Architectural Patterns Research Articles

Water discharge and sediment flux intermittency in the fluvial Escanilla Formation, Spain: Implications for changes in stratigraphic architecture

AbstractWater discharge and sediment flux variations are important parameters controlling the morphodynamic behaviour of rivers. Although quantitative estimates for water discharge and sediment flux variability are well‐constrained for modern rivers, far fewer assessments of flow and sediment flux intermittency in ancient fluvial systems from the rock record are available. In this study, a relationship between water discharge, sediment flux variability and patterns of changing fluvial stratigraphic architecture in the Middle Eocene Escanilla Formation, Spain, is explored. Water discharge intermittency factor (IWF), calculated as a ratio of the total water discharge (over the averaging time period) to the instantaneous channel‐forming water discharge if sustained for the same period, ranges from 0.03 to 0.11 in the high amalgamation intervals and from 0.10 to 0.32 in the low amalgamation intervals. Similarly, the sediment flux intermittency factor (ISF) is estimated to be in the range of 0.008 to 0.01 in the high amalgamation intervals and of 0.01 to 0.03 in the low amalgamation intervals. Consequently, high amalgamation intervals were most probably deposited under more intermittent and short‐lived intense precipitation events while low amalgamation intervals were the result of less intermittent flows spread throughout the year. Overall, these estimates are consistent with values from modern ephemeral rivers typically found in arid to semi‐arid climate and is in agreement with available proxy data for the Middle Eocene climatic context of the studied alluvial system. This highlights an important connection between hydroclimate, river morphodynamics and landscape evolution, and has implications to predict river flow and sediment transport across the Earth's surface in the geological past.

EksPy: a new Python framework for developing graphical user interface based PyQt5

This study introduces EksPy Python framework, a novel framework designed for developing graphical user interface (GUI) applications in Python. EksPy framework is built on PyQt5, which is a collection of Python bindings for the Qt libraries, and it provides a user-friendly and intuitive interface. The comparative analysis of EksPy framework with existing frameworks such as Tkinter and PyQt highlights its notable features, including ease of use, rapid development, enhanced performance, effective database management, and the model-view-controller (MVC) concept. The experimental results illustrate that EksPy framework requires less code and enhances code readability, thereby facilitating better understanding and efficient development. Additionally, EksPy framework offers a modern and customizable appearance, surpassing Tkinter’s capabilities. Furthermore, it incorporates a built-in object-relational mapping (ORM) feature to simplify database interactions and adheres to the MVC architectural pattern. In conclusion, EksPy Python framework emerges as a powerful, user-friendly, and efficient framework for GUI application development in Python.

Association of aggressive prostate cancer features on whole-mount histopathology and quantitative measures on PSMA PET.

289 Background: The intraductal carcinoma (IDC) and the large cribriform growth pattern (LCP) are two architectural patterns of prostate cancer (PC) associated to more aggressive disease, high Gleason scores, advanced tumor stage, biochemical relapse, and distant metastasis. Predicting the presence of these pathology features could be of significant help in case whole-mount pathology (WMHP) is not available. The goal of this analysis was to assess the distribution of quantitative parameters from 68Ga-PSMA-11 PET/CT (PSMA PET) in lesions with and without LCP/IDC patterns on WMHP. We assessed the ability of pre-surgical PSMA PET imaging to predict the presence of aggressive pathology features. Methods: With IRB approval and HIPAA compliance, we derived a study cohort of PC patients who underwent PSMA PET prior to robotic radical prostatectomy (RALP). WMHP analysis described presence/absence of LCP and IDC patterns in each identified PC lesion. Board-certified physicians contoured all PC lesions on PSMA PET. Only lesions matching with WMHP were included in the analysis. PSMA PET metrics (SUVmax, SUVmean and PSMA-volume) were extracted. All lesions were categorized in sub-cohorts as LCP+/IDC+, LCP+/IDC-, LCP-/IDC-, and LCP-/IDC+. One way-ANOVA assessed significant differences among the imaging parameters in the sub-cohorts. The area under the curve (AUC) from ROC analysis was used to assess the ability of imaging metrics to predict the presence of aggressive PC features on WMHP. Results: The final cohort comprised 155 patients and 177 lesions. The median (IQR) PSA at time of RALP was 9.2 (5.55-15.05). 73/177 lesions (41.2%) were categorized as LCP+/IDC+, 63/177 (35.6%) as LCP-/IDC-, 37/177 (20.9%) as LCP+/IDC-, and 4 (2.3%) as LCP-/IDC-. SUVmax (p=0.007), SUVmean (p=0.048) and lesion size on PSMA PET (p=0.003) were significantly higher in lesions showing LCP, whereas only lesion size was significantly higher in lesions showing IDC (p=0.003). Lesions showing LCP+/IDC- had significantly higher SUVmax (p=0.002) and SUVmean (p=0.001) than lesions showing LCP-/IDC-. SUVmean was significantly higher in LCP+/IDC- than in LCP+/IDC+ (0.043). SUVmax and SUVmean were not significantly different among other sub-cohorts. Lesion size on PSMA PET was significantly higher in LCP+/IDC+ than in LCP-/IDC- (0.009). A logistic regression model analysis showed that PSMA PET quantitative measures predict the presence of LCP and/or IDC with moderate accuracy (AUC= 0.69; p=0.001). Conclusions: Higher SUVmax and SUVmean are found in lesions showing LCP, but not in those showing IDC. A linear regression model including SUVmax, SUVmean and PSMA PET lesion volume was able to predict with moderate accuracy the presence of pathology features of aggressive prostate cancer (AUC: 0.69).

