Application Of Nanomaterials Research Articles

Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer: A bibliometric study

BACKGROUND Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these materials. However, the research hotspots and trends in the application of nanomaterials in gastric cancer (GC) remain obscure. AIM To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in GC. METHODS Publications related to the application of nanomaterials in GC were retrieved from the Web of Science Core Collection for this systematic review and bibliometric study. VOSviewer and CiteSpace were used for bibliometric and visualization analyses. RESULTS From 2000 to 2022, the application of nanomaterials in GC developed rapidly. The keyword co-occurrence analysis showed that the related research topics were divided into three clusters: (1) The application of nanomaterials in GC treatment; (2) The application and toxicity of nanomaterials in GC diagnosis; and (3) The effects of nanomaterials on the biological behavior of GC cells. Complexes, silver nanoparticles, and green synthesis are the latest high-frequency keywords that represent promising future research directions. CONCLUSION The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.

Selenium Nanomaterials Enhance Sheath Blight Resistance and Nutritional Quality of Rice: Mechanisms of Action and Human Health Benefit.

In the current work, the foliar application of selenium nanomaterials (Se0 NMs) suppressed sheath blight in rice (Oryza sativa). The beneficial effects were nanoscale specific and concentration dependent. Specifically, foliar amendment of 5 mg/L Se0 NMs decreased the disease severity by 68.8% in Rhizoctonia solani-infected rice; this level of control was 1.57- and 2.20-fold greater than that of the Se ions with equivalent Se mass and a commercially available pesticide (Thifluzamide). Mechanistically, (1) the controlled release ability of Se0 NMs enabled a wider safe concentration range and greater bioavailability to Se0 NMs, and (2) transcriptomic and metabolomic analyses demonstrated that Se0 NMs simultaneously promoted the salicylic acid- and jasmonic-acid-dependent acquired disease resistance pathways, antioxidative system, and flavonoid biosynthesis. Additionally, Se0 NMs improved rice yield by 31.1%, increased the nutritional quality by 6.4-7.2%, enhanced organic Se content by 44.8%, and decreased arsenic and cadmium contents by 38.7 and 42.1%, respectively, in grains as compared with infected controls. Human simulated gastrointestinal tract model results showed that the application of Se0 NMs enhanced the bioaccessibility of Se in grains by 22.0% and decreased the bioaccessibility of As and Cd in grains by 20.3 and 13.4%, respectively. These findings demonstrate that Se0 NMs can serve as an effective and sustainable strategy to increase food quality and security.

Optical and electrical properties and applications of two-dimensional carbon-based nanomaterials

As an emerging material, two-dimensional (2D) carbon-based nanomaterials have unique optical and electrical properties due to their unique atomic layer structure. On the one hand, due to their high transmittance, high carrier mobility, controllable Fermi level, and wide spectral light saturation absorption characteristics, they can be applied in new-generation solar cells, organic light-emitting diodes, touch screens, and fiber optic devices. On the other hand, due to their unique nanostructure, they have high specific surface area, low diffusion distance, high conductivity, and ion conductivity. They can serve as substrates and work together with other materials as electrode materials for future fuel cells and lithium-ion batteries and have significant advantages in fields such as sensors. This article mainly summarizes the impact of two-dimensional carbon-based nanomaterials represented by graphene, Mxene, and 2D covalent organic frameworks (COFs) on their optical and electrical properties, and summarizes the latest practical applications and research progress of these nanomaterials in the field of optics and electronics. In addition, a corresponding summary and outlook have been made on the problems that need to be solved in future applications of 2D carbon-based nanomaterials.

