This study primarily focuses on Organic Rankine Cycle (ORC) systems and their applications in low temperature waste heat recovery. With the harmful effects of CO2 coming to light and the ever increasing prices of fossil fuels, the importance of low grade heat recovery has grown significantly in the past few years. Several ORC solutions have been proposed to generate electricity from low temperature sources. The ORC systems discussed in this study have applications in various fields such as small-scale cogeneration solar thermal system, exhaust gases from the engine, domestic boilers, etc.This piece of work presents a thermodynamic analysis for the use of ORC systems to utilize exergy energy or low grade energy to generate power. The working fluids used in this analysis are R12, R113, R134a, R141b, R245ca, and R245fa with pressures ranging from 5 kPa to 1.005 MPa. Here, both the 1st and 2nd laws of thermodynamics have been analyzed by varying system independent parameters at various reference pressures. This paper aims at picking out the most suitable working fluid for the Organic Rankine Cycle among the ones mentioned.