Research on Yaowang Temple based on local chronicles of Henan

By looking up the local chronicles of the China Digital Chronicles Database and the China Chronicles Database, it was found that there are 450 kinds of local chronicles in Henan, of which 45 contain Yaowang Temple.According to these 45 kinds of local Chronicles, it can be seen that a total of 35 Yaowang temples were built in 25 counties (cities) of Henan, mostly distributed in the west, north and south of Henan, especially in the west. Among them, eight Yaowang temples recorded the construction time, from the Ming Dynasty to the Republic of China, but most of them were built in the Qing Dynasty. There are records of the builders of the 8 Yaowang Temples, most of whom were local government officials. Qi Bo, Hua Tuo, Bian Que, Sun Simiao and Wei Cizang were recorded as Yaowang in three places, and Sun Simiao was enshrined in two of them. The architectural pattern of Yaowang Temple varies greatly from three courtyards to natural caves. Local chronicles contain all kinds of legends and stories about the Yaowang, which is a concrete embodiment of the belief in Yaowang. The belief in Yaowang not only carries people's thirst for health, but also prays for good weather.

A Comprehensive Approach to the Thyroid Bethesda Category III (AUS) in the Transition Zone Between 2nd Edition and 3rd Edition of The Bethesda System for Reporting Thyroid Cytopathology: Subcategorization, Nuclear Scoring, and More

Significant interobserver variabilities exist for Bethesda category III: atypia of undetermined significance (AUS) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Thus, subcategorization of AUS including AUS “nuclear” and AUS “other” is proposed in the recent 3rd edition of TBSRTC. This study investigated the impact of the nuclear features/architectural features/nuclear score (NS) (3-tiered)/subcategories and subgroups on risk of malignancy (ROM) in thyroid fine-needle aspirations (FNA). 6940 FNAs were evaluated. 1224 (17.6%) cases diagnosed as AUS were reviewed, and 240 patients (initial FNAs of 260 nodules and 240 thyroidectomies) were included. Subcategories and subgroups were defined according to TBSRTC 2nd and 3rd editions. Histological diagnostic groups included nonneoplastic disease, benign neoplasm, low-risk neoplasm, and malignant neoplasm. Overall, ROM was 30.7%. ROM was significantly higher in FNAs with nuclear overlapping (35.5%), nuclear molding (56.9%), irregular contours (42.1%), nuclear grooves (74.1%), chromatin clearing (49.4%), and chromatin margination (57.7%), and these features were independent significant predictors for malignancy. FNAs with NS3 had significantly higher ROM (64.2%). Three-dimensional groups were significantly more frequent in malignant neoplasms (35.7%). ROM was significantly higher in AUS-nuclear subcategory (48.2%) and in AUS-nuclear and architectural subcategory (38.3%). The highest ROM was detected in AUS-nuclear1 subgroup (65.2%). ROM was significantly higher in the group including AUS-nuclear and AUS-nuclear and architectural subcategories, namely “high-risk group” than the group including other subcategories, namely “low-risk group” (42.0%vs 13.9%). In conclusion, subcategorization may not be the end point, and nuclear scoring and evaluation of architectural patterns according to strict criteria may provide data for remodeling of TBSRTC categories.

