Predictive Approach Research Articles

Leakage prediction approach and influencing factor analysis from seal test

Purpose Leakage serves as a core indicator of sealing performance degradation, particularly under high-speed and heavy-duty operational where increased leakage is common. Within heavy-duty vehicle transmissions, the leakage can lead to excessive pressure loss and eventual transmission failure. This study aims to introduce a predictive method for assessing sealing ring leakage in vehicle transmissions based on operating conditions. Design/methodology/approach Seal test was carried out using a specialized seal test rig. Various data points were collected during this test, including leakage, friction torque, oil temperature, oil pressure and rotating speed. The collected data underwent noise separation and reconstruction using the complete ensemble empirical mode decomposition with adaptive noise method. Subsequently, a leakage prediction model is developed using the random forest regression with parameter optimization. A quantitative evaluation for influencing factors in leakage prediction process is investigated. Findings The results achieve a mean accuracy index exceeding 95%, demonstrating close alignment between predicted and actual leakage values. Feature contribution results highlight that the trends of the oil temperature, friction torque and oil pressure significantly affect the leakage prediction, with the oil temperature trend exerting the most substantial influence. Originality/value This work sheds light on the interplay between operating conditions and sealing performance degradation, offering valuable insights for understanding and addressing sealing issues effectively. Peer review The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-07-2024-0271/

Comprehensive Symptom Prediction in Inpatients With Acute Psychiatric Disorders Using Wearable-Based Deep Learning Models: Development and Validation Study

Background Assessing the complex and multifaceted symptoms of patients with acute psychiatric disorders proves to be significantly challenging for clinicians. Moreover, the staff in acute psychiatric wards face high work intensity and risk of burnout, yet research on the introduction of digital technologies in this field remains limited. The combination of continuous and objective wearable sensor data acquired from patients with deep learning techniques holds the potential to overcome the limitations of traditional psychiatric assessments and support clinical decision-making. Objective This study aimed to develop and validate wearable-based deep learning models to comprehensively predict patient symptoms across various acute psychiatric wards in South Korea. Methods Participants diagnosed with schizophrenia and mood disorders were recruited from 4 wards across 3 hospitals and prospectively observed using wrist-worn wearable devices during their admission period. Trained raters conducted periodic clinical assessments using the Brief Psychiatric Rating Scale, Hamilton Anxiety Rating Scale, Montgomery-Asberg Depression Rating Scale, and Young Mania Rating Scale. Wearable devices collected patients’ heart rate, accelerometer, and location data. Deep learning models were developed to predict psychiatric symptoms using 2 distinct approaches: single symptoms individually (Single) and multiple symptoms simultaneously via multitask learning (Multi). These models further addressed 2 problems: within-subject relative changes (Deterioration) and between-subject absolute severity (Score). Four configurations were consequently developed for each scale: Single-Deterioration, Single-Score, Multi-Deterioration, and Multi-Score. Data of participants recruited before May 1, 2024, underwent cross-validation, and the resulting fine-tuned models were then externally validated using data from the remaining participants. Results Of the 244 enrolled participants, 191 (78.3%; 3954 person-days) were included in the final analysis after applying the exclusion criteria. The demographic and clinical characteristics of participants, as well as the distribution of sensor data, showed considerable variations across wards and hospitals. Data of 139 participants were used for cross-validation, while data of 52 participants were used for external validation. The Single-Deterioration and Multi-Deterioration models achieved similar overall accuracy values of 0.75 in cross-validation and 0.73 in external validation. The Single-Score and Multi-Score models attained overall R² values of 0.78 and 0.83 in cross-validation and 0.66 and 0.74 in external validation, respectively, with the Multi-Score model demonstrating superior performance. Conclusions Deep learning models based on wearable sensor data effectively classified symptom deterioration and predicted symptom severity in participants in acute psychiatric wards. Despite lower computational costs, Multi models demonstrated equivalent or superior performance than Single models, suggesting that multitask learning is a promising approach for comprehensive symptom prediction. However, significant variations were observed across wards, which presents a key challenge for developing clinical decision support systems in acute psychiatric wards. Future studies may benefit from recurring local validation or federated learning to address generalizability issues.

