To explore the applicability of different fungicide application schemes to control potato early blight (mainly caused by Alternaria solani) in China, field trials were conducted from 2020 to 2022, combining different fungicides with the tomato forecaster (TOMCAST) model and using weather variables to adjust the minimum temperature of TOMCAST to 7 °C. To effectively manage potato early blight, the TOMCAST model combines relative humidity (>88%) and air temperature to calculate daily severity values (DSVs). The application of fungicides (fungicide schedule) is as follows: untreated; two standard treatments, Amimiaoshou SC and Xishi SC, applied at the first appearance of disease symptoms; and two different TOMCAST treatments, in which fungicides are applied when the physiological days add up to 300 days and DSVs add up to 15. This study quantifies the intensity of early blight as the area under the disease progression curve and the final disease severity. Additionally, a progress curve for early blight is constructed to compare the development of early blight in different years and treatments. The TOMCAST-15 model reduces the number of fungicide applications in addition to significantly suppressing the development of early blight. Furthermore, fungicide application significantly increases the dry matter and starch contents of potatoes, and TOMCAST-15 × Amimiaoshou SC has similar enhancement effects on dry matter, protein, reducing sugar, and starch contents compared with Amomiaohou SC and Xishi SC. As a result, TOMCAST × Amimiaoshou SC may be an effective alternative to the standard treatment and have good applicability in China.