Approach For Creation Research Articles

Eco-friendly Approach for Creation of Resonant Silicon Nanoparticle Colloids

The commercial application of Mie-resonant nanophotonic technologies currently used in various laboratory studies, from biosensing to quantum optics, appears to be challenging. Development of colloidal-based fabrication approaches is a solution to face the issue. In our research, we studied the fabrication of resonant Si nanoparticle (NP) arrays on a surface with controlled wettability. First, we use nanosecond (ns) laser ablation in water and subsequent density gradient separation to obtain colloids of resonant spherical crystalline silicon NPs with a low polydispersity index. Then, the same industrial ns laser is applied to create a wetting gradient on the steel substrate to initiate a self-assembly of the NPs deposited by drop casting. Thus, we use a single commercial ns laser for producing both the NPs and the hydrophilic wetting gradient. We apply an easily operating size separation technique and only non-toxic media. This research contributes to the large-scale fabrication of various optical devices based on resonant high-refractive index nanostructures by ecologically friendly self-assembly techniques.

Right vs leftportal branch puncture in TIPS creation with controlled expansion covered stent: comparison of hemodynamic and clinical outcomes.

To retrospectively compare outcomes of TIPS performed by puncturing left portal vein (LPV) vs right portal vein (RPV) to access the portal system. One hundred ninety-three consecutive patients underwent TIPS with controlled expansion covered stent by using the LPV (37 patients) or the RPV (156 patients). Patients were followed until the last clinical evaluation, liver transplantation, or death. Demographics and clinical characteristics of the two groups were comparable. The median follow-up was 9.6 months (range 0.1-50.6).Portosystemic pressure gradient (PSG) before TIPS15.7 mmHg ± 4.7 in RPV group (RPVG)vs 15.4 mmHg ± 4.5 in LPV group (LPVG) (p = 0.725). After TIPS, PSG6.3 mmHg ± 2.8 in RPVGvs 6.2 mmHg ± 2.2 (p = 0.839). In LPVG, the stent was dilated to 8-mm in 95% of patients vs 77% of RPVG (p = 0.015). Two (5.4%) and 22 (14%) patients underwent TIPS revision in LPVG and RPVG (p = 0.15). The incidence of overt HE was 13% in LPVG and 24% in RPVG (p = 0.177). Rebleeding occurred in 3 of 49 patients (6%) with variceal bleeding as an indication: 2/41 patients (4.9%) in RPVG vs 1/8 patients (12.5%) in LPVG (p = 0.417). Among 126 patients with refractory ascites 20 patients (15.9%) neededparacentesis 3 months after the procedure: 18/101 patients (17.8%) in RPVG vs 2/25 patients (8%) in LPVG (p = 0.231).Thirty-seven patients (19%) died: 32 (21%) in RPVG and5 (14%) in LPVG (p = 0.337). Compared with RPV puncture, in TIPS created through the LPV, the targeted PSG was reached with a smaller stent diameter. However, no significant difference in clinical outcomes was observed. • A LPV approach for TIPS creation does not lead to better control of complications of portal hypertension as compared to a RPV approach.

IMPROVING THE EFFICIENCY OF AUTOMATION THE SCALING OF MICROSERVICES IN THE KUBERNETES CONTAINERIZED APPLICATION MANAGEMENT SYSTEM

Automatic container scaling in Kubernetes plays an important role in handling incoming requests from web application users. This article analyzes the stages of container scaling, their initialization and subsequent software launch. In order to achieve low latency of user requests in the case of dynamic load, the analysis of the process of automatic scaling of containers and the factors that will affect the scaling process was carried out. Having a full understanding of the processes and mechanisms by which scaling takes place, it became possible to develop a method and strategy for cleaning obstacles that slow down the autoscaling process itself and at the same time preserve the necessary properties of the existing scaling. Acceleration of scaling of containers, which will directly affect the speed of web services, becomes possible precisely because of the elimination of the delay in automatic scaling of containers. The work considered scaling optimization using not only container pre-creation networks, but also the use of container images, which enable the sharing of linked libraries in memory and the extension of Kubernetes’ declarative configuration management approach for parallel creation of multiple container instances. Based on the obtained research results, a method for optimizing the automatic scaling of containerized applications by eliminating the delay during a cold start has been developed. This latency manifests itself in the case of microservice autoscaling, where Kubernetes is expected to scale containers horizontally by creating additional replicas to the required number to handle the required traffic from the outside. The delay caused by the autoscaler affects the processing time of the user’s web service requests.