Applications of nanomaterials in medicine against cancer

Nowadays, all walks of life are developing with innovation at their core, and the subject of materials is no exception, while nanomaterials occupy an important position in the emerging field due to their unique properties and wide coverage. In addition, the incidence of cancer, a difficult disease with a very high mortality rate, is increasing day by day. Therefore, research on cancer has received extensive attention from society. Therefore, this paper explores how cancer can be treated by means of nanomaterials through the organization of current research and papers in the field. Research at this stage suggests that nanomaterials play a major auxiliary role in anti-cancer technology, as follows: enhancing the ability of other substances to disrupt cell membranes, assisting in the delivery of anti-tumor drugs, improving imaging capabilities, and enhancing the ability of some substances to inhibit tumor growth through specific mechanisms. In future research, the focus will be on minimizing the side effects of the treatment and improving its safety.

Preparation and electrocatalytic oxygen evolution of bimetallic phosphates (NiFe)2P/NF

Abstract The energy and environmental crisis pose a great challenge to human development in the 21st century. The design and development of clean and renewable energy and the solution for environmental pollution have become a hotspot in the current research. Based on the preparation of transition metal phosphates, transition metals were used as raw materials, Prussian blue-like NiFe(CN)6 as a precursor, which was in situ grown on nickel foam (NF) substrate. After low temperature phosphating treatment, a bimetallic phosphide electrocatalyst (NiFe)2P/NF was prepared on NF substrate. Using 1 mol·L−1 KOH solution as a basic electrolyte, based on the electrochemical workstation of a three-electrode system, the electrochemical catalytic oxygen evolution performance of the material was tested and evaluated. Experiments show that (NiFe)2P/NF catalyst has excellent oxygen evolution performance. In an alkaline medium, the overpotential required to obtain the catalytic current density of 10 mA·cm−2 is only 220 mV, and the Tafel slope is 67 mV·dec−1. This is largely due to: (1) (NiFe)2p/NF nanocatalysts were well dispersed on NF substrates, which increased the number of active sites exposed; (2) the hollow heterostructure of bimetallic phosphates promotes the electron interaction between (NiFe)2P and NF, increased the rate of charge transfer, and the electrical conductivity of the material is improved; and (3) theoretical calculations show that (NiFe)2P/NF hollow heterostructure can effectively reduce the dissociation barrier of water, promote the dissociation of water; furthermore, the kinetic reaction rate of electrocatalytic oxygen evolution is accelerated. Meanwhile, the catalyst still has high activity and high stability in 30 wt% concentrated alkali solution. Therefore, the construction of (NiFe)2P/NF electrocatalysts enriches the application of non-noble metal nanomaterials in the field of oxygen production from electrolytic water.

A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications

Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed the dynamic structure and nano–bio interactions of the protein corona. The binding of proteins not only imparts new surface identities to nanoparticles in biological fluids but also significantly influences their bioactivity, stability, and targeting specificity. Interestingly, recent endeavors have been undertaken to harness the potential of the protein corona instead of evading its presence. Exploitation of this ‘protein–nanoparticle alliance’ has significant potential to change the field of nanomedicine. Here, we present a thorough examination of the latest research on protein corona, encompassing its formation, dynamics, recent developments, and diverse bioapplications. Furthermore, we also aim to explore the interactions at the nano–bio interface, paving the way for innovative strategies to advance the application potential of the protein corona. By addressing challenges and promises in controlling protein corona formation, this review provides insights into the evolving landscape of the ‘protein–nanoparticle alliance’ and highlights emerging.

Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease

Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED). The currently available eye drops for DED treatment are palliative, short-lived and frequently administered due to the short precorneal residence time. Here, we developed nanozyme-based eye drops for DED by exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) and poly(vinyl alcohol) (PVA) to overcome these problems. The resultant formulation (PBnZ), which has dual-ROS scavenging abilities and prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect to alleviate DED. In vitro and in vivo experiments revealed that PBnZ could eliminate excess ROS through both its multienzyme-like activity and the ROS-scavenging activity of borate bonds. The positively charged nanozyme-based eye drops displayed a longer precorneal residence time due to physical adhesion and the dynamic borate bonds between phenyboronic acid and PVA or o-diol with mucin. The in vivo results showed that eye drops could effectively alleviate DED. These dual-function PBnZ nanozyme-based eye drops can provide insights into the development of novel treatment strategies for DED and other ROS-mediated inflammatory diseases and a rationale for the application of nanomaterials in clinical settings.Graphical

