Commercial reactor pressure vessel steels in nuclear power plant applications contain C and other minor non-clustering elements in addition to the clustering elements of Mn, Ni and Si. However, the effect of such non-clustering elements on irradiation-induced solute clustering in ferritic steels has seldom been addressed. Herein, we reveal that a commercial RPV steel and its Fe-Mn-Ni-Si model alloy with coarse/fine grains subjected to ion irradiation exhibits different irradiation-induced clustering, particularly in chemistry, mean size, and number density of irradiation-induced MnNiSi-clusters. The different chemical compositions of the clusters indicate different thermodynamics in driving solute clustering in RPV steel and its model alloy. The different number density and size evolutions of the clusters indicate different kinetics in governing irradiation-induced clustering. The presence of C and Mo, as non-clustering elements, is primarily responsible for the different clustering behaviors of Ni, Mn and Si in the two materials exposed to ion irradiation. The research finding is of significant implication for modelling and fundamental understanding irradiation-induced clustering in commercial RPV steels.