Arab World Research Articles

Segregation of the COL6A2 Variant (c.1817-3C>G) in a Consanguineous Saudi Family with Bethlem Myopathy

Introduction: Bethlem myopathy is a rare genetic disease caused by a variant mapped to 21q22, which harbors the collagen type VI alpha 2 chain (COL6A2) and collagen type VI alpha 1 chain (COL6A1) genes, and 2q37, which harbors the collagen type VI alpha 3 chain (COL6A3) gene. Disease onset can occur at any age, and the symptoms are related to those of muscular dystrophy. Since Bethlem myopathy is a rare disease, no previous studies have been conducted in Arab countries, including Saudi Arabia. Its variable presentation of nonspecific muscular contractions and severity represents a diagnostic dilemma. Case presentation: Here, we report a Saudi pediatric patient, who is 9 years old (proband), brought to the pediatric clinic of King Saud’s Hospital by his mother. The boy presented with difficulty standing, walking, and running with his classmates and unaffected siblings. He has a younger sibling, aged 6 years old, who reported having a limping gait and difficulty bending his right knee. Laboratory results for the proband were unremarkable except for a slight increase in creatine kinase (CK). Whole-exome sequencing (WES) was performed for five family members, including the proband and his symptomatic brother, their mother and two asymptomatic siblings. A very rare 3′ splice site acceptor intronic variant, NM_001849.4: c.1817-3C>G, located three nucleotides before exon 25, was identified in COL6A2. Bioinformatics tools (SpliceAI, dbscSNV, FATHMM-MKL, and MaxEntScan) predicted this variant as pathogenic. The proband and his 6-year-old sibling presented a homozygous genotype for the variant, whereas the mother and one asymptomatic sibling were heterozygous, and the other sibling carried homozygous wild-type alleles. Conclusions: This is the first study to report a case of Bethlem myopathy confirmed by WES in Saudi Arabia and all Arab nations. The identified variant is rare, and its segregation pattern suggests autosomal recessive inheritance. The segregation pattern and bioinformatics tool results may qualify this variant to be annotated as pathogenic, addressing the reported uncertainty of its classification. Our findings contribute to linking and filling the knowledge gap of diagnosing and managing patients with collagen VI-related myopathies, providing greater clinical and genetic understanding to the existing knowledge.

Triglyceride and Glucose Index as an Optimal Predictor of Metabolic Syndrome in Lebanese Adults

Background: Globally, the prevalence of metabolic syndrome (MetS) is on the rise, especially in Arab countries, which emphasizes the need for reliable ethnic-specific biochemical screening parameters. Methods: Two hundred twenty-one Lebanese adults were enrolled in this cross-sectional study. Biochemical parameters including Homeostasis Model Assessment (HOMA), Triglyceride and Glucose index (TyG), ratio of Triglycerides to High-Density Lipoprotein Cholesterol (TG/HDL-C), Atherogenic Index of Plasma (AIP), and Visceral Adiposity Index (VAI) were assessed for their prediction of MetS. Analysis of covariance, logistic regression, expected-versus-observed case ratio were used to determine model calibration, concordance statistic, area under the receiver operating characteristic curve (AUC) and 95% confidence intervals (CIs), sensitivity, specificity, and negative and positive predictive values (PPV, NPV). Results: The prevalence of MetS was 44.3%. All biochemical parameters were significantly associated with MetS, with a strong model discrimination (c-statistic between 0.77 and 0.94). In both sex categories, TyG best predicted MetS (females: cut-off value, 8.34; males: cut-off value, 8.43) and showed good estimation among females, but overestimation among males. HOMA had the lowest discriminatory power in both sex categories. Conclusions: This study suggests that TyG best predicts MetS, while HOMA has the lowest predictive power. Future larger studies need to focus on harmonizing ethnic specific cut-offs and further validating our results.

