The purpose of current study was to investigate the relationship between the approval-motivation, feeling loneliness, self-screening and respecting on social norms), and its effects on overuse of cellular-phone in Persian speaking students in Iran. A total number of 448 students (224 male and 224 female) were selected randomly from Tabriz University of Medical Sciences in Iran during September 2015-February 2016. For gathering data, we designed a researcher-made questionnaire for determining the practice, knowledge and attitude of university students regarding to the impact of inside senses (the approval-motivation, feeling loneliness, self-screening and respecting on social norms) on overuse of cell-phone. Data were analyzed with the software package of SPSS (version 23). Results showed that the studied parameters regarding to the dependence on cell-phone had statistically significant differences in terms of gender, age, faculty, education-grades, semester, and residence. There was also a statistical correlation between the approval-motivation, feeling loneliness, self-screening and respecting on social norms and over use of cell-phone. Among the demographic characteristics, approval motivation was only associated with gender.