Art Center Research Articles

P-728 Impact of calling mosaicism for a less stringent threshold on clinical pregnancies in more than 6000 PGT-A cycles

Abstract Study question How does calling mosaicism for a higher threshold affect euploidy, the chance of finding at least one euploid embryo and clinical pregnancy? Summary answer Increasing the threshold significantly increased euploidy percentage and the probability of finding at least one euploid embryo, as expected, but also the pregnancy outcomes. What is known already NGS technology has shed light on the occurrence of chromosomal mosaicism at the preimplantation stage of development. Evidence regarding clinical outcomes after transfer of embryos with putative mosaic results are accumulating (ESHRE Working Group on Chromosomal Mosaicism, 2022). A series of studies reporting the birth of healthy babies after the transfer of embryos with a chromosomal mosaic result on PGT-A (Greco et al., 2015; Kahraman et al., 2020; Viotti et al., 2019 and 2021), have been published. Data suggested lower implantation rates and higher miscarriage rates when mosaics were compared with euploid embryo transfers. Study design, size, duration This retrospective study covers a period from January 2017 to October 2022 and includes 6063 PGT-A cycles. A total of 18425 blastocysts were biopsied and analyzed with NGS. From January 2017 to December 2020, the cut-off value for reporting mosaicism and euploidy was %20; the rate of which was increased to 30% after January 2021. Chromosomes with PGT-A profiles that deviate from 2 copies by less than 30% were reported as normal. Participants/materials, setting, methods A total number of 12751 and 5674 blastocysts were biopsied between January 2017-December 2020 and January 2021-October 2022, respectively. PGT-A was performed on Ion Torrent S5 (Thermo Fisher Scientific). The mean female age for 20% and 30% cut-off groups were 36.7+-5.1, 35.9+-5.2, respectively. As this age difference was statistically significant, further analysis was performed in age subgroups < =38 and >38. Main results and the role of chance For PGT-A cycles with female age < =38, cycles with at least one euploid embryo in the 30% cut-off group increased from 74.0% to 77.5% whereas cycles with at least one mosaic embryo decreased from 40.8% to 37.0% (p = 0.0212; p = 0.0274). Cycles with at least one mosaic embryo without any euploid embryos decreased by 2% (9.2% to 7.2%) (p = 0.0522). The euploidy percentage out of all tested biopsies was significantly increased from 40.4% to 45.8% (p = 0.0001). For cycles with female age >38, ratio of PGT-A cycles with at least one euploid embryo increased from 28.1% to 30.3% in the 30% cut-off group but this was not statistically significant (p = 0.28). Cycles with at least one mosaic embryo were decreased from 15.1% to 10.8% and cycles with at least one mosaic embryo without any euploid embryo decreased from 9.5% to 5.6% in the 30% cut-off group (p = 0.006; p = 0.0018). The euploidy percentage was increased by 2.8% from 15.1% to 18.1% (p = 0.0115). The pregnancy outcomes were significantly higher for euploid embryos with the 30% cut-off compared to 20%, as clinical pregnancy was 64.5% vs. 59.1% and clinical pregnancy loss was 7.9% vs. 12.4% (p = 0.0022; p = 0.0011). Similarly, ongoing pregnancy was 5.2% higher, but non-significant. Limitations, reasons for caution These are the results of a single ART center which is using the same protocols for ovarian stimulation and endometrial preparation in the two periods above mentioned. Although not expected, minor changes may have occurred; similar practices have to be reported. Wider implications of the findings Mosaicism is undeniably a true biological phenomenon. However, trophectoderm biopsy and NGS are prone to create an artefactual false mosaicism. Relaxing the mosaicism calling rate by 10% may have added some better-quality blastocysts to the euploid pool giving the opportunity to embryologists of transferring blastocysts with higher implantation potential. Trial registration number Not applicable

P-237 In vitro time to maturation of Metaphase I oocytes: a time-lapse study correlating blastocyst formation and ploidy status

