The article states that given the complex nature of organized crime, the complex security environment around Ukraine and the criminogenic situation, the organization of a systematic fight against organized crime should become one of the priorities of public policy and requires effective interdepartmental measures and deepening law enforcement cooperation. It was found that organized crime in Ukraine is steadily developing and structuring, involving representatives of state authorities, local governments, law enforcement agencies, the judiciary, etc. in this process. The current state of organized crime threatens the national security and integrity of the state, which requires urgent administrative and legal measures to combat it. The fight against organized crime is not an isolated problem, to which there is now a simplified attitude to the inconsistent actions of individual actors, but a complex, complex administrative and legal mechanism that needs a strategic solution. The author analyzes the spread of organized crime by region of Ukraine during 2014–2018. Thus, in 2014 the most organized groups were found in Kyiv (14), Odessa (12), Kharkiv (10) Donetsk (9), Luhansk, Poltava, Chernivtsi regions (8 each), the least in Kyiv and Kherson regions (3 each). The author notes that high organization, the acquisition of transnational ties, in a certain inertia of national law, turns modern organized crime into a global threat to the world and international law and creates obstacles to socio-economic progress. The author argues that organized crime is the most complex and dangerous anti-social phenomenon, which is not limited to state borders. Today it poses a real threat to the state and society, manifested in the invasion of politics, economics, social, security, banking, financial and credit, law enforcement, privatization, investment, nature and other vital areas of the state, creating shadow criminal schemes in them.; establishing control over customs authorities; interference in the development of market relations; blocking effective reform processes in the state; organization of criminal activity in such areas as: drug trafficking, prostitution, gambling, illegal arms trafficking, theft and smuggling of vehicles, illegal migration, human trafficking, human organ transplantation; merging with international crime, creation of international organized transnational criminal organizations, etc.