Lysosomal storage disorders (LSDs) are a group of about 50 rare and genetically inherited metabolic diseases. In this review article, Rosella Tomanin et al. summarize some of the most important gene therapy approaches evaluated for LSD and give us an overview of the gene therapy clinical trials so far proposed. The authors also explain why gene therapy procedures for LSD could be a good model for the treatment of several other Mendelian diseases (pp. 692–701). Hyaluronan (HA) is an endogenous mediator of inflammation. To explore its role in neonatal sepsis, Helen CD Østerholt et al. investigated whether different molecular weight HA can influence expression of Toll-like receptors 2 and 4, and proinflammatory cytokine production in umbilical cord blood. They found that Toll-like receptor 4 expression decreased in the presence of high-molecular-weight hyaluronan, whereas cytokine levels increased in the presence of both forms of hyaluronan. The results confirm that hyaluronan affects the neonatal immune system (pp. 706–713). Synthetic oxytocin is the most commonly used drug to induce or augment labour contractions. The assumption that exogenous oxytocin does not cross the placenta and the foetal blood–brain barrier has been questioned. In a pilot study including twenty healthy primiparpae, Ibone Olza Fernandez et al. found that intrapartum exogenous oxytocin seems to disturb sucking and breastfeeding duration (pp. 749–754). In this follow-up study, six patients with severe hypospadias were evaluated in the prepubertal period, 6–8 years after urethral reconstruction with cultured autologous cells. All patients had good cosmetic appearance, good voiding function, straight artificial erections and an even, non-hair-bearing urethral inner surface at the transplanted site. Magdalena Fossum et al. conclude that tissue engineering for severe hypospadias repair can be performed in a safe manner (pp. 755–760). When the vitamin D levels were measured in a group of 54 Swedish depressed adolescents, vitamin D deficiency was found in 48 of them. After 3 months of vitamin D supplementation, there was a significant increase in well-being as well as a decrease in depression scores. In addition, Göran Högberg et al. found a positive correlation between serum vitamin D levels and well-being (pp. 779–783).