Abstract Study question What is the impact of metaphase I (MI) time to mature period (TTM) regarding blastocyst development and ploidy status? Summary answer A short period of TTM (0.1 to 1.0) is related to an increase number of blastocyst formation when compared to longer TTM (1.1 to 3.0). What is known already To achieve meiotic competence, coordinated nuclear and cytoplasmic changes must occur in the oocyte to support fertilization and DNA replication and to ensure correct ploidy of the zygote and embryonic genome activation. Concomitant with chromosome condensation and migration, oocyte maturation goes by cytoplasm reorganization throughout the transitions of MI, polar body extrusion and MII. Despite the optimization of COH protocols, nearly 20% of the retrieved oocytes remain immature at the GV or MI stages. In vitro maturation of MI could increase the number of available embryos; however, longer culture time may affect oocyte quality, resulting in abnormal fertilization and cleavage. Study design, size, duration Prospective cohort study from 244 patients (n = 277 cycles) that had at least 1 MI oocyte after oocyte retrieval (OPU) following controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) treatment according to medical referral in an single private ART center from January/2019 to November/2022. All MI oocytes were placed in a time-lapse incubator (TL, EmbryoScope, Vitrolife, Sweden) to check the exact time of first polar body extrusion (TTM to MII) before intracytoplasmic sperm injection (ICSI). Participants/materials, setting, methods Three hours after OPU, oocytes were denuded and assessed for maturation. Six-hundred and seven MI oocytes were followed in TL and those that reached the MII stage in a maximum of 6 hours post-OPU, were injected by ICSI (at 6h post-OPU) and stratified according to the TTM (0.1-1.0 hours and 1.1-3.0 hours). Fertilization rate, blastocyst formation, and ploidy were assessed. Kruskal-Wallis, chi-squared and Fisher tests were applied for statistical analysis. p < 0,05 was considered significant. Main results and the role of chance Patient mean age (n = 244) was 38,50 ± 3,40 years. From those, 25 patients (10.3%) had 2 cycles and 4 patients (1.6%) had 3 cycles with at least 1 MI oocyte. Age, anti-Müllerian hormone (AMH), #OPU, #MII, %MII (MII/OPU), #MI and MI% (MI/OPU) mean were not statistically different in patients with 1, 2 or 3 cycles in our cohort. One hundred forty-nine patients (61%) in 165 cycles (59.6%) had at least 1 oocyte that reached MII stage. In total, 248 oocytes were injected after 0.1-1.0h (group 1, n = 104, 41.9%) and 1.1-3.0h (group 2, n = 144 oocytes, 58.1%) of in vitro maturation. Age (38,99 ± 3,01 vs 38,85 ± 3,31), AMH (1,27 ± 1,29 vs 1,63 ± 1,87), #OPU (8,98 ± 4,32 vs 8,90 ± 4,34), #MII (4,41 ± 2,74 vs 4,44 ± 2,178), %MII (47.6% ± 18.8% vs 48.4% ± 17.1%) and %MI that followed to ICSI (59.2% ± 28.5% vs 54.8% ± 29.2%) were not different between groups 1 and 2 respectively. The mean number of MI that followed to ICSI were higher in group 1 (1,28 ± 0,48 vs 1,10 ± 0,32, p = 0.0008). Normal fertilization (2PN) and embryo cleavage were similar between groups (54.8% vs 45.1%, p = 0.157, 96.6% vs 93.3%, p = 0.467, respectively). However, blastocyst formation rate (#blastocyst/#fertilized) was higher in group 1 (n = 33, 55.9% vs n = 26, 34.7%, p = 0.015). Euploidy rates were similar between groups (9/28, 32% vs 4/24, 16%, p = 0.336). Limitations, reasons for caution Besides the retrospective nature of this study, male factor and infertility reason were not considered in this analysis. Due to the low number of blastocyst formation and consequentially ploidy assessment and number of embryo transfer, the results regarding euploidy rate may be underestimated and pregnancy rates were not included. Wider implications of the findings Oocytes that reached maturity up to 1 hour after denudation showed higher blastocyst formation rate, thus increasing embryo availability to transfer. In vitro-matured oocytes exhibit increased spindle and chromosomal abnormalities compared with oocytes matured in vivo, which may explain the lower rates of euploid embryos, especially in group 2. Trial registration number Not applicable.

P-183 Blastocyst speed versus blastocyst look: Which is the better predictor of clinical pregnancy and live birth following time-lapse culture and single blastocyst transfer?

