Nanyang and Xiangyang Basin is located in the east of Qinling Mountains and Daba Mountain, and the west of Dabie Mountain and Tongbai Mountain. Its north is the Funiu Mountain seated at the east end of Qinling Mountain, and the south is the east end of the Daba Mountains. The main geological environment problems in the area include collapse, landslides, ground fissure, high fluorine water, expansive soil etc. On the basis of collecting the data of geological environment in the basin area, the article regards Nanyang and Xiangyang Basin area and its surrounding area as research objects, and then builds the geological environment database of the study area through GIS platform. Based on the analysis of the factors that affect the geological disasters susceptibility in the study area, an evaluation index system of geological disaster susceptibility was established. The paper expounds the process and steps of applying analytic hierarchy process (AHP) to geological disaster susceptibility assessment, and uses this method (AHP) to establish the hierarchical analysis structural model and the judgment matrix of geological disaster susceptibility comprehensive evaluation, so as to determine the influence of geological disasters. The weight of degree factors establishes a mathematical model for the evaluation of susceptibility to catastrophic disasters in geological disasters and comprehensive evaluation of susceptibility to geology in regional geological disasters. Through using the evaluation module developed by MapGIS, the geological disaster susceptibility of the study area can be divided, and there are four zones: highly-prone area, mid-prone areas, low-prone areas, undeveloped area. This article analyzes the causes of geological disaster susceptibility in the study area, and the research results can provide the basis for geological environment management, planning and disaster prevention and reduction in the study area. At the same time, the reliability of the evaluation results is discussed by comparing the evaluation results with actual geological disasters.