Desertification is major issue in arid and semi-arid lands (ASAL) with devastating environmental and socio-economic impacts. Time series analysis was applied on 19 years’ pixel-wise monthly mean Normalized Difference Vegetation Index (NDVI) data. The aim of this study was to identify a time series model that can be used to predict NDVI at the pixel level in an arid region in Kenya. The Holt-Winters and Seasonal Auto Regressive Integrated Moving Average (SARIMA) models were developed and statistical analysis was carried out using both models on the study area. We performed a grid search to optimise and determine the best hyper parameters for the models. Results from the grid search identified the Holt-Winters model as an additive model and a SARIMA model with a trend autoregressive (AR) order of 1, a trend moving average (MA) order of 1 and a seasonal MA order of 2, with both models having a seasonal period of 12 months. It was concluded that the Holt-Winters model showed the best performance for 600 ✕ 600 pixels (MAE = 0.0744, RMSE = 0.096) compared to the SARIMA model.