Artery Intima-media Thickness In Patients Research Articles

Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?

BackgroundPsoriasis is a chronic inflammatory disease that is associated with many inflammatory conditions such as atherosclerosis, hypertension, among others. SCUBE-1 is a protein that plays a role in angiogenesis. ObjectivesThe present study aimed to investigate whether SCUBE-1 could indicate subclinical atherosclerosis in psoriatic patients, and to compare SCUBE-1 levels, measurement of carotid artery ıntima-media thickness (CIMT), and metabolic parameters in psoriasis patients and healthy controls. MethodsForty-six patients with psoriasis and 43 healthy controls were included. The severity of the disease was assessed with Psoriasis Area Severity Index (PASI) in the patient group. Levels of SCUBE-1, CRP, lipids, and fasting glucose were measured with the enzyme-linked ımmunosorbent assay (ELISA) method, and CIMT measurements were performed by the same cardiologist. ResultsSCUBE-1 levels and CIMT values were significantly higher in the patient group (for both p < 0.05). Moreover, systolic blood pressure, CRP levels, and waist circumference were higher in the patient group even though both groups had similar BMIs (for all p < 0.05). A positive correlation was found between SCUBE-1 and CIMT values among patients, and multiple regression analyses revealed that SCUBE-1 and CIMT are significantly associated with psoriasis as well. Study limitationsA low number of participants and not including any other inflammatory marker related to angiogenesis or atherosclerosis such as VEGF, adiponectin are the main limitations of the present study. ConclusionDespite the severity of the disease, even in psoriasis patients with mild disease the SCUBE-1 level may be an indicator of subclinical atherosclerosis and indicate the risk of cardiovascular disease in the future.

A comparative cross-sectional study on evaluation of carotid artery intima-media thickness in patients of psoriasis vulgaris: an early predictor of subclinical atherosclerosis

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; Psoriasis is associated with atherosclerosis and increased cardiovascular risk. Carotid artery intima-media thickness (CIMT) is used as a non-invasive marker in the assessment of subclinical atherosclerosis. In this study, by using a doppler ultra-sonogram, subclinical atherosclerosis in patients with psoriasis was evaluated in need of special follow-up to reduce cardiovascular morbidity. It was aimed to evaluate the mean CIMT, determine the prevalence of subclinical atherosclerosis and to evaluate the association between the severity, duration of psoriasis and CIMT.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; A hospital-based cross-sectional study was done on 25 patients with psoriasis and age, gender, and body mass index (BMI) matched 25 healthy controls over 2 months. CIMT was measured using a doppler ultra-sonogram.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; Compared to the controls, patients had higher CIMT. 24% of patients had subclinical atherosclerosis compared to 12% of controls. Chronic smokers with psoriasis had a significant association with subclinical atherosclerosis. Because of the COVID-19 pandemic, it was unable to determine the severity and prognosis of subclinical atherosclerosis through follow up.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; This study provides an insight into the higher prevalence of subclinical atherosclerosis in psoriasis patients, smokers in particular. CIMT can serve as an important noninvasive marker to assess cardiovascular risk.&lt;/p&gt;

Relation Between Oxidative Stress and Carotid Artery Atherosclerosis in Hemodyalisis Patients

Abstract Oxidative stress represents a significant risk factor for the accelerated development of atherosclerosis in a population of patients on regular hemodialysis. Oxidative stress induced by hemodialysis can be triggered with both the bioincompatibility of dialysis membrane and increased endotoxin concentration in a hemodialysis solution. The aim of this study was to investigate the correlation between the parameters of oxidative stress, microinflammation, nutrition, secondary hyperparathyroidism and carotid artery intima-media thickness in patients on regular hemodialysis.One hundred and twenty five patients treated with standard hemodialysis and on-line hemodiafiltration with "high-flux" polysulfone dialysis membrane were examined. The following parameters of oxidative stress were measured : index of lipid peroxidation - measured as TBARS, nitric oxide in the form of nitrite - NO2-, super oxide anion radical - O2- and hydrogen peroxide - H2O2, catalase, superoxide dismutase (SOD) and reduced glutathione activity. For statistical analysis of results, the following tests were used: the Kolmogorov-Smirnov test, the Spirman test and the Pearson correlation test. Oxidative stress affects atherosclerosis of the carotid arteries in patients treated with regular hemodialysis and online hemodiafiltration. There is a statistically significant positive correlation between H2O2 concentration and the thickness of the carotid arteries` intima-media. High statistically significant positive correlation was found between TBARS concentration and carotid arteries intima-media thickness, while a high statistically significant negative correlation was found between SOD activity and a carotid artery intima-media thickness. There is a statistically significant negative correlation between the serum albumin and prealbumin concentration and a carotid artery intima-media thickness. Oxidative stress may be a significant risk factor for the carotid artery atherosclerosis development in patients treated with regular hemodialysis.

