Transformation of the architectural heritage of large cities, which also includes that of industrial areas, can be seen as a development and reconstruction driver of modern urban development. In this work, we aimed to propose methods for spatial transformation of urban industrial or mixed areas in the structure of a large city. A structural assessment of the urban planning practice and experience in the city of Tyumen was conducted to identify architectural and planning approaches to the reconstruction of depressive post-industrial areas. Following an analysis of the existing location and concentration of industrial areas, along with their main parameters, and the experience of experimental design of renovated districts, the Babarinka industrial district in the northern part of the city was selected. This district is characterized by its direct interconnection with the city center, a combined type and small-cell structure of the existing buildings, and its historical interrelation with the open space of the river. Typological and morphological features of the existing industrial areas in the city, interacting with the surrounding urban areas in different ways, were determined based on the theory of mixed urban development. A combined assessment of urban planning data enables the key parameters of urban transformation to be determined and the basic planning structures to be identified. The latter include spatial planning, transportation and pedestrian networks, landscaping, and functional zoning. These planning structures determine the key qualitative parameters of the transformation design concept of industrial areas, thus serving as criteria for evaluating various-scale design solutions.