Arizona Sexual Experience Scale Research Articles

Influence of Antipsychotic Agents on the Sexuality of Patients Diagnosed with Schizophrenia

Sexuality is a natural component of human behavior. The general population has been extensively studied since the first half of the 20th century. On the other hand, regarding patients treated for schizophrenia, discussing sexual disorders was initially considered inappropriate because it was believed they should not be sexually active. Given these findings, this work proposes to study the sexuality of patients with schizophrenia. Our objectives were to assess the sexuality of patients with schizophrenia, to identify factors associated with sexual dysfunction among these patients, and to determine practitioners' attitudes toward the sexuality of our study population. This is a cross-sectional study carried out in the Psychiatry Department of Kairouan (outpatient department), including 46 patients diagnosed with schizophrenia. A pre-established information sheet was completed for each patient recruited, including sociodemographic and clinical data; on the other hand, 3 scales ensured a sexual psychometric evaluation: Psychotropic-Related Sexual Dysfunction Questionnaire, Arizona Sexual Experiences Scale, and Changes in Sexual Functioning Questionnaire-Male Clinical Version. Concerning the evaluation of sexuality according to the scales used, sexual dysfunction according to Psychotropic-Related Sexual Dysfunction Questionnaire scores was observed in 31 patients (67.4%). According to Arizona Sexual Experiences Scale scores, 24 patients (52%) had a sexual dysfunction, and for the total score of the Changes in Sexual Functioning Questionnaire-Male Clinical Version, 27 patients (58.7%) had a sexual dysfunction. We cannot confirm the existence of a relationship between the dose of the current treatment (in chlorpromazine equivalent) used and the results of the test assessing sexuality. In addition to these results, we can deduce the existence of a statistically significant association between the antipsychotic agent used and the results of the Psychotropic-Related Sexual Dysfunction Questionnaire only. We recommend that screening for sexual dysfunction in patients followed for schizophrenia should be systematic, regardless of the antipsychotic molecule type and dosage. In this regard, we recommend the establishment of a better therapeutic relationship between caregivers and patients with schizophrenia, based on empathy and trust, so that the latter feel comfortable enough to address the sexual dimension in general and sexual dysfunction in particular.

Prevalence of Sexual Dysfunction in Females Suffering from Depression in a Tertiary Care Centre in Western U.P.

Background: There is a need to explore the sexual functioning of women with depression as one part of sexualityis that it helps in developing an intimate emotional and physical relationship with another person, and thisrelationship may serve as a buffer against life stresses. Our aim was to study the prevalence and types of sexualdysfunction in depressed women patients and to compare them with non-depressed women.Materials and Methods: A total of 270 participants who attended a teaching hospital were selected for thestudy – 135 cases and 135 controls. Sociodemographic and clinical details were collected. Mini InternationalNeuropsychiatry Interview (M.I.N.I), Hamilton Depression Rating Scale (HAM-D), Arizona Sexual Experiences(ASEX) scale, and Female Sexual Functioning Index (FSFI) scale were used. Sexual dysfunction was assessed inboth groups.Results: Among the cases, 47.40% had mild depression, 44.44% had moderate depression, and 8.15% were severelydepressed. On the ASEX, 46.66% of the cases had sexual dysfunction, while it was only 8.89% among the controls.The difference in sexual dysfunction among cases and controls was statistically significant. Using the FSFI, 40% ofthe cases had female sexual dysfunction (FSD), and it was only 11.1% in controls.Conclusion: Sexual dysfunction was more common in females with clinical depression than in those withoutdepression. Numerous factors can operate in the causation of FSD. This study underlines the importance ofscreening females with depression for FSD, for its early diagnosis and management.

Evaluation of sexual functional status and consistency of scales in patients with hypogonadotropic hypogonadism before and after testosterone replacement therapy: a single-center experience.

