This paper presents a review of available lithostratigraphic and isotopic data, in addition to other information collected from projects of the Geological Survey of Brazil (SGB-CPRM), for the Rio Piranhas-Serido Domain (PSD). This domain is one of the tectonostratigraphic compartments of the central-northeast portion of the Borborema Province (Northeast Brazil), bound by the Picui-Joao Câmara, Patos and Portalegre shear zones. More recent isotopic determinations (U-Pb dating of zircon) and geological maps (usually on a 1:100000 scale) have clearly detected and/or redefined several units, e.g., the Amarante, Campo Grande, Granjeiro and Saquinho complexes, in addition to the Serra do Inga body (Archean), Arabia Complex (Siderian), Caico Complex and Serra da Formiga Suite (Rhyacian), Poco da Cruz Suite (Orosirian-Statherian), Serido Group (Ediacaran) and Ediacaran to Early-Cambrian magmatic suites, in addition to pegmatites and granitic pegmatites. With respect to the supracrustal rocks of the Serido Group, the deposition in the Ediacaran is based on field relations and on the ages of detrital zircons, which showed a greater contribution from Mesoarchean to Neoproterozoic sources, the vast majority of which may come from the PSD itself. Current records indicate that the evolution of the PSD started in the Eoarchean, and peaked in the Neoproterozoic with the Brasiliano event, which is characterized by sedimentation of the Serido Group, intrusion of plutonic bodies, deformation and metamorphism (especially at the regional level), in addition to the formation or reactivation of important shear zones. Such evolution is acknowledged on the basis of the accretion of oceanic arcs during the Paleoproterozoic (containing Archean fragments), including the generation of juvenile magmas and a protocrust (Caico Complex). The Neoproterozoic record, associated with the Brasiliano event, is considered by several authors as reworking with no or little contribution of juvenile material, with deposition of the Serido Group, emplacement of several Ediacaran to Early-Cambrian magmatic suites, accompanied by the formation of shear zones, predominantly in the southern and eastern portion of the domain.