High Altitude Areas Research Articles

Season-dependent climate sensitivity of the surface runoff of major rivers in Changbai Mountain

Due to the sensitivity of runoff to changes in seasonal snowpack, the changes in surface runoff within high-latitude and high-elevation areas are more complex than in other areas. However, this sensitivity is often overlooked when correlating changes in runoff with meteorological variables. Here, we analyze changes in surface runoff during snowmelt and snowless periods and their sensitivity to climate change from 1960 to 2019 in the upstream watersheds of the Songhua, Yalu, and Tumen Rivers in Changbai Mountain. Most runoff indices, except for low flow in the Yalu River, exhibited decreasing trends during snowmelt and snowless periods. Precipitation was the primary variable responsible for surface runoff during snowless and snowmelt periods. Notably, rainfall replenished all runoff indices during snowless periods, particularly under high flow conditions. The average and high flows were also primarily supplemented by rainfall during snowmelt periods. However, low flow was positively correlated with snowmelt in the Songhua and Tumen Rivers and with temperature in the Songhua, Yalu and Tumen Rivers during snowmelt periods. Additionally, extreme runoff events were closely associated with extreme precipitation. These findings demonstrate the seasonal and index-dependent climate sensitivity of surface runoff within Changbai Mountain, offering insights into the surface runoff response mechanism to climate change in high-altitude mountainous areas. Under future climate change conditions, frequent and intense extreme precipitation events may increase the risk of flooding, owing to the high sensitivity of high flows to precipitation, posing a serious threat to regional ecological security.

Analysis of the relationship between epistaxis and homocysteine and climatic factors in ultra-high altitude area

Objective:To analyze the related influencing factors of epistaxis in extremely high altitude area, and to provide evidence for the prevention and treatment of epistaxis in extremely high altitude area. Methods:From January 2021 to December 2022, 206 outpatients with epistaxis, 54 inpatients with epistaxis and 69 inpatients withoutepistaxis in theDepartment of Otorhinolarygology, Naqu People's Hospital were collected. The previous history, drinking history, smoking history, serum homocysteine（Hcy）, white blood cell count（WBC）, red blood cell count（RBC）, hematocrit（HCT）, hemoglobin（HGB） and mean hemoglobin concentration（MCHC） were compared between inpatients with or without epistaxis. The factors with significant differences were analyzed by binary Logistic regression. The monthly average temperature,air pressure, humidity and 2-minute wind speed were collected from January 2021 to December 2022 in Naqu City to analyze the correlation between epistaxis and climate factors. Results:The number of patients with hypertension in the case group was more than that in the control group, and the difference was significant（P=0.013）. Serum Hcy level in the case group was higher than that in the control group（P<0.001）. RBC, HCT, HGB and MCHC were lower than that in the control group（P=0.001, 0.001, 0.001, 0.039）, and the difference was significant. History of hypertension and Hcy were risk factors for epistaxis. Patients with a history of hypertension were 3.713 times more likely to suffer from epistaxis than those without a history of hypertension（P=0.022）. Each 1 increase in Hcy concentration increased the risk of epistaxis by 13.1%（P=0.001）. Conclusion:Patients with epistaxis in Naqu area had higher serum Hcy level and lower RBC, HCT, HGB and MCHC. History of hypertension and Hcy were risk factors for epistaxis. Patients with a history of hypertension were 3.713 times more likely to suffer from epistaxis than those without a history of hypertension. Every 1 increase in Hcy concentration increased the risk of epistaxis by 13.1%. Active intervention of hypertension and serum Hcy can effectively prevent the incidence of epistaxis.