EchoPT: A Pretrained Transformer Architecture that Predicts 2D In-Air Sonar Images for Mobile Robotics

The predictive brain hypothesis suggests that perception can be interpreted as the process of minimizing the error between predicted perception tokens generated via an internal world model and actual sensory input tokens. When implementing working examples of this hypothesis in the context of in-air sonar, significant difficulties arise due to the sparse nature of the reflection model that governs ultrasonic sensing. Despite these challenges, creating consistent world models using sonar data is crucial for implementing predictive processing of ultrasound data in robotics. In an effort to enable robust robot behavior using ultrasound as the sole exteroceptive sensor modality, this paper introduces EchoPT (Echo-Predicting Pretrained Transformer), a pretrained transformer architecture designed to predict 2D sonar images from previous sensory data and robot ego-motion information. We detail the transformer architecture that drives EchoPT and compare the performance of our model to several state-of-the-art techniques. In addition to presenting and evaluating our EchoPT model, we demonstrate the effectiveness of this predictive perception approach in two robotic tasks.

A comparison of statistical and machine learning models for spatio-temporal prediction of ambient air pollutant concentrations in Scotland

AbstractThe spatio-temporal prediction of air pollutant concentrations is vital for assessing regulatory compliance and for producing exposure estimates in epidemiological studies. Numerous approaches have been utilised for making such predictions, including land use regression models, additive models, spatio-temporal smoothing models and machine learning prediction algorithms. However, relatively few studies have compared the predictive performance of these models thoroughly, which is one of the novel contributions of this paper. For the specific challenge of predicting monthly average concentrations of NO$$_{2}$$ 2 , PM$$_{10}$$ 10 and $$\hbox {PM}_{2.5}$$ PM 2.5 in Scotland, we find that random forests typically outperform (or are as good as) more traditional statistical prediction approaches. Additionally, we utilise the best performing model to provide a new data resource, namely, predictions of monthly average concentrations (with uncertainty quantification) of the above pollutants on a regular 1 km$$^{2}$$ 2 grid for all of Scotland between 2016 and 2020.

Research on Forecasting Sales of Pure Electric Vehicles in China Based on the Seasonal Autoregressive Integrated Moving Average–Gray Relational Analysis–Support Vector Regression Model

Aiming to address the complexity and challenges of predicting pure electric vehicle (EV) sales, this paper integrates a time series model, support vector machine and combined model to forecast EV sales in China. Firstly, a seasonal autoregressive integrated moving average (SARIMA) model was constructed using historical EV sales data, and the model was trained on sales statistics to obtain forecasting results. Secondly, variables that were highly correlated with sales were analyzed using gray relational analysis (GRA) and utilized as input parameters for the support vector regression (SVR) model, which was constructed to optimize sales predictions for EVs. Finally, a combined model incorporating different algorithms was verified against market sales data to explore the optimal sales prediction approach. The results indicate that the SARIMA-GRA-SVR model with the squared prediction error and inverse method achieved the best predictive performance, with MAPE, MAE and RMSE values of 12%, 1.45 and 2.08, respectively. This empirical study validates the effectiveness and superiority of the SARIMA-GRA-SVR model in forecasting EV sales.

RCCNet: A Spatial-Temporal Neural Network Model for Logistics Delivery Timely Rate Prediction

In logistics service, the delivery timely rate is a key experience indicator, which is highly essential to the competitive advantage of express companies. Prediction on it enables intervention on couriers with low predicted results in advance, thus ensuring employee productivity and customer satisfaction. Currently, few related works focus on couriers’ level delivery timely rate prediction, and there are complex spatial correlations between couriers and road districts in the express scenario, which makes traditional real-time prediction approaches hard to utilize. To deal with this, we propose a deep spatial-temporal neural network, RCCNet to model spatial-temporal correlations. Specifically, we adopt Node2vec, which can encode the road network-based graph directly to capture spatial correlations between road districts. Further, we calculate couriers’ historical time-series similarity to build a graph and employ graph convolutional networks to capture the correlation between couriers. We also leverage historical sequential information with long short-term memory networks. We conduct experiments with real-world express datasets. Compared with other competitive baseline methods widely used in industry, the experiment results demonstrate its superior performance over multiple baselines.

