Trimaran and pentamaran are multihull types with an odd number of hulls, namely three and five hulls, generally consisting of one center hull and two or four side hulls smaller than the center hull, which can reduce ship resistance. The trimaran and pentamaran have a more complex phenomenon than the monohull, because of the interaction between the main hull and the side hull, which causes interference caused by changes in flow velocity, pressure changes, and wave interactions generated by each hull. The objective of this study is to analyze the resistance of trimaran and pentamaran NPL-4b models with transom-symmetrical hull and separation distances, specifically S/L ratios of 0.2, 0.3, and 0.4. Since a more limited base of experience exists for multihull ships, experimental or numerical modeling techniques are essential for designers. Numeric investigations were conducted using Numeca software, and experiments were performed in a towing tank. Both methods follow ITTC procedures. Furthermore, the numerical analysis with CFD simulation modifies the Navier-Stokes equation using the turbulence model k-ꞷ SST to generate the RANS equation so that unsteady fluid flow problems can be calculated. It can be implemented in predicting resistance in Froude numbers (Fr) 0.2 to 0.6 at the systematic series of trimaran and pentamaran hull shapes at the model scale. The simulation results were compared to experimental data to validate the resistance of the ships. Overall, good resistance was produced by the trimaran and pentamaran in the C configuration at an S/L ratio of 0.4 with a total resistance coefficient CT of 6.60 x 10-3 and 7.37 x 10-3, respectively. The two results are in good agreement, both methods have a discrepancy of 3.70 %. Fluctuations influence the resistance in the wetted surface area (WSA), wave interactions between hulls, ship velocity, and wave propagation in the aft hull.