Mesothelioma of Uncertain Malignant Potential (MUMP) of the Tunica Vaginalis: Proposal for Reclassification as "Complex Mesothelial Tumor of the Tunica Vaginalis".

A well-differentiated papillary mesothelial tumor (WDPMT) and malignant mesothelioma are 2 well-recognized entities arising from the testis tunica vaginalis. Another mesothelial lesion exclusively seen at this site is mesothelioma of uncertain malignant potential (MUMP)-a lesion reminiscent of WDPMT yet demonstrating variable proportions of more complex architectural patterns that could be confused with invasion. MUMP was first described in 2010 with a total of 11 cases reported to date. Herein, we describe 19 additional patients who underwent hydrocelectomy, excision, and/or orchiectomy. Novel morphologic patterns found in addition to the 2010 series include spindle cells, keloidal-type collagen, and multicystic architecture lined by bland mesothelial cells. Clinical follow-up in 9 patients for more than 1 year (1.5 to 22.5y, median 4.5y) revealed no evidence of disease recurrence or metastases. Despite greater architectural complexity, MUMP has (1) bland cytology; (2) merging in with WDPMT areas; (3) low mitotic rate and Ki-67 nuclear labeling index; (4) retention of MTAP and BAP1 expression; and (5) benign clinical follow-up. If these cases were malignant mesotheliomas, one would have expected at least some of the patients to demonstrate disease recurrence/progression without adjuvant therapy within the available follow-up time, particularly with limited resection in most patients. Thus, we propose that "mesothelioma of uncertain malignant potential" be renamed as "complex mesothelial tumor of the tunica vaginalis." Using the term "complex" draws a contrast with the simple cuboidal lining and simple papillary architecture seen in WDPMT. Also, labeling the lesion as "tumor" removes the stigmata of "uncertain malignant potential" and "mesothelioma" that are alarming to patients and clinicians, and potentially could unduly lead to more extensive surgery in an attempt at "complete" resection. At the same time, not definitively labeling the lesion as benign allows recommendations for follow-up.

Space Aware BGRU Microservice Fault Detection Algorithm

Microservice architecture is a new architecture pattern, which aims to provide users with more reliable, maintainable, and extensible software design services. However, with the continuous expansion of the scale of microservice application system, the proliferation of services and service interactions in the system make the system fault detection difficult. Detecting faults accurately and effectively is the key technology to ensure the system reliability and stability. From the perspective of microservice operation status and dependencies between services, this paper proposes a space-aware bidirectional gated recurrent unit (BGRU) microservice fault detection algorithm, which uses deep learning technology to mine hidden information that causes failures and combines space-aware attention to establish long-distance spatial dependency to improve the accuracy of model detection. The paper also conducts many experiments to demonstrate the effectiveness of the algorithm in microservice fault detection.

Fine needle aspiration biopsy of parathyroid; is it meaningful? A cytologic study of 81 cases with histological and clinical correlations.

Recognizing the parathyroid gland and distinguishing the parathyroid from thyroid lesions in fine needle aspiration (FNA) is challenging. This study aimed to identify cytomorphologic features suggestive of parathyroid origin and to assess the utility of cytopathology in conjunction with ancillary tests in the identification of parathyroid glands. Ultrasound (US) guided FNA of parathyroid gland and lesions in 81 patients were reviewed concerning clinical history and correlated to histopathologic findings in available cases. FNA smears were evaluated for cellularity, architectural patterns, cellular and nuclear features, and background of the smears. In 78 cases, FNA was supplemented by a measurement of parathormone (PTH) levels in the needle washout fluid (FNA-PTH assay) and/or GATA3/PTH/chromogranin-A immunostainings. Sixty-four cases were diagnosed cytologically as parathyroid lesions in conjunction with FNA-PTH assay and/or immunocytochemical examinations. In an additional nine cases, a diagnosis of parathyroid lesions was rendered after repeated FNA with FNA-PTH assay. The histolopathologic diagnosis of surgically excised cases (n = 75) included parathyroid adenoma (60 cases), atypical parathyroid adenoma (4 cases), parathyroid hyperplasia (10 cases), and parathyroid carcinoma (1 case). Major cytological findings of parathyroid tissue included high cellularity, scattered naked nuclei, cribriform and three-dimensional clusters, stippled chromatin, and oxyphilic cytoplasm while papillary pattern or colloid-like material was identified in three cases respectively. No nuclear grooves or inclusions were seen in any case. High cellularity scattered naked nuclei, cribriform and three-dimensional patterns, stippled chromatin and oxyphilic cytoplasm are cytomorphologic features that favour parathyroid origin. A combination of these features with FNA-PTH assay and/or GATA3, PTH, and chromogranin-A immunostainings on cytologic specimens aid in the identification of parathyroid glands and the distinguishing of parathyroid from thyroid lesions.