International disputes over joint oil and gas fields in the Arab east region

The international dispute over shared oil and gas reserves is a complex global matter with political, legal, and economic implications. Oil and gas are national assets that must be carefully managed. This study has addressed an essential issue commonly arising in conflicts among the countries in the Arab East region. Multiple oil contracts have been concluded, but these are critical for establishing the necessary groundwork for exploring and investing in shared oil and gas reserves. However, the exploitation and development of these common or trans-regional fields sometimes give rise to legal and political complications, adversely affecting the equitable development and investment of these shared, cross-border resources. This study examines the primary sources of dispute in the Arab East region and the absence of peaceful and suitable resolutions for the parties involved. A comprehensive analysis using a historical, descriptive, and analytical approach revealed multiple conflicts among the Arab East Region states around shared oil and gas reserves, including conflicts among Arab nations and Iran disputes. The intensity of these confrontations has hindered the utilization, advancement, and investment in shared resources, resulting in substantial losses for all countries involved.

Expert Consensus Recommendations on a Biosimilars Value Framework for the Gulf Cooperation Council Countries.

This paper aims to develop a biosimilar value framework with local stakeholders in Gulf Cooperation Council (GCC) countries. A convenience sample of ten key opinion leaders from the United Arab Emirates, Kingdom of Saudi Arabia, Kuwait, Oman and Qatar participated in an expert panel meeting in November 2022 that examined factors positively influencing biosimilar adoption in these countries. The discussion was structured around a conceptual biosimilar value framework and an overview of biosimilar policies as derived from a targeted review of the peer-reviewed and grey literature. The expert panel agreed on a biosimilar value framework for the GCC countries that is founded on trust, cost savings and contextual considerations. They emphasized the importance of launching educational initiatives that build trust in and expand knowledge of all stakeholders about biosimilars. This also includes making stakeholders aware of the various value propositions of biosimilars as an instrument to produce, for example, cost savings. Finally, they stressed that biosimilar adoption is influenced by contextual factors such as incentives and implementation efforts. Our proposed biosimilars value framekwork is the first set of recommendations in the Arab countries designed to help policymakers and decision-makers promote biosimilar adoption, both in high-income GCC countries and in low- and middle-income countries.

The Cooperation Council for the Arab States of the Gulf – New, Promising Actor in the Middle East

The Cooperation Council for the Arab States of the Gulf – New, Promising Actor in the Middle East

Bringing back the tribe: why we should not abandon the study of tribes in the Arab world

Once broadly applied, the term “tribe” has been discredited and is now rarely used in the social sciences. Critics argue that the concept is vague, is evocative of primitive and backwards connotations, and has been inappropriately applied to societies that are not “tribal.” While these criticisms are well-founded and legitimate, I argue in this Perspective piece that we must not abandon the study of tribes in the Arab world. The concept of “tribe” continues to be salient for Arab citizens and one that they aptly assign to themselves. To address criticisms of previous studies, I offer three ways to reform scholarly pursuit on tribes: (1) adopting a thin conception of tribe (2) treating the concept as a dynamic not static unit and (3) being led by on-the-ground reality and not by theoretical biases regarding the applicability of this term.

Bibliography of Recent Works

This section lists articles and reviews of books relevant to Palestine and the Arab-Israeli conflict. Entries are classified under the following headings: Palestine in Global and Comparative Perspectives; Palestine and the Palestinians; Literature and the Arts; Middle East and the Arab World; Israel and Zionism; and Recent Theses and Dissertations.