Triglyceride-glucose index and common carotid artery intima-media thickness in patients with ischemic stroke

BackgroundTriglyceride glucose (TyG) index was recently reported to be associated with an increased risk of the development and recurrence of cardiovascular events, and atherosclerosis is a main speculative mechanism. However, data on the relationship between TyG index and atherosclerosis, especially in the setting of ischemic stroke, is rare. We aimed to explore the association between TyG index and carotid atherosclerosis in patients with ischemic stroke.MethodsA total of 1523 ischemic stroke patients with TyG index and carotid artery imaging data were enrolled in this analysis. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Carotid atherosclerosis was measured by common carotid artery intima-media thickness (cIMT), and abnormal cIMT was defined as a mean cIMT and maximum cIMT value ≥ 1 mm. Multivariable logistic regression models and restricted cubic spline models were used to assess the relationships between TyG index and abnormal cIMT. Risk reclassification and calibration of models with TyG index were analyzed.ResultsThe multivariable-adjusted odds ratios (95% CIs) in quartile 4 versus quartile 1 of TyG index were 1.56 (1.06–2.28) for abnormal mean cIMT and 1.46 (1.02–2.08) for abnormal maximum cIMT, respectively. There were linear relationships between TyG index and abnormal mean cIMT (P for linearity = 0.005) and abnormal maximum cIMT (P for linearity = 0.027). In addition, the TyG index provided incremental predictive capacity beyond established risk factors, shown by an increase in net reclassification improvement and integrated discrimination improvement (all P < 0.05).ConclusionsA higher TyG index was associated with carotid atherosclerosis measured by cIMT in patients with ischemic stroke, suggesting that TyG could be a promising atherosclerotic marker.

Ischemic Stroke and its Association with Risk Factors at Nepalgunj Medical College Teaching Hospital Kohalpur

Introduction: Incidence of stroke increases with age and growing elderly population worldwide, the number of patients with stroke are likely to increase. It is the third most common cause of death in world in that 85% are ischemic in nature. Atherosclerosis is a major risk factor in cerebrovascular diseases. Carotid Intima Media thickness (CIMT) is a surrogate marker of atherosclerosis and provides a non-invasive method for the risk assessment of cerebrovascular diseases.&#x0D; Aims: To study the atherosclerotic risk profile of patients admitted with ischemic stroke in medical ward with study of the carotid artery intima-media thickness in patients with acute ischemic stroke.&#x0D; Methods: 92 patients with ischemic strokes were studied in this observational study. Carotid Doppler was performed in all patients with emphasis on carotid artery stenosis and intima thickening. Analysis of Association of various risk factors was done in detail. Study period was from June 2019 to May 2020.&#x0D; Results: Higher degree of stenosis was associated with hypoechoic plaques and cortical strokes. Hypertension was the most common and most significant risk factor. Multiple risk factors also appear to have synergistic actions.&#x0D; Conclusion: Various modifiable risk factors provide valuable target for primary and secondary prevention of stroke. Carotid Doppler is a very cheap and highly effective tool for further management of stroke patients. Most of the asymptomatic patients, risk factors may warrant precautionary carotid Doppler, and may result in significant reduction in disease burden on the families and the community and should be encouraged.