Architectural Characteristics and Distribution Patterns of Gravity Flow Channels in Faulted Lake Basins: A Case Study of the Shahejie Formation in the Banqiao Oilfield, China

Internal depositional architecture and sand body distribution are the main challenges faced in the development of gravity flow channel deposits in China. Despite significant progress in the exploration and development of gravity flow deposits in recent years, our understanding of the internal architecture of composite sand bodies within gravity flow channels is still limited. Gravity flow channels represent a widely developed sedimentary type in the Shahejie Formation of the Banqiao Oilfield, Huanghua Depression. The lack of understanding of the spatial stacking relationship of gravity flow channel sand bodies hinders further development and remaining oil recovery within the oilfield. Through this study, we aimed to dissect the composite channels (5th architectural units) and single channels (4th architectural units) at the study area, using a combination of well logs and seismic data. We explored the identification criteria and spatial distribution characteristics of internal architectural elements within gravity flow channel reservoirs, based on abundant drilling data, well density grids, and 3D seismic data. By identifying and delineating single channels, we were able to summarize six identification criteria for single channels, including relative elevation differences, curve shapes, and the number of interbeds. We obtained the sand body scale and aspect ratio of single channels and established three depositional architectural patterns, i.e., isolated, lateral migration, and vertical accretion, thus revealing the differences in the spatial stacking relationships of sand bodies in different structural locations (blocks). This work provides new insights into the depositional architectural patterns of gravity flow channel deposits in the Banqiao Oilfield, Huanghua Depression.

Clinical and histopathological features of lentigo maligna and lentigo maligna melanoma: a retrospective analysis in Korea.

Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are rare in Asian countries. The histopathological diagnosis of LM is often challenging, and misdiagnosis is common. Although histopathologic features of LM/LMM are known, statistical analysis of them were scarcely reported. In this study, we aimed to investigate the histopathological characteristics of LM/LMM in Korean patients and identify key histopathological clues distinguishing LM from benign lentigo. We performed a retrospective study of the clinical and histopathological features of patients diagnosed with LM/LMM at our center between 2011 and 2022. We assessed the histopathological features in each case based on 16 pathological criteria according to previous literature. Pathologically confirmed cases of benign lentigo were analyzed for comparison. Twenty-one patients (10 with LM and 11 with LMM) were analyzed. Several statistically significant difference existed between the features of LM and benign lentigo (N = 10), including asymmetry of overall structure (p < 0.001), cytologic atypia (p < 0.001), predominant single-cell proliferation (p < 0.001), melanocytic nests (p = 0.033), melanocytes forming rows (p = 0.003), pagetoid spread of melanocytes (p < 0.001), and hair follicle invasion by atypical melanocytes (p < 0.001). Degree of solar elastosis was more severe in group "Age ≥ 60" (p = 0.015), and group "Diameter ≥ 20 mm" (p = 0.043). Presence of elongated rete ridges were less common in the older than 60 age group (p = 0.015) and group "Diameter ≥ 20 mm." Invasion was associated with mitosis (p = 0.001, OR 49.285), multinucleated cells (p = 0.035, OR 17.769), and degree of lymphocyte infiltration (p = 0.004). This study investigated the clinical and histopathologic characteristics of LM and LMM in Koreans. Although histopathological diagnosis is challenging, especially in the early stages of LM, our data showed essential histopathological changes in architectural, cytological, and dermal patterns. Considering the potential aggressiveness of LM/LMM, it is essential to recognize its histopathological features and provide timely management.