Circular solutions in developing countries: Coping with sustainability tensions by means of technical functionality and business model relevance

AbstractTo foster sustainable development, transition to circular economy should happen globally. Lately, however, the implementation of circular solutions has been particularly slow in the developing countries where these solutions could bring about particularly positive changes. A successful circular solution couples technical functionality with business model relevance. In developing countries, the implementation of circular solutions reveals sustainability tensions that originate in resource scarcity, institutional voids, and market affordability. We have studied implementation of circular solutions that small companies operating in these conditions have developed. The systematic analysis of 79 cases shows how sustainability tensions influence on companies' everyday business conduct and their long‐term strategic orientation toward circular economy. We have also identified commonly applied business model features that allow companies to cope with the sustainability tensions. These features include: (1) locally tailored value proposition, (2) collective action approach in value creation, and (3) creativity in value capture. Ultimately, locally functional, embedded, and widely accepted circular solutions have potential to facilitate wider socio‐technical transitions toward more sustainable business practices.

The Approach to Typology of The Biocultural Landscape In Slovakia.

The European Landscape Convention aims to promote landscape protection, management and planning. This must be done based on identification and knowledge of those basic landscape types that were created by the interaction of human and nature over the course of historical development. This paper presents a methodological approach for creation and evaluation of representative biocultural types of landscape, in order to elaborate an effective strategy for landscape protection, and proposes a management strategy of sustainable use of representative biocultural landscapes of Slovakia. That will ensure the regular maintenance of the landscape in view of current global trends and factors affecting the landscape. Our interdisciplinary approach is based on previous landscape classifications and the interaction of natural and cultural elements. The classification of the biocultural landscape is obtained as a result of multi-criteria analysis in GIS and synthesis of maps of potential vegetation, real ecosystems and current land use, abiotic conditions of representative geoecosystems of Slovakia, and other specific statistical data. We assessed the perception and significance of individual landscape types by way of a questionnaire survey. In Slovakia, seven basic types of landscape were singled out, ranging from natural to semi-natural to anthropogenic, within which other subtypes were specified. We assessed the protection of individual types, as well as threats and degradation of the landscape. Insufficient protection is given to the most valuable types of biocultural landscape and new tools and methods of support and protection have to be implemented.

Understanding and supporting the design systems practice

Design systems represent a user interaction design and development approach that is currently of avid interest in the industry. However, little research work has been done to synthesize knowledge related to design systems in order to inform the design of tools to support their creation, maintenance, and usage practices. This paper represents an important step in which we explored the issues that design system projects usually deal with and the perceptions and values of design system project leaders. Through this exploration, we aim to investigate the needs for tools that support the design system approach. We found that the open source communities around design systems focused on discussing issues related to behaviors of user interface components of design systems. At the same time, leaders of design system projects faced considerable challenges when evolving their design systems to make them both capable of capturing stable design knowledge and flexible to the needs of the various concrete products. They valued a bottom-up approach for design system creation and maintenance, in which components are elevated and merged from the evolving products. Our findings synthesize the knowledge and lay foundations for designing techniques and tools aimed at supporting the design system practice and related modern user interaction design and development approaches.

The interactive reading task: Transformer-based automatic item generation.

Automatic item generation (AIG) has the potential to greatly expand the number of items for educational assessments, while simultaneously allowing for a more construct-driven approach to item development. However, the traditional item modeling approach in AIG is limited in scope to content areas that are relatively easy to model (such as math problems), and depends on highly skilled content experts to create each model. In this paper we describe the interactive reading task, a transformer-based deep language modeling approach for creating reading comprehension assessments. This approach allows a fully automated process for the creation of source passages together with a wide range of comprehension questions about the passages. The format of the questions allows automatic scoring of responses with high fidelity (e.g., selected response questions). We present the results of a large-scale pilot of the interactive reading task, with hundreds of passages and thousands of questions. These passages were administered as part of the practice test of the Duolingo English Test. Human review of the materials and psychometric analyses of test taker results demonstrate the feasibility of this approach for automatic creation of complex educational assessments.