This study aimed to investigate the frequency of sexual dysfunction and the effect of short-term testosterone replacement therapy on sexual functions in congenital hypogonadism patients. Furthermore, we sought to reveal the consistency of the self-report scales used for the diagnosis of sexual dysfunction and the relationship between biochemical parameters. The study was conducted on 47 young male patients aged above 18 years who were diagnosed with hypogonadotropic hypogonadism. Short (IIEF-5) and long (IIEF-15) forms of the International Index of Erectile Function and Arizona Sexual Experiences Scale (ASEX) were applied before treatment under the supervision of a physician. The patients' blood pressure, height, and weight were measured, and their luteinizing hormone (LH), FSH, and total testosterone levels were recorded. Patients who started their treatments were called for a follow-up checkup after 6 months. Their blood pressure, height, and weight were measured by reapplying the ASEX, IIEF-5, and IIEF-15. In addition, their LH, FSH, and total testosterone levels in the biochemical tests were rerecorded. In this study, the sexual dysfunction status of patients diagnosed with hypogonadotropic hypogonadism before and after treatment was evaluated using the ASEX, IIEF-15, and IIEF-5 scales. A decrease in sexual dysfunction was observed in all three scales after treatment compared with that before treatment. The IIEF-5 and IIEF-15 scales were found to be uncorrelated in terms of the pretreatment values but were correlated in terms of the post-treatment values. Although a correlation was observed between ASEX and IIEF- 5 before treatment, no correlation was detected between ASEX and IIEF-15. After the treatment, ASEX was found to be correlated with both IIEF-5 and IIEF-15. The results of the scales indicated the correlation in all categories, except the pretreatment results of the IIEF-15 scale. The results of the current study demonstrated a significant improvement in the sexual function of hypogonadism patients undergoing short-term testosterone therapy. The ASEX, IIEF-5, and IIEF-15 scales used in the diagnosis and follow-up of sexual dysfunction were useful for evaluating sexual functions in hypogonadotropic hypogonadism patients.

Sexual dysfunction in first-episode schizophrenia spectrum disorders

Sexual dysfunction (SD) is common in patients with schizophrenia. In this study, we examined the prevalence and correlates of SD in a sample of patients with first-episode schizophrenia spectrum disorders (FES) (n = 77). Sexual functioning was examined using the Arizona Sexual Experiences Scale. Clinical measures of interest included the duration of untreated psychosis, psychopathology, depressive symptoms, functionality, and quality of life. Biochemical testing was also performed to measure prolactin, lipid profiles, and fasting glucose levels. In total, 27 (35%) patients met the criteria for SD, which was significantly more prevalent in females than males (p = 0.027). Higher depression scores, poorer social and occupational functioning, and lower high-density lipoprotein cholesterol levels predicted overall SD. Female sex, more pronounced global psychopathology, and poorer quality of life were also predictors of domain-specific SD, adjusting for the extent of antipsychotic exposure. SD has a high prevalence in patients with FES, particularly females. There is a need for a more nuanced understanding of SD in recent-onset schizophrenia, and to establish its relevance in terms of comorbid depressive symptoms and poor quality of life. SD may require specific attention and tailored treatment in females with FES. • We examined the prevalence and correlates of SD in FES. • SD was assessed in 77 patients with FES using the ASEX. • Female sex and depressive symptoms predicted SD. • Females had worse SD across multiple ASEX domains (1, 2, 4, 5). • FES characteristics were associated with SD in a sex- and domain-specific manner.

Dyadic adjustment and the relationship between sexual self-consciousness and sexual dysfunction in individuals with spinal cord injuries: A descriptive study

