Artificial Bone Implants Research Articles

Management of acetabular comminuted fractures combined with compressive defects

目的 探讨治疗髋臼粉碎性骨折合并压缩性缺损的手术方法.方法1997年7月～2005年2月,收治髋臼粉碎性骨折合并压缩性缺损43例,其中陈旧性骨折25例,新鲜骨折16例,畸形(大于90 d)2例;复杂骨折与缺损34例,简单骨折与缺损9例.缺损体积3～9 cm3,平均4.5cm3.采用改良髋臼入路,应用髋臼三维记忆内固定系统(ATMFS)三维记忆锁定碎骨;髋臼碎骨关节面整复法;自体髂骨髋臼后壁解剖性重建法;自体骨+人工骨填塞及骨腊隔离法等术后相关措施.结果所有患者随访5～86个月,平均15.7个月.粉碎骨折关节面粉碎+填补压缩体积至头臼解剖复位31例;自体髂骨后壁解剖性重建头臼解剖复位12例;40例患者经过平均5.3个月患侧髋关节功能达到健侧水平,1例股骨头缺血性坏死,2例异位骨化+股骨头缺血性坏死导致髋关节骨融合.结论本文介绍了治疗髋臼粉碎性骨折合并压缩性缺损的新方法与措施,有效地提高了股骨头与髋臼解剖对应率,为髋关节功能的恢复提供了新的思路。

Clinical application of bioactive artificial bone implantation

Clinical application of bioactive artificial bone implantation

A novel fluorescent silica tracer for biological silicification studies

Background: Biological silica production has drawn intense attention and several molecules involved in biosilicification have been identified. Cellular mechanisms, however, remain unknown mainly due to the lack of probes required for obtaining information on live specimens. Results: The fluorescence spectra of the compound 2-(4-pyridyl)-5-((4-(2-dimethylaminoethylaminocarbamoyl)methoxy)phenyl)oxazole (PDMPO) are affected by the presence of >3.2 mM silicic acid. Increase in intensity and shift in the fluorescence coincide with the polymerization of Si. The unique PDMPO–silica fluorescence is explored here to visualize Si deposition in living diatoms. The fluorophore is selectively incorporated and co-deposited with Si into the newly synthesized frustules (the outer silica shells) showing an intense green fluorescence. Conclusions: We suggest that a fluorescence shift is due to an interaction between PDMPO and polymeric silicic acid. PDMPO is an excellent probe for imaging newly deposited silica in living cells and has also a potential for a wide range of applications in various Si-related disciplines, including biology of living organisms as diatoms, sponges, and higher plants, clinical research (e.g. lung fibrosis and cancer, bone development, artificial bone implantation), and chemistry and physics of materials research.

Current Chemistry: Nanostructured Biomaterials: a Novel Approach to Artificial Bone Implants

Manuscript received: 14 September 2001. Final version: 3 December 2001.

Application of Bioactive Ceramics for Functional Surgery in Masticatory Organs

Transplanted and replanted autogenous teeth or implanted artificial roots become easily ankylotic. However, if adequate functional loads are applied to them continuously postop with proper fixation, ankylosis can be prevented. The author found this fact through studies on autogenous tooth replantation 20 years ago. Therefore, not only can tooth transplantation, replantation, and artificial root implantation be done successfully with adequate functional loads, but surgical orthodontics as well as plastic operation of jaw deformity can also benefit in the same way. This therapeutic method is called functional surgery. The ankylotic process can be more effectively prevented by applying bioceramic granules. Using these methods, (a) 30 vital teeth in 23 patients were transplanted or replanted. Follow-up duration was 6 to 96 months. (b) Artificial roots made of compact sintered hydroxyapatite (apatite) were implanted under the new concept of functional surgery. In all, 57 artificial roots in 19 patients were implanted and observed for over 5 years. (c) Masticatory skeletal deformities of the viscerocranium were treated with the new concept of functional surgery applying sintered apatite. For this purpose, artificial bone implantation or simple gnathoplasty, tooth transplantation, and artificial root implantation was carried out in 15 patients, after which mastication training was applied with concomitant corrections of function inclination, i.e., oral-perioral habits. In these clinical experiments, excellent favorable results were obtained. The following conclusion was obtained: Introducing the new concept of functional surgery using bioceramics, not only tooth transplantation, as well as artificial root therapeutics, but deformity of the jaw can be steadily treated.