Application Of Three-dimensional Printing Research Articles

Tissue Engineering Nasal Cartilage Grafts with Three-Dimensional Printing: A Comprehensive Review.

Nasal cartilage serves a crucial structural function for the nose, where rebuilding the cartilaginous framework is an essential aspect of nasal reconstruction. Conventional methods of nasal reconstruction rely on autologous cartilage harvested from patients, which contributes to donor site pain and the potential for site-specific complications. Some patients are not ideal candidates for this procedure due to a lack of adequate substitute cartilage due to age-related calcification, differences in tissue quality, or due to prior surgeries. Tissue engineering, combined with three-dimensional printing technologies, has emerged as a promising method of generating biomimetic tissues to circumvent these issues to restore normal function and aesthetics. We conducted a comprehensive literature review to examine the applications of three-dimensional printing in conjunction with tissue engineering for the generation of nasal cartilage grafts. This review aims to compare various approaches and discuss critical considerations in the design of these grafts.

Evaluation of Mechanical Properties of ABS-like Resin for Stereolithography Versus ABS for Fused Deposition Modeling in Three-Dimensional Printing Applications for Odontology.

This study investigates the differences in mechanical properties between acrylonitrile butadiene styrene (ABS) samples produced using fused deposition modeling (FDM) and stereolithography (SLA) using ABS filaments and ABS-like resin, respectively. The central question is to determine how these distinct printing techniques affect the properties of ABS and ABS-like resin and which method delivers superior performance for specific applications, particularly in dental treatments. The evaluation methods used in this study included Shore D hardness, accelerated aging, tensile testing, Izod impact testing, flexural resistance measured by a 3-point bending test, and compression testing. Poisson's ratio was also assessed, along with microstructure characterization, density measurement, confocal microscopy, dilatometry, wettability, Fourier-transform infrared spectroscopy (FTIR), and nanoindentation. It was concluded that ABS has the same hardness in both manufacturing methods; however, the FDM process results in significantly superior mechanical properties compared to SLA. Microscopy demonstrates a more accurate sample geometry when fabricated with SLA. It is also concluded that printable ABS is suitable for applications in dentistry to fabricate models and surgical guides using the SLA and FDM methods, as well as facial protectors for sports using the FDM method.

Influence of design parameters on sustained drug release properties of 3D-printed theophylline tablets

The application of three-dimensional printing (3DP) in the pharmaceutical industry brings a broad spectrum of benefits to patients by addressing individual needs and improve treatment success. This study investigates the sustained release properties of 3DP tablets containing Theophylline (TPH), which is commonly used to treat respiratory diseases and recently having a comeback due to its potential in the treatment of conditions like Covid-19. Since TPH is a narrow therapeutic window (NTW) drug with serious side effects in the event of overdose, the release properties must be observed particularly closely. We employed a state-of-the-art single screw extrusion 3D printer, which is fed with granules containing the drug. By employing a Taguchi orthogonal array design of experiments (DOE), tablet design parameters and factor related process stability were sought to be evaluated fundamentally. Following this, examinations regarding tailored TPH dosages were undertaken and a relationship between the real printed dose of selected tablet designs and their sustained drug release was established. The release profiles were analyzed using different mathematical model fits and compared in terms of mean dissolution times (MDT). Finally, in-vivo/in-vitro correlation (IVIVC) and physiologically based pharmacokinetic (PBPK) modeling showed that a paradigm patient group could be covered with the dosage forms produced.

A commentary on 'Application of three-dimensional printing in cardiovascular diseases: a bibliometric analysis'.

A commentary on 'Application of three-dimensional printing in cardiovascular diseases: a bibliometric analysis'.

Commentary on 'Application of three-dimensional printing in cardiovascular diseases: a bibliometric analysis'.

Commentary on 'Application of three-dimensional printing in cardiovascular diseases: a bibliometric analysis'.

Dansylated Nitrile N-Oxide as the Fluorescent Dye Clickable to Unsaturated Bonds without Catalyst.