Arabic validation and cross-cultural adaptation of climate anxiety scale

BackgroundClimate change is an enduring global phenomenon that describes a long-lasting effect of change in weather and temperature of the earth. This study aimed to validate an Arabic version of the Climate Anxiety Scale (ACAS) to assess the anxiety associated with climate change. MethodsA cross-sectional survey was conducted using both online via Google Forms and face-to-face via hard copies, in five Arab countries, Lebanon, Palestine, Egypt, Saudia Arabia, and the United Arab Emirates). The internal consistency of the scale was assessed using the Cronbach's alpha. Exploratory factor analysis (EFA) conducted over principal component analysis assessed the scale dimensionality. Then, confirmatory factor analysis was conducted to investigate the EFA hypothesis of ACAS on anxiety about climate change. ResultsOf the 350 participants, 54.9 % were female, 77.7% lived in urban areas, 15.4% were from North Africa, 46.6 % were from Arab Gulf countries, and 38.0 % were from Bilad Al-Sham. Nearly two-thirds (62.3%) were single, 72.3% had a university degree, 94.9% were aware of climate change, 38.3 % participated in environmental protection programs, and 62.3% reported climate-related anxiety. The item content validity index (CVI) was 0.82–1.00, and the scale CVI (S-CVI) was 0.95. Overall Cronbach's alpha was 0.925 with a 95% confidence interval (CI) [0.902–0.940]. The Kaiser-Mayer-Olkin (KMO) test was 0.93, and Bartlett's test was significant (χ2 = 2762.6 p < 0.001). Bifactor model indices showed high explained common variance (ECV) (0.78), ωH (0.85), relative omega (0.91), H index (0.93), and factor determinacy (FD) (0.96) for the general factor. The general factor explained 78% of the common variance, whereas the group factors shared 22.0%. Model reliability coefficient omega (omega/omega S) for general factor, functional domain, and cognitive domain were 0.94, 0.92, and 0.89, respectively, suggesting a satisfactory fit threshold. ConclusionsThe ACAS tool is valid and reliable for assessing anxiety-related climate change among the Arab Population.

Realigning Social Protection Across the Nexus: Reflections from Protracted Crises in the Arab Region

Humanitarian emergencies are increasingly protracted and characterised by multiple compounding crises. International social security standards provide a roadmap for building national social protection systems. In the Arab States region, the International Labour Organization has been critically assessing how to apply these standards across the humanitarian, development, and peace nexus when countries face protracted crises. This article presents case studies in four countries: Iraq, Jordan, Lebanon, and the Occupied Palestinian Territory. It addresses questions on how to strengthen humanitarian–development transitions using international standards, where entry points exist or challenges remain, and how these transitions may contribute to strengthening peace through social cohesion.

Sheikh Abdullah Al‐Salem's use of soft power and public relations: Transformation from emirate to state

AbstractThis paper describes the main factors that helped facilitate the transformation of Kuwait from an Emirate ‘Emarah’ (a non‐state) to an internationally recognised state during the rule of Sheikh Abdullah Al‐Salem from 1950 to 1965. It identifies the soft power actions and public relations communication strategies that facilitated the transformation of Kuwait from Sheikhdom to statehood. Sheikh Al‐Salem's strategies set the foundations for Kuwait to become recognised and respected in international affairs, not only in the Middle East but also globally. Data were collected and reviewed from the academic literature, from public records, legal documents, letters, press releases and newspaper and magazine articles as well as songs and TV interviews. The evidence shows that Sheikh Al‐Salem's use of soft power actions and public relations techniques were influential in facilitating the formation of the new state and made Kuwait an important player in the international arena while maintaining Arab nationalism and Islamic values.

Phytochemical composition, in vitro cytotoxicity, and in silico docking properties of Tamarix tetragyna L.

Tamarix tetragyna is a plant grows in Mediterranean area and some Arab countries. It possesses numerous medicinal values. Purpose of our study is to explore biological activity of tamarix tetragyna extracts of both leaves and stem with investigating their phytochemical composition. The investigated extracts’ phyto-constituent composition was determined using gas chromatographic-mass spectrometric method. In addition, in vitro cytoxicity activity versus cancer cell lines such MCF-7, HepG-2, HCT-116, and A-549 was examined by MTT assay method, together with exploring its apoptosis effect by flow cytometry and western blot analysis techniques. Moreover, some phytochemical compounds were identified, and in-silico evaluated against anticancer molecular targets. Plant extracts showed good cytotoxic activity against both A-549 and HCT-116 cancer cell lines. With an IC50 value of 23.90 µg/ml that led to apoptosis and G2/M-phase arrest in A-549 cells, cytotoxicity data demonstrate leaves’ extract effectiveness against these cells. Upon GC-MS analysis, it revealed presence of some bioactive components such as Stigmast-5-en-3-ol and 2-methoxy-4-vinyl phenol, which are known for their cytotoxic activity. Our findings suggest that methanolic extracts of Tamarix tetragyna parts may have potential therapeutic uses as anticancer against A-549 cells, which opens up further avenues for investigation into its industrial applications.