A novel approach for multivariate time series interval prediction of water quality at wastewater treatment plants

ABSTRACT This study proposes a novel approach for predicting variations in water quality at wastewater treatment plants (WWTPs), which is crucial for optimizing process management and pollution control. The model combines convolutional bi-directional gated recursive units (CBGRUs) with Adaptive Bandwidth Kernel Function Density Estimation (ABKDE) to address the challenge of multivariate time series interval prediction of WWTP water quality. Initially, wavelet transform (WT) was employed to smooth the water quality data, reducing noise and fluctuations. Linear correlation coefficient (CC) and non-linear mutual information (MI) techniques were then utilized to select input variables. The CBGRU model was applied to capture temporal correlations in the time series, integrating the Multiple Heads of Attention (MHA) mechanism to enhance the model's ability to comprehend complex relationships within the data. ABKDE was employed, supplemented by bootstrap to establish upper and lower bounds of the prediction intervals. Ablation experiments and comparative analyses with benchmark models confirmed the superior performance of the model in point prediction, interval prediction, the analysis of forecast period, and fluctuation detection for water quality data. Also, this study verifies the model's broad applicability and robustness to anomalous data. This study contributes significantly to improved effluent treatment efficiency and water quality control in WWTPs.

Hybrid Machine Learning Approaches for 5G Traffic Prediction

ABSTRACT Accurate traffic prediction poses great difficulties because of the continuously increasing scale and diversity of 5G network traffic, which is driven by user demands. Moreover, certain characteristics of 5G traffic are constantly changing; thus, simulations using traditional models often lead to incorrect estimations or inefficient utilization of available resources. Consequently, we propose a hybrid machine learning model that integrates support vector machine (SVM) and decision tree algorithms to enhance efficiency of 5G traffic prediction. The structure of the hybrid model dynamically adjusts by adding or removing hidden layers and units within the network to improve prediction performance. The efficacy of the proposed model is evaluated using metrics like mean squared error, mean absolute error, and root mean squared error (RMSE). Findings show that the hybrid model consistently achieves lower error rates than SVM alone. Further performance enhancement of the hybrid model in predicting 5G traffic is also supported by comparisons of R-squared values against signal-to-noise ratios. These outcomes show the potential of the proposed method to improve traffic prediction accuracy in 5G networks, serving as a powerful tool for network control.