Purpose This study was conducted to determine the dyadic adjustment between individuals with SCI and their spouses and the relationship between their sexual self-consciousness and sexual life and to evaluate it according to the objectification theory. Method This descriptive and cross-sectional study was conducted with 131 married individuals with SCI registered in the physical therapy and rehabilitation outpatient clinic of a university hospital between February 2020 and April 2021. The data of the study were collected using a Descriptive Information Form, the American Spinal Injury Association Impairment Scale (ASIA), the Dyadic Adjustment Scale (DAS), the Sexual Self-Consciousness Scale (SSCS), and the Arizona Sexual Experiences Scale (ASEX). In the study, the predictors of the sexual life of individuals with SCI were evaluated with the Stepwise Multiple Linear Regression analysis. In addition, predictors of sexual dysfunction in individuals with SCI were evaluated by the logistic regression analysis. The results were discussed within the framework of objectification theory. Results According to the results of the study, .67.2% of the individuals with spinal cord injuries experienced sexual functionality problems; increased age, falling injuries, and being in ASIA grade A increased sexual self-awareness and sexual dysfunction; and being a male with SCI increased sexual focus. It was found that the adjustment between individuals with SCI and their spouses was a predictor that significantly reduced sexual embarrassment, sexual self-consciousness, and sexual dysfunction and that the strong adjustment between couples was an important factor for the prevention of sexual dysfunction development. Conclusion It was found that most individuals with spinal cord injuries experienced sexual dysfunction. The importance of dyadic adjustment and sexual self-consciousness has come to the fore in the sexual life of these individuals.

Study of sexual side effects in patients undergoing treatment with anti-depressants

Sexual side effects with psychotropic medications can cause major distress. Antidepressants are known to cause sexual side effects.To study the sexual side effects in patients undergoing treatment with anti-depressants.Sixty patients of both genders undergoing treatment with antidepressants and having sexual complaints due to medicines were evaluated. A semi structured questionnaire was used to record demographic details. Arizona Sexual Experience Scale (ASEX) was used to assess sexual dysfunction.In our study majority patients were males 42 (70%) and diagnosed as having major depressive disorder 51 (85%). SSRIs were main agent responsible for the same 46 (76.7%).Majority patients reported sexual side effects with antidepressants which can affect their subjective quality of life. Hence, patients should be assessed properly for sexual issues and treated accordingly.

DOES TIMELY INTERVENTION DEFINE SURGICAL OUTCOMES IN CAUDA EQUINA SYNDROME

Retrospective analysis of prospectively collected data. To assess func Study Design: Objective: tional outcome of patients irrespective of timing of surgical intervention in cases with cauda equina syndrome. Cauda equina syndrome Background: (CES) is a spinal emergency requiring immediate surgical intervention. CES presents with constellation of symptoms like saddle anaesthesia, bladder or bowel dysfunction, sexual dysfunction, lower limb motor power loss having deep socioeconomic consequences on part of patients and medicolegal consequences on part of clinicians. 40 patients data were collected and compiled retrospectivel Methodology: y. Demographic data, Surgical data, Functional data in the form of bladder, bowel, sexual and motor power recovery were collected at 3 weeks, 6 months , 12 months follow-up and analysed based on Urinary symptom prole score, Neurogenic bowel dysfunction score, Arizona sexual experience scale, Medical Research Council grading respectively. Results: Though early presentation by the patient and emergent surgical intervention by clinician does play a decisive role in full and faster recovery of symptoms but our study suggests that even when patients presented with delay at our outpatient department and surgery was done on emergency basis, desired outcome was achieved in maximum number of cases presenting with incomplete CES.

A STUDY ON EVALUATION OF SEXUAL DYSFUNCTION IN MALE PATIENTS WITH ALCOHOL DEPENDENCE SYNDROME IN A PERIPHERAL TERTIARY CENTRE OF KARNATAKA

Background: Conicting to the popular belief concerning the erogenous effects of alcohol, there exists scientic evidence which conclude on sexual dysfunction caused by chronic alcohol use, which leads to marked distress and interpersonal difculty. Aim: To estimate the relationship between sexual dysfunction in male patients with alcohol dependence syndrome. Materials and Methods: The study employed a cross-sectional descriptive design and recruited 47 male patients who came for de-addiction in a tertiary care centre. The evaluation was conducted using a specially designed intake proforma and tools such as Severity of Alcohol Dependence Questionnaire, Arizona Sexual Experience Scale, and International Classication of Disease 10 DCR. Results: 74.5% of the patients had sexual dysfunction – the most common type being dysfunction in achieving orgasm (74.5%), followed by unsatised sexual pleasure (66%), difculty in sexual arousal (53.2%), and erectile dysfunction (46.8%). Sexual dysfunction was found to be signicantly associated with the duration of alcohol dependence, amount of alcohol consumed per day, and severity of alcohol dependence. Conclusions: The study highlights the detrimental effects of alcohol on sexual function that we can use in motivational interviewing of patients with alcohol dependence syndrome.