The Integration of Artificial Intelligence in Physicians' Daily Practice for Diagnosis, Prediction, And Disease Management in the Arab World

Artificial intelligence (AI) is developing rapidly. Integrating AI into healthcare practices in the Arab world will transform diagnosis, prediction, and disease management. Today, countries such as Saudi Arabia and the United Arab Emirates (UAE) are at the forefront of AI adoption in healthcare, supported by strategic frameworks such as Saudi Arabia's Vision 2030 and the UAE National Artificial Intelligence Strategy 2031. However, adopting AI in daily healthcare practice on a large scale faces many obstacles that need to be overcome. Keywords: Artificial intelligence, AI, healthcare practice, diagnosis, prediction, and disease management, Arab world.

From text to allegory: ideological turns in Shamel Abatha’s translation of Animal Farm in the socio-political context of Egypt’s Pre-Arab Spring

ABSTRACT The influence of ideology on the process of translation has been one of the most controversial debates among scholars and translators who may undergo multiple challenges due to certain ideological demands, whether they be political, cultural or religious. In the Arab world, the socio-political scene has been dominated by ideological shifts since the outbreak of the Arab Spring. These shifts have influenced Arab scholars and translators in many possible ways, one of which is the reproduction of incisive narratives that not only account for the causes and effects of revolutions that swept different regions in the Arab world but also provoke political reform. In this vein, this article investigates Shamel Abatha’s translation of George Orwell’s Animal Farm (1945) to Arabic. It specifically explores Abatha’s political orientations which result in daring textual manipulations of Orwell’s text before the Arab Spring in Egypt in 2011. Following Mona Baker’s narrative theory, the article demonstrates how Abatha’s target text turns into a socio-political national allegory that embodies critical ideological implications. The corpus consists of selected comparisons between Orwell’s Animal Farm and Abatha’s مزرعة الحيوانات [mazraat alḥywānāt] (2009) to show how translation strategies expound the impact of the latter’s political environment on his translation.

The Climate-Asthma Connection: Examining the Influence of Climate Change Anxiety on Asthma Control and Quality of Life: A Multi-National Study.

This study aims to identify the impact of climate change anxiety and asthma control on asthmatics' quality of life and examine the moderating role of climate change anxiety in this linkage. A multi-national cross-sectional study was conducted in four Arabian countries on 1266 asthmatics selected by convenience sampling. Data were collected from November 2023 to February 2024 using a climate anxiety scale, mini-asthma quality of life questionnaire, and an asthma control questionnaire. Climate anxiety was higher among middle-aged participants, as well as those with longer disease durations and previous hospitalisations. Climate anxiety showed strong negative correlations with asthma control (r = -0.704, p ≤ 0.05) and asthma quality of life (r = - 0.638, p ≤ 0.05). Climate anxiety and asthma control are powerful predictors of quality of life among asthmatics. Climate anxiety moderates the relationship between asthma control and quality of life, making it less positive (B = -0.094, p > 0.001). Covariates such as gender, age, comorbidities, employment status, disease duration, and previous hospitalisation showed significant associations with asthma quality of life. Assessment and mitigation of climate anxiety among asthmatics is a key strategy for controlling asthma and improving the quality of life. So, nurses must incorporate climate anxiety assessment into the care plan for asthmatics. Climate change is a global concern, and insights into how climate-related psychological stressors exacerbate asthma symptoms and overall health outcomes are necessary. The findings provide actionable data for healthcare professionals to underscore the need for integrated healthcare approaches considering environmental and psychological factors. This study adheres to strengthening the reporting of observational studies in epidemiology (STROBE) statement. Clients with asthma across multiple nationalities actively contributed to our paper.

