Ginkgo biloba L.) tablets by using a visible/short-wave near-infrared spectroscopy (Vis/NIRS) system. The tablet varieties used in the research include Da na kang, Xin bang, Tian bao ning, Yi kang, Hua na xing, Dou le, Lv yuan, Hai wang, and Ji yao. All samples (n=270) were scanned in the Vis/NIR region between 325-1075nm using a spectrograph. Principal component artificial neural network (PC-ANN) was used to identify the tablet varieties. In PC-ANN models, the scores of the principal components were chosen as the input nodes for the input layer of ANN. Independent component analysis (ICA) was executed to select several optimal wavelengths based on loading weights. The absorbance values log (1/R), corresponding to the wavelengths of 481nm, 1000nm, 460nm, 572nm, 658nm, 401nm, 998nm, 996nm, 468nm and 661nm were then chosen as the input data of artificial neural network (IC-ANN), and the discrimination rate was reached at 95.6%, which was better than PC-ANN. The results indicated that ginkgo tablets discrimination was good based on the both methods.