ECG‐based epileptic seizure prediction: Challenges of current data‐driven models

AbstractObjectiveUp to a third of patients with epilepsy fail to achieve satisfactory seizure control. A reliable method of predicting seizures would alleviate psychological and physical impact. Dysregulation in heart rate variability (HRV) has been found to precede epileptic seizures and may serve as an extracerebral predictive biomarker. This study aims to identify the preictal HRV dynamics and unveil the factors impeding the clinical application of ECG‐based seizure prediction.MethodsThirty‐nine adult patients (eight women; median age: 38, [IQR = 31, 56.5]) with 252 seizures were included. Each patient had more than three recorded epileptic seizures, each at least 2 hours apart. For each seizure, one hour of ECG prior to seizure onset was analyzed and 97 HRV features were extracted from overlapping three‐minute windows with 10s stride. Two separate patient‐specific experiments were performed using a support vector machine (SVM). Firstly, the separability of training data was examined in a non‐causal trial. Secondly, the prediction was attempted in pseudo‐prospective conditions. Finally, visualized HRV data, clinical metadata, and results were correlated.ResultsThe mean receiver operating characteristic (ROC) area under the curve (AUC) for the non‐causal experiment was 0.823 (±0.12), with 208 (82.5%) seizures achieving an improvement over chance (IoC) classification score (p < 0.05, Hanley & McNeil test). In pseudo‐prospective classification, the ROC‐AUC was 0.569 (±0.17), and 86 (49.4%) seizures were classified with IoC. Off‐sample optimized SVMs failed to improve performance. Major limiting factors identified include non‐stationarity, variable preictal duration and dynamics. The latter is expressed as both inter‐seizure onset zone (SOZ) and intra‐SOZ variability.SignificanceThe pseudo‐prospective preictal classification achieving IoC in approximately half of tested seizures suggests the presence of genuine preictal HRV dynamics, but the overall performance does not warrant clinical application at present. The limiting factors identified are often overlooked in non‐causal study designs. While current deterministic prediction methods prove inadequate, probabilistic approaches may offer a promising alternative.Plain Language SummaryMany patients with epilepsy suffer from uncontrollable seizures and would greatly benefit from a reliable seizure prediction method. Currently, no such system is available to meet this need. Previous studies suggest that changes in the electrocardiogram (ECG) precede seizures by several minutes. In our work, we evaluated whether variations in heart rate could be used to predict epileptic seizures. Our findings indicate that we are still far from achieving results suitable for clinical application and highlight several limiting factors of present seizure prediction approaches.

Omics Studies in CKD: Diagnostic Opportunities and Therapeutic Potential

ABSTRACTOmics technologies have significantly advanced the prediction and therapeutic approaches for chronic kidney disease (CKD) by providing comprehensive molecular insights. This is a review of the current state and future prospects of integrating biomarkers into the clinical practice for CKD, aiming to improve patient outcomes by targeted therapeutic interventions. In fact, the integration of genomic, transcriptomic, proteomic, and metabolomic data has enhanced our understanding of CKD pathogenesis and identified novel biomarkers for an early diagnosis and targeted treatment. Advanced computational methods and artificial intelligence (AI) have further refined multi‐omics data analysis, leading to more accurate prediction models for disease progression and therapeutic responses. These developments highlight the potential to improve CKD patient care with a precise and individualized treatment plan .

NIMG-74. A NOVEL APPROACH FOR PERSONALIZED RADIOTHERAPY TARGET VOLUME DEFINITION USING METABOLIC MRI AND DEEP LEARNING-DRIVEN PREDICTIONS OF GLIOBLASTOMA RECURRENCE

Abstract BACKGROUND Machine-learning models have demonstrated great promise in predicting tumor infiltration beyond anatomical margins in glioblastoma. Yet standard-of-care (SOC) radiation therapy (RT) planning only utilizes a uniform, isotropic 2cm-expansion of the T1-post-contrast-lesion or T2-lesion to generate a clinical target volume (CTV), without considering heterogeneity in tumor infiltration. We hypothesize that using a novel deep-learning approach to predict regions of tumor progression with metabolic and diffusion-weighted MRI will result in personalized CTVs that are more sensitive to detecting normal-appearing infiltrating tumor beyond the T2-lesion, sparing more healthy brain compared to SOC-CTVs. METHODS Anatomical, diffusion-weighted, and metabolic MRI from 101 patients with glioblastoma, acquired post-surgery but prior to chemoradiation, were retrospectively used to predict regions of new contrast-enhancement or T2-hyperintensity at confirmed progression. A segmentation-based predictive deep-learning approach with personalized loss-functions and evaluation metrics (“Progression-Coverage-Coefficient”, PCC) that weight Dice coefficient terms by tumor size was employed with a 66/17/18 train/validation/test split of patients and the resulting DL-CTV compared to two SOC-CTVs: 1) the RTOG[T2-FLAIR+2cm]-CTV, 2) the EORTC[T1c+2cm]-CTV. RESULTS Our best deep-learning-CTV trained using anatomical, diffusion, and metabolic MRI achieved significantly improved median test specificity (0.87 vs. 0.77; p<0.005) and comparable sensitivity (0.92 vs. 0.95; p=0.1) and PCC (0.81 vs. 0.79; p=0.1) to the SOC RTOG[T2-FLAIR+2cm]-CTV, sparing more normal brain tissue. Compared to the more conservative EORTC[T1c+2cm]-CTV, our approach had significantly higher test sensitivity (0.92 vs. 0.85; p<0.00001) and PCC (0.81 vs. 0.77; p=0.003) in covering the progressed lesion, while maintaining similar specificity (0.87 vs. 0.89; p=0.3). Test performance dropped by 9.6% and 12.4% when removing metabolic and both metabolic and diffusion metrics, respectively (p<0.001). CONCLUSION This study demonstrates the benefit of using metabolic and diffusion MRI with deep learning for personalized RT planning by targeting regions of anatomically normal infiltrative disease that are highly likely to progress, while reducing treatment to normal brain.

