Problem setting. In the conditions of martial law, the problems of rebuilding the national innovative economy and legal regulation of the activities of innovative infrastructure entities are of primary importance for ensuring national security and adapting to new challenges. Effective legal regulation of the functioning of innovation infrastructure entities using a systemic approach is able to ensure the proper level of development and functioning of the national innovation ecosystem and all its subsystems, including regional ones. However, at present, the state innovation policy and regional innovation policy do not have an effective relationship and an effective mechanism for supporting the activities of innovation infrastructure entities. Analysis of recent researches and publications. Problems of legal support and improvement of the functioning of the national innovation infrastructure and its elements have been studied by many scientists. S. V. Hlibko considered the issue of legal support for the strategy of the innovation process based on the organization of the functioning of the innovation infrastructure, including the features of the infrastructure support for the innovation process. O. V. Rozghon investigated the mechanism of technology transfer and its implementation in the innovation process. The issues of legal regulation of public procurement as a means of state regulation aimed at stimulating innovative activity in the European Union were considered in the scientific works of V. A. Chubenko. Purpose of research is to study the topical legal issues of ensuring the systematic legal regulation of the functioning of innovation infrastructure. Article’s main body. The legal support of the national innovation ecosystem should have effective means of supporting and stimulating the implementation of innovative activities and the corresponding infrastructural support of the innovation process, taking into account modern challenges and generally defined strategic orientations of the state in this area, at the same time, the construction of an effective innovation policy should also take place according to the principle of adaptive formation, taking into account real the needs of regulatory regulation, the current state of innovation development, the need to ensure effective interaction between all subjects of the innovation infrastructure and components of the national innovation system. It has been correctly determined that various legislative and by-laws in the field of innovative infrastructure development are insufficiently consistent and meaningfully connected, for the vast majority of elements of innovative infrastructure, both the content and the order of creation, specifics of activity, mechanisms of state regulation, etc. have not been defined. Therefore, the regulatory and legal provision of innovative infrastructure should be of a sys-temic nature, taking into account the peculiarities of carrying out innovative activities in the conditions of martial law and the urgency of the processes of Ukraine’s integration into the European political, economic, security, and legal space and the approaching acquisition of Ukraine’s membership in the European Union. Thus, ensuring the systematic legal regulation of the activities of innovation infrastructure entities is a key task in creating a favorable environment for the development of innovations; to achieve this goal, it is necessary to implement complex approaches and develop appropriate legislative mechanisms. In addition, ensuring the system of legal regulation of innovative activity requires a comprehensive approach and improvement of current legislation, taking into account the requirements of the modern innovation market and the need to accelerate European integration processes. Conclusions and prospects for the development. Based on the analysis of issues regarding the state of regulatory regulation of the functioning of innovative infrastructure, it is reasonable to conclude that the main shortcomings in the regulation of the specified area are: unsystematic legal regulation of the development of innovative infrastructure; lack of a purposeful and consistent state innovation policy coordinated with regional directions of innovation development; lack of effective systematic forecasting and strategic planning of the development of the sphere of innovative activity; insufficient regulatory and legal settlement of issues of innovation infrastructure development (including the declarative nature of innovation legislation and its inconsistency with strategic planning documents); lack of effective mechanisms for state support and stimulation of innovative infrastructure, etc. The solution of the mentioned problems requires the improvement of the state innovation policy regarding the support and development of the innovation infrastructure, the formation of a complete system of forecast and program documents of the country’s innovation development based on a comprehensive analysis of the situation, taking into account the influence of external and internal factors and the expected trends of changes in the influence of these factors in the long term.