Patients with end-stage renal disease on chronic hemodialysis often face socioeconomic challenges. The Veterans Health Administration supports those on disability with regular follow-ups. This study aimed to investigate the associations between disability and arteriovenous graft (AVG) placement outcomes in a veteran patient population. All veteran patients who had primary AVG placement (January 1, 2006, to January 1, 2019) were reviewed. Patient factors collected included disability status, patient demographics, comorbidities, medication use, smoking status, prior precursors, and history of previous central venous access. AVG outcomes examined included successful cannulation, days rested, functional patency, total endovascular interventions, and thrombosis events. Statistical tests used included the Fisher exact test and Student t-tests. A total of 88 patients had an AVG placed, and 69% of patients were on disability with a mean age of 64.9 ± 10.7 years. There was no statistical difference in race, body mass index, comorbidities, antiplatelet, or anticoagulation. Patients with disability were found to have a statistically higher percentage of prior hemodialysis access arteriovenous fistula (63.9% vs 37%; P = .02) when compared with the nondisabled patient cohort. Patients with disability were found to have statistically longer days rested (65.8 ± 132.6 vs 33.5 ± 35.5 days; P = .03), higher thrombosis events (1.7 ± 2.1 vs 0.6 ± 0.7; P = .001), and total number of endovascular interventions (3.2 ± 4.3 vs 1.2 ± 1.8; P = .004). When case matching to control for prior hemodialysis access history, a statistically significantly higher mean number of days rested (P = .001) and thrombosis events (P = .03) were found in the disability cohort (Table). Disability status is associated with increased access days rested, total endovascular interventions, and thrombosis events. Our data imply that patients with disabilities might have increased underlying comorbid states driving access outcomes. In addition, such status in the VA system might indicate an increased bias toward intervention and possible delay in access utilization.TableHemodialysis access outcome differences between those undergoing primary arteriovenous graft placement (AVG) without and with an established disability statusNo disability (n = 27)Disability (n = 61)P valueSuccessful cannulation, No. (%)20 (74.1)51 (83.6).29aRested (mean days ± SD)33 ± 3666 ± 132.03bFunctional patency (mean days ± SD)417 ± 533706 ± 519.61bEndovascular interventions (mean ± SD)1.2 ± 1.83.2 ± 4.3.004bThrombosis events (mean ± SD)0.6 ± 0.71.7 ± 2.1.001bSD, Standard deviation.aFactors were analyzed using the Fisher exact test.bFactors were analyzed using the Student t-test. Open table in a new tab