Abstract Study question To compare predictive value for pregnancy and live birth of morphological versus morphokinetic assessment of blastocysts after time-lapse culture and single blastocyst transfer. Summary answer Blastocyst morphokinetic assessment was not superior in predicting pregnancy and live birth compared to blastocyst morphology, but provides additional information, particularly for morphologically poorer-quality blastocysts. What is known already Blastocyst culture with time-lapse technology enables evaluation of both morphokinetic developmental speed and classical morphology including Gardner scoring of the blastocyst. One approach to assess the developmental speed of blastocysts is to use the morphokinetic classification proposed by Campbell, Fishel, et al., based on time to start of blastulation (tSB) and the duration of forming the blastocyst (dB). However, beyond the advantages of undisturbed embryo culture, the value of the kinetic data from time-lapse is debated. Study design, size, duration EDCOS (Embryo Developmental profiles from Controlled Ovarian Stimulation cycles using follitropin alfa) is a multicentre, prospective cohort study of patients undergoing IVF/ICSI whose embryos were cultured in time-lapse incubator devices in 10 ART centres throughout Denmark and Sweden. Patients undergoing IVF/ICSI (including donor oocyte cycles) who had ovarian stimulation with follitropin alfa (Bemfola®) and had zygotes and embryos available for monitoring in the EmbryoScope™ time-lapse incubator device (Vitrolife) were invited to join this study. Participants/materials, setting, methods Morphological and morphokinetic prognostic classifications for single blastocyst transfers (SET) were determined for three study subpopulations: fresh autologous SET (311 women), frozen autologous SET (246 women; 345 transfers) and frozen donor SET (38 women; 59 transfers). All blastocysts were graded morphologically in five grades from Amorph (best) to Emorph (worst) based on their Gardner score and morphokinetically in three grades from Akin (best) to Ckin (worst) based on tSB and dB. Main results and the role of chance Overall ongoing pregnancy and live birth rates (OPR/LBR) for morphokinetic classifications Akin, Bkin and Ckin were 36.1%, 30.0% and 16.3% (P = 0.021) and 30.4%, 21.8% and 9.1% (P = 0.000), respectively. OPR and LBR for morphological classifications Amorph, Bmorph, Cmorph, Dmorph and Emorph were 41.9%, 37.8%, 30.8%, 19.0% and 15.6% (P = 0.000) and 36.6%, 29.1%, 15.6%, 16.5% and 8.3% (P = 0.002), respectively. For Dmorph blastocysts, OPR and LBR for morphokinetic classifications Akin, Bkin and Ckin were 50%, 21.4% and 7.1% (P = 0.009) and 33.3%, 10.8% and 0% (P = 0.003), respectively. Receiver operating characteristic curve analyses achieved areas under the curve for fresh autologous SET of 55.7%, 58.9% and 67.2% for the morphokinetic, morphological and combined classifications, respectively; and 53.4%, 64.0% and 65.6%, respectively, for frozen autologous SET. Limitations, reasons for caution This was an observational study with no control group, conducted under usual clinical practice. Data were collected prospectively, although clinics could deselect and rank blastocysts according to their own procedures. However, the outcome of subsequent frozen blastocyst transfer cycles was also analysed. Wider implications of the findings Selection of a blastocyst for transfer based on morphokinetic assessment at the blastocyst stage was not superior to classical blastocyst morphological assessment after time-lapse culture but is a viable option. Combining morphokinetic and morphological evaluation provides additional supporting information to guide in blastocyst selection, especially for morphologically poorer-quality blastocysts. Trial registration number Not applicable

P-274 Clinical limitations of manual oocyte quality scoring by embryologists are overcome by an artificial intelligence (AI) oocyte image analysis tool

Abstract Study question Do manual embryologist annotations (individual/combined) of dysmorphisms within mature denuded oocytes display better correlation with blastocyst development compared to an AI oocyte assessment tool? Summary answer Manual scoring cannot reliably determine oocyte quality in comparison to oocyte assessments by an AI image analysis tool (MAGENTA), which significantly correlates with blastocyst formation. What is known already Despite the importance of oocyte quality on blastocyst development, there is no validated visual oocyte assessment employed in clinical practice. While individual oocyte dysmorphisms can be identified, none have been shown to consistently correlate with laboratory and reproductive outcomes. Even when manual oocyte scoring systems have been employed to aggregate multiple dysmorphisms, correlations to blastocyst development fall short. An AI image analysis tool (MAGENTA) has been trained to correlate parameters of the mature denuded oocyte, including those that may be imperceptible to the human eye, to reproductive outcomes, producing more objective, accurate and time-saving assessments. Study design, size, duration A retrospective dataset consisting of 1009 mature denuded oocytes from 166 IVF-ICSI patients attending Bahçeci Umut ART Centre (Istanbul, Turkey) during 2016-2019 was assessed. 879 oocytes were included in the final data analysis, after removing oocytes with missing manual morphological assessments, lab outcomes (fertilization and blastocyst development), or whose static images could not be linked to outcomes. The resulting 879 oocytes correspond to 149 patients from ages 22-45 (mean age of 33.9 years old). Participants/materials, setting, methods Two embryologists, blinded to outcomes, retrospectively annotated oocyte images for 7 dysmorphism categories: shape/size, cytoplasmic granularity, polar body fragmentation, zona pellucida thickness, perivitelline space thickness, smooth endoplasmic reticulum (SER) presence, and vacuole presence. Annotations were assigned points and combined into an overall manual score ranging from 0-10 based on a recent review (Bartolacci 2022). Each, previously unseen, oocyte image was analyzed by MAGENTA, assigning a score (0-10), where increasing scores correlate to greater blastocyst development. Main results and the role of chance The correlation between each of the 7 observed morphological categories and blastocyst outcome were assessed individually using the Chi-squared test. Only the presence of SER was found to be significantly correlated with whether an oocyte became a blastocyst (p < 0.05), however the sample size was small (27 out of 879; 3% of the dataset). Manual and MAGENTA scores were each assessed for correlation to blastocyst outcome by Welch’s two-sample t-test. The mean manual score for the whole dataset is 9.2. No differences in mean manual score were observed between oocytes that developed into blastocysts (9.1) and those that did not (9.2). The manual scoring system assigns a score of 10 unless dysmorphisms are noted, defaulting to the assumption that oocytes are of high quality unless noted otherwise. This is reflected in the skewed distribution of most oocytes receiving high scores due to a lack of visible dysmorphisms. Conversely, the mean MAGENTA score for the whole dataset is 4.2. Oocytes that developed into blastocysts had a significantly higher mean MAGENTA score (4.7) compared to oocytes that did not (4.2) (p < 0.05). The distribution of the MAGENTA scores were more evenly distributed across the entire spectrum of scores (0-10). Limitations, reasons for caution To avoid reducing sample size, male factor influence on blastocyst development was not removed. Manual oocyte annotations were performed retrospectively, consequently allowing embryologists more time to assess than typically available. The number of oocytes with polar body fragmentation was too few to appropriately assess with the Chi-squared test. Wider implications of the findings Because oocyte dysmorphisms are rare, subjective, and don’t consistently correlate with blastocyst development, annotating them is clinically nonbeneficial and an inefficient use of an embryologist’s time. MAGENTA oocyte assessments are immediate, objective, correlate with blastocyst development, and are easily incorporated into a laboratory workflow for improved clinical insights and decision-making. Trial registration number Not applicable.

