AR Group Research Articles

Exclusive human milk feeding and prevalence of early adiposity rebound in ELBW infants: a retrospective cohort study

The purpose of the present study was to evaluate the prevalence of early adiposity rebound (EAR) and factors associated with its occurrence in a cohort of extremely low birth weight infants (ELBW). We conducted a retrospective longitudinal study including ELBW infants followed-up for up to 10 years after discharge. EAR was defined as occurring before 5 years of age. A multivariate binary logistic regression analysis was performed to evaluate maternal and perinatal variables independently associated with EAR. Out of 212 ELBW infants included in the analysis, 40.6% developed EAR and 21.5% showed it before 4 years of age. Only formula milk feeding at discharge was independently associated with a higher risk of EAR. The mean BMI of children with EAR was higher than that of children without EAR. Furthermore, the prevalence of overweight and obesity was higher in the EAR group than in the timely AR group. Conclusions: ELBW infants in our cohort developed EAR in a relatively high percentage of cases. In this already at-risk population, EAR may represent a further risk factor for an adverse metabolic outcome. Monitoring preterm infants’ growth within a long-term follow-up program and promoting and supporting human milk feeding is advisable.What is Known:• Preterm-born infants are at high risk for long-term adverse health outcomes, especially cardiovascular and metabolic.• The occurrence of early adiposity rebound (EAR) is associated with the risk of later obesity and metabolic syndrome.What is New:• The occurrence of EAR in ELBW infants may represent an additional risk factor for later adverse metabolic outcomes in an already vulnerable population.• Future preventive strategies should include a long-term follow-up and the promotion of exclusive breastfeeding.

Preparation of Ar–P–N-structured flame retardant via Kabachnik–Fields reaction for fire safety and mechanical reinforcement of polyurethane

Fire safety of polyurethanes (PUs) has limited their further practical applications. To address this problem, we designed novel phosphorus-based flame retardants (P-FR) by incorporating aryl (Ar) groups via Kabachnik–Fields reaction, realizing π–π interaction-reinforced Ar2 and Ar5. Total heat release and peak heat release rate of PU/Ar5, whose flame-retardancy-index of 5.02 due to reduced combustion time, decreased 23.24 and 9.23 %, respectively, compared with neat PU. Moreover, UL94 rating for PU/Ar5 was improved from V-2 to V-0. These results demonstrate that Ar5 effectively generate a barrier effect that blocks oxygen, fuel, and heat. Sluggish mobility and phase transition are responsible for such enhancement due to a delay effect with the existence of π–π interactions and steric hindrance. Encouragingly, tensile strength and toughness of PU/Ar5 were greatly improved by 1345.8 and 670.3 %, respectively, compared with neat PU. We believe that this study could provide a promising method for introducing specific function to flame retardants to enhance fire safety and mechanical properties of composites.

Does augmented reality help in industrial training? A comprehensive evaluation based on natural human behavior and knowledge retention

The complexity and diversity of products significantly increases the difficulty of training workers in modern industries. AR training, as a combination of industrial digital development and new interactive means, has attracted increasingly more attention. However, in human factor and education, research regarding AR based training is still in its infancy. To understand how AR could help industrial training from a human perspective, we evaluate a HoloLens-based AR training method for an assembly task on natural human behavior and the training effectiveness. Forty-four participants were equally divided into AR and ordinary training groups with the equivalent instructional materials, which included text information and 3D models. Results show that although AR did not significantly affect the overall workload and system usability assessment (SUS) recorded, several experimental values increased significantly compared with the ordinary training method, including task completion time, time required to interpret text-based information, amount of attention switching, and training effectiveness. Consequently, the use of AR did not result in a completion time and workload reduction; however, we found that training with the AR system was more effective than ordinary training in increasing the knowledge retention of participants without increasing their overall workload, especially for the month-term memory. Nonetheless, a longer time was required by the users to familiarize themselves with the AR environment and read the text information. The findings of this work could contribute to the design of future AR training systems in industry considering natural human behavior and enhance training effectiveness.

