Background and Objectives: Prevention of peptic ulcer disease is an important determinant of health over the course of life. The early years of life are a period of considerable opportunity for growth or vulnerability to harm. Therefore, it is of great importance that an adult should be aware about the risk factors and various ways to prevent peptic ulcer disease as possible This study aimed to assess the knowledge of adults regarding risk factors and prevention of peptic ulcer disease among selected rural areas of Udaipur. Method: A pre-experimental one group pre-test post-test design was adopted. The study involved 50 adults with in a selected rural area at Udaipur. Data collection included pre-test and post-test assessments of knowledge, demographic surveys, and statistical analysis to evaluate knowledge changes and associations. The self-instructional module was distributed and covered the following areas like: Introduction, Definition, Causes, Risk factors & Prevention. The effectiveness was measured by comparing pre-test and post-test scores, and associations were analyzed using chi-square tests. Results: The data revels that 60% of adult had inadequate knowledge, 24% had moderately adequate knowledge and only 16% had adequate knowledge in pre-test and that 68% had adequate knowledge 14% had moderately adequate knowledge and only 18% had inadequate knowledge in post-test. After the intervention, majority (34%) of adults had good knowledge level whereas during pre-test only (8%) of adults had good knowledge Before intervention the mean knowledge score was 20.22. After intervention, the mean knowledge score was increased to 22.37. Statistically there was a significant difference in the mean knowledge score before and after the intervention (t = 10.95*, df = 19, P<0.05). Hence the hypothesis, there will be a significant difference in the pre and post-test mean knowledge score after the intervention was accepted. The data concluded that, there was a significant increase in the mean knowledge score after intervention because of self-instructional module Interpretation and Conclusion: The study revealed that the self-instructional module was effective in improving the knowledge regarding the prevention of peptic ulcers Keywords: Peptic Ulcer Disease, Self-Instructional Module, Knowledge, Risk factor