P-226 Conventional IVF rather than ICSI when only on oocyte is retrieved: time to overcome irrational fears

Abstract Study question Is the use of conventional-IVF (c-IVF) a viable option in single oocyte retrieved cycles? Summary answer The use of c-IVF on single oocyte seems to be a successful strategy in terms of laboratory performance indicators outlined in the Vienna Consensus. What is known already Intracytoplasmic Sperm Injection (ICSI) has greatly improved the chances of reproductive success in cases of male factor infertility, but it is often used without strong evidence, such as in cases of low numbers of retrieved oocytes, assuming it will avoid unexpected total fertilization failure (TFF). On these bases, several ART centers irrationally opt for ICSI when few oocytes are retrieved. This approach is due to the fear of facing TFF the following day. This situation is boosted when only one oocyte is available. Available studies on c-IVF in these circumstances are generally reassuring, but evidence is limited and inconclusive. Study design, size, duration This is a monocentric retrospective observational study performed at the Infertility Unit of the Fondazione Ca' Granda Ospedale Maggiore Policlinico between 2014 and 2021. The primary outcome of the study is normal fertilization rate, which is expected to be ≥ 60% according to the Vienna Consensus. The study sample (about 300 cycles) was calculated to obtain a 95% CI within the range of ± 5%. A binomial distribution model was used to determine the 95%CI of proportions. Participants/materials, setting, methods Only women who had recovered one oocyte at the oocyte retrieval were included in the study. Collected data included age of both partners, previous pregnancies, female BMI, antral follicle count, total motile sperm count. A multivariate analysis was performed to identify predictive factors for fertilization. Based on the policy of our Center, c-IVF was performed only in case of normal sperm variables according to WHO 2010 manual and in the absence of history of TFF. Main results and the role of chance Out of 700 cycles with single oocyte retrievals, 304 were treated with c-IVF, which resulted in normal fertilization (2PN) in 209 cases, corresponding to a fertilization rate of 69% (95%CI: 63-74%). In 13 cycles, oocytes were shown to be immature (germinal vesicle or metaphase I) at the time of fertilization check. In these cases, fertilization could not occur. If we exclude them, the fertilization rate raised to 72% (209/291) (95%CI: 66-77%). This fertilization rate was within the Vienna Consensus KPI for competency range and was no more than 5% lower compared to the benchmark value. Clinical pregnancy and live birth rates per cycle were 14% and 11%, respectively. Finally, we compared baseline characteristics of cycles with normal fertilization to those with failed fertilization. Both univariate and multivariate analyses failed to identify predictive factors of fertilization. Limitations, reasons for caution The retrospective nature and the absence of a control group do not allow us to draw robust and definitive conclusions. However, the large sample sized allowed us a precise estimation of the fertilization rate. Wider implications of the findings Fear about TFF is not a valid reason to opt for ICSI in women retrieving only one oocyte. The use of ICSI increases costs without providing benefits. We also failed di identify predictive factors of fertilization, hampering the possibility to select a subgroup of women who may benefit from ICSI. Trial registration number Not applicable

P-527 What is the influence of blastocyst hatching position on clinical pregnancy rates?

