Zn with moderate biodegradation rate and favorable biocompatibility is emerging as promising bone implants. However, inadequate mechanical strength of Zn impedes its widespread clinical use. In this study, a novel high strength Zn-Al alloy was developed by combining micro-alloying Sn and spark plasma sintering. The fine grain structure generated the large grain boundary area, which exhibited high resistance mechanical loading. Meanwhile, the Zn-Sn eutectic could hinder dislocation motion and caused strengthening. As a result, the ultimate compressive strength was greatly increased by 103.8 %, from 121.06±1 MPa for Zn alloy to 246.80±5.29 MPa for Zn-Al-Sn alloy, and the hardness was greatly increased by 69.7 %. Furthermore, the cytocompatibility assessment also indicated that the Zn-Al-Sn alloy exhibited favorable biocompatibility with BMSCs. This study showed that the newly developed Zn-Al-Sn alloy had great potential to be next-generation bone-implants.