The Arctic Oscillation (AO) has been observed to undergo distinct decadal structural fluctuations that significantly influence regional weather and climate. Understanding the drivers and mechanisms behind the AO’s spatial nonstationarity is critical for improving climate predictions related to the AO. We present evidence that the Atlantic Multidecadal Oscillation (AMO) plays a pivotal role in modulating AO’s Pacific center in recent decades. The poleward amplified cooling associated with negative AMO enhances the north-south temperature gradient and results the strengthened westerly winds and stratospheric polar vortex (SPV) responses, which reflects more planetary waves from the North Pacific to the North Atlantic. This enhances the atmospheric coupling between these regions and leads to a more pronounced Pacific center within the AO pattern. Numerical simulations from ECHAM5 and 35 CMIP6 models further corroborate the essential role of the AMO. These findings advance our understanding of the mechanisms driving the variability of the AO pattern.