A comparison between augmented reality and traditional in-person teaching for vascular anastomotic surgical skills training

BackgroundAugmented reality (AR) superimposes computer-generated content to a real-world environment through multitudinous devices, and is used across multiple training fora. Its use in vascular surgery education is yet to be formally investigated. The aim is to assess feasibility and effectiveness of remote teaching of vascular anastomosis skills enhanced by AR in the form of the HoloLens2 Head-Mounted Display technology with traditional in-person skills teaching. A remote trainer used video, gestures and images superimposed over participants' field of vision via the HoloLens2 to teach the skills. MethodsTwenty-eight participants underwent a preassessment performing an end-to-end vascular anastomosis on an artificial vessel. They were allocated randomly to an AR or in-person group, and underwent two teaching sessions. Individuals were asked to complete a postsession feedback form and assessment (video recorded and anonymized). The videos were marked by two blinded, independent assessors using the Objective Structured Assessment of Technical Skills (OSATS) scoring. ResultsThere was an overall improvement in both cohorts in OSATS score after the intervention by +7.083 in the in-person group and +8.275 in the AR. Independent t test was performed and a P value of .422 was obtained, indicating no statistically significant difference in the change in OSATS scores when comparing the skills teaching received in-person with that through AR. ConclusionsRemote teaching enhanced by AR is feasible and effective for the teaching of vascular surgical anastomosis skills and noninferior to in-person teaching. There is scope for development of the use of AR in vascular surgical skills training.

Multiple verdazyl radicals appended to a triarylamine scaffold

We report the synthesis of three triphenylamine-based verdazyl radicals. These include a mono, bis, and tris(verdazyl) at the 4-position(s) of the N–Ar groups, containing one, two, and three unpaired electrons, respectively. Each of these compounds is air stable and fully characterized using EPR spectroscopy, high-resolution mass spectrometry, infrared spectroscopy, UV/Vis spectroscopy, and cyclic voltammetry. From the UV/Vis absorbance data, the optical absorbance energy gaps were found to be ∼2.35 eV for all three verdazyl-containing compounds. Cyclic voltammetry was used to estimate the energy levels of the singly occupied molecular orbitals, which are −4.91, −5.12, and −4.98 eV for mono, bis, and tris(verdazyl) compounds, respectively. Spin–spin exchange interactions were observed in the EPR spectra of both the bis and tris(verdazyl)s, leading to additional hyperfine coupling patterns and assignment of the ground states as triplet and quartet, respectively.

A Novel pedicle screw placement Surgery Based on Integration of Surgical guides and Augmented Reality.

Augmented reality is a new technology that, when applied to spinal surgery, offers the potential for efficient, safe, and accurate placement of pedicle screws. This study investigated whether augmented reality combined with a guide board improved the safety and accuracy of pedicle screw placement compared to traditional free-hand screw placement. Four trainers were divided into augmented reality navigation and free-hand groups. Each group consisted of a novice and an experienced spine surgeon. A total of 80 pedicle screws were implanted. First, the AR group reconstructed the 3D model and planned the screw insertion route according to the CT data of L2 lumbar vertebrae. Next, the Microsoft HoloLens™ 2 was used to identify the vertebral model, and the planned virtual path was superimposed on the real cone model. Next, the screw was placed according to the projected trajectory. Finally, Micron Tracker was used to measure the deviation of screws from the preoperatively planned trajectory, and pedicle screws were evaluated using the Gertzbein-Robbins scale. In the augmented reality group, the linear deviation of experienced doctors and novices was 1.59 ± 0.39 mm and 1.73 ± 0.52 mm, and the angle deviation was 2.72 ± 0.61° and 2.87 ± 0.63°, respectively. In the free-hand group, the linear deviation of experienced doctors and novices was 2.88 ± 0.58mm and 5.25 ± 0.62mm, and the angle deviation was 4.41 ± 1.18° and 7.15 ±1.45°, respectively. The screw accuracy rate was 97.5% in the augmented reality navigation group and 77.5% in the free-hand group. Augmented reality navigation improves the accuracy and safety of pedicle screw implantation compared with the traditional free-hand method and can assist inexperienced doctors in completing the surgery.