Long-term exposure to low-level ozone and the risk of hypertension: A prospective cohort study conducted in a low-pollution region of southwestern China

BackgroundThe current evidence regarding the association between long-term exposure to ozone (O3) and hypertension incidence is limited and inconclusive, particularly at low O3 concentrations. Therefore, our research aims to investigate the potential link between long-term O3 exposure and hypertension in a region with low pollution levels. MethodsFrom 2010 to 2012, we conducted a cohort prospective study by recruiting nearly 10,000 attendees through multistage cluster random sampling in Guizhou Province, China. These individuals were followed up from 2016 to 2020, and 5563 cases were finally included in the analysis. We employed a high-resolution model with both temporal and spatial accuracy to estimate the maximum daily 8-h average O3 and utilized annual average O3 concentrations for three exposure periods (2009_10, 2007_10, 2005_10) as the exposure indicator. Time-dependent covariates Cox regression model was exerted to estimate the hazard ratios (HRs) of hypertension incidence. Generalized linear model was employed to assess the association between O3 and systolic, diastolic, pulse, and mean arterial pressure. The dose-response curve was explored using a restricted cubic spline function. Results1213 hypertension incidents occurred during 39,001.80 person-years, with an incidence density of 31.10/1000 Person Years (PYs). The average O3 concentrations during the three exposure periods were 66.76 μg/m3, 67.85 μg/m3, and 67.21 μg/m3, respectively. Per 1 μg/m3 increase in O3 exposure was associated with 11 % increase in the incidence of hypertension in the single-pollution model, and the association was more pronounced in Han, urban, and higher altitude areas. SBP, PP, and MAP were increased by 0.619 (95 % CI, 0.361–0.877) mm Hg, 0.477 (95 % CI, 0.275–0.679) mm Hg, 0.301 (95 % CI, 0.127–0.475) mm Hg, respectively. Furthermore, we observed a nonlinear exposure-response relationship between O3 and hypertension incidence. ConclusionsLong-term exposure to low-level O3 exposure is associated with an increased risk of hypertension.

Effect of dissolved-oxygen on the flotation behavior of pyrite at high altitude area

Effect of dissolved-oxygen on the flotation behavior of pyrite at high altitude area

Construction of Lentiviral Vectors Carrying Six Pluripotency Genes in Yak to Obtain Yak iPSC Cells.

Yak is an excellent germplasm resource on the Tibetan Plateau and is able to live in high-altitude areas with hypoxic, cold, and harsh environments. Studies on induced pluripotent stem cells (iPSCs) in large ruminants commonly involve a combination strategy involving six transcription factors, Oct4, Sox2, Klf4, c-Myc, Nanog, and Lin28 (OSKMNL). This strategy tends to utilize genes from the same species to optimize pluripotency maintenance. In this study, we cloned the six pluripotency genes (OSKMNL) from yak and constructed a multi-cistronic lentiviral vector carrying these genes. This vector efficiently delivered the genes into yak fibroblasts, aiming to promote the reprogramming process. We verified that the treated cells had several pluripotency characteristics, marking the first successful construction of a lentiviral system carrying yak pluripotency genes. This achievement lays the foundation for subsequent establishment of yak iPSCs and holds significant implications for yak-breed improvement and germplasm-resource conservation.

Associations between sugar-sweetened beverages consumption, duration of physical exercise, and depressive symptoms among Tibetan university students at high altitude.