Fluorescent polymeric materials have been exploited in the fields of aesthetical purposes, biomedical engineering, and three-dimensional printing applications. While the fluorescent materials are prepared by the polymerization of fluorescent monomer or the blending a fluorescent dye with common polymer, the covalent immobilization of fluorescent dye onto common polymers is not the practical technique. In this paper, dansylated nitrile N-oxide (Dansyl-NO) has been designed and synthesized to be a stable nitrile N-oxide as the derivative of 2-hydroxy-1-naphthaldehyde. While Dansyl-NO shows good reactivity to an alkene and an alkyne to give fluorescent Dansyl-Ene and Dansyl-Yne, respectively, it hardly reacts to a nitrile. The results indicate that Dansyl-NO serves as a fluorescent dye clickable to alkenes and alkynes. To know the effects of solvent on the fluorescent properties, the UV-vis and fluorescence spectra of Dansyl-Ene are measured in three solvents. Dansyl-Ene shows fluorescent solvatochromism, which appears to be red-shifted along with the increase in solvent polarity. Poly(styrene-co-butadiene) directly reacts with Dansyl-NO to give fluorescent modified SB. The emission spectrum of modified SB is blue-shifted compared with that of Dansyl-Ene. The blue-shift could be possibly attributed to the presence of less polar polymer skeleton around the dansyl moieties of modified SB.

Application of three-dimensional printing in plastic surgery: a bibliometric analysis.

Recent years have seen the publication of numerous papers on the application of three-dimensional (3D) printing in plastic surgery. Despite this growing interest, a comprehensive bibliometric analysis of the field has yet to be conducted. To address this gap, we undertook a bibliometric study to map out the knowledge structure and identify research hotspots related to 3D printing in plastic surgery. We analyzed publications from 1995 to 2024, found in the Web of Science Core Collection (WoSCC), utilizing tools such as VOSviewer, CiteSpace, and the R package "bibliometrix". Our analysis included 1,057 documents contributed by 5,545 authors from 1,620 organizations across 71 regions, and these were published in 400 journals. We observed a steady growth in annual publications, with Europe, Asia, North America, and Oceania leading in research output. Notably, Shanghai Jiao Tong University emerged as a primary research institution in this domain. The Journal of Craniofacial Surgery and Journal of Oral and Maxillofacial Surgery have made significant contributions to the field, with Thieringer, Florian M being the most prolific and frequently cited author. Key areas of focus include medical education and surgical procedures, with "3D printing", "virtual surgical planning" and "reconstructive/orthognathic surgery" highlighted as future research hotspots. Our study provides a detailed bibliometric analysis, revealing the evolution and progress of 3D printing technologies in plastic surgery. As these technologies continue to advance, their impact on clinical practice and patient lives is expected to be profound.

Bibliometric analysis of three-dimensional printing applications in cardiovascular diseases: a correspondence.

Bibliometric analysis of three-dimensional printing applications in cardiovascular diseases: a correspondence.

Application of three-dimensional printing in cardiovascular diseases: a bibliometric analysis.

This paper aimed to explore the application of three-dimensional (3D) printing in cardiovascular diseases, to reach an insight in this field and prospect the future trend. The articles were selected from the Web of Science Core Collection database. Excel 2019, VOSviewer 1.6.16, and CiteSpace 6.1.R6 were used to analyze the information. A total of 467 papers of 3D printing in cardiovascular diseases were identified, and the first included literature appeared in 2000. A total of 692 institutions from 52 countries participated in the relevant research, while the United States of America contributed to 160 articles and were in a leading position. The most productive institution was Curtin University , and Zhonghua Sun who has posted the most articles ( n =8) was also from there. The Frontiers in Cardiovascular Medicine published most papers ( n =25). The Journal of Thoracic and Cardiovascular Surgery coveted the most citations ( n =520). Related topics of frontiers will still focus on congenital heart disease, valvular heart disease, and left atrial appendage closure. The authors summarized the publication information of the application of 3D printing in cardiovascular diseases related literature from 2000 to 2023, including country and institution of origin, authors, and publication journal. This study can reflect the current hotspots and novel directions for the application of 3D printing in cardiovascular diseases.