Diagnostic Value of Carotid Artery Intima-media Thickness in Patients with Type 2 Diabetes and Its Correlation with HbA1c Levels

Objectives: This study aimed to assess the role of carotid ultrasonography and measure the carotid artery intima-media thickness (CIMT) and its correlation with hemoglobin A1c (HbA1c) to observe cardiovascular disease (CVD) risks in patients with type 2 diabetes mellitus (T2DM). Methods: In this observational study, 205 consecutive patients with T2DM from Golestan Hospital, Ahvaz, Iran, were included. We performed HbA1c measurements using high-pressure liquid chromatography (HPLC) with a thermo-system. Carotid arteries ultrasonography was performed with an Aloka SSD 5500 apparatus with a 7.5 MHz transducer. The CIMT was measured in the supine position with a slight neck extension. Results: There was no statistically significant difference between the two study groups in the duration of diabetes with CIMT (P = 0.425), while the differences in creatinine, HbA1c, and urine albumin were statistically significant (P = 0.020, P = 0.041, and P = 0.016, respectively). There was no correlation between CIMT and age (r = 0.19, P = 0.792) and duration of diabetes (r = 0.125, P = 0.081). Furthermore, there was no remarkable association between CIMT and weight (r = 0.12, P = 0.881) and FBS ( r = 0.062, P = 0.405). There was also a non-significant negative correlation between HbA1c% and CIMT (r = -0.127, P = 0.127). Conclusions: Ultrasound measurement of CIMT is a safe and relatively cost-effective way of diagnosing atherosclerosis. Thus, the ultrasound's predictive value as a safe and non-invasive examination may alert the related field experts early enough to intervene to prevent major cardiovascular complications.

Remnant Cholesterol and Common Carotid Artery Intima-Media Thickness in Patients With Ischemic Stroke.

Remnant cholesterol makes great contribution to residual risk of cardiovascular disease, but population-based evidence on the relationship between remnant cholesterol and atherosclerosis is rare. Common carotid artery intima-media thickness (cIMT) is an imaging marker of subclinical atherosclerosis. We aimed to explore the association between remnant cholesterol levels and cIMT in patients with ischemic stroke. One thousand four hundred ninety-six ischemic stroke patients with baseline serum lipids and carotid artery imaging data were included in this analysis. Fasting remnant cholesterol was calculated as total cholesterol minus HDL (high-density lipoprotein) cholesterol minus LDL (low-density lipoprotein) cholesterol. Abnormal cIMT was defined as mean cIMT and maximum cIMT value ≥1 mm. Logistic regression and restricted cubic spline models were used to assess the relationships between remnant cholesterol levels and abnormal cIMT. The multivariable-adjusted odds ratios (95% CIs) for the highest versus lowest quartile of remnant cholesterol were 2.06 (1.46-2.91) for abnormal mean cIMT and 1.70 (1.23-2.35) for abnormal maximum cIMT. There were linear associations between remnant cholesterol levels and both abnormal mean cIMT (P for linearity, <0.001) and abnormal maximum cIMT (P for linearity, 0.003). Moreover, the remnant cholesterol-cIMT association remained significant in the subsample of patients with optimal LDL cholesterol levels (n=179). Elevated fasting remnant cholesterol levels were positively associated with mean cIMT and maximum cIMT in patients with ischemic stroke, even in patients with optimal LDL cholesterol levels. Future prospective studies are needed to verify our findings and to assess the effect of remnant cholesterol-lowering interventions in patients with ischemic stroke.

Asymptomatic Carotid Artery Stenosis among Patients with Type II Diabetes Mellitus

Objectives: To assess Carotid artery intima-media thickness in patients with type II diabetes mellitus.Study design and setting: This descriptive cross-sectional study was conducted at Department of Medicine, CMH Quettafrom June 2018 to May 2019.Methodology: Total 176 known type II diabetes mellitus (DM) patients were included in study. Age ranged from 30-70years. Patients using statin drugs, chronic kidney disease and decompensated liver cirrhosis were excluded. Carotid arteryultrasonography was carried out by radiologist. Carotid artery intima-media thickness (CIMT) was achieved with a 7 MHzB-mode ultrasound system. The intima-media thickness (IMT) was demarcated as the distance between the leading edgeof the luminal echo to the leading edge of the adventitia of the media. This distance was measured during the diastolicphase. This was measured 3 cm before the carotid bifurcation. Also, carotid bifurcation and internal carotid artery 2 cmdistally from the carotid bifurcation was scanned.Results: Mean age was 47.86 ± 6.46 years. Most of the patients 125 (71.02%) were consisted of 30 to 50 years of age.Among them the 176 patients, 92 (52.27%) were male and 84 (47.73%) were females. Male to female ratio comprised of1.1:1. Results further revealed that 43(24.43%) patients showed asymptomatic Carotid artery intima-media thickness. Restthere was no asymptomatic Carotid artery intima-media thickness in 133 (75.57%) patients