Depressive symptoms have become a public health issue of common concern in countries all over the world, and have many negative impacts on university students' study and life. Depressive symptoms are influenced by many factors, including sugar-sweetened beverages (SSBs) consumption and duration of physical activity. However, no study has been conducted on the association between sugar-sweetened beverage consumption, duration of physical exercise, and depressive symptoms among Tibetan university students at high altitudes. In this study, a self-assessment survey of SSBs consumption, duration of physical exercise, and depressive symptoms was conducted on 6,259 (2,745 boys, 43.86%) Tibetan university students aged 19-22 years in Lhasa and Ganzi areas, China, using stratified whole population sampling. The associations were also analyzed using one-way analysis of variance, binary logistic regression analysis, and ordered logistic regression analysis in the generalised linear model. The proportions of mild depression symptoms, moderate depression symptoms, and major depressive symptoms among Tibetan boys university students in high-altitude areas of China were 18.0, 22.9, and 1.5%, respectively; the proportions of girls students were 20.1, 21.9, and 1.5%, respectively, 1.5%, and the differences in the detection rates of depressive symptoms between sex were statistically significant (χ 2 value = 14.253, p < 0.01). Ordered logistic regression analyses showed that using duration of physical exercise >60 min/d and SSBs ≤1 times/week as the reference group, the duration of physical exercise <30 min/d and SSBs ≥5 times/week groups had the highest risk of developing depressive symptoms was the highest risk (OR = 6.98, 95% CI: 5.05-9.65; p < 0.001). This study confirmed that there was a positive association between SSBs consumption and depressive symptoms and a negative association between the duration of physical exercise and depressive symptoms among Tibetan university students at high altitudes in China. In the future, SSBs consumption should be effectively controlled and the duration of physical exercise should be increased to reduce the occurrence of depressive symptoms and promote the physical and mental health of Tibetan university students in high-altitude areas.

Clinicopathological Aspects of Dilation and Curettage (D&C) Biopsies Taken from Patients Living at High Altitude in Taif, KSA, with a Special Emphasis on Chronic Endometritis.

Chronic endometritis (CE) is a persistent inflammation of the uterine lining. Although it has a minimal clinical presentation, CE adversely affects the reproductive ability of women. The aims of this study were to detect pathological endometrial patterns in D&C biopsies and to evaluate chronic endometritis in patients living in a high-altitude area (1800 m above sea level) in order to determine the clinical pathological features and prevalence. A cross-sectional study conducted at King Faisal Maternity Hospital included 100 samples of D&C biopsies from women complaining of various gynecological symptoms not due to gestational causes. The biopsies underwent tissue processing, H&E staining, and CD138 detection. Blood samples were taken for serological detection of infectious diseases, complete blood count, and chemical parameters. The mean age of women in the study with CE was 48.5 ± 8.5 years, and that of those without CE was 46.9 ± 9.7 years. The most common complaints were abnormal uterine bleeding, accounting for 83%. CE was present in 8% of cases, and there was a nonsignificant difference in hematological parameters between women with CE and those with other pathological diagnoses. There were also nonsignificant differences in chemical parameters, except for FSH and LH levels, which showed a significant difference, with p-values of 0.05 and 0.02, respectively. It can be concluded that the most common gynecological complaint of women in this study was abnormal uterine bleeding. The most commonly diagnosed pathological endometrial disorder in D&C biopsies was disordered proliferative endometrium, followed by endometrial polyps and endometrial hyperplasia. All of these are usually associated with hormonal disturbance, which appeared to be very common in the women in this study. The prevalence of chronic endometritis detected in our study was 8%, which is relatively high.

Experimental study on the flame trajectory evolution of horizontal jet fires under reduced pressures

Jet fire including process pipeline/tank leakage, oil exploitation industry of tail gas treatment flare or other industrial combustors as a common phenomenon can be found at high altitude areas. This work characterizes the flame trajectory evolution of horizontal jet fires under reduced pressures, which is rarely studied. The experimental results show that the horizontal flame projection distance increases monotonously, but the vertical flame length first increases and afterward decreases with the increase of heat release rate and the decrease of ambient pressure. Meanwhile, flame trajectory length increases significantly and then slowly with increasing heat release rate, but first increases to a maximum value and afterward declines with decreasing ambient pressure. Meanwhile, the turning point of vertical flame length appears earlier than that of flame trajectory length with increasing heat release rate (or jet velocity at source) and decreasing ambient pressure. Then, a mathematical model based on the flame arc hypothesis and a dimensionless model were proposed to describe the flame trajectory length, the momentum-buoyancy length scale Lm=(M0/g′)1/3 was used to normalize the flame trajectory length. The measured flame trajectory length in terms of the nozzle diameter, heat release rate, and ambient pressure was satisfactorily correlated by the proposed models.