Abstract Study question Is there a relationship between the hatching zone in the blastocyst and its gestational potential? Summary answer Blastocysts that presented a hatching area opposite to the inner cell mass showed lower clinical pregnancy rates. What is known already Embryo implantation in the uterine endometrium is dependent on blastocyst hatching out of the zona pellucida, allowing the cells of the trophectoderm to establish contact with the uterine epithelium. Hatching begins with the continuous expansion of the blastocoel, thinning the zona pellucida. The blastocyst then exits through a rupture, called the hatching zone. In humans, trophoblast cells close to the inner cell mass (ICM) – polar trophoectoderm – rapidly proliferate and differentiate to follow endometrial invasion, being thus distinct from the remaining trophoectoderm. The association between the hatching zone (according to ICM localization) and implantation rates is scarce. Study design, size, duration This is a prospective observational cohort study with 588 patients that underwent in vitro fertilization (IVF) cycles with autologous oocytes and had a fresh or frozen hatching blastocyst embryo transfer between January/2018 and August/2022 in a private ART center. All embryos were cultured in a time-lapse system (Embryoscope, Vitrolife) and were fertilized by ICSI or IVF. Only embryos with known reproductive outcomes (the presence/absence of gestational sac and heartbeat) were included in this analysis. Participants/materials, setting, methods Embryos with evidence of natural hatching (either by penetration of trophectoderm cells, or by regular disruption of the trophectoderm followed by embryo extrusion) were included. Using the ICM as reference, blastocysts were classified according to its hatching position in four categories: mass, opposite to mass, intermediate (between mass and opposite) and multiple hatching. ANOVA, Fisher and chi-squared tests were applied properly for statistical analysis. p < 0,05 was considered significant. Main results and the role of chance The majority of embryos were classified as intermediate (n = 540, 77.4%), followed by opposite to mass (n = 88, 12.6%), mass (n = 50, 7.2%) and multiple hatching sites (n = 20, 2.8%), in a total of 698 embryos analyzed. Maternal age was similar between groups (36,22±3,65; 36,03±3,3; 36,07±3,23; 37,35±3,57, p = 0.35, for mass, intermediate, opposite to mass and multiple hatching respectively). The majority of embryos presented hatching by penetration of trophoectoderm cells (n = 685, 98.1%), regardless of hatching position and mode of insemination (IVF or ICSI). Biopsied embryos were included since they had reached natural hatching before trophoectoderm biopsy. There was no difference in the proportion of euploid (64%) and non-biopsied (36%) embryos transfers according to hatching position subgroups (68% vs 32%; 64.3% vs 35.7%; 63.3% vs 36.4%; 50% vs 50% for mass, intermediate, opposite and multiple hatching respectively, p = 0.56). Positive pregnancy rate were lower in the opposite to ICM group (47.7%, p = 0.04) when compared to intermediate group (59.3%). Positive pregnancy rates in mass and multiple hatching sites were 54% and 55% respectively. Clinical pregnancy rate were also lower in the opposite to ICM group (45.5%, p = 0.04) when compared to intermediate group (57%). Clinical pregnancy rates in mass and multiple hatching sites were 52% and 50% respectively. Limitations, reasons for caution Two experienced senior embryologists classified the blastocyst hatching position; however, operator subjectivity cannot be excluded. The influence of the ICSI hole in the hatching type (penetration or disruption) and position is debatable; nevertheless, both types and all hatching position classification were present in ICSI and IVF insemination. Wider implications of the findings The hatching zone of the embryo is potentially a variable of attention for embryo selection. The proliferation and differentiation of trophoblast cells opposite to the inner cell mass may affect the ability of the embryo to progress in the apposition, adhesion and, mostly importantly, invasion of the uterine endometrium. Trial registration number Not applicable.

Enhancing critical thinking and English-speaking skills of gifted students through philosophy for children approach

This study aimed at investigating the effectiveness of "Philosophy for Children (P4C)" approach on the critical thinking and English-speaking skills of twenty-three 7th grade gifted students learning English as a foreign language at a Science and Art Center (SAC) in the city of Denizli, Türkiye. In the study a mixed methods research design was adopted with the participation of randomly assigned experimental and control groups. While quantitative data were collected through the Cornell Critical Thinking Test (CCTT) X level and the Cambridge English Speaking Test (A2 level for Schools), qualitative data were collected through reflective diaries written by the experimental group participants and evaluation forms. While the control group followed the usual SAC English speaking lessons, English speaking lessons for the experimental group were based on the P4C approach. According to the quantitative data findings, there was an increase in the scores of both groups in terms of speaking skills in English, however this difference was not statistically significant. In terms of critical-thinking skills, there was a slight decrease between the pre-test and post-test scores of the control group and an increase in the scores of the experimental group and this difference was statistically significant. In addition, the qualitative data revealed that the experimental group participants generally provided positive feedback on P4C practices and speaking lessons based on the P4C approach created positive effects on their critical thinking and speaking skills in English, while such an application did not create a significant effect on their speaking skills in English.