Role of NLRP3 in the exacerbation of ozone-induced allergic rhinitis

ObjectiveAllergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory disorder of the nasal mucosa, and the impact of ozone on AR is gaining increasing attention. Although NOD-like receptor thermal protein domain associated protein 3 (NLRP3) plays a crucial role in the pathogenesis of AR, its regulatory mechanisms in ozone-induced exacerbation remain unclear. Therefore, we explored the impact of ozone inhalation on inflammation in AR and investigated the regulatory mechanisms involving NLRP3. MethodsFifty female Sprague–Dawley rats were selected and divided into five groups: normal control (NC), normal with ozone exposure (NE), AR model, AR with ozone exposure (ARE), and ARE treated with the NLRP3 inhibitor MCC950 (ARE+MCC950). Behavioral changes were observed in the rats, and the expression of NLRP3, active-caspase 1, and GSDMD-N was detected by western blotting. The expression levels of interleukin (IL)− 4, IL-5, IL-13, IL-1β, and ovalbumin-specific IgE (OVA-sIgE) in nasal lavage fluid as well as IL-6 in the serum were measured by ELISA. The expression and distribution of NLRP3 and IL-1β in nasal mucosal tissue were detected by immunohistochemistry, and pathological changes and eosinophilic infiltration in nasal mucosal tissue were observed by hematoxylin and eosin (HE) staining. The effects of ozone exposure on inflammation in the nasal mucosal tissue of rats with AR and the relationship between NLRP3 and inflammation were analyzed. ResultsUpregulation of NLRP3 was observed in the AR rat model, and ozone further aggravated the expression of NLRP3 in the nasal mucosal tissue. Compared to the AR, NC, and NE groups, NLRP3 inflammasomes were activated in the ARE group, and the expression levels of related indexes active-caspase 1 and GSDMD-N were significantly increased; the expression levels of Th2 inflammatory factors IL-4, IL-5, IL-13, and OVA-sIgE were increased, and inflammatory factors such as IL-1β and IL-6 expression was also significantly increased. HE staining revealed that ozone aggravated damage to the nasal mucosal tissue in AR. Compared with the ARE group, the expression of NLRP3 inflammasomes was downregulated, sneezing and scratching symptoms were reduced, inflammatory indicators in nasal lavage fluid were decreased, and nasal mucosal tissue damage was alleviated in rats in the ARE+MCC950 group. ConclusionOzone exposure significantly increased the inflammatory response in an animal model of AR. MCC950 can selectively inhibit the expression of NLRP3, inhibit the activity of inflammasomes, and reduce nasal mucosal inflammation by regulating the NLRP3-caspase-1-IL-1β pathway.

Risk prediction of bladder cancer among person with diabetes: A derivation and validation study.

This study aimed to devise and validate a clinical scoring system for risk prediction of bladder cancer to guide urgent cystoscopy evaluation among people with diabetes. People with diabetes who received cystoscopy from a large database in the Chinese population (2009-2018). We recruited a derivation cohort based on random sampling from 70% of all individuals. We used the adjusted odds ratios (aORs) for independent risk factors to devise a risk score, ranging from 0 to 5: 0-2 'average risk' (AR) and 3-5 'high risk' (HR). A total of 5905 people with diabetes, among whom 123 people with BCa were included. The prevalence rate in the derivation (n = 4174) and validation cohorts (n = 1731) was 2.2% and 1.8% respectively. Using the scoring system constructed, 79.6% and 20.4% in the derivation cohort were classified as AR and HR respectively. The prevalence rate in the AR and HR groups was 1.57% and 4.58% respectively. The risk score consisted of age (18-70: 0; >70: 2), male sex (1), ever/ex-smoker (1) and duration of diabetes (≥10 years: 1). Individuals in the HR group had 3.26-fold (95% CI = 1.65-6.44, p = 0.025) increased prevalence of bladder than the AR group. The concordance (c-) statistics was 0.72, implying a good discriminatory capability of the risk score to stratify high-risk individuals who should consider earlier cystoscopy. The risk prediction algorithm may inform urgency of cystoscopy appointments, thus allowing a more efficient use of resources and contributing to early detection of BCa among people planned to be referred.

Incidence of Bowel Wall Swelling Induced by Iodine-Contrast Media and Its Association With Gastrointestinal Manifestation.