IIoT System Canvas — From architecture patterns towards an IIoT development framework

Industrial Internet of Things (IIoT) solutions are poised to enable digital transformation across industry verticals. However, the diversity of IIoT applications has resulted in a multitude of constantly evolving technologies, standards, and reference architectures with differing terminologies and frequent incompatibilities. A unified approach to describe and develop IIoT systems is needed not only to ease development, but also identify cross-cutting research gaps and exploit synergies.Building on a substantial literature survey, this work proposes the IIoT Development Framework, taking a systems engineering perspective to derive an IIoT Systems Development Process along with several key tools: After defining business objectives, an IIoT system is broken down into system components using the IIoT Architecture Pattern. Second, functionalities for each component are identified leveraging morphological boxes. Third, suitable technologies capable of providing these functionalities need to be selected. For this task, technology selection criteria and processes as well as technology comparison sheets are detailed, covering key technologies. Throughout the entire process of technology selection, the IIoT System Canvas is the central tool summarizing components, required functionalities and selected technologies to provide a comprehensive end-to-end view of the entire IIoT system. It may be understood as a modeling template akin to the Business Model Canvas.The IIoT Development Framework aims to achieve three objectives: Completeness (covering all aspects of IIoT systems), actionability (low barriers for researchers and practitioners) and generalizability (covering not just one product family, but cutting across industry verticals). The framework is validated by comparison to the state of the art and application to a set of use cases covering multiple industry verticals with differing requirements, showing superior results especially in terms of completeness and actionability, while maintaining generalizability.

A Comparative Study Of MVC Architecture Model Of Open Source Server Side Scripting Language Jsp And Php For Client-Server Architecture Based Applications Development

The Model-View-Controller (MVC) architecture pattern has become a popular way to structure web applications, separating the data, presentation, and application logic into modular components. This review paper provides a comparative analysis of implementing MVC architecture using two major open-source server-side scripting languages - JavaServer Pages (JSP) and PHP. Over 10,000 open source projects utilizing JSP/Java and PHP are analyzed to compare how the languages lend themselves to the MVC pattern. The challenges and advantages of both platforms for real-world development of thin-client applications are assessed. Quantitative metrics on performance, scalability, code reuse and integration with MVC frameworks like Spring and Laravel are provided. The findings indicate strengths and weaknesses unique to both languages, with outcome being that PHP+Laravel offers faster initial development time, while JSP+Spring provides more enterprise-grade scalability. The insights can guide developers to make an informed choice between the two platforms for MVC-based, client-server application development.

Model and tools of the navigation system between educational institution buildings using augmented reality technology

A problem of navigation within large educational complexes has been identified, which poses a particular challenge for new students, visitors, and staff. It has been established that the implementation of augmented reality technologies considerably enhances the intuitiveness and usability of the navigation system. A comprehensive structural and mathematical model of the navigation system based on augmented reality technologies has been meticulously developed. This model formalizes the functional dependencies among the system components, enabling a deeper analysis of interconnections and optimization of operational processes. The working algorithm of the system, which utilizes cutting-edge augmented reality technology, is thoroughly described. A software solution for navigating between university buildings, using advanced augmented reality technology, has been developed. This system simplifies the spatial orientation within the campus during transitions between buildings, significantly enhancing the user experience. An interface that seamlessly combines intuitive understanding with visual attractiveness has been proposed, aiding users in effectively planning their academic day. Additionally, the system includes a module that provides visitors with essential information about respective university buildings and access to class schedules. The system architecture comprises several key blocks: the sensor block, the software and data processing block, the campus map integration block, the user interface block, and the interaction and personalization block. These components together ensure a seamless and personalized user experience. The design of the components has employed a systematic approach that ensures interface personalization, stringent data security, and efficient user interaction. In developing the application, the Kotlin programming language, MVVM architectural pattern, Dagger 2 libraries, and the ARCore platform for augmented reality, specifically tailored for the Android platform, were utilized. These technologies provide flexibility, scalability, and efficiency in development. Future research directions have been proposed, which include the further refinement of the software and the expansion of the system's functionality. Additional modules are planned to be developed to meet the evolving needs of the student body and staff of educational institutions, thus enhancing accessibility and integration with other information systems of the educational establishment.

A Comprehensive Review of Interactive System Architecture

This paper presents a detailed review of interactive software architecture (ISA). ISA has emerged as an important aspect in software engineering offering a framework that prioritizes user interaction, real-time responsiveness and adaptability. The paper explores various aspects crucial for the design, development, and maintenance of robust and scalable software systems. The review encompasses architectural patterns, design principles, scalability, maintainability, security, and emerging trends. The paper also examines the significance of ISA and challenges for the same. Objective: The objective of the paper is to provide a comprehensive understanding of the key considerations in interactive system architecture and how they impact the overall success of a software project. The paper also goes on to discuss the challenges and benefits of implementation of ISA Methodology: the study adopted a desktop approach by reviewing existing literature on the topic at hand so as to provide a simplified understanding of the interactive system architecture. Recommendations: at the end of the paper it provides recommendation on future developments in this field.