Occupational therapists' acceptance of 3D printing

INTRODUCTION: In occupational therapy, three-dimensional printing is being explored as an alternative design and manufacturing technique to the conventional fabrication of orthotics and assistive devices. The global applications and literature are rapidly growing, but the South African - specific literature is deficient. The Technology Acceptance Model depicts that one's perception of any particular technology is a significant determinant of their acceptance of it, determining whether the technology system is successfully adopted or disregarded AIM: To determine the perceived acceptance of three-dimensional printing technology amongst occupational therapists in KwaZulu-Natal and whether exposure to the technology system, in the form of a three-dimensional printing workshop, influences their perception of the technology METHOD: The study followed a multi-method design consisting of two phases; phase one involved the creation of the intervention tool (workshop), which was developed through a process guided by Design-Based Research. Phase two involved the implementation of the intervention and data collection. Therapists documented their perceptions in a questionnaire before and after exposure; following a pre and post-test design, enabling comparison. The questionnaires were based on the Technology Acceptance Model, including 13 questions scored on a seven-point Likert scale and five open-ended questions. The quantitative data were analysed descriptively, and qualitative data were analysed thematically RESULTS: All four categories of the Technology Acceptance Model-based questionnaire displayed a significant change (p < 0.05) between the pre and post-test responses, with a medium effect size CONCLUSION: Exposure to three-dimensional printing influences therapists' perception of the technology IMPLICATIONS FOR PRACTICE • The application of Three-Dimensional Printing (3DP) in occupational therapy practice has the potential to enable increased accuracy and precision of items fabricated by therapists; enabling customisation and individualisation to the exact specifications of a patient. • 3DP can open doors to a broad spectrum of items that are not easily accessible, affordable, or not even available, accessing ideas and blueprints from a global pool of resources through open-source sites. • With the process of fabrication being digital, not only does this reduce manual labour, but fabricating without touching the patient can reduce pain and prevent disruption of a repair/ surgical site/ wound. • The digital process also allows patients to see and visualise the product during the design process, enabling input prior to printing, contributing to reduced wastage.

The attractiveness of 4D printing in the medical field: Revealing scientific and technological advances in design factors and applications

Currently, there is an increasing demand in the medical field for low-cost, high-quality products as well as personalized solutions, and different manufacturing methods are being investigated to provide innovative solutions. Four-dimensional (4D) printing is a promising technology that could overcome the challenges associated with the applications of three-dimensional printing in regenerative medicine and biomedical devices. A revolution is expected in this regard, and it is essential to keep abreast of the latest developments. Under this context, the purpose of this paper is to reveal scientific and technological advances of 4D printing in the medical field using a competitive technology intelligence (CTI) methodology. To this end, publications were analyzed from the Scopus database between January 1, 2017, and May 9, 2023. The main trends were identified for both design factors and applications. In the first case, the following were considered: 4D printing methods, external stimuli, materials, mathematical models, and interaction mechanisms. In contrast, in the second case, the applications of 4D printing involved were considered: drug delivery systems, stents, and scaffolds. The obtained design factors results included improvements in mechanical properties of hydrogels by adding magnetic nanoparticles, biopolyurethane, and other materials, the development of cell-friendly bioprinting methods to print cellular structures, and the use of theoretical-experimental approaches to predict shape deformation of structures. While for applications, results included advances in the development of expandable drug delivery systems, fabrication of stents for the treatment of vascular and tracheal stenosis, and the design of scaffolds to treat cartilage defects and bone regeneration. This study provides insights to researchers, academics, and companies involved in research and development as well as innovation that are looking for new solutions to improve health by incorporating breakthrough technologies such as 4D printing.

Practical applications of three-dimensional printing for process improvement in the cytopathology laboratory.