Association Between the Framingham Risk Score and Carotid Artery Intima-Media Thickness in Patients With Human Immunodeficiency Virus

Cardiovascular diseases (CVD) are more prevalent among HIV-infected subjects. We examined the associations between carotid artery intima-media thickness (CIMT), conventional CVD risk factors, and HIV-related risk factors among Hispanics with HIV infection. This cross-sectional study involved 96 consecutive HIV patients on stable antiretroviral therapy and without history of CVD in a university-based outpatient clinic who underwent carotid ultrasound evaluation. Increased CIMT was defined as common carotid artery-CIMT values greater than or equal to seventy-fifth percentile for the patient's age, sex, and race/ethnicity based on CIMT nomograms from large population studies. The sample was comprised of 96 Hispanic Americans aged 39.7 ± 11.9, 89% of whom were men, 64% were on a protease inhibitor, and 11% had increased CIMT (95% confidence intervals 5.9% to 19.6%). In univariable analysis, increased CIMT was significantly associated (p <0.05) with older age, metabolic syndrome, intermediate/high Framingham risk score, HIV infection duration ≥5 years, integrase inhibitors, and protease inhibitors. In multivariable analysis, only Framingham risk score (p = 0.009) was independently associated with increased CIMT. The median common carotid artery-CIMT value was significantly greater in patients with intermediate/high compared with those with low Framingham risk score (0.60 vs 0.49 mm; p <0.001). In conclusion, given the significant association between increased CIMT and Framingham risk score, adherence to prevention guidelines to reduce CVD risk factor burden in this population is strongly recommended.

Association of monocyte to high-density lipoprotein cholesterol ratio with carotid artery intima-media thickness in patients with systemic lupus erythematosus.

The purpose of this study was to evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and carotid atherosclerostic plaque in patients with systemic lupus erythematosus (SLE). A total of214 SLE patients were divided into two groups according to the results of ultrasonic examination: carotid arterial atherosclerotic plaque groups and noncarotid arterial atherosclerosis groups. The values of monocyte to high-density lipoprotein-cholesterol ratio (MHR) increase in carotid arterial atherosclerotic plaque groups compared with noncarotid arterial atherosclerosis groups (0.32±0.18 vs0.26±0.15; p=0.015). There was a significant correlation between MHR and carotid artery intima-media thickness (r=0.228; p=0.001) in patients with SLE. Our study suggests that the values of MHR could be a marker to assess carotid artery intima-media thickness in patients with SLE.

Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity

Aim: The sodium-sparing effect of insulin leads to increase in total sodium pool of the body which is a chronic stimulus for atrial natriuretic peptide (ANP). In our study we aimed to determine the relationship between ANP and microvascular complications of diabetes. Methods: 60 patients, 30-70 years old, with the diagnosis of type 2 diabetes mellitus (DM) are enrolled into the study. Patients with a chronic disease other than DM are excluded. Blood samples for routine biochemical tests are taken after at least 12 h fasting at 8-9 am. Blood samples for glucose and insulin levels are taken 2 h after a standard meal. Blood tubes with EDTA are used for ANP levels. The microvascular complications of the patients are evaluated. Results: 32 of the patients had microvascular complications. Age, BMI, waist and hip circumferences, and ANP levels were significantly higher in the group with microvascular complications. There were no significant differences in waist-to-hip ratio, blood glucose, HbA1c, fasting insulin, postprandial insulin, fasting HOMA, postprandial HOMA as well as sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between ANP and obesity, retinopathy, neuropathy, nephropathy, diabetes time, HbA1c, or sex are evaluated separately, the only significant parameters related to ANP were obesity and retinopathy. Conclusion: In our study we have found that there was a significant relationship between ANP levels and microvascular complications of diabetes. Future studies are needed to show if ANP is the stimulus of microvascular complication development/progression or only an epiphenomenon.

