ObjectivesThe aim of this study is to present our experience with three patients who underwent a neonatal Yasui procedure, and to show the new decision-making algorithm. MethodsThis is a series of three neonates operated on at our hospital between 2017 and 2022. ResultsAll the patients underwent a primary Yasui. The duration of cardiopulmonary bypass was 275, 249 and 391min, in patient 1, 2 and 3, respectively. After surgery, the Intensive Care Unit stay of patients 1, 2 and 3 was 29, 22 and 24 days, respectively. The patients were discharged in good condition. Subsequent complications during follow-up included the need for percutaneous intervention in patient 1 for the implantation of a stent in the right pulmonary branch (at 6 months postoperatively) and a stent in the right ventricle-pulmonary artery conduit (at 42 months). Patient 2 required right ventricle-pulmonary artery conduit replacement and repair of moderate-severe left ventricular outflow tract obstruction at 16 months postoperatively. Patient 3 needed a reoperation at 3 months postoperatively due to aortic arch stenosis at different levels and a residual ventricular septal defect. Currently, all patients are alive with adequate echocardiographic biventricular function. ConclusionsIn experienced centers, primary Yasui repair can be performed in the neonatal period with satisfactory results.