With the increased availability of three-dimensional (3D) printers, innovative teaching and training materials have been created in medical fields. For pathology, the use of 3D printing has been largely limited to anatomic representations of disease processes or the development of supplies during the coronavirus disease 2019 pandemic. Herein, an institution's 3D printing laboratory and staff with expertise in additive manufacturing illustrate how this can address design issues in cytopathology specimen collection and processing. The authors' institutional 3D printing laboratory, along with students and trainees, used computer-aided design and 3D printers to iterate on design, create prototypes, and generate final usable materials using additive manufacturing. The program Microsoft Forms was used to solicit qualitative and quantitative feedback. The 3D-printed models were created to assist with cytopreparation, rapid on-site evaluation, and storage of materials in the preanalytical phase of processing. These parts provided better organization of materials for cytology specimen collection and staining, in addition to optimizing storage of specimens with multiple sized containers to optimize patient safety. The apparatus also allowed liquids to be stabilized in transport and removed faster at the time of rapid on-site evaluation. Rectangular boxes were also created to optimally organize all components of a specimen in cytopreparation to simplify and expedite the processes of accessioning and processing, which can minimize errors. These practical applications of 3D printing in the cytopathology laboratory demonstrate the utility of the design and printing process on improving aspects of the workflow in cytopathology laboratories to maximize efficiency, organization, and patient safety.

Three-Dimensional Printing Applications in Pediatric Spinal Surgery: A Systematic Review.

Systematic Review. 3DP technology use has become increasingly more common in the field of medicine and is notable for its growing utility in spine surgery applications. Many studies have evaluated the use of pedicle screw placement guides and spine models in adult spine patients, but there is little evidence assessing its efficacy in pediatric spine patient populations. This systematic review identifies and evaluates the current applications and surgical outcomes of 3-Dimensional Printing (3DP) technology in pediatric spinal surgery. A search of publications was conducted using literature databases and relevant keywords in concordance with PRISMA guidelines. Inclusion criteria consisted of original studies, and studies focusing on the use of 3DP technology in pediatric spinal surgery. Studies with a focus on adult populations, non-deformity surgery, animal subjects, systematic or literature reviews, editorials, or non-English studies were excluded from further analysis. After application of inclusion/exclusion criteria, we identified 25 studies with 3DP applications in pediatric spinal surgery. Overall, the studies found significantly improved screw placement accuracy using 3DP pedicle screw placement guides but did not identify significant differences in operative time or blood loss. All studies that utilized 3D spine models in preoperative planning found it helpful and noted an increased screw placement accuracy rate of 89.9%. 3DP applications and techniques are currently used in pre-operative planning using pedicle screw drill guides and spine models to improve patient outcomes in pediatric spinal deformity patients.

Three-Dimensional Printing Applications in Food Industry

Three-dimensional (3D) printing has gained increasing attention for its unique ability to create geometrically complex designs, which not only can be used for mass manufacturing but also has environmental and economic benefits. Additionally, as far as the food industry is concerned, this emerging technology has the potential to personalize products in terms of shape and/or nutritional requirements creating a wide range of food items with specially made shapes, colors, textures, tastes, and even nutrition using suitable raw materials/food components. In the future, 3D food printing could make complex food models with special interior design. This review gives attention to intelligent food packaging. Point-of-use machinery for manufacturing smart packaging, with a 3D printing approach, enables the use of multifunctional smart components and is self-identifying and highly sensitive, while using biocompatible non-toxic materials is cheaper than traditional manufacturing methods. This would create smart food packaging and in turn prevent customers from purchasing unsuitable food and thus reduce food waste. Future studies can make the process more compatible and efficient with a wide variety of materials that could be used to improve the 3D printing process.

Diverse Applications of Three-Dimensional Printing in Biomedical Engineering: A Review.

A three-dimensional (3D) printing is a robotically controlled state-of-the-art technology that is promising for all branches of engineering with a meritorious emphasis to biomedical engineering. The purpose of 3D printing (3DP) is to create exact superstructures without any framework in a brief period with high reproducibility to create intricate and complex patient-tailored structures for organ regeneration, drug delivery, imaging processes, designing personalized dose-specific tablets, developing 3D models of organs to plan surgery and to understand the pathology of disease, manufacturing cost-effective surgical tools, and fabricating implants and organ substitute devices for prolonging the lives of patients, etc. The formulation of bioinks and programmed G codes help to obtain precise 3D structures, which determines the stability and functioning of the 3D-printed structures. Three-dimensional printing for medical applications is ambitious and challenging but made possible with the culmination of research expertise from various fields. Exploring and expanding 3DP for biomedical and clinical applications can be life-saving solutions. The 3D printers are cost-effective and eco-friendly, as they do not release any toxic pollutants or waste materials that pollute the environment. The sampling requirements and processing parameters are amenable, which further eases the production. This review highlights the role of 3D printers in the health care sector, focusing on their roles in tablet development, imaging techniques, disease model development, and tissue regeneration.