THE GENESIS OF THE TERMS “PHYSICAL THEATRE” AND “PLASTICHESKIY THEATRE”

Each era of theatre history has its own characteristics and is distinguished by its main trends, work of prominent stage figures, key terms and concepts. Modern theatre art has radically changed as a result of global changes in the economy, politics and culture. Some topical distinctive properties date back to the turn of the XIX-XX centuries, when the attitude towards drama text, artistic solution and form of the performance, space of the stage changed.Currently, with each year, more new forms are added to Kazakhstani theatre space. New performing arts centers and groups, positioning themselves as, for example, a physical theatre, a plasticheskiy theatre or a dance theatre, are created. Therefore, it has become relevant to study the phenomenon of productions, wherein movement is the main means of expression.The terms "physical theatre" and "plasticheskiy theatre" have become wide spread in the performing arts of Kazakhstan. They have firmly entered modern theatrical vocabulary causing some disputes and discussions at the same time. The purpose of this article is to define the terms "physical theatre" and "plasticheskiy theatre" and establish their connection.The article systematizes information related to the appearance of the terms under consideration. Materials by contemporary foreign theatre researchers, works of leading practitioners and theorists of the XX century stage are used. An attempt to identify the genesis and specifics of the development of "physical" and "plasticheskiy" theatres, as well as determine the content of the concepts "physical theatre" and "plasticheskiy theatre”, which are becoming increasingly widespread in the modern theatre of Kazakhstan, is made. These results can be used by theatre practitioners in the creative process and by teachers and students of performing arts departments of creative universities in the educational cycle.

Şehitlik Dergâhı’nda Yenilikçi, Modern ve Bilge Bir Bektaşi Babası Nafi Baba (1835-1912)

Nafi Baba, Bektaşiliğin yasaklı dönemi şartlarında yetişen en önemli Bektaşi babalarındandır. 1835 yılında Şehitlik’te dünyaya gelmiştir. Küçük yaşta özel dersler alarak eğitim hayatına başlamış, zamanın önemli dersiamlarından dini ilimler tahsil etmiştir. 1846’da kendisine tevcih edilen İstanbul müderrisliği payesiyle ilmi kariyeri başlamıştır. Medrese tahsili de alan Nafi Baba’nın ilmi payesi Süleymaniye müderrisliği ve Halep mevleviyetine kadar yükselmiştir. 1861 yılında Şehitlik Dergâhı postnişinliğine getirilmiş, medrese eğitimi almasına rağmen sıradan bir müderris gibi hareket etmediği gibi kendine mahsus bir Bektaşi babası olmuştur. Arapça ve Farsça dillerinin yanı sıra Batı dillerinden Fransızca ve İngilizce’yi de öğrenmiş, düşünce dünyası ve yaşam tarzı olarak modern ve yenilikçi bir anlayışı benimsemiştir. Şehitlik Dergâhı’nı bir ilim, kültür ve sanat merkezine dönüştürerek İstanbul’un entelektüel kesiminin müdavimleri arasında yer aldığı bir kurum haline getirmiştir. Bu dönemde dergâhın müdavimleri arasında Filozof Rıza Tevfik, Karikatürist Cem, Gedai, Rami, Hüseyin Kamî ve Künci (Günci) gibi dönemin meşhur düşünür, sanatkâr ve şairleri de bulunuyordu. Jön Türklerle siyasi ilişkiler kurup meşruti idareye geçişi savunması ve bir misyoner okul olan Robert Kolej’in kurulmasına katkılar sunması Nafi Baba’nın modern kişiliğinin yansımalarıdır. Torunlarına da Robert Kolej’de eğitim aldırmış, onlardan bu okulda öğretmenlik ve idarecilik yapanlar çıkmıştır. Bu çalışmada bir İstanbul beyefendisi, modern, yenilikçi ve bilge bir kişilik olarak Nafi Baba’nın hayatı ana kaynaklar ışığında ele alınmaktadır. Anahtar Kelimeler: İstanbul, II. Mahmut, Bektaşilik, Şehitlik Dergâhı, Mahmut Baba, Nafi Baba.

Meyer Schapiro, the Jewish Museum, and Living Artists: A Scholar’s Overlooked Activism

Abstract Meyer Schapiro was among a handful of New York’s most prominent Jewish thinkers writing about modern art during the post-Second World War period, just as the international center of new art had shifted there from Paris. Unlike his contemporaries Clement Greenberg and Harold Rosenberg, however, Schapiro is thought to have “seldom” or only “subliminally” addressed questions of Jewish identity, suggesting that he avoided or suppressed the matter. Yet his nearly four-decade-long relationship with the Jewish Museum of New York tells a different story. Schapiro’s unpublished correspondence, memoranda, and addresses reveal his role in transforming the Jewish Museum into a venue for avant-garde art and his urging Jewish acceptance of modern art, including works that were not visibly Jewish or that were created by non-Jews. These efforts reflect the ways his kinship with the Jewish community prompted his articulation of universal values of humanitarianism and social justice that he associated with Judaism, values that coincided with his social activism. The archival materials also show how Schapiro engaged with questions of Jewish identity as he drew on his scholarly knowledge and his affinity with the Jewish community to further the appreciation of modern art for the benefit of Jewish and non-Jewish artists and audiences.