Applying different nanomaterials to improve the performance of lithium-ion batteries

Due to their superior qualities, lithium-ion batteries (LIBs) have lately taken the top spot among rechargeable secondary batteries. To achieve the increasing demand for electricity in the related industries, its improvement and development are in full swing, especially the nanomaterials have become an important direction of improvement because of their special structure matching with charging-discharging mechanisms. This paper focuses on the application of nanomaterials in the LIBs. It briefly introduces carbon-based and silicon-based nanomaterials, metal (alloy), metal oxide (sulfide), MOFs nanomaterials, and Mxenes in lithium-ion batteries and lithium-sulfur batteries by reviewing the pertinent literature from recent years. including the reasons for their application, the application mechanism and the effectiveness of their improvement. It has been discovered that nanoparticles have numerous and intricate uses in the LIBs. It is hoped that this study can provide new ideas for the structural design and functional modification of nanomaterials in battery applications in the future.

Applications of quartz crystal microbalance with dissipation in nanomedicine (QCM-D): a personal experience

Due to their unique physical and chemical properties, the potential application of nanomaterials in medicine is partic¬ularly attractive. Despite the many advantages that nanomaterials can offer as diagnostic and therapeutic tools, their transition from the bench to clinical practice is extremely challenging. One of the many barriers that nanomedicines may encounter is their toxicological effect. In fact, the development of novel nanomaterials / nanoparticles must pro¬ceed always in tandem with the assessment of any potential toxicological effects associated to them. Once nano¬materials reach the systemic circulation, they interact with endothelial cells, plasma proteins, and other blood compo¬nents. There is no doubt that the study of nanomaterials-blood interactions is crucial to warrant the biocompatibility of nanomaterials developed for human use.

A Comprehensive Review and Future Perspectives of Nanomaterials in Nonlinear Optics and Photonics

Purpose: Nanomaterials have sparked a paradigm shift in nonlinear optics and photonics, presenting unparalleled advantages over bulk materials. Their distinctive attributes, encompassing a substantial surface area, customizable optical properties, and quantum confinement effects, position them as optimal candidates for an array of nonlinear optical applications. Despite their immense potential, the field faces several challenges and future directions. These encompass tailoring nanomaterials for precise applications, establishing scalable fabrication methods, ensuring device stability, broadening application scopes, comprehending fundamental nonlinear optical mechanisms, and advancing predictive theoretical models. Addressing these challenges promises to propel nonlinear optics and photonics into new frontiers, fostering technological advancements that benefit society across multiple domains. Methodology: This paper uses exploratory research methodology to analyse, compare, evaluate, interpret, and create new knowledge to address the challenges and to predict future perspectives of nanomaterials in nonlinear optics and photonics by collecting relevant information using appropriate keywords through Google, Google scholar, and AI-driven GPT search engines. Results & Discussion: This paper underscores nanomaterials' transformative impact on nonlinear optics and photonics. With their unparalleled characteristics and versatile applications, nanomaterials are poised to revolutionize various technologies, offering innovative solutions to contemporary challenges and heralding a new era of scientific progress and technological innovation in various fields including development of Optical Computers. Originality/Value: The paper explores the significance of Nanomaterials in Nonlinear Optics and Photonics, overviews the characteristics of nanomaterials in nonlinear Optics, identifies various important Applications of Nanomaterials in Nonlinear Optics and Photonics, evaluates Prominent Nanomaterials in Nonlinear Optics, and hence analyses and interprets Challenges and Future Directions. Type of Paper: Exploratory Study.

