Frequency disturbances caused by load perturbations of multi area interconnected power system are reduced by using proper control schemes provided via secondary control loop along with primary control of generation plants. These secondary controllers provide simultaneous control signal to individual machines of a particular area when the control scheme is area centralized. This area centralized mechanism provides quick control action with less computational burden since control problem dimensions gets reduced even the area consists multiple plants/machines. Such centralized new cascade control scheme is proposed in this paper to supervise the secondary control mechanism and it is implemented with parallel connection of 2-Degree of Freedom Proportional-Integral-Derivative (2-DOF PID) controller combined with regular PID controller. The performance of this new controller is studied on multi area multi machine interconnected power system with participation factor concept and later its relative performance in terms of dynamic and steady state specifications are compared with conventional PID and 2-DOF PID controllers. These control parameters are tuned by Invasive Weed Optimization (IWO) algorithm to achieve better system outputs. Case studies presented in this paper show the advantages of proposed control scheme.