Quality of Life and Its Associated Factors Among Patients with Psoriasis Attending the Dermatology Department at Public Hospitals in Harar Town, Eastern Ethiopia

&amp;lt;i&amp;gt;Background&amp;lt;/i&amp;gt;: Psoriasis is a skin disorder that inflames the skin and joints, increasing susceptibility to obesity, heart disease, and diabetes. It is more common in higher-altitude areas and affects 100 million people worldwide. Understanding the subtypes and treatments is crucial for the management of the condition. &amp;lt;i&amp;gt;Method&amp;lt;/i&amp;gt;: The study used a cross-sectional design to assess quality of life and identify factors associated with poor quality of life among patients with psoriasis in the region. The study involved 219 patients. Data collection was carried out through structured interviews with patients with psoriasis attending public hospitals in Harar, eastern Ethiopia. Bivariate and multivariate logistic regression analyzes were performed to identify factors associated with poor quality of life among patients with psoriasis. Variables demonstrating a p-value &amp;gt; 0.20 in bivariate analyzes were included in the multivariate logistic regression model. Statistical significance was determined with a p-value &amp;lt; 0.05. &amp;lt;i&amp;gt;Results&amp;lt;/i&amp;gt;: the proportion of poor quality of life was 54.8%. Factors associated with poor quality of life could not read and write (AOR = 14, 95% CI 2.08, 94.2), Duration of more than 5 years (AOR = 3.1, 95% CI 1.49, 6.41), New body site and in disease patients at both sites (AOR = 9.2, 95% CI 2.96, 28.56) and (AOR = 7.2, 95% CI 2.37, 21.95), respectively. Moderate affected body surface area (AOR= 2.98, 95% CI 1.15, 6.41)). And have a comorbidity (AOR= 2.69, 95%CI: 1.01, 7.20). &amp;lt;i&amp;gt;Conclusions&amp;lt;/i&amp;gt;: The study revealed that 54.8% of the patients experienced severe quality of life impairment, with factors such as illiteracy, duration of the disease over five years, psoriasis at new sites of the body, moderate body surface area affected, and comorbidities significantly associated with poor quality of life. The study shed light on the challenges faced by patients with psoriasis in Harar, highlighting the need for comprehensive care strategies to improve their quality of life and well-being.

Effect of Climate Change on Wildlife

Climate change is a global catastrophe that disrupts the balance of ecosystem by altering the climatic measures. Human being are not the only living species on earth that is affected by climate change. All the inhabitants on Earth are dependent on suitable living conditions for their survival. All human and non-human species on Earth either directly or indirectly relying on each other. Wildlife is the key indicator of climatic changes in the environment as they are part of various biological and ecological cycles in the atmosphere. Over the century, the atmospheric temperature has increased around 1.1°C. Changes in climatic conditions is affecting the terrestrial and aquatic biomes in plenty of ways. Limiting basic living conditions of animals by destruction of their natural habitation and its transformation into urban lands which intensifies the human-wildlife interactions. Migration of temperature sensitive species to the areas of higher altitude. High temperatures have increased the occurrence of wild-land fires, floods and droughts five times more than past 50 years. Animals naturally respond to altering climatic conditions by exhibiting changes in their general and reproductive behavior, growth patterns, increased zoonotic diseases. All these above cited effect put them to the status of endangered species and ultimately to the extinction. Strategic approaches i.e., protection, management, planning and evaluation of natural biomes to conserve the Earth’s biodiversity must be opted to avoid the extinction of wild species.

Proteomics and metabolomics analyses of urine for investigation of gallstone disease in a high-altitude area.