Finasteride for Androgenetic Alopecia Is Not Associated with Sexual Dysfunction: A Survey-Based, Single-Centre, Controlled Study

<i><b>Background:</b></i> The occurrence of sexual dysfunction side-effects associated with finasteride use in men with androgenetic alopecia (AGA) is thought to be less prevalent than is publicized. There is a need to investigate sexual dysfunction among finasteride users with population-based controls. <i><b>Objective:</b></i> To evaluate the presence of sexual dysfunction in men using finasteride or not using finasteride. <i><b>Method:</b></i> Adult men visiting a dermatologist’s office for any reason were asked to complete a survey including a modified version of the Arizona Sexual Experience Scale (ASEX) to assess the presence of sexual dysfunction with and without finasteride use. <i><b>Results:</b></i> Data from 762 men aged 18-82 were collected: 663 finasteride users and 99 non-finasteride users. There were no significant differences between finasteride users and non-user controls in reporting sexual dysfunction using the ASEX. Regression analysis indicated that self-reporting libido loss and reduced sexual performance, not finasteride use, predict a higher ASEX score. <i><b>Conclusion:</b></i> The use of finasteride does not result in sexual dysfunction in men with AGA. These data are consistent with other large survey-based controlled studies.

Depression, Anxiety, Sexual Disorders and Influencing Factors in Patients with Breast Cancer

<h3>Purpose/Objective(s)</h3> Based on the idea that the expected depression, anxiety and sexual disorders in cancer patients can be psycho-sociologically relieved when early detection and support is provided, we aimed to reveal the level of depression, anxiety and sexual dysfunction levels in our patients with breast cancer and the factors affecting this situation. <h3>Materials/Methods</h3> On a voluntary basis the study included 329 patients diagnosed with non-metastatic breast cancer whose surgery was completed. Eight centers were included in the study and ethics committee approval was obtained. Socio-demographic Information Form, Beck Depression and Anxiety Scale, Arizona Sexual Experiences Scale were used in the evaluation. <h3>Results</h3> As a result of the scale analysis, 220 (66.9%) patients had minimal and mild depression, 109 (33.1%) patients had moderate and severe depression. Anxiety was detected in 210 (63.8%) and anxiety was severe in 60 (18.2%) patients. The sexual scale score was above 15 in 49 (72.1%) patients. Scale analyzes were summarized in Table 1. According to age, depression was more common in the group over the age of 42 and sexual scores were found to be significantly higher (p:0.008). Anxiety, depression, and sexual scale scores were significantly higher in patients who: underwent mastectomy, were not informed about sexual side effects, were not satisfied with the surgery, were smokers, and had comorbid diabetes. Depression and sexual scores were found to be significantly higher in patients with tumor size greater than 2.5 cm, depression and anxiety scores were found to be significantly higher in node positive patients, and sexual scores were found to be significantly higher in those that had less than high school education. Having or not having family history of cancer, marital status, presence of hypertension, or alcohol use were found to have no effect on the scales. <h3>Conclusion</h3> In our study, minimal to severe depression was found in all patients. The incidence of anxiety is also high. Sexual function scores were also found to be high in patients with anxiety and depression, indicating that these patients have sexual dysfunction. These results demonstrate the importance of closely monitoring anxiety and depression levels during oncological treatment in breast cancer patients and to get psychiatric support when necessary. Oncology physicians did not provide the necessary information about sexual side effects to their patients that may be adversely affected both by organ loss and hormonally. Our aim should not only be just focusing on the treatment of cancer, but also to support our patients in their psychological and sexual health for their quality of life.