The aim of this study was to investigate the incidence of bowel wall swelling after iodine-contrast media injection and its relationship with gastrointestinal symptoms. The incidence of bowel wall swelling was examined in 75 patients who showed adverse reactions to iodine-contrast media (AR[+] group) and 75 controls without adverse reactions (AR[-] group). Bowel wall swelling was identified if there was increased wall thickness on postcontrast computed tomography when compared with precontrast computed tomography. Swelling less than 2-fold of the original wall thickness was defined as grade 1 bowel angioedema, and swelling more than 2-fold was defined as grade 2. The incidence of bowel wall swelling was significantly higher in the AR(+) group (26.6%) than in the AR(-) group (10.6%) ( P = 0.01). Grade 1 bowel wall swelling was observed in 12.0% and 10.7% of AR(+) and AR(-) groups, respectively, whereas grade 2 was observed in 14.7% and 0%, respectively. Bowel wall swelling was observed in the duodenum and jejunum but not in the stomach, ileum, or colon in any patient in either group. In the AR(+) group, nausea and/or vomiting was observed in 15 patients, among whom bowel wall swelling was observed in 9 patients (60%). The frequency of nausea and/or vomiting was significantly higher in the patients with bowel wall swelling (45.0%, 9/20) compared with those without (10.9%, 6/55). Bowel wall swelling was more frequent and severe in patients with adverse reactions to iodine-contrast media than those without and was associated with nausea and/or vomiting.

Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems.

An asymmetric intramolecular hydroalkylation of unactivated internal olefins with tethered cyclic ketones was realized by the cooperative catalysis of a newly designed chiral amine (SPD-NH2) and Pd(II) complex, providing straightforward access to either bridged or fused bicyclic systems containing three stereogenic centers with excellent enantioselectivity (up to 99% ee) and diastereoselectivity (up to >20:1 dr). Notably, the bicyclic products could be conveniently transformed into a diverse range of key structures frequently found in bioactive terpenes, such as ∆6-protoilludene, cracroson D, and vulgarisins. The steric hindrance between the Ar group of the SPD-NH2 catalyst and the branched chain of the substrate, hydrogen-bonding interactions between the N-H of the enamine motif and the C=O of the directing group MQ, and the counterion of the Pd(II) complex were identified as key factors for excellent stereoinduction in this dual catalytic process by density functional theory calculations.

Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems

AbstractAn asymmetric intramolecular hydroalkylation of unactivated internal olefins with tethered cyclic ketones was realized by the cooperative catalysis of a newly designed chiral amine (SPD‐NH2) and PdII complex, providing straightforward access to either bridged or fused bicyclic systems containing three stereogenic centers with excellent enantioselectivity (up to 99 % ee) and diastereoselectivity (up to >20 : 1 dr). Notably, the bicyclic products could be conveniently transformed into a diverse range of key structures frequently found in bioactive terpenes, such as Δ6‐protoilludene, cracroson D, and vulgarisins. The steric hindrance between the Ar group of the SPD‐NH2 catalyst and the branched chain of the substrate, hydrogen‐bonding interactions between the N−H of the enamine motif and the C=O of the directing group MQ, and the counterion of the PdII complex were identified as key factors for excellent stereoinduction in this dual catalytic process by density functional theory calculations.

Dynamic aortic changes during the cardiac cycle in patients with aortic valve disease analyzed by computed tomography combined with PhyZiodynamics software.

Endovascular therapy for the ascending aorta is expected in the future, but the dynamic changes in the ascending aorta are unclear. The purpose of the present study was to evaluate dynamic changes in the aortic cross-sectional area and examine related determinants. The subjects included 75 patients (aortic regurgitation [AR] in 18 patients, aortic stenosis [AS] in 46 patients, and 11 controls) who underwent dynamic computed tomography (CT) prior to cardiac treatment. According to the centerline method, the cross-sectional areas of the ascending and descending aortas at the same level were analyzed. The rate of change from the minimum value to the maximum value in one heartbeat and peak rate of change in cross-sectional area (peak area change) were measured. The rates of change of the ascending and descending aortas were 4.4% and 6.4% (P < 0.05) and the peak area change was 0.3 mm2/msec vs. 0.2 mm2/msec (P < 0.05), respectively. In both the ascending and descending aortas, the rate of change and the peak area change were significantly greater in the AR group than in the AS and control groups. Results of the multiple regression analysis showed that greater stroke volumes (SVs) were associated with greater change in the ascending aorta and a faster momentary expansion rate. Furthermore, it was observed that the momentary expansion rate declined with age. The ascending aortic diameter changes significantly in one heartbeat and differs depending on AR, age, and SV. 17 - 006. May 29, 2017 Retrospectively registered.

Augmented reality-assisted navigation system contributes to better intraoperative and short-time outcomes of laparoscopic pancreaticoduodenectomy: a retrospective cohort study.

