ABSTRACT Reported mole fraction solubilities of trans-resveratrol in aqueous mixtures of acetone in the temperature interval from (273.2 to 313.2) K were correlated by means of some cosolvency models, like multi-linear models of Jouyban-Acree and Jouyban-Acree-van’t Hoff and non-linear models of the modified Wilson and CNIBS/R-K model. Apparent thermodynamic quantities of the dissolution processes were computed using the van’t Hoff and Gibbs equations. Gibbs energies and enthalpies were positive in all cases, while negative and positive entropies were observed. The plot of enthalpy vs. Gibbs energy of dissolution was non-linear with negative slopes in the region of 0.00 ≤ x 1 ≤ 0.70 but positive slopes in the region of 0.70 ≤ x 1 ≤ 1.00. Further, by means of the inverse Kirkwood-Buff integrals is observed that trans-resveratrol is preferentially solvated by water in water-rich and acetone-rich mixtures but preferentially solvated by acetone in the composition interval of 0.21 < x 1 < 0.77.