PENGARUH SENAM KREASI TERHADAP MOTORIK KASAR PADA ANAK-ANAK UMUR 5-6 TAHUN DI KELURAHAN MESAT SENI

The purpose of this study was to determine whether there was an influence on children's gross motor development, creative gymnastic methods using a random sampling research design. The population in this study were 10 children at the arts center. The sampling technique was total sampling and the variable in this study was creative gymnastics. Data analysis using t-test statistics. The instruments used in this study were agility, speed and balance test instruments. The mean result of the initial test was 224 and the final test was 238. From the results of the difference test, it was obtained for the experimental group 55.0 that the t-count value was 10,042 with a table value of 2.01 with a significance of 0.00 ≥ 0.05. So it can be concluded that the method of physical exercise is increasing.

The academy of pedagogy: From a teacher training college to a vibrant university

Based mainly on archival documents gathered from Bahir Dar University (BDU) record office and the UNESCO Head Office in Paris, this qualitative study chronicles and analyzes the history of the Academy of Pedagogy from its inception until it transformed itself into Bahir Dar University. The establishment of the Academy of Pedagogy was the result of a meticulous but ambitious feasibility study conducted by two education experts from the University of London employed by UNESCO as consultants. The consultants recommended the establishment of a college specializing in training teacher educators in a four-year program in Bahir Dar. The study also recommended the construction of a primary school and a teacher training institute to enable teacher trainers to undertake teaching practice, curriculum revision, and action research. Other recommendations included the installation of an educational broadcasting service and the commencement of in-service training for primary school teachers. The study was so ambitious that it suggested the establishment of a Child Development Research Unit, an Ethiopian Arts Center, a Textbook and Journal Publishing Unit, a Comparative African Studies Institute, a Rural Sociology Research Unit, a Health Education Unit, an Evaluation and Archives Unit, and a Model Community. However, the outbreak of the Ethiopian revolution in 1974, forced the academy to follow a different path. Since then, a lot of changes including curriculum revision took place. In 1980, the Academy was renamed Bahir Dar Teachers College (BDTC). Finally, in 2000, BDTC joined the Polytechnic Institute to form Bahir Dar University.

Üstün Yetenekli Bireylerin Vatandaşlık Kavramına İlişkin Algıları

Introduction: Citizenship plays a crucial role in protecting the identity of states and societies. Citizenship becomes even more important for gifted people who make important contributions to the scientific and technological development of a country. From this point of view, this study aims to explore the perceptions of gifted people trained at Science and Art Centers (SAC) in relation to the concept of citizenship. Method: The study was conducted using a phenomenological design, one of the qualitative research designs. The study group of the research consisted of 23 6th grade students, 13 boys and 10 girls, studying at Science and Art Centers (BİLSEM) in İstanbul in the academic year 2020-2021. The data of the study was collected using a structured interview form developed by the researchers. Descriptive analysis was used to analyse the data. Findings: It was found that gifted students defined citizenship as a person living in a place and having some basic duties and rights to the place to which they belong. The students mostly defined themselves as good citizens and stated that a good citizen has responsibilities towards his environment and country. In the context of the view that the state is a political institution in which people live together, the understanding of a social and legal state dominates. The main responsibility of citizens is seen in being hardworking and respecting the country and society. The majority of students feel connected to their country, with the most important factor for this connection being culture and history. While the most positive aspect of being a citizen of Turkey is its historical heritage, it is noteworthy that some of the students wish to be citizens of the developed Western countries. Discussion: The students’ views are largely consistent with studies in the literature on citizenship and state definitions and citizenship of other countries based on brain drain. However, unlike other studies, this one emphasized researcher personality, which is one of the distinguishing characteristics of gifted individuals, among the characteristics of citizens.

Primary School Teachers' Experiences in the Identification of Gifted Students and Nominating Them to Science and Art Centers

Introduction: This study aims to examine the experiences of primary school teachers in the identification of gifted students and nominating them to science and art centers.Method: This research was carried out within the scope of phenomenology design, one of the qualitative research designs. The research study group was determined by the criterion sampling method, one of the purposeful sampling methods. The research study group consisted of 15 primary school teachers working in İstanbul. The study data were obtained through semi-structured interview forms developed by the researchers and personal interviews conducted with the study group. The data were analyzed by content analysis. Researcher triangulation was used in the analysis of the data. To minimize data loss, the data were recorded with a voice recorder.Findings: According to the study's findings, it was determined that the classroom teachers took into account the students' cognitive, affective, and social characteristics while identification them with giftedness and made observations depending on the process.Discussion: Although many features are used to identify gifted students when the relevant literature is examined, it has been determined that cognitive features are frequently used in the identification of gifted students.