Multi-temporal image analysis of wetland dynamics using machine learning algorithms

Wetlands play a crucial role in enhancing groundwater quality, mitigating natural hazards, controlling erosion, and providing essential habitats for unique flora and wildlife. Despite their significance, wetlands are facing decline in various global locations, underscoring the need for effective mapping, monitoring, and predictive modeling approaches. Recent advances in machine learning, time series earth observation data, and cloud computing have opened up new possibilities to address the challenges of large-scale wetlands mapping and dynamics forecasting. This research conducts a comprehensive analysis of wetland dynamics in the Thatta region, encompassing Haleji & Kinjhar Lake in Pakistan, and evaluates the efficacy of different classification systems. Leveraging Google Earth Engine, Landsat imagery, and various spectral indices, we assess four classification techniques to derive accurate wetland mapping results. Our findings demonstrate that Random Forest emerged as the most efficient and accurate method, achieving 87% accuracy across all time periods. Change detection analysis reveals a significant and alarming decline in Haleji & Kinjhar Lake wetlands over 1990–2020, primarily driven by agricultural expansion, urbanization, groundwater extraction, and climate change impacts like rising temperatures and reduced precipitation. If left unaddressed, this continued wetland loss could have severe implications for aquatic and terrestrial species, water and soil quality, wildlife populations, and local livelihoods. The study predicts future wetland dynamics under different scenarios - enhancing drainage for farmland conversion (10–20% increase), increasing urbanization (10–20% expansion), escalating groundwater extraction (7.2m annual decline), and climate change (up to 5 °C warming and 54% precipitation deficit by 2050). These scenarios forecast sustained long-term wetland deterioration driven by anthropogenic pressures and climate change. To guide conservation strategies, the research integrates satellite data analytics, machine learning algorithms, and spatial modeling to generate actionable insights into multifaceted wetland vulnerabilities. Findings provide a robust baseline to inform policies ensuring sustainable management and preservation of these vital ecosystems amidst escalating human and climate threats. Over 1990–2020, the Thatta region witnessed a 352.8 sq.km loss of wetlands, necessitating urgent restoration efforts to safeguard their invaluable ecosystem services.

A Machine Learning Approach for Breast Cancer Risk Prediction in Digital Mammography

Breast cancer is among the most prevalent cancers in the female population globally. Therefore, screening campaigns as well as approaches to identify patients at risk are particularly important for the early detection of suspect lesions. This study aims to propose a workflow for the automatic classification of patients based on one of the most relevant risk factors in breast cancer, which is represented by breast density. The proposed classification methodology takes advantage of the features automatically extracted from mammographic images, as digital mammography represents the major screening tool in women. Textural features were extracted from the breast parenchyma through a radiomics approach, and they were used to train different machine learning algorithms and neural network models to classify the breast density according to the standard Breast Imaging Reporting and Data System (BI-RADS) guidelines. Both binary and multiclass tasks have been carried out and compared in terms of performance metrics. Preliminary results show interesting classification accuracy (93.55% for the binary task and 82.14% for the multiclass task), which are promising compared to the current literature. As the proposed workflow relies on straightforward and computationally efficient algorithms, it could serve as a basis for a fast-track protocol for the screening of mammograms to reduce the radiologists’ workload.

