Memory-based computing using associative memory is a promising way to reduce the energy consumption of important classes of streaming applications by avoiding redundant computations. A set of frequent patterns that represent basic functions are pre-stored in Ternary Content Addressable Memory (TCAM) and reused. The primary limitation to using associative memory in modern parallel processors is the large search energy required by TCAMs. In TCAMs, all rows that match, except hit rows, precharge and discharge for every search operation, resulting in high energy consumption. In this paper, we propose a new Multiple-Access Single-Charge (MASC) TCAM architecture which is capable of searching TCAM contents multiple times with only a single precharge cycle. In contrast to previous designs, the MASC TCAM keeps the match-line voltage of all miss-rows high and uses their charge for the next search operation, while only the hit rows discharge. We use periodic refresh to control the accuracy of the search. We also implement a new type of approximate associative memory by setting longer refresh times for MASC TCAMs, which yields search results within 1–2 bit Hamming distances of the exact value. To further decrease the energy consumption of MASC TCAM and reduce the area, we implement MASC with crossbar TCAMs. Our evaluation on AMD Southern Island GPU shows that using MASC (crossbar MASC) associative memory can improve the average floating point units energy efficiency by 33.4, 38.1, and 36.7 percent (37.7, 42.6, and 43.1 percent) for exact matching, selective 1-HD and 2-HD approximations respectively, providing an acceptable quality of service (PSNR > 30 dB and average relative error <10 percent). This shows that MASC (crossbar MASC) can achieve 1.77X (1.93X) higher energy savings as compared to the state of the art implementation of GPGPU that uses voltage overscaling on TCAM.