The predictive value of plasma visfatin and adiponectin in early atherosclerosis in patients with type 2 diabetes

Objective To evaluate the association between plasma levels of visfatin and adiponectin with carotid arterial intima-media thickness in patients with type 2 diabetes. Methods A total of 100 elderly patients with type 2 diabetes and 30 healthy elderly controls were recruited from August 2015 to August 2016 at our hospital.Based on carotid arterial intima-media thickness(IMT)assessed via color Doppler ultrasonography, patients with diabetes were further divided into a thickened IMT group(40 cases)and a non-thickened IMT group(60 cases). Plasma levels of visfatin and adiponectin were analyzed and compared, and their associations with carotid arterial IMT were evaluated. Results Compared with the control group, patients in both the thickened IMT group and the non-thickened IMT group had significantly higher serum levels of visfatin(19.1±2.8)μg/L vs.(40.6±3.9)μg/L, (28.9±3.6)μg/L, which was markedly higher in the thickened IMT group than in the non-thickened IMT group(P<0.05). In addition, compared with the control group, patients in the thickened IMT group and the non-thickened IMT group had significantly lower serum levels of adiponectin(1 590±330)mg/L, (610±170)mg/L, (930±210)mg/L, which was markedly lower in the thickened IMT group than in the non-thickened IMT group(P<0.05). Furthermore, Pearson's analysis showed that the plasma level of visfatin was positively correlated with carotid arterial IMT(r=0.721, P<0.05), and the plasma level of adiponectin was negatively correlated with carotid arterial IMT(r=-0.688, P<0.05). Conclusions Plasma levels of visfatin and adiponectin are closely related to carotid arterial IMT in patients with type 2 diabetes, andmay be used as plasma markers for the prediction of early atherosclerosis. Key words: Nicotinamide phosphoribosyltransferase; Adiponectin; Diabetes mellitus, type 2; Carotid arterial

Proprotein convertase subtilisin/kexin type 9 (PCSK9) level in patients with familial hypercholesterolemia in Russia

Aim: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates the amount of LDL receptors and plasma cholesterol concentrations, it’s new target for lipid lowering therapy and perspective biomarker for predicting cardiovascular events based on some resent data. The aim was to investigate the association of the PCSK9 protein with lipid parameters, carotid artery intima-media thickness in patients with familial hypercholesterolemia (FH).

Association of Level of Proprotein Convertase Subtilisin/Kexin Type 9 with Intima-Media Thickness in Patients with Familial Hypercholesterolemia.

We studied association of PCSK9 protein with the carotid artery intima-media thickness in patients with familial hypercholesterolemia (N=53; age 49.9±6.9 years) treated with statins. Blood level of PCSK9 protein was measured by ELISA; ultrasonography of the carotid arteries with measurement of the thickness of the intima-media complex of the common carotid arteries in the distal segment for 10 mm from the bifurcation on the far wall of the vessel was performed in on-line mode. The mean values were calculated for both sides, the maximum mean value was included in the analysis. It was shown that PCSK9 levels positively correlate with carotid artery intima-media thickness in patients with familial hypercholesterolemia.

Ultrasound evaluation of carotid artery intima-media thickness in patients with risk factors for cardiovascular disease