Optimizing influenza vaccine allocation: A predictive analytics approach for informed public health planning

Abstract Disclaimer In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose Excessive purchasing of influenza vaccine can lead to costly overages and waste of resources. Insufficient quantities, however, can jeopardize population health. Our project aimed to use predictive analytics to determine the influenza vaccine quantities that would be needed for the next influenza season while minimizing vaccine waste and meeting patient care demands. Methods Several data sources were evaluated to develop a predictive analytics model to better estimate future influenza vaccine orders during upcoming influenza seasons. A retrospective analysis of influenza vaccine administrations over the last 4 influenza seasons allowed the team to develop an algorithm to predict influenza vaccine needs. Two regions within Mayo Clinic were selected to determine the validity of our ordering process. These 2 regions, identified as regions 3 and 5, ordered influenza vaccines based on the algorithm, while the other 3 regions acted as control groups, ordering though traditional methods based on purchasing data. Results Predictive analysis for the 2 intervention regions resulted in a savings of over $1 million when compared to traditional ordering methods. The model predicted that the quantity of vaccine ordered should be 17,574.16 and 9,164.29 quadrivalent influenza vaccines for regions 3 and 5, respectively. On the basis of actual administration data, 15,902 vaccines for region 3 and 9,016 vaccines for region 5 will be administered by the end of the season, both of which are less than the predicted amount needed, demonstrating the accuracy of the analytics. Conclusion Compared to the traditional ordering method, ordering using predictive analytics allowed the team to more accurately determine future order volumes and spend, yielding significant cost savings.

Stakeholder-led proactive risk assessment of medication safety in the pharmaceutical supply chain

Abstract Introduction In 2022/23, 1.08 billion medications were dispensed to patients using NHS England, at a cost of £19.04 billion1 . However, Elliot et al (2019)2 estimate every year there are 237 million medication errors at some point of the medication process, with a high associated cost. Increasingly, media is reporting medication shortages of critical medicines3 that can contribute to errors of omission. Medication errors suggests system, tasks and processes should be explored to understand if they have been poorly designed. This paper is a pre-Brexit study that examines the pharmaceutical supply chain with stakeholders. Aim To explore risk to medication safety in the pharmaceutical supply chain using qualitative interviews of stakeholders across the supply chain and proactive risk assessment method SHERPA (Systematic Human Error Reduction and Prediction Approach). Method 1. Qualitative interviews with process models System process models were developed (by literature, field observations and interviewees) and employed to elicit stakeholder perceptions about risk to medication safety in 31 qualitative interviews. Participants included pharmacists, wholesalers, pharmaceutical industry representatives, regulators and policymakers. Ethical approval was granted by Cambridge LREC to include healthcare professionals and 6 patients. Interviews were audio-recorded, transcribed and thematically analysed using N-Vivo. 2. Focus group for SHERPA Six stakeholders participated in the SHERPA focus group4 , including pharmacists and representatives from pharmaceutical manufacturing and wholesale industries. Interview participants were invited and those that agreed, attended. The SHERPA template was completed by the group. The session was audio-recorded, transcribed and thematically analysed using N-Vivo. Results The system models led to a greater understanding of the current system ‘as-is’ and created an overview of the supply chain. SHERPA is a validated method and provided the rigour to risk assess the supply chain process and identify sources of risk. However, the error mode terminology required adjustment to healthcare. Across all supply routes, the main source of risk was failure to supply medicines that caused errors of omission and the risk of counterfeit medicines. Failure to supply resulted from shortages that take place from trading activities that result in stockpiling or exporting of medicines. A lack of robust regulation and parallel imports increased the risk of counterfeit medicines. Stakeholders highlighted deficiencies in the supply chain and poor performance of stakeholders, as medication safety concerns. In order of frequency, the deficiencies include fragmented supply chain; complacency by stakeholders; poor communication and integration across supply chain; and end-user often regarded as the pharmacist, rather than the patient. Discussion and conclusion From the findings, strategies emerged as possible solutions. These included communication of shortages in each component of supply chain; robust counterfeit strategies; use of technology (automation/digital tools); and re-design tasks and processes in dispensaries and wards. Staff training, education, and revalidation of stakeholders is vital. Key limitations in this study include biases that can occur from recruitment strategy and small sample size. The SHERPA method posed terminology problems. In conclusion, this multi-method approach reveals risk and possible solutions to improve safety and reduce cost in the NHS. It is clear this study needs to be repeated to understand the impact of Brexit and current reconfiguration of NHS.