Augmented reality-assisted navigation system (AR-ANS) are currently good techniques for hepatectomy, however its application and efficacy for laparoscopic pancreatoduodenectomy have not been reported. This study sought to focus on and evaluate the advantage of laparoscopic pancreatoduodenectomy guided by the AR-ANS in intraoperative and short-time outcomes. Eighty-two patients who underwent laparoscopic pancreatoduodenectomy from January 2018 to May 2022 were enrolled and divided into the AR and non-AR groups. Clinical base-line features, operation time, intraoperative blood loss, blood transfusion rate, perioperative complications and mortality were analyzed. Augmented reality-guided laparoscopic pancreaticoduodenectomy was performed in the AR group (n=41), whereas laparoscopic pancreatoduodenectomy was carried out routinely in the non-AR group (n=41). There was no significant difference in baseline data between the two groups (P>0.05); Although the operation time of the AR group was longer than that of the non-AR group (420.15±94.38 vs. 348.98±76.15, P<0.001), the AR group had a less intraoperative blood loss (219.51±167.03 vs. 312.20±195.51, P=0.023), lower blood transfusion rate(24.4% vs. 65.9%, P<0.001), lower occurrence rates of postoperative pancreatic fistula(12.2% vs. 46.3%, P=0.002) and bile leakage(0% vs. 14.6%, P=0.026), and shorter postoperative hospital stay (11.29±2.78 vs. 20.04±11.22, P<0.001) compared with the non-AR group. Augmented reality-guided laparoscopic pancreatoduodenectomy has significant advantages in identifying important vascular structures, minimizing intraoperative damage, and reducing postoperative complications, suggesting that it is a safe, feasible method with a bright future in the clinical setting.

Neuroprotective effect of Astragali Radix on cerebral infarction based on proteomics.

Objective: Astragali Radix (AR, Huangqi in Chinese) has a neuroprotective effect on cerebral infarction (CI). In order to explore the biological basis and therapeutic mechanism of AR in CI, a double-blind randomized controlled trial was established in this study, and proteomics analysis was carried out on serum samples of patients. Methods: The patients were divided into the AR group (n = 35) and the control group (n = 30). The curative effect was evaluated by the traditional Chinese medicine (TCM) syndrome score and clinical indicators, and the serum of the two groups was analyzed by proteomics. Based on bioinformatics analysis methods, the changes in differential proteins between two groups of samples were explored, and the key proteins were validated through enzyme-linked immunosorbent assay (ELISA). Results: The results of this study showed that the scores of deficiency of vital energy (DVE), blood stasis (BS), and NIH Stroke Scale (NIHSS) decreased significantly (p < 0.05), while the scores of the Barthel Index (BI) increased, indicating that AR could significantly improve the symptoms of CI patients. In addition, we found that compared with the control group, AR upregulated 43 proteins and downregulated 20 proteins, especially focusing on anti-atherosclerosis and neuroprotective effects. Moreover, ELISA indicated the levels of IL-6, TNF-α, VCAM-1, MCP-1, and ICAM-1 were significantly decreased in the serum of the AR group (p < 0.05, p < 0.01). Conclusion: This study found that AR can significantly recover the clinical symptoms of CI. Serum proteomics research results show that AR may act on IL-6, TNF-α, VCAM-1, MCP-1, and ICAM-1, and play anti-atherosclerosis and neuroprotective roles. Clinical Trial Registration: [clinicaltrials.gov], identifier [NCT02846207].

Effects of an augmented reality aided system on the placement precision of orthodontic miniscrews: A pilot study

Background/purposeAugmented reality (AR) is gaining popularity in medical applications, which may aid clinicians in achieving improved clinical outcomes. The purpose of this study was to determine the positional and angle errors of orthodontic miniscrew placement by using a self-developed AR aided system. Materials and methodsCone beam computed tomography (CBCT) and patient printed models were used in in vitro experiments. The participants were divided into a control group and an AR group, in which traditional orthodontic methods and the AR-aided system were used respectively. After the information obtained from the CBCT images and navigation system was combined on the display device, the AR-aided system indicated the planned miniscrew position to guide the clinicians during the placement of miniscrews. Both methods were compared by a senior and a junior dentist, and the position and angle of miniscrew placement were statistically analyzed using Wilcoxon's signed-rank and Mann–Whitney U tests. ResultsWhen the AR-aided system was used, the accuracy of miniscrew placement in the mesiodistal position considerably increased (83%) when the procedure was performed by a senior clinician. In addition, the accuracy of miniscrew placement in the mesiodistal position and the angle of miniscrew placement considerably increased by approximately 67% and 72%, respectively, when the procedure was performed by a junior clinician. The position error of miniscrew placement was smaller for the junior clinician when the AR-aided system was used than for the senior clinician. ConclusionThe AR-aided system improved the accuracy of miniscrew placement regardless of the clinician's level of experience.

