The fifth generation (5G) wireless systems have been begun to be widely deployed over the world in recent years. As the 5G technology will not be able to meet the demands of the huge data traffic growth from massively interconnected devices that is forecasted for future years, the attention of the research community is shifting toward what will be the next innovations in wireless communication architectures and technologies for beyond 5G. The topic of beyond 5G wireless communication technologies has gained much momentum in the industry and the research community very recently. In this issue of IEEE Wireless Communications, we are pleased to present two Special Issues to bring together researchers, industry practitioners, and individuals working on the related areas to address some of these technical challenges for 5G and beyond wireless communication technologies. The Special Issue on “6G: The Paradigm for Future Wireless Communications” includes a collection of nine articles presented by Guest Editors S. Mumtaz, C. Jiang, A. Tölli, A. Al-Dulaimi, M. Butt, H. M. Asif, and I. Ashraf; the other Special Issue, on “Smart, Optimal, and Explainable Orchestration of Network Slices in 5G and Beyond Networks,” includes a collection of five articles presented by Guest Editors Z. M. Fadlullah, M. M. Fouda, K. Rabie, and R. Li. Thanks to the two Guest Editor teams who did an excellent job in editing these two Special Issues for our readers. Please stay tuned for new developments in the research area of beyond 5G wireless communication technologies, and read the editorials and the articles in the Special Issues.