Physical, rheological and micro characteristics of ARA/Nano-TiO2 composite modified asphalt before and after short-term aging

This paper aims to investigate the composite application of nanomaterials and natural asphalt in order to enhance the road performance of asphalt pavement. The objective is to develop high-performance modified asphalt that improves the durability, reliability, and load resistance of asphalt roads while reducing resource waste and environmental pollution. The composite modified asphalt was prepared by adding different blends of Albanian natural rock asphalt (ARA) and 1% of nano titanium dioxide (Nano-TiO2), and the basic properties and rheological properties of the asphalt before and after aging were tested by using basic performance tests and temperature scanning tests. Subsequently, the microscopic morphological characteristics of the asphalt were observed by scanning electron microscope and atomic force microscope, and the number of bee structures, the area share of bee structures, root mean square roughness Rq, and arithmetic mean roughness Ra were used as microscopic quantitative indexes. The results indicate that the complex modulus and rutting coefficient of ARA/Nano-TiO2 composite-modified asphalt increase with an increase in ARA dosage when the dosage of Nano-TiO2 is 1%. The asphalt modified with Nano-TiO2 composite blended with 15% ARA exhibits higher residual needle penetration, composite modulus ratio, rutting coefficient ratio and lower softening point increment compared to 70# asphalt. The bitumen modified with titanium dioxide nanocomposite blended with 15% ARA exhibits higher Rq and Ra and a more stable phase structure before and after aging. 15% of ARA/Nano-TiO2 composite-modified asphalt has higher Rq and Ra before and after aging, and its phase structure is more stable. The results show that ARA/Nano-TiO2 composite-modified asphalt has better high-temperature deformation resistance and aging resistance than 70# and that 15% ARA is recommended as the optimum amount of composite-modified asphalt.

A novel signal amplified sandwich aptamer-based visual lateral flow assay based on self-assembly bifunctional nucleic acid for rapid and sensitive detection of CKMB

At present, rapid and sensitive detection of disease biomarkers is still the focus of early clinical diagnosis. As a rapid response to point-of-care testing (POCT), lateral flow assay (LFA) has been given serious attention. Unfortunately, due to the sensitivity limitations, LFA, especially AuNPs-based LFA, was difficult to play an important role in the detection of trace biomarkers. The combination of different signal amplification methods increases the complexity of operation and use, or prolongs the detection time, which sacrifices the advantages of fast and convenient of LFA. Hence, a novel sandwich aptamer-based visual LFA based on bifunctional nucleic acid (bFNA-LFA) was proposed for rapid and sensitive detection of creatine kinase MB (CKMB) in this study. Based on hybridization chain reaction (HCR) and nucleic acid hybridization, a bifunctional nucleic acid with target recognition and signal amplification was prepared, which effectively improved the sensitivity of CKMB detection without increasing the reaction time and depending on the detecting equipment. Under optimal reaction conditions, the limit of detection of 7.92 ng/mL was observed, which was 20 times lower than that of sandwich aptamer-based AuNPs LFA in the previous study. The proposed bFNA-LFA assay expanded a new idea in improving the sensitivity of LFA, and provided a reference for the subsequent application of nucleic acid nanomaterials in the detection of protein biomarkers.

Critical parameters to standardize the size and concentration determination of nanomaterials by nanoparticle tracking analysis

The size and concentration are critical for the diagnostic and therapeutic applications of nanomaterials but the accurate measurement remains challenging. Nanoparticle tracking analysis (NTA) is widely used for size and concentration determination. However, highly repeatable standard operating procedures (SOPs) are absent. We adopted the “search-evaluate-test” strategy to standardize the measurement by searching the critical parameters. The particles per frame are linearly proportional to the sample concentration and the measured results are more accurate and repeatable when the concentration is 108-109 particles/ml. The optimal detection threshold is around 5. The optimal camera level is such that it allows clear observation of particles without diffractive rings and overexposure. The optimal speed is ≤ 50 in AU and ∼ 10 μl/min in flow rate. We then evaluated the protocol using polydisperse polystyrene particles and we found that NTA could discriminate particles in bimodal mixtures with high size resolution but the performance on multimodal mixtures is not as good as that of resistive pulse sensing (RPS). We further analyzed the polystyrene particles, SiO2 particles, and biological samples by NTA following the SOPs. The size and concentration measured by NTA differentially varies to those determined by RPS and transmission electron microscopy.