The incidence of gallstones is high in Qinghai Province. However, the molecular mechanisms underlying the development of gallstones remain unclear. In this study, we collected urine samples from 30 patients with gallstones and 30 healthy controls. The urine samples were analysed using multi-omics platforms. Proteomics analysis was conducted using data-independent acquisition, whereas metabolomics analysis was performed using liquid chromatography-mass spectrometry(LC-MS). Among the patients with gallstones, we identified 49 down-regulated and 185 up-regulated differentially expressed proteins as well as 195 up-regulated and 189 down-regulated differentially expressed metabolites. Six pathways were significantly enriched: glycosaminoglycan degradation, arginine and proline metabolism, histidine metabolism, pantothenate and coenzyme A biosynthesis, drug metabolism-other enzymes, and the pentose phosphate pathway. Notably, 10 differentially expressed proteins and metabolites showed excellent predictive performance and were selected as potential biomarkers. The findings of our metabolomics and proteomics analyses provide new insights into novel biomarkers for patients with cholelithiasis in high-altitude areas.

Impact of floods on food security in rural Afghanistan

Floods, affecting roughly one million Afghans annually and causing substantial economic losses, is one of the most frequent disasters. This study examines the impacts of floods on household food security in rural Afghanistan, where 80 % of the population relies on subsistence farming and consists of 80 % of the food-insecure population. Based on the 2022 Data in Emergency Monitoring Round 5 dataset, a two-stage least squares with an instrumental variable is applied to analyze the relationship, considering district altitude and unconditional aid. Our findings reveal the negative impacts of floods, i.e., flood exposure decreases the Food Consumption Score (FCS) by 7.1 points and the Household Dietary Diversity Score (HDDS) by 0.14 points. Additionally, flood exposure increases the Household Hunger Scale (HHS) by 0.77 points and significantly raises the probability of moderate and severe food insecurity by 11 % and 20 %, respectively. Food aid offers a lifeline, boosting FCS by 1.54 points and reducing HHS by 0.42 points while mitigating food insecurity risks. High-altitude areas experience greater vulnerability, with higher hunger levels and lower dietary diversity compared to lowlands. Our research suggests prioritizing preventative strategies like area-based policies and flood preparedness plans over solely relying on post-disaster relief initiatives. Additionally, accounting for topographical variations, at least at the district level, is crucial for future food security studies in Afghanistan and similar contexts. These findings hold significant implications for achieving UN Sustainable Development Goals 2 (Zero Hunger) and 13 (Climate Action).

Spatial and temporal distribution and environmental determinants of freeze-thaw erosion intensity in Qiangtang grasslands, China

Context Analysing freeze-thaw erosion is of great significance to ecological environment protection and land resource utilisation in high altitude areas. Aims We used seven indicators (temperature, precipitation, vegetation cover, elevation, slope, slope orientation, and sand content) to calculate the freeze-thaw erosion intensity index for different seasons from 2000 to 2019. Methods We used a graded weighted evaluation model and a geographical detector method to analyse spatiotemporal pattern and driving factors of freeze-thaw erosion intensity in Qiangtang grasslands. Key results (1) From 2000 to 2019, the total area of freeze-thaw erosion was higher in the non-growing season than in the growing season. The area of moderate and above-average freeze-thaw erosion increased over time in the non-growing season but decreased in the growing season. The spatial distribution of freeze-thaw erosion was mainly determined by the annual range of precipitation and temperature, which reflect the intensity and frequency of freezing and thawing cycles. (2) Vegetation cover was an indirect factor that influenced the soil moisture and stability. The slope was another important factor that affected the spatial distribution of freeze-thaw erosion in different regions. Conclusions The results show that in 2000–2019 the area of freeze-thaw erosion showed a downward trend. The erosion degree in the non-growing season is on the rise. Implications Our study provides new insights into the dynamics and mechanisms of freeze-thaw erosion in Qiangtang grasslands and contributes to the understanding and management of water and climate change impacts on this region.

A study on the correlation between hyperuricemia and TG/HDL-c ratio in the Naxi ethnic group at high-altitude regions of Yunnan.