Experimental Investigations and Multi-Response Optimization of Dynamic Magnetic Field-Assisted Electrochemical Spark Drilling Using Grey Relational Analysis

Magnetic field-assisted electrochemical spark drilling (MA-ECSD) is a cost-effective triplex hybrid machining technique that has been developed to enhance the machining depth and surface roughness of insulated and hard-to-scribe materials. The study presented adopts a reformed approach for creation of dynamic magnetic field during drilling of Sodalime glass where a 34 AWG copper wire coiled electromagnet has been installed in the in-house designed and fabricated setup of MA-ECSD. The experimental plan is based on Box–Behnken design (BBD) of Response Surface Methodology (RSM) and significance of parameters is determined using ANOVA. Multi-objective optimization (MOO) is performed by applying Grey Relational Analysis (GRA). A noncontact optical profilometer measures the machining depths and surface roughness of drilled holes. The installed electromagnet generated dynamic magnetic field intensity (MFI) ranging between 0.00 and 0.18 Tesla. Preliminary experiments were conducted to select and set the range of input parameters. Significant effect of voltage, NaOH concentration and MFI on machining depth and surface roughness is found and optimal parameter settings obtained are 24[Formula: see text]V, 30[Formula: see text]wt% and 0.09 Tesla. Machining depth increased by about 13.03% with rise in voltage-NaOH concentration and surface roughness improved by 25.3% with elevation in voltage-MFI. Dynamic MFI generated from electromagnet helped in smooth motion of electrolyte in the fine space amidst cathode and glass slide due to magnetohydrodynamic effect (MHD) which resulted in enhanced machining depth and surface roughness. The experimental and predicted results obtained after confirmatory test are appreciable which is evident from SEM images and images obtained from Optical profilometer.

Unlocking New Reactivities in Enzymes by Iminium Catalysis

AbstractThe application of biocatalysis in conquering challenging synthesis requires the constant input of new enzymes. Developing novel biocatalysts by absorbing catalysis modes from synthetic chemistry has yielded fruitful new‐to‐nature enzymes. Organocatalysis was originally bio‐inspired and has become the third pillar of asymmetric catalysis. Transferring organocatalytic reactions back to enzyme platforms is a promising approach for biocatalyst creation. Herein, we summarize recent developments in the design of novel biocatalysts that adopt iminium catalysis, a fundamental branch in organocatalysis. By repurposing existing enzymes or constructing artificial enzymes, various biocatalysts for iminium catalysis have been created and optimized via protein engineering to promote valuable abiological transformations. Recent advances in iminium biocatalysis illustrate the power of combining chemomimetic biocatalyst design and directed evolution to generate useful new‐to‐nature enzymes.

Unlocking New Reactivities in Enzymes by Iminium Catalysis.

The application of biocatalysis in conquering challenging synthesis requires the constant input of new enzymes. Developing novel biocatalysts by absorbing catalysis modes from synthetic chemistry has yielded fruitful new‐to‐nature enzymes. Organocatalysis was originally bio‐inspired and has become the third pillar of asymmetric catalysis. Transferring organocatalytic reactions back to enzyme platforms is a promising approach for biocatalyst creation. Herein, we summarize recent developments in the design of novel biocatalysts that adopt iminium catalysis, a fundamental branch in organocatalysis. By repurposing existing enzymes or constructing artificial enzymes, various biocatalysts for iminium catalysis have been created and optimized via protein engineering to promote valuable abiological transformations. Recent advances in iminium biocatalysis illustrate the power of combining chemomimetic biocatalyst design and directed evolution to generate useful new‐to‐nature enzymes.

Universal Flu mRNA Vaccine: Promises, Prospects, and Problems.

