The application of precast segmental bridge columns (PSBCs) is still restricted in seismicity areas due to concerns such as lower lateral stiffness and column base bearing capacity. To enhance the applicability of PSBCs, this study proposed a novel approach of confining them with grouted GFRP tubes. Four novel and one reference specimens were tested under low cyclic loading to evaluate the effects of energy dissipation (ED) bars ratios, concrete interlayer strength, type of segment concrete, and concrete pouring methods within the outer GFRP tube (OGT) on the seismic behavior. Experimental results reveal that the failure modes of all specimens were triggered by the yielding of ED bars and the break of OGT at the top of ED bars. No crushed concrete at column bases or cracks at the segment joint were observed during the test due to the good confinement of GFRP tubes. All the specimens exhibited stable hysteretic behavior with small residual drift ratios and low strength degradation. Furthermore, finite element models (FEMs) were generated to predict the hysteretic behavior of novel specimens. The effects of some parameters such as OGT thickness, ED bars diameter, and concrete strength were further studied.