Analysis of urine differential proteins in patients with allergic rhinitis

BackgroundAllergic rhinitis (AR) is one of the most common clinical allergic diseases. Early diagnosis and medical intervention will benefit patients with allergic rhinitis. In this study, we focused on changes in urine proteomics in AR patients to investigate their potential clinical utility in AR diagnosis and evaluation. Material and methodsTMT-labeled mass spectrometry-based proteomics was carried out to identify differentially expressed proteins (DEPs) in urine between allergic rhinitis patients and normal control groups. The molecular biological role of DEPs was investigated by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and protein-protein interaction (PPI) network analysis. ResultsEnrichment analysis showed that the differentially expressed proteins were mainly related to cell-cell adhesion, complement and coagulation cascades, peptidase activity regulation, MAP kinase activity, etc. Compared with the NC group, HLA-DRB1, WFDC12, and DEFA4, among the top ten up-regulated proteins in the urine of the AR group, were related to the biological process of the humoral immune response. Among the top 10 down-regulated proteins, GUSB, SQSTM1, and KIT are related to protein domain-specific binding in terms of molecular function. ConclusionsWe found differential protein changes between AR patients and normal subjects may be related to the pathophysiological changes of AR, which provides the possibility for further exploration of urinary proteomics biomarkers in the future.

P405 IS THE IMPAIREMENT OF MITOCHONDRIAL QUALITY CONTROL MECHANISM INVOLVED IN THE ONSET AND PROGRESSION OF AORTIC VALVE STENOSIS?

Abstract Background and aim Calcific aortic valve stenosis (CAVS) is the most common valvular disease and its pathogenesis is poorly understood. Despite the standards in cardiovascular surgery have improved, the establishment of new therapies is an ambitious goal. In the last 15 years, some studies tried to shed light on the dysregulation of the cellular self–digestion process in CAVS, but the results obtained remained controversial. This work aims to definitively establish the role of autophagy in CAVS, to analyze the involvement of other determinants that impact on the mitochondrial quality control mechanisms and to explore possible paths for pharmacological interventions in the treatment of this disease. Methods This study has been performed on 104 patients in which biological samples (cells and serum) have been analyzed using biochemical approaches and then have been correlated to clinical data. AV cusps were obtained from 59 patients unfergoing surgical aortic valve replacement from march 2018 to July 2019. Of them, 44 suffered from aortic stenosis and 15 from aortic regurgitation (control group). Results The two population didn‘t differ for baseline pre operative characteristics, except for male sex that was more represented in the AR group (73% vs 43% p=0.05). In CAVS patients, we unveiled a significant deficiency in mitochondrial respiration and in ATP production coupled to increase production of lactates. Moreover, mitochondrial population in the pathologic group was older, with significant alterations in biogenesis and mitophagy pathways. We are also reporting an update about the role of autophagy accompanying the calcification process and the advanced stages of the disease. In fact, we provided evidence for a rapamycin–based therapeutic strategy to eventually revert the process and to report the calcified phenotype back to the wild type one. Conclusions Our data suggest that the CAVS phenotype is featured by defects in mitochondrial quality control mechanisms and that autophagy is not activated enough to counteract cell death and sustain cell functions. Boosting autophagy and mitophagy from short– to long–term reverts quite all pathological phenotypes.

A comparison of the effects of remote coaching HIIT training and combined exercise training on the physical and mental health of university students.