“The Face of the Buffalo”: Interspecies Relationality in Nawal El Saadawi’s God Dies by the Nile

In several interviews, the Egyptian American writer and feminist Nawal El Saadawi has emphasized her commitment to women’s rights and gender justice in Africa and the Arab world. However, there is hardly any reference regarding her engagement with animals. Yet her writing is replete with animal subjectivity. Therefore, this paper examines animal representations in El Saadawi’s God Dies by the Nile by unearthing what we conceptualize as her “complex animal imaginary,” a concept encompassing the anthropomorphic and zoomorphic currents in her novel. Although her narrative language constitutes and conveys such vocabularies, this hardly undermines El Saadawi’s recognition of interspecies relationality and how central the nonhuman is to the flourishing of humans. As such, we highlight her register of animality that presents humans in zoomorphic imagery, stressing that this strategy not only makes legible human suffering but also flattens animal subjectivity, thereby reducing the buffalo, named Aziza, in this case, to a figure of abjection. However, we argue that this representational strategy neither erases animal vitality nor reinscribes speciesism. But instead, it uncovers animal suffering in society. By focusing on interspecies relationality in God Dies, we amplify El Saadawi’s contribution to ongoing conversations on animal studies, postcolonial ecocriticism, and posthumanism.

Validity and reproducibility of a food frequency questionnaire to determine dietary intakes among Lebanese athletes.

Nutrition is a basic need for athletes; thus, adequate dietary intake is crucial for maintaining overall health, facilitating training adaptations and boosting athletic performance. Accurate dietary assessment tools are required to minimize the challenges faced by athletes. This study verifies the validity and reproducibility of a 157 item semi-quantitative food frequency questionnaire (FFQ) among Lebanese athletes. This is the only Arabic questionnaire in Lebanon that estimates food consumption for athletes which can also be used in Arabic speaking countries. There has been no previous validated food frequency questionnaire that estimated food consumption for athletes in Lebanon. A total of 194 athletes were included in the study to assess the validity of the food frequency questionnaire against four days dietary recalls by comparing the total nutrient intake values from the food frequency questionnaire with the mean values of four 24-hour dietary recalls using Spearman correlation coefficient and Bland Altman plots. In order to measure the reproducibility, the intra class correlation coefficients were calculated by repeating the same food frequency questionnaire after one month. The intra-class correlation coefficient between the two-food frequency questionnaires ranged from average (0.739 for carbohydrates) to good (0.870 for energy (Kcal)), to excellent (0.919 for proteins) concerning macronutrients and ranged from average (0.688 for vitamin D), to excellent (0.952 for vitamin B12), indicating an acceptable reproducibility. Spearman's correlation coefficients of dietary intake estimate from the food frequency questionnaire and the four dietary recalls varied between 0.304 for sodium, 0.469 for magnesium to 0.953 for caloric intake (kcal). Bland-Altman plots illustrated a percentage of agreement ranging between 94.3% for fats to 96.4% for proteins. This food frequency questionnaire has a reliable validity and reproducibility to evaluate dietary assessments and is an appropriate tool for future interventions to ensure the adoption of adequate eating strategies by athletes.

Jordan’s Regime Security Under the COVID-19 Pandemic: Securitisation Against Visible and Invisible Threats

The Jordanian authoritarian regime, headed by the Hashemite royal family, has developed a robust regime security system. Having defeated the Arab Nationalists and Palestinian militias, the most significant threats in the Kingdom’s history, and achieved peace with Israel, the monarchy appears to have legitimised its sovereignty and domestic rule. Meanwhile, nonterritorial threats represented by jihadists have continued intermittently despite a surveillance network and continuous securitisation by authorities. Worryingly, decades-long employment problems and inflationary risks are chronic security risks in Jordan in the 21st century. This study examines how Jordan’s regime is functioning against new and old internal security risks during an unprecedented emergency, the COVID-19 pandemic. Under several lockdowns, the government could securitise prominent social forces including Islamists and professional associations for regulation violations. However, it needed to be more effective against the grassroots movement that continued to criticise the government while using cyberspace as its main battleground. Most critical cases, such as the 2021 uproar over former Crown Prince Hamza, primarily became virtual movements. The battle without winners and losers, fought using information and communication technologies from the perspective of digital authoritarianism by the government and liberation technology by resistance forces, posed a new challenge for Jordan’s regime security.