Discussing sexual health among Flemish patients with Parkinson's disease.

Discussing sexual health among Flemish patients with Parkinson's disease.

Sexual Dysfunction and Related Factors in Patients With Parkinson's Disease.

The current cross-sectional study investigated sexual dysfunction and related factors in patients with Parkinson's disease (PD). The sample comprised 76 patients with PD in the neurology clinic of a training and research hospital. Data were collected using the Hospital Anxiety and Depression Scale and Arizona Sexual Experiences Scale. Approximately nine (88.2%) in 10 participants had sexual dysfunction. Sexual dysfunction depended on sex, educational background, employment status, side effects, body image, difficulty falling asleep, self-care, and walking dependence. Sexual dysfunction was positively correlated with age and symptoms of depression and anxiety. Sexual dysfunction was more prevalent in females than males. Advanced age and high risk of depression resulted in increased prevalence of sexual dysfunction. Health care professionals should evaluate the causes of sexual dysfunction and plan and implement appropriate interventions for patients with PD. [Journal of Psychosocial Nursing and Mental Health Services, 61(3), 45-55.].

Association Between Sexual Dysfunction and Dose of Atypical Antipsychotics: Essential to Learn the Basics.

There is paucity of data on sexual dysfunction associated with atypical antipsychotics in Indian population. We estimated the prevalence of sexual dysfunction and assessed dose dependency, if any, in patients on monotherapy of atypical antipsychotics. This cross-sectional study analyzed the data from patients with F20 to F29 (International Classification of Diseases 10th Revision, ICD-10) receiving monotherapy of risperidone (group1), olanzapine (group2), or quetiapine (group3) for at least 4weeks. The sexual function of participants was assessed using Arizona sexual experiences (ASEX) scale. Chlorpromazine (CPZ) equivalent dose and doses in terms of dose years were calculated. Kruskal-Wallis test, Mann-Whitney U-test, and Pearson correlation were used for analysis. Of the 154 subjects, 65.58% were males, with 44%, 48%, and 8% receiving risperidone, olanzapine, and quetiapine, respectively. The mean duration of treatment was 20.9weeks. Lower ASEX scores were reported with quetiapine. The differences in mean ASEX scores between groups1 and 2 were statistically significant for sex drive (P=.016), sexual arousal (P=.025), and overall score (P=.037). Sexual dysfunction was more frequent with risperidone (48.5%) than with olanzapine (28.4%) and quetiapine (0%). In group1, the duration of therapy positively correlated with the mean scores of sexual desire (P=.003) and arousal (P=.033), but this was not the case for group2 (receiving olanzapine). The mean CPZ equivalent doses were comparable between the groups (P=.064); those receiving <200mg CPZ dose equivalents showed greater sexual impairment. We conclude that the occurrence of atypical antipsychotic-induced sexual dysfunction is not dose dependent. Olanzapine has a better safety profile in terms of sexual dysfunction, whereas the data reflecting the experience with quetiapine are insufficient.

The Impact of the COVID-19 Pandemic and Social Isolation on the Sexual Functioning of Women Who Have Been Treated for Vaginismus.