To compare the differences in the effects of based on remote coached high intensity interval training and combined exercise training on the physical and mental health of university students. Sixty university students were recruited from Shandong Normal University and randomly divided into HIIT group (n = 30) and AR group (n = 30), with the HIIT group using high-intensity interval training intervention and the AR group using combined exercise (aerobic combined with resistance) training intervention for 8 weeks. Mental health indicators, fitness indicators and body composition indicators were measured at the beginning and end of the intervention. After 8 weeks, among the mental health indicators, the results of the Symptom Self-Rating Scale (SCL-90) test showed a significant improvement in the HIIT group in terms of total score, somatization, obsessive-compulsive, interpersonal sensitivity, depression, hostility, and psychoticism (p < 0.05); the AR group showed significant improvements in psychoticism (P < 0.05). There were no significant differences between the two groups. The results of the Pittsburgh Sleep Quality Index scale (PSQI) showed a significant difference in sleep efficiency in the HIIT group with an inverse improvement in scores; the AR group showed no significant improvement in each test item. The results of the between-group covariance showed significant differences in sleep efficiency and hypnotic drugs in the HIIT group (p < 0.05). Among the fitness indicators, the HIIT group showed significant improvements in maximum oxygen uptake, grip strength and flexibility (P < 0.05); the AR group showed significant improvements in back muscle strength and flexibility (P < 0.05). The results of the between-group covariance showed significant improvements in maximum oxygen uptake in the HIIT group (P < 0.01). Regarding body composition indicators, there was a significant improvement in Body weight, BMI, Body fat percentage and Waist-to-hip ratio in both the HIIT and AR groups (P < 0.01). There were no significant differences between the two groups. HIIT and combined exercise training based on remote coaching had some improvement on fitness level and body composition of university students, HIIT was more advantageous in improving aerobic endurance, and HIIT based on remote coaching may have better effect than combined exercise in mental health. Chinese Clinical Trial Register, ChiECRCT20220149. Registered on 16 May 2022.

Seven-Week Accommodating Resistance Training Improves Wingate Peak Power But Not Muscular Strength or Endurance in Strength-Trained Females.

Parten, AL, Barker, GA, O'Neal, EK, and Waldman, HS. Seven-week accommodating resistance training improves Wingate peak power but not muscular strength or endurance in strength-trained females. J Strength Cond Res 37(9): 1789-1794, 2023-Accommodating resistance (AR) is a training technique that includes attaching elastic bands or chains to a loaded barbell to alter the resistance profile throughout the barbell movement. This study was the first to quantify the effects of AR versus a traditional resistance (TR) training program on changes in strength and power profiles in a trained female cohort. Resistance-trained (training history: 2.4 ± 1.4 years) females (age: 22.1 ± 3.0 years) completed baseline and postintervention tasks which included 1 repetition maximum (1RM) testing in the back squat (BS) and bench press (BP), a repetitions to failure in the BP (60% of 1RM), and 1 30-s Wingate test. After baseline testing, subjects were stratified (based on relative strength) into either the AR ( n = 9) or TR ( n = 10) group and then completed a supervised, 7-week training intervention. Both groups improved their 1RM in both lifts, but no statistical differences were found between groups in 1RM for BS, BP, or BP to failure ( p > 0.05). However, the AR group increased Wingate peak power (837 ± 221 to 901 ± 215 W; p = 0.04), whereas TR (868 ± 244 to 8,343 ± 182 W; p = 0.47) did not. This study supports AR with lighter relative barbell load incurs similar strength adaptations as TR. For coaches training athletes concerned with power, AR may be advantageous for improving rate of force development as demonstrated by large increases in peak Wingate power.

Effect of augmented reality navigation technology on perioperative safety in partial nephrectomies: A meta-analysis and systematic review.

To evaluate the impact of augmented reality surgical navigation (ARSN) technology on short-term outcomes of partial nephrectomy (PN). A systematic literature search was conducted in PubMed, Embase, Cochrane, and Web of Science for eligible studies published through March 28, 2022. Two researchers independently performed the article screening, data extraction and quality review. Data analysis was performed using Cochrane Review Manager software. A total of 583 patients from eight studies were included in the analysis, with 313 in the ARSN-assisted PN group (AR group) and 270 in the conventional PN group (NAR group). ARSN-assisted PN showed better outcomes than conventional surgery in terms of operative time, estimated blood loss, global ischemia rate, warm ischemia time, and enucleation rate. However, there were no significant differences in the rate of Conversion to radical nephrectomy (RN), postoperative estimated glomerular filtration rate (eGFR), positive margin rate, and postoperative complication rate. The utilization of ARSN can improve the perioperative safety of PN. Compared with conventional PN, ARSN-assisted PN can reduce intraoperative blood loss, shorten operative time, and improve renal ischemia. Although direct evidence is lacking, our results still suggest a potential advantage of ARSN in improving renal recovery after PN. However, as the ARSN system is still in an exploratory stage, its relevance in PN have been poorly reported. Additional high-quality randomized controlled trial (RCT) studies will be required to confirm the effect of ARSN on PN. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=301798, identifier PROSPERO ID: CRD42022301798.