The study aimed to explore the risk factors for hyperuricemia (HUA) in the Naxi ethnic population residing in high-altitude areas of Yunnan, China, and assess the clinical value of the triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio as a diagnostic marker. In this cross-sectional study, clinical data were collected from the health checkup population in the People's Hospital of Yulong Naxi Autonomous County, Yunnan Province, from January 2021 to January 2023. Participants were divided into quartiles based on the TG/HDL-c ratio (Q1, Q2, Q3, and Q4) for group analysis using chi-square tests, t-tests, and rank sum tests. Logistic regression analysis and linear regression models were employed to further investigate the correlation between the prevalence of hyperuricemia and TG/HDL-c ratio in this high-altitude Naxi population. A total of 714 participants from the health checkup population were included in the study, of whom 61.5% were male participants and 38.5% were female participants, and the average age was 41.21 ± 11.69 years. The mean uric acid level was 388.51 ± 99.24. After correcting for confounding factors, TG/HDL-c, serum creatinine (Scr), blood urea nitrogen (BUN), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), red blood cells (RBCs), and hemoglobin (Hb) showed a positive correlation with blood uric acid. Further analysis involved categorizing the TG/HDL-c ratio from a continuous variable to a categorical variable using quartiles. The fully adjusted model showed results that were consistent with the trend observed in the continuous variable analysis when considering the TG/HDL-c ratio as a categorical variable. In addition, in all unadjusted and adjusted models, the serum uric acid (SUA) levels in the high TG/HDL-c ratio group were significantly higher than those in the low TG/HDL-c ratio group (trend p < 0.001). Further linear relationship analysis indicated that after adjusting for covariates, there was an approximate linear relationship between the TG/HDL-c and SUA levels, with a coefficient (β) of 5.421. The prevalence of hyperuricemia is greater in high-altitude areas of Yunnan, showing a nearly linear positive correlation with the TG/HDL-c ratio. Monitoring TG/HDL-c levels may benefit patients with hyperuricemia.

Evaluating high-resolution aviation emissions using real-time flight data

Amidst robust global economic growth and advancing globalization, the aviation market is poised for significant expansion. Consequently, the environmental impact of aviation emissions is growing in significance. However, due to limitations in real flight data and aviation emissions index models, further clarification of the emission characteristics throughout entire flights is necessary. To better assess the emission characteristics of entire flights, this study employs real Quick Access Recorder (QAR) data and a high-precision aviation emissions index model, yielding four-dimensional emission data (time, longitude, latitude, altitude) from flights. The analysis compares QAR data with emissions from scheduled flight data (SFD) and Broadcast Automatic Correlation Monitoring (ADS-B) projections, explores seasonal variations in aviation emissions, and assesses the impact of sustainable aviation fuels (SAFs) on emissions reductions. For both number and mass of nvPM emissions, as well as nitrogen oxide emissions, the rankings are: ADS-B-E > SFD-E > QAR-E; for CO, SFD-E > ADS-B-E > QAR-E, particularly during the climb-cruise-descent (CCD) cycle. There are significant differences in the emission of aviation pollutants in airport area and high-altitude area in different seasons. Employing four types of Sustainable Aviation Fuels (SAFs) significantly reduces both the mass and the number of nvPM emissions. Therefore, it is recommended to utilize more QAR data to refine the assessment of the environmental impact of aviation emissions.

Analysis and evaluation of Camellia oleifera Abel. Germplasm fruit traits from the high-altitude areas of East Guizhou Province, China