Clinical Applications of Three-Dimensional Printing in Upper Extremity Surgery: A Systematic Review.

We searched the databases PubMed and Web of Science for clinical studies that described clinical application of 3D printing for upper extremity surgery including trauma and malformations. We evaluated study characteristics, clinical entity, type of clinical application, concerned anatomical structures, reported outcomes, and evidence level. We finally included 51 publications with a total of 355 patients, of which 12 were clinical studies (evidence level II/III) and 39 case series (evidence level IV/V). The types of clinical applications were for intraoperative templates (33% of a total of 51 studies), body implants (29%), preoperative planning (27%), prostheses (15%), and orthoses (1%). Over two third of studies were linked to trauma-related injuries (67%). The clinical application of 3D printing in upper extremity surgery offers great potential for personalized approaches to aid in individualized perioperative management, improvement of function, and ultimately help to benefit certain aspects in the quality of life.

Application of Three-Dimensional Printing in the Fracture Management

Application of Three-Dimensional Printing in the Fracture Management

The Role of Three-dimensional Printed Models in Women's Health.

Three-dimensional printing is an innovative technology that has gained prominence in recent years due to its attractive features such as affordability, efficiency, and quick production. The technology is used to produce a three-dimensional model by depositing materials in layers using specific printers. In the medical field, it has been increasingly used in various specialties, including neurosurgery, cardiology, and orthopedics, most commonly for the pre-planning of complex surgeries. In addition, it has been applied in therapeutic treatments, patient education, and training wof medical professionals. In the field of obstetrics and gynecology, there is a limited number of studies in which three-dimensional printed models were applied. In this review, we aim to provide an overview of three-dimensional printing applications in the medical field, highlighting the few reported applications in obstetrics and gynecology. We also review all relevant studies and discuss the current challenges and limitations of adopting the technology in routine clinical practice. The technology has the potential to expand for wider applications related to women's health, including patient counseling, surgical training, and medical education.

Thermal and Mechanical Degradation of Recycled Polylactic Acid Filaments for Three-Dimensional Printing Applications.

The recycling of filaments used in three-dimensional (3D) printing systems not only mitigates the environmental issues associated with conventional 3D printing approaches but also simultaneously reduces manufacturing costs. This study investigates the effects of successive recycling of polylactic acid (PLA) filaments, which were used in the printing process, on the mechanical properties of recycled filaments and printed objects. The mechanical strengths of the printed PLA and the adhesion strengths between 3D-printed beads were evaluated via the tensile testing of the horizontally and vertically fabricated specimens. Gel permeation chromatography analysis revealed a reduction in the molecular weight of the polymer as a result of recycling, leading to a decrease in the mechanical strength of the 3D-printed product. Additionally, scanning electron microscopy images of the cutting plane showed that the fabricated beads were broken in the case of the horizontally fabricated specimen, whereas in the case of the vertically fabricated samples, the adhesion between the beads was weak. These findings indicate that the mechanical strength in the in-plane and out-of-plane directions must be improved by increasing the mechanical strength of the bead itself as well as the adhesion strength of the beads.

Applications of Three-Dimensional Printing in the Management of Complex Aortic Diseases

The use of three-dimensional (3D) printing is gaining considerable success in many medical fields, including surgery; however, the spread of this innovation in cardiac and vascular surgery is still limited. This article reports our pilot experience with this technology, applied as an additional tool for 20 patients treated for complex vascular or cardiac surgical diseases. We have analyzed the feasibility of a "3D printing and aortic diseases project," which helps to obtain a more complete approach to these conditions. 3D models have been used as a resource to improve preoperative planning and simulation, both for open and endovascular procedures; furthermore, real 3D aortic models were used to develop doctor-patients communication, allowing better knowledge and awareness of their disease and of the planned surgical procedure. A 3D printing project seems feasible and applicable as an adjunctive tool in the diagnostic-therapeutic path of complex aortic diseases, with the need for future studies to verify the results.