ARTICLESIon transport in rabbit ileal mucosa. I. Na and Cl fluxes and short-circuit currentM Field, D Fromm, and I McCollM Field, D Fromm, and I McCollPublished Online:01 May 1971https://doi.org/10.1152/ajplegacy.1971.220.5.1388MoreSectionsPDF (3 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByIon Channels of the Gastrointestinal Epithelial CellsDetection of Toxins of Vibrio cholerae O1 and Non-O18 April 2014Proteases in Vibrio cholerae and Their Role in Pathogenesis13 November 2013Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 ChannelsGastroenterology, Vol. 142, No. 2Non-ionic surfactants and gastric mucosal transport of paraquat12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 33, No. 1Involvement of Prostaglandins in Histamine-induced Fluid and Electrolyte Secretion by Rat Colon12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 40, No. 2The Response of the Intestinal Mucosa to Prostaglandin E2 during Withdrawal from Morphine12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 40, No. 4Calcium-calmodulin-dependent Activation of Adenylate Cyclase in Prostaglandin-induced Electrically-monitored Intestinal Secretion in the Rat12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 44, No. 2Comparison of the effects of loperamide and loperamide oxide on absorptive processes in rat small intestine12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 45, No. 10Zinc inhibits calcium-mediated and nitric oxide-mediated ion secretion in human enterocytesEuropean Journal of Pharmacology, Vol. 626, No. 2-3Functional coupling of the downregulated in adenoma Cl−/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3Mark W. 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General Subjects, Vol. 632, No. 1Structural and functional membrane polarity in cultured monolayers of MDCK cellsThe Journal of Membrane Biology, Vol. 52, No. 2Response of the rat small-intestine epithelium to methotrexate.Gut, Vol. 21, No. 6THE ROLE OF BICARBONATE IONS AND OF ADENOSINE 3',5'-MONOPHOSPHATE (cAMP) IN CHLORIDE TRANSPORT BY EPITHELIAL CELLS OF BULLFROG SMALL INTESTINEAnnals of the New York Academy of Sciences, Vol. 341, No. 1 Anion and ProEffects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3',5'-monophosphate metabolism in rabbit ileumInfection and Immunity, Vol. 26, No. 3Effects of Histamine Receptor Antagonists on Ion Transport by Isolated Ileum of the RabbitGastroenterology, Vol. 77, No. 5Serotonin action on short-circuit current and ion transport across isolated rabbit ileal mucosaLife Sciences, Vol. 24, No. 17Energetics of coupled Na+ and Cl− entry into epithelial cells of bullfrog small intestineBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 551, No. 1Effects of Ethanol on Membrane TransportElectrolyte absorption by gallbladders: Models of transportLife Sciences, Vol. 23, No. 15Ion transport across the isolated intestinal mucosa of the winter flounder,Pseudopleuronectes americanusThe Journal of Membrane Biology, Vol. 41, No. 3Increased Tissue Conductance and Ion Transport in Guinea Pig Ileum After Exposure to Staphylococcus aureus Delta-Toxin In VitroInfection and Immunity, Vol. 21, No. 1Mechanisms of transport of Na, Cl, and K in the human colonGastroenterology, Vol. 74, No. 6Effects of theophylline on salicylate transport in isolated rat jejunumBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 507, No. 3Cholera Toxin, Adenylate Cyclase, and the Process of Active Secretion in the Small Intestine: The Pathogenesis of Diarrhea in CholeraEffects of ethanol on sodium, 3-O-methyl glucose, andl-alanine transport in the jejunumThe American Journal of Digestive Diseases, Vol. 23, No. 1The pathogenesis of diarrhoeaTransactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 72, No. 3Na and Cl transport and short-circuit current in rabbit ileum26 July 2013 | The Journal of Membrane Biology, Vol. 31, No. 1Electrical properties and active solute transport in rat small intestine26 July 2013 | The Journal of Membrane Biology, Vol. 31, No. 1Ca ionophore-stimulated ion secretion in rabbit ileal mucosa: Relation to actions of cyclic 3′,5′-AMP and carbamylcholineThe Journal of Membrane Biology, Vol. 35, No. 1Alterations in electrophysiology of isolated amphibian small intestine produced by removing the muscle layersBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 467, No. 1Passive permeabilities of luminal and basolateral membranes in the isolated mucosal epithelium of guinea pig small intestineNaunyn-Schmiedeberg's Archives of Pharmacology, Vol. 297, No. 3A new solid-state microelectrode for measuring intra-cellular chloride activitiesBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 465, No. 1Chloride Transport Across Isolated Opercular Epithelium of Killifish: A Membrane Rich in Chloride CellsScience, Vol. 195, No. 4274Transport across epitheliaBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 464, No. 2Transport in Membrane Vesicles Isolated from the Mammalian Kidney and IntestineIon transport by rabbit colonThe Journal of Membrane Biology, Vol. 27, No. 1Effect of intraluminal bicarbonate and chloride on fluid absorption by the rat renal proximal tubuleKidney International, Vol. 9, No. 6Effects of Alcohol on Ion Transport by Isolated Gastric and Esophageal MucosaGastroenterology, Vol. 70, No. 2Das PeritoneumBioelectric Parameters and Sodium Transport in Bullfrog Small IntestineCoupled Sodium-Chloride Transport by Small Intestine and GallbladderEnergetics of the Na+-dependent transport of D-glucose in renal brush border membrane vesicles.Journal of Biological Chemistry, Vol. 250, No. 22Effects of Cyclic Adenosine 3':5'-Monophosphate and Related Agents on Acid Secretion by Isolated Rabbit Gastric MucosaGastroenterology, Vol. 69, No. 2Active secretion of calcium, sodium and chloride by adult rat duodenum in vitroBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 382, No. 2The effect of the bicarbonate ion on the gallbladder salt pumpThe Journal of Membrane Biology, Vol. 18, No. 1Intestinal SecretionGastroenterology, Vol. 66, No. 5Ion Transport Across Isolated Ileal Mucosa Invaded by SalmonellaGastroenterology, Vol. 66, No. 2Effects of 25-Hydroxyvitamin D3 on Rat Duodenum, Jejunum, and IleumJournal of Biological Chemistry, Vol. 249, No. 4Sodium and Chloride Transport across Isolated Rabbit IIeumCoupling between Na+ and sugar transport in small intestineBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, Vol. 300, No. 1Drug Transfer across Intact Rat Intestinal Mucosa Following Surgical Removal of Serosa and Muscularis ExternaJournal of Pharmaceutical Sciences, Vol. 62, No. 2An Overview of Intestinal Absorptive and Secretory ProcessesGastroenterology, Vol. 63, No. 1Oxygen Gradients In Vivo Seen by a High Oxygen Affinity HB Polymer More from this issue > Volume 220Issue 5May 1971Pages 1388-1396 Copyright & PermissionsCopyright © 1971 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1971.220.5.1388PubMed5574657History Published online 1 May 1971 Published in print 1 May 1971 Metrics