The study was conducted in order to highlight that making a positive drilling borehole in the base area is a very difficult course and which requires the contribution of several complementary disciplines, namely geology, geomorphology, geophysics, the Topography, rainfall etc. Multi-sectoral analysis is necessary to solve a complex problem of a successful implantation of boreholes in the basement area. The analytical approach for the search for aquifers in the basement area and especially in a semi-arid area such as the province of Guéra. Nowadays the research and the management of groundwater requires the contribution of several related disciplines in order to produce decision -making information. The GIS thanks to spatial analysis allows rapid analysis with its spatial analysis component and offers a powerful spatial modelling tool. In this perspective, remote sensing allowed us to make an extraction of the lines from satellite images, the multi -criteria analysis was applied, and it allowed the development of thematic maps. The approach was made with the analysis of the characteristics of the boreholes carried out in the area, in particular the flow rate, the depth and the thickness of alteration. This allowed us to make a following observation on 295 forges made 195 flows rate belong to the very low class or 50.08%, 85 flows rate belonging to the middle class or 28.8% and 60 flows rate correspond to the strong class or 20.03%. Thus, the multi -criteria analysis by uttering at each element which enters the implantation a weight which has been of great use to us in the development of the Aquifer potential map of the study area. For this study in we used software such as Excel for drilling data, ArcMap 10.8 for GIS, PCI Geomatica software for the extraction of lineaments.