Diagnostic Utility of Cell block and Immunocytochemistry in Differentiating Malignant from Non-malignant Effusions: A Cross-sectional Study

Introduction: Cytological evaluation of body cavity fluids has been widely employed in diagnosing the underlying aetiology. Differentiating reactive mesothelial cell proliferations from metastatic malignant cells based on cytomorphology alone is challenging. Therefore, the use of cell blocks in conjunction with immunocytochemistry can significantly improve diagnostic accuracy. Aim: To investigate the role of cell blocks and immunocytochemistry in distinguishing malignant from non- malignant effusion fluids. Materials and Methods: A prospective cross-sectional study was conducted on 70 serous effusion fluid samples (ascitic and pleural fluids) received in the Cytology section of the Pathology Department from October 2021 to November 2022. Relevant clinical details, including demographic information, age, gender, presenting complaints, and radiological and laboratory investigations, were documented from the patients’ medical records. All fluids underwent conventional cytology, and the remaining fluid was used for cell block preparations. Immunocytochemistry was performed using Ber-EP4 and Calretinin immuno-markers to differentiate between reactive mesothelial cells and malignant cells. The association between cytosmear/cell block and immunocytochemistry was calculated using the chi-square test. Results: Out of the 70 cases, 44 were pleural fluids, and 26 were ascitic fluids. Conventional cytology identified 11 positive cases, 20 suspicious cases, and 39 negative cases for malignancy. However, after cell block examination, the total number of positive cases reduced to 9, suspicious cases decreased to 12, and negative cases increased to 49, resulting in a 14.3% increase in diagnostic accuracy. Immunocytochemistry using Ber-EP4 showed strong positivity in 12 cases, indicating epithelial malignancy (adenocarcinoma), while 9 cases were Ber-EP4 negative. Calretinin positivity was observed in the mesothelial cells of all 21 cases where immunohistochemistry was performed, resulting in a 17.5% increase in diagnostic accuracy. Conclusion: The combination of cell block technique with conventional cytology improves the diagnostic yield and accuracy by providing better interpretation of architectural patterns and cytomorphology. Additionally, the application of immunocytochemistry using Ber-EP4 and Calretinin aids in distinguishing malignant from non-malignant serous effusions.

Intestinal metastases of colorectal cancer.

We present the case of an 82-year-old woman with a history of well-differentiated adenocarcinoma of the cecum, stage pT3N1M0, treated ten years before with right hemicolectomy and adjuvant chemotherapy (Capecitabine and Bevacizumab). She developed painless obstructive jaundice of sudden onset. Computed tomography (CT) showed an ampullary nodule with secondary dilatation of the biliary and the pancreatic ducts. Subsequent duodenoscopy and endoscopic ultrasound identified the presence of multiple 3-10 mm tumor-like nodules from the first to the second duodenal knee, the largest one infiltrating the papillary area and preventing its cannulation. Biopsy revealed a moderately differentiated adenocarcinoma with cribriform, nidiform and acinar architectural patterns and positive immunohistochemistry for CK20 and CDX2, compatible with colon origin. The patient was treated with five cycles of chemotherapy (FOLFOX) with the disappearance of the duodenal nodules, although during follow-up she developed disease progression with a left adnexal metastasis with identical histological and immunohistochemical pattern.

СОПРОВОЖДЕНИЕ ВЫВОДА ИЗ ЭКСПЛУАТАЦИИ ЯДЕРНЫХ УСТАНОВОК С ПРИМЕНЕНИЕМ ЦИФРОВЫХ ПРОДУКТОВ

The article discusses the development of a digital product for the decommissioning of nuclear and radiationhazardous facilities at the conceptual level. The need for such development is conditioned by the fulfillment of the requirements for import substitution of software in strategically important sectors of the Russian Federation, the importance of ensuring information security (data in the project is often marked «For official use») and the availability of additional functionality for specific projects that is not provided in other applications. The authors describe the features of nuclear decommissioning projects and form functional requirements for the digital product, proposing architectural patterns. In particular, the clientserver architecture with microservices was chosen for the development of this digital product. Main technologies and methodologies for the clientside application (frontend) include HTML, CSS, React, and FeatureSliced Design. JavaScript and TypeScript languages used to create the frontend of the application. To organize the backend, it is recommended to use Docker, Nest.js, and Node.js. Data storage is handled using the PostgreSQL database and S3 cloud storage. Using the example of one of the modules (Gantt Chart) of the digital product, the methods and libraries used are described in detail. Overall, the combination of these technologies ensures that the digital product is importindependent and meets all the requirements for successful development.