Background: Multiple factors that impact the mental and hormonal condition of the person influence female sexual function. To our knowledge, however, hardly any research has investigated the sexual function during the COVID-19 pandemic for women who were treated for vaginismus.Aim: The purpose of this research is to examine how sexual function, frequency of sexual activity, and dyspareunia altered in women who had been treated for vaginismus before the pandemic.Methods: This observational study ultimately included 204 patients with completely treated vaginismus at the Women's Health Clinic . Before and during the pandemic, the following data was collected: age, education level, profession, frequency of sexual activity, Arizona Sexual Experiences Scale (ASEX) scores, Golombok-Rust Inventory of Sexual Satisfaction (GRISS) scores, and Hamilton Depression Rating Scale (HDRS) scores.Results: Before the pandemic, the mean ASEX score of women in the research group was 12.56±3.41 , and during the pandemic, ASEX average scores of the women significantly increased to 16.88±5.56 . The GRISS total scores were 28.7±10.1 (range, 14-50) following therapy and 23.9±14.8 (8-58) during the pandemic. After therapy, the HDRS score was 9.58±5.53 (1-19) , while it was 15.21±6.43 (5-26) during the pandemic. During the coronavirus disease 2019 (COVID-19) pandemic, mental health declined significantly, indicating a mild state of depression unrelated to vaginismus. During the pandemic, the mean frequency of sexual activity was 2.9±1.4 per week, and the frequency of sexual encounters did not considerably vary.Clinical Implications: Therapists should examine the pandemic's impacts on all sexual function symptom categories and modify their treatment plans appropriately. The findings indicate that lowering COVID-19-related stress may be especially useful in minimizing the negative impact of COVID-19 on symptoms. We noticed that vaginismus-treated women did not relapse during the pandemic.Limitations: The study population was comprised of women attending a particular women health clinic. This can place a certain bias on the demography of the patient population.Conclusion: The present research indicated that the frequency of sexual activity among women treated for vaginismus did not alter, and notwithstanding a rise in stress and depression ratings, the majority of sexual function scores, including pain, improved during the pandemic. Nonetheless, dissatisfaction and anorgasmia subscales deteriorated, while ASEX satisfaction did not improve to the same extent, suggesting deleterious consequences on sexual function.

Sexual dysfunction in women suffering from major depressive disorder: A cross-sectional study

Abstract Background: Compared to a healthy population, sexual dysfunction is higher in major depressive disorder (MDD). Identification and management of sexual dysfunction profoundly impact marital satisfaction, quality of life, and compliance with treatment in patients with depression. Aims and Objectives: The primary objective was to determine the proportion of sexual dysfunction among women suffering from MDD attending the psychiatry department of a tertiary care center. The secondary objectives were (1) to study the correlation between the severity of depression and sexual dysfunction in women with MDD and (2) to study the relationship between sociodemographic and clinical variables with sexual dysfunction. Settings and Design: This was a cross-sectional study carried out among 40 women diagnosed with MDD attending the psychiatry department of our tertiary care institute. Materials and Methods: After taking informed consent, relevant sociodemographic details and clinical variables were recorded using a semi-structured questionnaire. MDD was diagnosed according to the Diagnostic Statistical Manual of Mental Disorders-Fifth Edition, and its severity was assessed using Hamilton rating scale for depression. Sexual dysfunction was measured using the Arizona sexual experience scale. Statistical Analysis: Spearman’s correlation coefficient was used to assess the correlation between the severity of depression and sexual dysfunction. The Chi-square test was used to test the relationship between categorical variables. Analysis of data was done using appropriate statistical software. Results: The proportion of sexual dysfunction among women with MDD was 65%. The most common sexual dysfunction was low sexual desire (57.5%). There was a positive correlation between the severity of depression and the presence of sexual dysfunction, with Spearman’s correlation coefficient (rho = 0.765, P = 0.000). Age, attainment of menopause, history of alcohol and tobacco use in the spouse, and severity of depression were significant with sexual dysfunction using the Chi-square test. Conclusions: The proportion of sexual dysfunction was high among women suffering from MDD. The severity of depression and the presence of sexual dysfunction are positively correlated.

Efficacy of Online Psychoeducation and Cognitive Behavior Therapy on Female Sexual Interest/Arousal Disorder: Single Case Design

This case report of brief research communication utilized single case design aimed at studying the efficacy of online psychoeducation and cognitive behavior therapy (CBT) on female sexual interest/arousal disorder. Arizona Sexual Experience Scale (ASEX) was used for data collection. Findings of the study showed that client’s pretest and posttest results significantly differ after online psychoeducation and CBT; sexual arousal, sex drive (desire), vaginal lubrication, orgasm, and orgasm satisfaction significantly improved. Furthermore, significant improvement in the frequency of sexual relationship was found. Outcome of this study should guide clinical psychologists in the area of intervention for sexual disorder, especially among women. It should also serve as a reference material for women suffering with sexual dysfunction and serve as an encouragement not to die in silence but seek for professional help.