From Data to Diagnosis: Machine Learning Revolutionizes Epidemiological Predictions

The outbreak of epidemiological diseases creates a major impact on humanity as well as on the world’s economy. The consequence of such infectious diseases affects the survival of mankind. The government has to stand up to the negative influence of these epidemiological diseases and facilitate society with medical resources and economical support. In recent times, COVID-19 has been one of the epidemiological diseases that created lethal effects and a greater slump in the economy. Therefore, the prediction of outbreaks is essential for epidemiological diseases. It may be either frequent or sudden infections in society. The unexpected raise in the application of prediction models in recent years is outstanding. A study on these epidemiological prediction models and their usage from the year 2018 onwards is highlighted in this article. The popularity of various prediction approaches is emphasized and summarized in this article.

Enhanced Fuzzy Score-Based Decision Support System for Early Stroke Prediction

According to the Global Health Observatory (GHO), stroke ranks second worldwide in causing dementia, right after Alzheimer's disease. The mortality rate linked to dementia resulting from stroke is high because symptoms are often recognized late, and stroke can be misinterpreted as other brain disorders. Early detection and diagnosis of stroke is crucial. Therefore, increasing awareness of stroke symptoms and implementing preventive measures becomes imperative. Prompt intervention by healthcare professionals can improve outcomes and reduce long-term complications of stroke. The research introduces an innovative approach for early stroke prediction using a fuzzy scoring-based Decision Support System. This approach encompasses three main modules: Mind-map based Data Modeling, Fuzzy scoring computing, and ML-based Decision System. By incorporating fuzzy logic, the approach extracts valuable knowledge from imprecise and uncertain data. Combining the fuzzy stroke risk model with a machine learning-based decision support system aims to enhance stroke prediction accuracy and improve preventive measures and patient outcomes. The approach's effectiveness was validated using real clinical data and tested with various machine learning classifiers, including K-Nearest Neighbour (KNN), Logistic Regression (LR), Decision Tree (DT), Artificial Neural Network (ANN), and Support Vector Machine (SVM). The results showed a strong correlation between stroke cases and computed risk-scoring values. In comparison to predictions without fuzzy scoring and other related works, the stroke risk prediction using the proposed approach demonstrated higher accuracy, making it a promising method for early stroke detection and prevention.

Graph-based machine learning model for weight prediction in protein–protein networks

Proteins interact with each other in complex ways to perform significant biological functions. These interactions, known as protein–protein interactions (PPIs), can be depicted as a graph where proteins are nodes and their interactions are edges. The development of high-throughput experimental technologies allows for the generation of numerous data which permits increasing the sophistication of PPI models. However, despite significant progress, current PPI networks remain incomplete. Discovering missing interactions through experimental techniques can be costly, time-consuming, and challenging. Therefore, computational approaches have emerged as valuable tools for predicting missing interactions. In PPI networks, a graph is usually used to model the interactions between proteins. An edge between two proteins indicates a known interaction, while the absence of an edge means the interaction is not known or missed. However, this binary representation overlooks the reliability of known interactions when predicting new ones. To address this challenge, we propose a novel approach for link prediction in weighted protein–protein networks, where interaction weights denote confidence scores. By leveraging data from the yeast Saccharomyces cerevisiae obtained from the STRING database, we introduce a new model that combines similarity-based algorithms and aggregated confidence score weights for accurate link prediction purposes. Our model significantly improves prediction accuracy, surpassing traditional approaches in terms of Mean Absolute Error, Mean Relative Absolute Error, and Root Mean Square Error. Our proposed approach holds the potential for improved accuracy in predicting PPIs, which is crucial for better understanding the underlying biological processes.