Objective: The study purpose was to assess the change of carotid artery intima-media thickness (CAIMT) in patients with cardiovascular risk factors (CVRF), and determine the main factor that causing the abnormal IMT.Methods: We collected the data of 89 patients who underwent a carotid artery ultrasound between February 2011 and November 2012 (43 men and 46 women aged between 20-80 years old). All patients included in the study had one of the following cardiovascular risk factors: smoking (n = 40), arterial hypertension (n = 25) or diabetes mellitus (n = 24). The IMT of the common carotid artery was measured and the results were correlated with the recorded risk factor. Correlation with the patient’s age and gender was also performed.Results: The study revealed abnormal IMT (&gt; 1 mm) in a total of 71 (79.8%) patients. These included 22 (88%) patients with hypertension, 19 (79.2%) patients with diabetes mellitus and 30 (75%) patients who were smokers (p &lt; .05 for all 3 risk factors). While aging was also associated with increased IMT (p &lt; .05), no gender differences were noted (p &gt; .05).Conclusions: The present study showed that ultrasound is an excellent, noninvasive method for evaluation of carotid intima-media thickness. The main risk factors associated with abnormal carotid IMT were hypertension, diabetes mellitus, smoking andpatient’s age.

Assessment of Carotid Artery Intima-Media Thickness in Patients with Obstructive Sleep Apnea

Assessment of Carotid Artery Intima-Media Thickness in Patients with Obstructive Sleep Apnea

English

English

Reduction of internal carotid artery intima-media thickness in patients with moderate-to-severe obstructive sleep apnea syndrome after nasal surgery and uvulopalatopharyngoplasty

Conclusion Multi-level surgeries for the nasal cavity and palate can reduce the severity of obstructive sleep apnea with major narrowing above the retropalatal airway and reduce the carotid intima-media thickness, which can provide cardiovascular benefits to patients. Objective To evaluate the outcomes of moderate-to-severe obstructive sleep apnea syndrome by surgeries and the change of internal carotid artery intima-media thickness after surgeries. Subjects and methods Sixty-four patients with obstructive sleep apnea, narrowing at the nasal cavity, and retropalatal airways were enrolled in this study. Fifty-two patients underwent nasal surgery and modified uvulopalatopharyngoplasty. Twelve patients who refused surgeries and continuous positive airway pressure treatment received only conservative treatment. All patients were evaluated within 1 month before and 6 months after treatment using polysomnography, upper airway endoscopy, and B mode ultrasound. Results The success rate was 61.5% (32/52 patients) in the surgery group. There were significant differences between the surgery group and non-surgery group 6 months after treatment in the apnea hypopnea index, minimum and mean oxygen saturation, blood pressure, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and internal Carotid intima-media thickness. The changes in the oxygen saturation and the apnea hypopnea index showed significant correlations with the changes in the intima-media thickness.

Correlation between homocysteine level and carotid artery intima-media thickness in patients with nonalcoholic steatohepatitis

Correlation between homocysteine level and carotid artery intima-media thickness in patients with nonalcoholic steatohepatitis

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

Both of the carotid artery intima-media thickness (IMT) and mean platelet volume (MPV) may add to the risk of atherosclerosis for predicting cardiovascular events. It is not known, however, whether there is an association between them in diabetes patients. The aim of the study was to detect the relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus, and to determine the correlation of MPV with body mass index (BMI), duration of diabetes, glycosylated hemoglobin A1 (HbA1C), fasting blood glucose (FBG), C-reactive protein (CRP), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), serum uric acid (UA), ankle-brachial index (ABI), history of hypertension, and smoking in diabetic patients, respectively. A total of 128 subjects were enrolled into this study, who admitted consecutively to our clinic from January 1, 2013 to January 30, 2014. They were divided into three groups according to their IMT: normal IMT group (A, IMT ≦1.1 mm, n = 26), IMT thickness group (B, IMT >1.1 mm, n = 45), IMT thickening with plaque group (C, n = 57). A significant difference with respect to BMI, HBA1c, TG, HDL-C, CRP, UA, FBG, ABI, and cigarette use between the study groups was not found (P > 0.05). MPV was significantly higher in group A as compared to both group B and group C (7.94 ± 0.97 fl, 7.24 ± 0.71 fl, 7.03 ± 0.79 fl, respectively, P〈0.001), MPV had a high positive correlation with IMT (P〈0.001) and age, as with TC and LDL-C (P〈0.05). The level of MPV content decreased as the diabetic macroangiopathy progressed. Level of MPV was correlated with IMT in diabetic patients. MPV might be a useful marker for detecting atherosclerosis risk in diabetic patients.