The negative impact of timed intercourse in infertile couples: A prospective cohort study

Objective: To study the differences in sexual dysfunction and time to pregnancy (TTP) between infertile couples pursuing timed intercourse (TI – around the time of ovulation) and regular intercourse (RI – at least twice a week). Methods: In this prospective cohort study, we recruited all infertile couples presenting to the regional infertility clinics from January 2016 to December 2018, pursuing TI ( n = 283) or RI ( n = 88), and having no pre-existing sexual or psychiatric illness, and no medical contraindications to frequent intercourse. Sexual dysfunction was assessed using the Arizona Sexual Experience Scale and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The couples for whom natural conception was possible were followed up to determine TTP using Kaplan–Meier analysis. Results: TI significantly increased the risk of sexual dysfunction than RI for both males and females, even after adjusting for age, medical disorders, obesity, smoking, cause of infertility, and previous assisted reproductive techniques. TI increased the risk of erectile dysfunction, premature ejaculation, male hypoactive sexual dysfunction, female sexual interest-arousal disorder, and female orgasmic disorder. The TTP for natural conception was similar between them. Conclusion: TI increased the risk of sexual dysfunction without accelerating the time to achieve pregnancy, compared with RI. Level of evidence: Not applicable

A systematic review and meta-analysis of sexual dysfunction in patients with hidradenitis suppurativa.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition associated with significant psychosocial comorbidity. To date, the relationship between HS and sexual dysfunction has not been assessed through meta-analysis. A systematic review was performed by OVID Medline, EMBASE, Cochrane Central, PsycINFO via EBSCO, Web of Science, and LILACS. Original English language studies assessing HS and sexual function published prior to April 2020 were screened. Scores from the Female Sexual Function Index (FSFI), International Index of Erectile Function (IIEF), Arizona Sexual Experiences Scale (ASEX), Frankfurt Self-Concept Scale for Sexuality (FKKS SEX), and Dermatology Life Quality Index (DLQI) were analyzed. Sixteen studies met inclusion criteria, and nine were eligible for meta-analysis. Pooled mean FSFI score for female HS patients met criteria for sexual dysfunction (mean = 20.32, P < 0.001). Females with HS reported worse FSFI scores than controls (pooled mean difference = -5.704, P = 0.003, I2 =0). Mean IIEF score among males with HS was 47.96 (P < 0.001). Males with HS also reported worse IIEF scores than controls (pooled mean difference = -18.77, P = 0.00, I2 = 0). Females with HS performed worse on sexual function inventories than males with HS (SMD = -0.72, P = 0.009, I2 = 0). Both male and female HS patients reported significantly more sexual impairment than same-sex controls. Female HS patients also experience more sexual impairment than males and on average meet criteria for sexual dysfunction (FSFI <26.55). Clinicians should be aware that their patients with HS, especially females, may be suffering from sexual dysfunction and treated them appropriately.

P-118 Timed Intercourse exacerbates the risk of sexual dysfunction in men &amp;amp; women without an improvement in time to pregnancy