The seasonal flu vaccine is, essentially, the only known way to prevent influenza epidemics. However, this approach has limited efficacy due to the high diversity of influenza viruses. Several techniques could potentially overcome this obstacle. A recent first-in-human study of a chimeric hemagglutinin-based universal influenza virus vaccine demonstrated promising results. The coronavirus pandemic triggered the development of fundamentally new vaccine platforms that have demonstrated their effectiveness in humans. Currently, there are around a dozen messenger RNA and self-amplifying RNA flu vaccines in clinical or preclinical trials. However, the applicability of novel approaches for a universal influenza vaccine creation remains unclear. The current review aims to cover the current state of this problem and to suggest future directions for RNA-based flu vaccine development.

Technical and electroacoustic aspects of miniature omnidirectional sound sources used in acoustic scale modeling

Acoustic similarity theory allows us to create scaled room acoustic models which are simple to construct but usually difficult to measure correctly. One of the most common problems is the sound source, which works in the wide frequency range (800–40000 Hz, 500–63000 Hz) and has an omnidirectional sound propagation pattern. The lecture will present the novel approach for miniature sound sources design and creation for the most common measurement functions—laboratory objects and materials measurements (absorption, diffusion) in the scaled reverberation chamber, sound insulation scale modeling, and the room acoustic measurements in reduced models. Each of those applications has special sound source requirements, which allow us to differentiate their construction type. The most important aspects of the designing process were investigated, such as the number of transducers used and their placement, types of speakers, enclosure shape, and dimensions. The lecture will expose the sound sources used in Technical Acoustic Laboratory in AGH, Cracow, for the given measurement functions. The design recommendations developed based on FEM modeling, and experimental testing will be discussed regarding the existing objects, allowing future users to recreate in similar shape or adjust to other, predefined scale modeling measurement functions.

Virtual reality for procedural education: Lumbar medial branch radiofrequency neurotomy

Virtual reality (VR) simulation is an emerging tool in medical education. Simulation conducted in VR can reproduce procedural scenarios and allow for immersive interaction with anatomic models. This has the potential to improve understanding of anatomy and concepts relevant to interventional procedures.Here, we present a “proof-of-concept” modeling of lumbar thermal radiofrequency neurotomy through cost-effective, commercially available VR hardware and software. With this technology, we can demonstrate key fluoroscopic views and needle trajectories based on specific recommendations from Spine Intervention Society guidelines. Furthermore, the learner can manipulate the model in multiple 3-dimensional axes to visualize anatomy relevant to key fluoroscopic views. Finally, the content can be exported by recording a live casting stream, thus offering an approach for future content creation and collaboration.VR technology is an emerging educational modality that offers immersive and interactive features that may offer advantages to traditional visual teaching modalities.

Real-time large-area imaging of the corneal subbasal nerve plexus

The morphometric assessment of the corneal subbasal nerve plexus (SNP) by confocal microscopy holds great potential as a sensitive biomarker for various ocular and systemic conditions and diseases. Automated wide-field montages (or large-area mosaic images) of the SNP provide an opportunity to overcome the limited field of view of the available imaging systems without the need for manual, subjective image selection for morphometric characterization. However, current wide-field montaging solutions usually calculate the mosaic image after the examination session, without a reliable means for the clinician to predict or estimate the resulting mosaic image quality during the examination. This contribution describes a novel approach for a real-time creation and visualization of a mosaic image of the SNP that facilitates an informed evaluation of the quality of the acquired image data immediately at the time of recording. In cases of insufficient data quality, the examination can be aborted and repeated immediately, while the patient is still at the microscope. Online mosaicking also offers the chance to identify an overlap of the imaged tissue region with previous SNP mosaic images, which can be particularly advantageous for follow-up examinations.

Analysis of environmental transitions for tool development

In the pursuit of a sustainable economy, several transitions are initiated which affect the way of doing business. The most prominent transitions, the energy transition and the transition towards a circular economy, are exemplary for the way companies are impacted. By the analysis of the differences and similarities between the two transitions, the challenges for companies are identified. The value chain needs to implement the demanded adaptations to be competitive. Therefore, the environmental performance and capacity to make the required adaptation of all value chain partners are of relevance for business continuation. A future tool should support companies in the assessment of the value chain partners to be adaptive. The paper describes the design brief for the development of the tool that should incentivize companies to focus on and provide guidance for a multi-capital approach for value creation and to transition to a sustainable value chain.

