The object of this research is an open queueing network (QN) with a single class of customers, in which the total number of customers is limited. Service parameters are dependent on time, the routing of customers is determined by an arbitrary stochastic transition probability matrix, which is also depends on time. The service times of customers in each queue of the system is exponentially distributed with FIFO service, and it is assumed that a birth and death process generates and destroys the customers. The random vector, which determines the network state, forming a Markov random process is introduced. The purpose of the research is an asymptotic analysis of this Markov process, describing the queueing network state with a large number of customers, obtained from a system of differential equations, and used to find the mean relative number of customers in the network queues at any time. The results are illustrated with a specific example. This approach can be used tp model processes of customer service in the insurance companies, banks, logistics companies and other cyber-economical or service organizations.