Abstract Study question Investigate the differences in sexual dysfunction and time to pregnancy between infertile couples pursuing timed intercourse and Regular Intercourse (RI at least twice a week). Summary answer TI significantly increased the risk of SD compared to RI for both males and females after adjusting all other contributing factors. What is known already Timed Intercourse (TI) involves aligning sexual intercourse to the time around ovulation to increase the chance of conception in couples trying to conceive. Whilst TI is often advocated to increase conception rates and potentially accelerate the time to pregnancy (TTP) for infertile couples, the stressful nature of this approach may be associated with adverse effects such as sexual dysfunction (SD) within the couple. Study design, size, duration This prospective cohort study recruited 371 infertile couples who had been trying to conceive for more than a year, presenting to three regional infertility clinics between January 2016 and December 2018. 283 couples pursued TI and 88 couples pursued RI for a year, with all couples having no pre-existing sexual or psychiatric illness, and no medical contraindications to frequent intercourse. Participants/materials, setting, methods The SD score of both partners was assessed at the first visit using the validated Arizona Sexual Experiences Scale (ASEX) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). TTP was determined using Kaplan Meier Analysis in couples for whom natural conception was possible and no reversible fertility pathology was identified. Main results and the role of chance Timed Intercourse (TI) involves aligning sexual intercourse to the time around ovulation to increase the chance of conception in couples trying to conceive. Whilst TI is often advocated to increase conception rates and potentially accelerate the time to pregnancy (TTP) for infertile couples, the stressful nature of this approach may be associated with adverse effects such as sexual dysfunction (SD) within the couple. TI significantly increased the risk of SD compared to RI for both males (Odds ratio [OR] 15.24, 95% confidence interval [CI] 7.96-29.15) and females (OR 5.52, 95% CI 2.38- 12.78), after adjusting for age, medical disorders, obesity, smoking, cause of infertility, and previous assisted reproductive techniques. TI carried a higher risk of developing erectile dysfunction, premature ejaculation, male hypoactive sexual dysfunction, female sexual interest-arousal disorder, and female orgasmic disorder. The TTP for natural conception was similar between TI and RI (p = 0.1365). Limitations, reasons for caution TI, a well-known strategy for increasing conception rates, did not improve time to natural conception compared to regular sexual intercourse. In contrast, the risk of sexual dysfunction in both men and women was significantly higher in TI, compared with RI. Wider implications of the findings This large study raises the question of effectiveness of the long-held belief that TI (intercourse limited around the ovulation-time, based on different methods of ovulation-prediction) improves pregnancy outcomes. Trial registration number N/A

Depression, sexual dysfunction, life satisfaction and marriage satisfaction in women with multiple sclerosis

BackgroundMarriage satisfaction is one of the factors that affects life satisfaction in healthy people and patients. In the current literature, it is found there is a positive correlation between marriage and life satisfaction. Many factors such as sexual dysfunction, depression and neurological disorders affect negatively marriage and life satisfactions. However, there is not enough research dealing with how multiple sclerosis (MS) affects women's marital and life satisfaction. This study aimed to examine marital satisfaction and life satisfaction of female patients with MS (pwMS) in relation to sexual dysfunction and depression. A total of 139 married women (MS Group: 81, Control Group: 58) were recruited in the study. Then both groups’ participants were requested to fill the relevant documentary; Demographic Information Form, Marital Life Scale (MLS), Life Satisfaction Scale (LSS), Arizona Sexual Experiences Scale (ASEX), and Beck Depression Inventory (BDI).ResultsRegarding the percentages of the relevant parameters; it was examined that 60.96% of pwMS and 62.07% of control group have depression, respectively. In addition, 89.16% of pwMS and 86.21% of control group have sexual dysfunction, respectively. Furthermore, 55.52% of pwMS and 44.83% of control group have high life satisfaction, whereas 60.24% of pwMS and 56.90% of control group have high marriage satisfaction, respectively. There was a strong positive correlation between marriage satisfaction and life satisfaction (p < 0.001) and there was a weak negative correlation between marriage satisfaction and sexual dysfunction (p < 0.001). In addition, there were weak negative correlations between marriage satisfaction and depression level (p < 0.001) and between life satisfaction and sexual dysfunction (p < 0.001), respectively. Similarly, there was a weak negative correlation between life satisfaction and depression level (p < 0.001), whereas there was a weak positive correlation between depression level and sexual dysfunction (p < 0.001). Finally, while there was no significant difference in the marriage satisfaction and sexual dysfunction between the groups in points of life satisfaction and depression level (p > 0.05).ConclusionSexual dysfunction and depression are important problems that affect women’s marriage and life satisfaction. Sexual dysfunction is a common problem for women, regardless of MS.