Digital processes in the GCC countries in the first third of the 21ST century: industry features and the need to align industry gaps

The countries of the Cooperation Council for the Arab States of the Persian Gulf (GCC), like many other countries of the world, today live in the realities of digital development and implement the achievements of world science and technology in various spheres and sectors of their economy and life in general. The purpose of the article is to identify the existing level of digitalization in the GCC countries in regional and sectoral aspects. The article shows that in the process of digitalization in the region and individual countries, the needs of digitalization of the national economy have been formed to support sustainable socio-economic development and solve a number of other tasks, for example, environmental, energy, etc. At the same time, specific threats have formed, among which in this article the author identifies industry digital gaps. The author concludes that during the period under study (2000–2023), the GCC identified industry leaders and outsiders in the process of digitalization. The author refers to the first extractive industries, oil refining, construction, as well as the service sector. The prospects for the development of digital systems in the GCC countries are assessed by the author as generally positive, but in the GCC it is important to eliminate digital gaps in the sectoral structure of the economy at the regional and country levels. To do this, according to the author, it is necessary to use legal, organizational, financial and other measures in the GCC countries, including the intensification of international cooperation in the digital sphere in the region and beyond. The study was conducted on the basis of reports from regional and international organizations (UNCTAD, IMF, League of Arab States, Arab Monetary Fund, etc.)

Predicting language, cognition, and social skills in individuals with Autism spectrum disorder using the Arabic validation of Gilliam Autism Rating scale-Third Edition

The Gilliam Autism Rating Scale-Third Edition (GARS-3) has emerged as a pivotal instrument in the diagnostic assessment of Autism Spectrum Disorder (ASD), with its utility extending across linguistic and cultural boundaries. This study endeavors to adapt and validate the GARS-3 for the Arabic-speaking population, addressing the paucity of culturally congruent diagnostic tools in the Arab world. The primary objective is to validate the Arabic version of GARS-3 (A-GARS-3) to assess children with and without ASD, ensuring the scale’s reliability and validity within the target population. A methodical cross-sectional study design was employed, encompassing a sample of 178 participants from both educational and clinical settings in Saudi Arabia. The process involved direct translation, expert panel review, back-translation, and pilot testing to ensure semantic equivalence and cultural relevance. Data were collected using the A-GARS-3, and analyses included Exploratory and Confirmatory Factor Analysis (EFA and CFA), internal consistency reliability measures, and a One-Way Analysis of Variance (ANOVA) to establish concurrent validity. The A-GARS-3 demonstrated high internal consistency (Cronbach’s alpha = 0.971; McDonald’s omega = 0.972) and strong construct validity, with factor loadings and model fit indices substantiating the factor structure. Predictive validity was confirmed through significant correlations between the Autism Index and the subscales, particularly in the domains of social interaction and communication. The A-GARS-3 is a psychometrically sound instrument that offers reliable assessment for ASD within the Arab cultural context. The positive validation outcomes indicate that the scale is an effective, culturally adapted tool for the localized diagnosis of ASD. The validated scale has significant implications for enhancing ASD screening and diagnostic practices in Arabic-speaking regions, potentially improving early diagnosis and intervention strategies.

Tribes as Non-State Actors in the Arab Monarchies of the Persian Gulf at the Present Stage (the Case of the UAE)

The article examines the tribal structures of the UAE as non-state actors. The author pays special attention to the definition of the concept of “tribe” in the Arab world and its interpretation in relation to the countries of the Persian Gulf and, in particular, the UAE as one of the most complex tribal systems in the region. It explores the question of tribal identity and its manifestations at the present stage, as well as its influence on the position of tribes as political actors. Based on the classification of non-state actors by Vitaliy Naumkin and Vasiliy Kuznetsov, the author examines the tribe as a local and state-oriented actor. Three situations are identified in which the tribe as an actor can manifest itself most clearly. The author concludes that tribes cannot be considered as fully-fledged non-state actors, but that they retain significant potential for mobilisation and political action in crisis situations.