Camellia oleifera, a significant woody edible oil species, was examined using 48 germplasm resources from high-altitude regions in East Guizhou Province, China, to analyze fruit quality. The analysis aimed to identify high-performance germplasm, providing theoretical and research foundations for selecting and cross-breeding superior C. oleifera varieties in these regions. Fifteen primary traits of mature fruits were measured and analyzed, including four phenotypic traits (single fruit weight, transverse diameter, longitudinal diameter, peel thickness) and eleven quality traits (fresh seed yield rate, dry seed yield rate, dry kernel yield rate, seed kernel oil content, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, α-linolenic acid, cis-11-eicosenoic acid). A comprehensive evaluation employing cluster and principal component analyses (PCA) was conducted. The cluster analysis categorized the germplasms into five groups at a squared Euclidean distance of 14, with the first category comprising 17 germplasms, the second 28, and the third, fourth, and fifth each containing one. PCA reduced the 15 traits to five principal components (PCs), with PC1 having the highest eigenvalue of 3.57 and a contribution rate of 23.8%, mainly representing phenotypic traits. PC2, contributing 20.44%, represented linoleic acid, while PC3, PC4, and PC5, with contribution rates of 12.99%, 9.13%, and 7.45% respectively, predominantly represented seed kernel oil content, fresh seed yield, and palmitoleic acid. Employing a weighted sum method, a comprehensive evaluation function was developed to calculate total scores for each superior individual, forming the basis for rankings and selections. Notable variability was detected in single fruit weight, peel thickness, and fresh and dry seed yields, while oleic acid exhibited the lowest coefficient of variation. Dry seed yield showed a robust positive correlation with seed kernel oil content and the concentrations of palmitic and linoleic acids, whereas seed kernel oil content was inversely correlated with cis-11-eicosenoic acid levels. Five PCs with eigenvalues > 1 were identified, highlighting the top ten superior individuals: QD (Qian Dong: the code of eastern Guizhou Province)-33 > QD-34 > QD-48 > QD-38 > QD-27 > QD-15 > QD-35 > QD-5 > QD-14 > QD-36. Thus, the 48 C. oleifera germplasms from East Guizhou’s high-altitude areas demonstrate significant potential for enhancing traits such as single fruit weight, peel thickness, and fresh and dry seed yields. Specifically, QD-33, QD-34, and QD-48 exhibited superior comprehensive performance, designating them as prime candidates for variety selection and breeding.

Cerebral venous thrombosis at high altitude: more severe symptoms and specific predisposing factors than plain areas

BackgroundExposure to a high-altitude environment is a risk factor for cerebral venous thrombosis (CVT) probably due to hypercoagulability. The study aims to explore the unique characteristics of CVT patients in high-altitude areas of China by comparing them with those in plain areas.MethodsWe retrospectively included consecutive patients with CVT admitted to Tibet Autonomous Region People’s Hospital (altitude 3650 m) and Peking Union Medical College Hospital (altitude 43.5 m) between January 2015 and December 2023. Patients from the plateau and the plain were considered two independent groups in this study. The risk factors, clinical and radiological presentations, treatment, and outcomes were analyzed and compared between the two groups.ResultsA total of 169 patients with CVT were included in the study, 48 patients from plateau and 121 patients from plain. The median age was 27 and 34 years old, and women accounted for 66.7% and 54.5% respectively. Headache (91.7% vs. 71.1%, P = 0.004), altered consciousness (31.3% vs. 16.5%, P = 0.033), hemorrhage (41.7% vs. 19.0%, P = 0.002), and venous infarction (50.0% vs. 25.6%, P = 0.002) on imaging were more common in patients from plateau than those from plain. Pregnancy or puerperium was significantly more common in highland patients (25% vs. 5.8%, P < 0.001). The levels of D-Dimer (1.7 vs. 0.8 mg/L FEU, P = 0.01), fibrinogen (3.7 vs. 3.0 g/L, P < 0.001), hemoglobin (157 vs. 129 g/L, P = 0.01), white blood cells (9.6 vs. 7.5*1012/L, P < 0.001) and highly sensitive C-reactive protein (20.2 vs. 3.2 mg/L, P = 0.005) were remarkably higher in highland patients. The percentage of receiving anticoagulant therapy was lower in high-altitude patients (70.8% vs. 93.4%, P < 0.001). Favorable outcome at follow-up was observed in 81.4% of highland patients and 90.7% of lowland patients, with a median follow-up time of 330 days and 703 days respectively.ConclusionsThe more severe clinical and imaging manifestations along with prominent inflammatory and hypercoagulable states were observed in plateau CVT patients, probably due to exposure to the hypoxic environment at high altitude. Pregnancy or puerperium were more common in highland patients. The overall prognosis of CVT patients from both groups were favorable.

Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism.

Sedative hypnotics effectively improve sleep quality under high-altitude hypoxia by reducing central nervous system excitability. High-altitude hypoxia causes sleep disorders and modifies the metabolism and mechanisms of drug action, impacting medication therapy's effectiveness. This review aims to provide a theoretical basis for the treatment of central nervous system diseases in high-altitude areas by summarizing the progress and mechanism of sedative-hypnotics in hypoxic environments, as well as the impact of highaltitude hypoxia on sleep.

Registration of Newly Released Hull Less Food Barley (&amp;lt;i&amp;gt;HondiumVulgare L.&amp;lt;/i&amp;gt;) Variety, ‘Sena’, for High Potential Barley Growing Areas in Ethiopia

Twenty hull less barley genotypes from the local crossing program and germplasms introduced from ICARDA were evaluated in a multi-location variety trial to identify stable genotypes with high grain yield, desirable agronomic characters and good level of disease resistance. Results of combined analysis showed that genotype (G5 and G19) with pedigree name &amp;lt;i&amp;gt;TOCTE/M112/6/VMORALESCBSS04M00436T-11M-0Y-0M-3M-0AP and PENCO/CHEVRON-BAR/3/LEGACYU//PENCO/CHEVRON=BAR CBSS04Y00048S-23Y2M-0Y-0M-0Y-0AP--0TR-0TR &amp;lt;/i&amp;gt;exhibited the highest mean grain yield with good agronomic performance and good level of disease resistance across the testing environments, while genotype. Accordingly, the two varieties were promoted to variety verification trial in 2022, and genotype G5 released in 2023; this genotype was named Sena. The variety showed good physical grain quality, coupled with high grain yield of 5.2 t/ha. Sena variety is suitable to the high potential barley growing areas. This variety is characterized by early maturity, white seed color, has good physical grain quality, resistance to leaf rust and scald, moderate resistance to net blotch, moderate tolerance to barley shoot fly, lodging tolerance and good biomass yield. The variety’s demonstration and seed multiplication is underway. Therefore, cultivation of the new variety in the higher altitude areas of major barley growing environments of the country is highly recommended. Six-rowed semi hulled barley Sena was developed by Sinana Agricultural Research Center (SARC), Southeastern Oromia region, Ethiopia. If the variety is sufficiently demonstrated, scaled up and adopted by farmers, it can play significant role in increasing hull less barley production and productivity thereby increasing the income of farmers and can also be source of raw material for local market engaged in the &amp;lt;i&amp;gt;kolo&amp;lt;/i&amp;gt; production.

Enhanced Catalytic Synthesis of Flavonoid by UV-B Radiation in Artemisia argyi

Enzymatic synthesis of specific active substances is an important foundation for biological adaptations to various stresses. In this study, we investigated the metabolic response of the medicinal herb Artemisia argyi to UV-B radiation through transcriptome and metabolome analysis. In all tested samples, there were 544 shared differentially expressed genes, most of which were linked to the metabolism of flavonoids and fatty acids. A total of 283 differential metabolites were identified and classified into 10 categories, with flavonoids being the largest category. Through an integrated analysis of genes and metabolites involved in flavonoid biosynthesis, flavonoids were predicted to be critical for the adaptation of A. argyi to UV radiation. The increased plant hormones methyl jasmonate and salicylic acid were considered as key regulatory approaches for catalyzing the large-scale synthesis of flavonoids. We explored this by investigating the flavonoid production of A. argyi grown at different altitudes. It showed that total flavonoid content of A. argyi planted in high-altitude areas was 45% higher than that in low-altitude areas. These findings not only deepen our understanding of flavonoid anabolism and its regulation but also provide a reliable strategy for improving flavonoid content in the genus Artemisia.