Predictive combination model for CH4 separation and CO2 sequestration with CO2 injection into coal seams: VMD-STA-BiLSTM-ELM hybrid neural network modeling

In the experimental process of separating coal seam gas using the CO2 displacement method, establishing a predictive model for key variables is essential to optimize displacement parameters, increase coal seam gas recovery, and improve CO2 sequestration efficiency. Traditional modeling methods often struggle with the complex nature of industrial data and are susceptible to overfitting due to multicollinearity caused by long-term datasets. This paper presents a hybrid predictive model based on variational mode decomposition (VMD), a spatiotemporal attention mechanism (STA), a bidirectional long short-term memory network (BiLSTM), and an extreme learning machine (ELM). During the offline phase, VMD is used to decompose raw data into intrinsic mode functions (IMFs). The hidden state from the last time step of the STA-BiLSTM is then added to the original data to enrich the features for ELM training. In the online prediction phase, the outputs from the VMD-STA-BiLSTM and VMD-STA-BiLSTM-ELM models are combined using an error reciprocal method to generate the final prediction. The proposed model is validated with experimental datasets from CO2 displacement for coal seam CH4 under various conditions, as well as with N2-ECBM and CO2-ECBM engineering datasets. The results show that the hybrid model surpasses VMD-ELM, STA-BiLSTM-ELM, BiLSTM, STA-BiLSTM, ELM, TCN, and Attention-TCN models in predictive accuracy. Even in multi-step and rolling predictions, the model exhibits minimal impact from cumulative errors, maintaining accurate forecasts with strong generalization and robustness. It effectively captures feature patterns across different datasets and accurately predicts unknown data. The model shows potential for application in diverse scenarios and complex environments, offering reliable support and decision-making for the field application of CO2 displacement in coal seam CH4 separation. It is an effective and promising predictive approach to enhance coal seam gas recovery and CO2 sequestration efficiency.

A Semi-Quantitative Approach to Nontarget Compositional Analysis of Complex Samples.

Nontarget analysis (NTA) by liquid chromatography coupled to high-resolution mass spectrometry improves the capacity to comprehend the molecular composition of complex mixtures compared to targeted analysis techniques. However, the detection of unknown compounds means that quantification in NTA is challenging. This study proposes a new semi-quantitative methodology for use in the NTA of organic aerosol. Quantification of unknowns is achieved using the average ionization efficiency of multiple quantification standards which elute within the same retention time window as the unknown analytes. In total, 110 authentic standards constructed 25 retention time windows for the quantification of oxygenated (CHO) and organonitrogen (CHON) species. The method was validated on extracts of biomass burning organic aerosol (BBOA) and compared to quantification with authentic standards and had an average prediction error of 1.52 times. Furthermore, 70% of concentrations were estimated within a factor of 2 (prediction errors between 0.5 and 2 times) from the authentic standard quantification. The semi-quantification method also showed good agreement for the quantification of CHO compounds compared to predictive ionization efficiency-based methods, whereas for CHON species, the prediction error of the semi-quantification method (1.63) was significantly lower than the predictive ionization efficiency approach (14.94). Application to BBOA for the derivation of relative abundances of CHO and CHON species showed that using peak area underestimated the relative abundance of CHO by 19% and overestimated that of CHON by 11% compared to the semi-quantification method. These differences could lead to significant misinterpretations of source apportionment in complex samples, highlighting the need to account for ionization differences in NTA approaches.