Residential Spatial Arrangement Patterns in Ari Nur's Novel Memory Dilation

Buildings are a form of architecture that has an important role in life. Residential architecture such as a house is one of human needs and a manifestation of the understanding of the function, ideas, and behavior of its occupants. In designing a house it is very important to determine the pattern of spatial arrangement. The problem that exists is how the spatial arrangement pattern of a residential house is adapted to the function and nature of the room which can provide comfort to the occupants. This research aims to see the spatial order patterns contained in the novel Dilatasi Memori by Ari Nur. The way to collect data/analysis information is by reading the novel as a whole, and then taking quotations from sentences related to the components of residential spatial layout patterns in architecture. The spatial arrangement pattern should be a space that has benefits and is influenced by the activities and character of the occupants which will influence the division of space, choice of colors, and furniture. From this research, it can be seen how the pattern of spatial arrangement in the novel Dilatasi Memori by Ari Nur contains several zones that are adapted to their function, namely Public Area, Private Area, Semi-Private Area, and Service Area.

SparsePro: An efficient fine-mapping method integrating summary statistics and functional annotations.

Identifying causal variants from genome-wide association studies (GWAS) is challenging due to widespread linkage disequilibrium (LD) and the possible existence of multiple causal variants in the same genomic locus. Functional annotations of the genome may help to prioritize variants that are biologically relevant and thus improve fine-mapping of GWAS results. Classical fine-mapping methods conducting an exhaustive search of variant-level causal configurations have a high computational cost, especially when the underlying genetic architecture and LD patterns are complex. SuSiE provided an iterative Bayesian stepwise selection algorithm for efficient fine-mapping. In this work, we build connections between SuSiE and a paired mean field variational inference algorithm through the implementation of a sparse projection, and propose effective strategies for estimating hyperparameters and summarizing posterior probabilities. Moreover, we incorporate functional annotations into fine-mapping by jointly estimating enrichment weights to derive functionally-informed priors. We evaluate the performance of SparsePro through extensive simulations using resources from the UK Biobank. Compared to state-of-the-art methods, SparsePro achieved improved power for fine-mapping with reduced computation time. We demonstrate the utility of SparsePro through fine-mapping of five functional biomarkers of clinically relevant phenotypes. In summary, we have developed an efficient fine-mapping method for integrating summary statistics and functional annotations. Our method can have wide utility in understanding the genetics of complex traits and increasing the yield of functional follow-up studies of GWAS. SparsePro software is available on GitHub at https://github.com/zhwm/SparsePro.

Morphologic Heterogeneity of Carcinoma with Signet Ring Cell Features at Different Primary Sites

Introduction: Signet ring cells (SRCs) may be observed in carcinomas from multiple primary sites. Elucidating unknown primaries from metastases with SRCs represents a diagnostic challenge. This study examined morphologic characteristics of adenocarcinomas with SRCs from stablished primary sites and described objective features, which can aid in identifying the site of origin. Methods: The series encompasses 257 cases of adenocarcinomas with SRCs from gastroesophageal junction (GEJ, n = 38), stomach (n = 48), pancreatobiliary system (n = 16), colorectum (n = 40), appendix (n = 32), breast (n = 41), and lung (n = 42). H&E sections were examined and scored using architectural and cytologic criteria. Morphometric analysis was performed using QuPath software. Results: Extracellular mucin was more abundant in GEJ, colorectal, and appendiceal carcinomas. Poorly cohesive morphology was the most frequent pattern in gastric and breast carcinomas. The cytoplasmic mucin/vacuole was predominantly clear and targetoid in breast carcinomas. Breast and gastric carcinomas showed the highest nuclear to cytoplasmic (N/C) ratio, whereas appendiceal carcinoma the lowest. Conclusion: Morphological evaluation (extracellular mucin, architectural patterns, and the nature of cytoplasmic mucin/vacuole) represents an important step to determine the cancer site of origin in adenocarcinomas with SRCs and guides further ancillary studies. Cytological morphometry may help further refine morphological criteria and facilitate the construction of digital-pathology algorithms.