Architect System Research Articles

Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT® analyzer

During a normal menstrual cycle, serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and progesterone can vary widely between cycles for the same woman, as well as between different woman. Reliable reference values based on the local population are important for correct interpretation of laboratory results. The purpose of our study was to determine detailed reference values for these hormones throughout the menstrual cycle using the Abbott ARCHITECT system. From 20 volunteers (age 20-36 years) with normal cycles and no use of oral contraceptives, samples were taken every day during their cycle. Volunteers received three vaginal ultrasound examinations (days 10 and 13, and 1 or 2 days after ovulation) to measure follicular and corpus luteum development. Hormone levels were measured using the corresponding ARCHITECT assay and were synchronized to the LH peak. Median, and 5th and 95th percentile values were determined for each day of the cycle, as well as for early follicular (days -15 to -6), late follicular (days -5 to -1), LH peak (day 0), early luteal (+1 to +4), mid-luteal (days +5 to +9), and late luteal (days +10 to +14) phases of the cycle. Based on our data, we were able to establish detailed reference values for LH, FSH, estradiol, and progesterone, which should aid in the interpretation of results for these reproductive hormones in a variety of circumstances.

Performance characteristics of the ARCHITECT ® Anti-HCV assay

Introduction: The ARCHITECT Anti-HCV assay is a fully automated high throughput chemiluminescent microparticle immunoassay (CMIA) for the detection of antibodies to structural and nonstructural proteins of the hepatitis C virus (HCV). To further enhance the performance of this test, the assay was modified to improve the specificity for blood donor specimens. Methods: The specificity of the enhanced ARCHITECT Anti-HCV assay was evaluated by screening blood donor samples randomly collected from various German blood banks, as well as hospitalized patient samples derived from Germany and the US. Additionally, antibody sensitivity was determined on commercially available anti-HCV seroconversion panels and on a commercially available worldwide anti-HCV genotype performance panel. Results: Apparent specificity of the modified ARCHITECT Anti-HCV assay in a blood donor population consisting of 3811 specimens was 99.92%, compared to 99.76% for the current on-market assay. Additionally, antibody sensitivity was determined on commercially available anti-HCV seroconversion panels. Seroconversion sensitivity equivalent to or better than the current on-market product was observed by testing 33 seroconversion panels. Conclusion: This study demonstrates that the modified version of the ARCHITECT Anti-HCV assay shows improved specificity for blood donor specimens compared to the current assay on market without compromising sensitivity. With the availability of the improved ARCHITECT Anti-HCV assay and the recent launch of the ARCHITECT HIV Ag/Ab Combo assay, the ARCHITECT system now offers a full hepatitis/retrovirus menu with excellent performance on a high throughput, random access, automated analyzer, ideally suited for blood screening and diagnostic applications.

1454 新装置による重ね合わせ接着継手の熱応力解析(S20-2 材料特性評価(2),S20 実験力学的手法による材料・製品の評価)

The bond joints are used in the various environments, and the indispensability for the industrial society. This is done under the high temperature, the normal temperature and the low temperature, the behavior of the stress in these conditions changes. In the case of the thermal experimental analysis, this has to consider the temperature of the environment. The authors made the new architect system for the purpose of the thermal experimental analysi. This is keeping at the constant temperature that is indicated, the specimen is doing at the same temperature. This is the experiments that is reproduced the same environment at the same temperature. This system is able to carried out the various temperature, the good result from this new system was able to get.

Incidence and prognosis of syncope

The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has recently established pediatric age- and sex-specific reference intervals for over 85 biochemical markers on the Abbott Architect system. Previously, CALIPER reference intervals for several biochemical markers were successfully transferred from Abbott assays to Roche, Beckman, Ortho, and Siemens assays. This study further broadens the CALIPER database by performing transference and verification for 52 biochemical assays on the Roche cobas 6000 and the Roche Modular P.Using CLSI C28-A3 and EP9-A2 guidelines, transference of the CALIPER reference intervals was attempted for 16 assays on the Roche cobas 6000 and 36 on the Modular P. Calculated reference intervals were further verified using 100 healthy CALIPER samples.Most assays showed strong correlation between assay systems and were transferable from Abbott to the Roche cobas 6000 (81%) and the Modular P (86%). Bicarbonate and magnesium were not transferable on either system and calcium and prealbumin were not transferable to the Modular P. Of the transferable analytes, 62% and 61% were verified on the cobas 6000 and the Modular P, respectively.This study extends the utility of the CALIPER database to two additional analytical systems, which facilitates the broad application of CALIPER reference intervals at pediatric centers utilizing Roche biochemical assays. Transference studies across different analytical platforms can later be collectively analyzed in an attempt to develop common reference intervals across all clinical chemistry instruments to harmonize laboratory test interpretation in diagnosis and monitoring of pediatric disease.

Analytical evaluation of 13 laboratory tests on the Abbott Architect system

This paper explains the development stages of an expert system BES for the evaluation and selection of the building elements. The work covers all kinds of building elements that are available in building construction including retaining walls, foundations, external walls, internal walls, floors, external stairs, internal stairs, roofs, external chimneys, internal chimneys, windows, and external doors and internal doors. The selection is based on the importance of performance requirements of the building elements and their expected performances. The selection is achieved by SMART Methodology, and the expert system shell “Exsys Corvid” is used to construct the expert system. Use of computer and Internet with its advantages in handling vast amount of data makes the system widely applicable and a useful design aid for architects. The decision-making feature of the system provides a suitable selection among numerous alternatives. The paper explains the experience gained through the use of this method and discusses further development of the system.

The University of Shiga Prefecture's Proposal to Public Architecture

The University of Shiga Prefecture was opened in April in 1995 with an ideal of ecological harmony with its environment, and, in education and study, is engaged in characteristic attempts, for example, the establishing of School of Environmental Science. Many attempts which reflect the ideal are also found in the facilities of the Master–Architect system, a beautiful lakeside university. It means our University's proposal to what a public architecture should be in future.