SESSION TITLE: Tuesday Medical Student/Resident Case Report Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: 10/22/2019 01:00 PM - 02:00 PM INTRODUCTION: Hypereosinophilic syndrome (HES) is a rare disorder characterized by peripheral blood eosinophilia of 〖1.5 x 10〗ˆ3/μL or higher and evidence of end organ manifestations attributable to the eosinophilia and not otherwise explained in the clinical setting. HES has an unknown prevalence, most often affects people age 20 through 50. Few patients with prolonged eosinophilia develop organ dysfunction that characterizes HES. CASE PRESENTATION: This is the case of a healthy 52-year-old man without history of significant systemic illness who presents with non-productive cough, daily febrile episodes and left upper extremity pain for a period 2 months. On physical examination, lungs are clear upon chest auscultation and left sided axillary pain is elicited upon arm abduction. Initial blood work revealed WBC 〖40.62 x 10〗ˆ3/μL; eosinophil count 〖23.56 x 10〗ˆ3/μL, elevated sedimentation rate 112 mm/hr. Initial diagnosing testing for HES was performed. Complete blood count was remarkable for increasing trend in leukocytes and eosinophils. Routine chemistries, including liver function tests were within normal limits. Quantitative serum immunoglobulin levels, including IgE were normal. Serum troponin, echocardiogram, electrocardiogram, Pulmonary function tests revealed no abnormalities. Bone marrow biopsy including cytogenetics had no myeloproliferative abnormalities. Flexible bronchoscopy with bronchoalveolar lavage revealed eosinophils count less than 3%, no evidence of bacteria, viral or fungal infection. Serology examination for diagnosis of parasitic infection, HIV testing, antineutrophil antibodies ANCA, Serum tryptase and B12 levels, PET scan, lymph node biopsy, EBV viral load were completely negative. The patient’s eosinophilia continued to rise, peaking at 56.00 x 103/μL, despite high-dose prednisone therapy (200 mg by mouth daily), he went in to respiratory failure, cardiac arrest and developed multi organ dysfunction. Hydroxyurea (1 g daily) was added. He improved after the addition of hydroxyurea, and a decrease trending of his eosinophil count was seen. Hydroxyurea was discontinued, and prednisone was tapered. DISCUSSION: HES is a rare heterogeneous disease, any organ system is vulnerable to get affected. The symptoms are common in many other medical problems, making an initial diagnosis more difficult. Sometimes no underlying cause can be found for an observed eosinophilia, even after an extensive diagnostic evaluation. In the absence of an identifiable reactive cause for the eosinophilia, a diagnosis of idiopathic HES can be established if there is evidence of organ involvement and dysfunction. CONCLUSIONS: Our case illustrates the importance of considering diagnosis in patients with significant eosinophilia. Have a high index of suspicion in the background of persistent peripheral eosinophilia; after exclusion of secondary causes. Reference #1: https://doi.org/10.1182/asheducation-2018.1.326 ASH Education Book November 30, 2018 vol. 2018 no. 1 326-331 Reference #2: Klion AD. How I treat hypereosinophilic syndromes. Blood. 2015;126(9):1069-1077. Reference #3: Khoury P, Abiodun AO, Holland-Thomas N, Fay MP, Klion AD. Hypereosinophilic syndrome subtype predicts responsiveness to glucocorticoids. J Allergy Clin Immunol Pract. 2018;6(1):190-195. DISCLOSURES: No relevant relationships by Hector Cintron-Colon, source=Web Response No relevant relationships by Ricardo Fernandez, source=Web Response No relevant relationships by Vanessa Fonseca Ferrer, source=Web Response No relevant relationships by WIlliam Marrero, source=Web Response No relevant relationships by Luis Piñeiro, source=Web Response