Target Professions Based Approach for Individual Learning Pathway Creation

University education is becoming more student-centered and personalized in recent years, whereas connections between professional skills and learning outcomes are recognized vaguely. The article proposes an approach to create relations between skills that students acquire in a higher education process and those required in various careers. The approach makes it possible to trace consistency between course material, educational programs, and professions. Thus, the implementation of skills and interdisciplinary connections allows to build the most relevant individual learning tracks for a specific career and provides students with valuable recommendations. The proposed approach is implemented in ITMO University’s (Russia) web service “Educational Program Maker,” initially designed for education process management. The system ensures the development of educational program elements, provides a platform for describing relations between educational entities, and enables users to choose a curriculum for a specific profession.

Aksiologija monetarnog prava u vanrednim okolnostima - primer prava nužnosti

The process of qualitative evolution of monetary law in modern economic and business circumstances has resulted, among other things, in its transformation from a discipline that belongs to the domain of legal and economic science to a discipline that increasingly takes into account the social needs and problems of ordinary people. The emphasis on a humane approach in the regulation of monetary relations in periods of crisis implies the duty of the Central Bank (as the supreme subject of monetary law) to include a component that measures the impact of the specific Central Bank program, measure or instrument on people's living standard, i.e. the quality of life of monetary users that can to be shaken in times of crisis. If, in addition to monetary law as an independent scientific discipline, there are subjective monetary rights of citizens to a safe and stable domestic currency, the Central Bank (as the bearer of monetary sovereignty) must help them in the circumstances when these rights are temporarily shaken and concurrently work to restore the credibility of the monetary system. Practice has shown that it is possible to achieve these goals by exploiting the potential of soft monetary legislation which is more adaptable the disruptions in the economy and takes more care of the well-being of the individual. The contribution of the subjects of monetary law in the implementation of this approach and success in the smart normative creation of new monetary solutions can differ more or less depending on the level of development of monetary awareness.

Horizontal Value Creation through IoT and Digital Twin Data

This paper describes the solution approaches for horizontal value creation using IoT and digital twin data. First, the various lifecycle stages that a product goes through are described. A classification of digital twins is then carried out. On this basis, the horizontal and vertical data integration is described, which forms the basis for future value creation.

P243 - An approach for creation of a contrast-enhanced phantom for breast imaging

P243 - An approach for creation of a contrast-enhanced phantom for breast imaging

Initial development of a self-assessment approach for coproduction value creation by an international community of practice.

Coproduction offers a new way of conceptualizing healthcare as a service that is co-created by people (health professionals and people seeking health services) rather than a product that is generated by providers or health systems and delivered to patients. This offers new possibilities for those introducing and testing changes, and it enables additional ways of creating value. Fjeldstad and colleagues describe the architecture of several kinds of value creating systems: (i) Chain; (ii) Shop; (iii) Network and (iv) Access. An international Value Creating Business Model Community of practice (VCBM CoP) was formed by the International Coproduction of Health Network and explored these types of systems and developed a self-assessment guide for health systems to use to assess value. An international community of practice comprising leaders, clinicians, patients and finance specialists representing 12 health systems from four countries (USA, UK, Israel and Sweden) met monthly for 1year and used a semi-structured process to iteratively refine and adapt Fjeldstad's model for use in healthcare and develop a draft self-assessment guide. The process concluded with initial focus group user experience sessions with six health systems. The community of practice successfully completed a 1-year journey of discovery, development and learning, resulting in two products: (1) a full-version self-assessment guide (detailed) and (2) an abbreviated 'short-form' of the guide. Initial focus-group results suggest that there is initial perceived feasibility, acceptability and utility of the guides and that further development and research is reasonable to pursue. Results suggest significant variation and context specificity in the use of the guide, simple and complex knowledge transfer applications in use, and the need for the development of simple and technology supported versions for use in the future. The VCBM CoP has successfully completed a 1-year collaborative learning cycle, resulting in the development of a self-assessment guide that is now ready for additional investigation using formal research methods. The CO-VALUE study has been designed to build on the work of the CoP and includes qualitative and quantitative assessment phases and a concept mapping study.