Toward a sustainable urban regeneration? Urban heritage between neoliberal forces and community preferences

The paper discusses a relationship between the neoliberal forces shaping contemporary urban transformations and the social sustainability of recent regeneration projects focused on urban heritage. Analysing two post-transitional cases, based on two different approaches, the paper will provide an insight into the dominant processes influencing both practices, as well as their anticipated/announced social sustainability and its achieved level. The first case is from Serbia - the Power Plant “Power and Light” - which was the first one generating alternating current in Belgrade. Located in the Dorcol area, this ex-industrial setting is situated close to the city center. Since 2005, the entire area has undergone a significant transformation into a luxurious residential and commercial complex, initiated by private investors and directed by city authorities in order to change the previous urban image. The second case, the Contemporary Art Center in Plovdiv, Bulgaria, represents different approach. Created in 1997, the center is a non-governmental organisation of public interest. In 1995 the Municipality of Plovdiv obtained the right to locate the center within the remains of the ancient baths of Rome, which were rebuilt under the Turkish Empire. As the 16th century monument, the building belonged to the municipality and in 2004, the three-year period of support started, provided by the association Art Today (the Swiss cultural program), as well as the National Heritage Fund in Bulgaria. The analysis will be based on the selected principles of social sustainability, simultaneously highlighting the problems of heritage (re)use and regeneration in a challenging global environment of uncertain financial flows and shifting local governmental priorities, which could put on hold or totally ignore the aspect of social sustainability.

Strange pedagogy: An artist-led educational model

This article highlights a series of artworks that reflect my approach to art education. Housed in an abandoned storefront-turned-gallery in Salt Lake City, the work was part of a project titled ‘The Wandering Art Center: From Lower Manhattan to the Colorado Plateau’. In my role as both artist and educator, I discuss how my art practice is the inspiration behind my teaching and how my teaching informs my art. This dialectic exchange includes the ecological, or more-than-human, members of my cultural ecology. The article maps this exchange as it explores the practice of walking, as both an artistic methodology and an educational strategy.

The Transformers

Research Article| June 01 2023 The Transformers: How Chan Is Missing Led to Better Luck Tomorrow Led to Everything Everywhere All at Once Renee Tajima-Peña Renee Tajima-Peña Renee Tajima-Peña is an Oscar-nominated filmmaker who has chronicled the Asian American experience as showrunner/series producer of Asian Americans, producer/director of Who Killed Vincent Chin? and My America...or Honk if You Love Buddha, and co-founder of the May 19th Project. Her films have screened at Cannes, New York, Sundance and the Whitney Biennial. She was founding faculty of the UC Santa Cruz Social Documentation Grad Program and is a professor and endowed chair of Asian American Studies at UCLA. Search for other works by this author on: This Site PubMed Google Scholar Film Quarterly (2023) 76 (4): 32–34. https://doi.org/10.1525/fq.2023.76.4.32 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Renee Tajima-Peña; The Transformers: How Chan Is Missing Led to Better Luck Tomorrow Led to Everything Everywhere All at Once. Film Quarterly 1 June 2023; 76 (4): 32–34. doi: https://doi.org/10.1525/fq.2023.76.4.32 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentFilm Quarterly Search During the past forty years in Asian American cinema there have been three premieres that took my breath away: Chan Is Missing in 1982. Better Luck Tomorrow in 2002. Everything Everywhere All at Once in 2022. Twenty years apart, all signaled that the earth had shifted on its axis and the creative landscape of Asian America was on a collision course with the old, retrograde images of the past. Something gloriously new and essentially Asian American was on the horizon. Wayne Wang’s Chan Is Missing, about two San Francisco cabbies on the hunt for their missing friend and their missing four thousand dollars, was the first. I was just out of college and working as the first paid staff person at New York’s Asian Cine-Vision, back in a time when a clueless twenty-one-year-old could run an Asian American arts center. ACV put on the Asian American International Film Festival,... You do not currently have access to this content.

More Than: Art Education and the Promise of Wholeness

Abstract In this invited paper for the 2022 Elliot Eisner Doctoral Research Award in Art Education Runner-Up from the National Art Education Association, Jody Stokes-Casey presents an iteration of a key argument from her dissertation Art Education Shaping Historical Narratives in the Mississippi Delta: A Polyptych Study of CARE, that art education through its mobilization as more than offers a promise of wholeness. Oral history quotes from the research site, a community art center in the Mississippi Delta known as CARE, offer illustrative folds throughout the article.

ANALISIS HIDROLOGI RANCANGAN MENGGUNAKAN METODE RASIONAL PADA SALURAN DRAINASE DI KELURAHAN SUMERTA KELOD KOTA DENPASAR

Tukad Kelandis is a tributary of the Tukad Ayung Watershed which is located downstream. In 2021 floods occurred in Tukad Kelandis resulting in one of the places affected by flooding, namely the Art Center area. So it is necessary to do research on the analysis of peak flood discharge on the Tukad Kelandis river using rational methods. Maximum runoff occurs when the rainfall is during the same time as the catchment area concentration time in the rational method. Based on the research results, the amount of planned flood discharge in the Tukad Kelandis watershed was obtained using the rational method for return periods of 2, 5, 10, 20, and 25 years, namely: Q2 Year = 273,890 m3/s, Q5 Year = 337,372 m3/s, Q10 Year = 373,194 m3/ s, Q20 Year = 399,610 m3/ s, Q25 Year = 413,406 m3/ s.

Recognizing Greatness in Our Own Time

Recognizing Greatness in Our Own Time