Grapefruit-Inspired Polymeric Capsule with Hierarchical Microstructure: Advanced Nanomaterial Carrier Platform for Energy Storage, Drug Delivery, Catalysis, and Environmental Applications.

Efficient support materials are crucial for maximizing the efficacy of nanomaterials in various applications such as energy storage, drug delivery, catalysis, and environmental remediation. However, traditional supports often hinder nanomaterial performance due to their high weight ratio and limited manageability, leading to issues like tube blocking and secondary pollution. To address this, a novel grapefruit-inspired polymeric capsule (GPC) as a promising carrier platform is introduced. The millimeter-scale GPC features a hydrophilic shell and an internal hierarchical microstructure with 80% void volume, providing ample space for encapsulating diverse nanomaterials including metals, polymers, metal-organic frameworks, and silica. Through liquid-phase bottom-up methods, it is successfully loaded Fe2O3, SiO2, polyacrylic acid, and Prussian blue nanomaterials onto the GPC, achieving high mass ratio (1776, 488, 898, and 634wt.%, respectively). The GPC shell prevents nanomaterial leakage and the influx of suspended solids, while its internal framework enhances structural stability and mass transfer rates. With long-term storage stability, high carrying capacity, and versatile applicability, the GPC significantly enhances the field applicability of nanomaterials.

Strategies Employed to Design Biocompatible Metal Nanoparticles for Medical Science and Biotechnology Applications.

The applicability of nanomaterials has evolved in biomedical domains thanks to advances in biocompatibility strategies and the mitigation of cytotoxic effects, allowing diagnostics, imaging, and therapeutic approaches. The application of nanoparticles (NP), particularly metal nanoparticles (mNPs), such as gold (Au) and silver (Ag), includes inherent challenges related to the material characteristics, surface modification, and bioconjugation techniques. By tailoring the surface properties through appropriate coating with biocompatible molecules or functionalization with active biomolecules, researchers can reach a harmonious interaction with biological systems or samples (mostly fluids or tissues). Thus, this review highlights the mechanisms associated with the obtention of biocompatible mNP and presents a comprehensive overview of methods that facilitate safe and efficient production. Therefore, we consider this review to be a valuable resource for all researchers navigating this dynamic field.

Application of nanomaterials in Li-ion batteries

Lithium-ion batteries (LIBs) have become an important energy storage solution in mobile devices, electric vehicles, and renewable energy storage. This research focuses on the key applications of nanomaterials in LIBs, which are attracting attention due to their unique electrochemical properties. This research first introduces the fundamentals and current challenges of LIBs, followed by a detailed list of various nanomaterials, including two-dimensional materials, metal oxides, carbon-based materials, and their wide-ranging applications in LIBs. The research on nanomaterials has revealed significant enhancements in battery performance, including increased capacity, extended cycle life, and improved charge and discharge rates. Furthermore, this research highlights the sustainability and environmental potential of nanomaterials and their important role in mitigating the scarcity of lithium resources. Finally, it will summarize the potential impact of these studies, highlight the research significance of nanomaterials in the field of battery technology, and provide useful guidance and inspiration for the future development of renewable energy storage and electric transportation. This research will help drive innovation in battery technology and pave the way for a more sustainable energy future.

Applications of Inorganic Nanomaterials against Tuberculosis: A Comprehensive Review.

Tuberculosis (TB) continues to pose a significant global health threat, with millions of new infections recorded annually. Current treatment strategies, such as Directly Observed Treatment (DOT), face challenges, including patient non-compliance and the emergence of drug-resistant TB strains. In response to these obstacles, innovative approaches utilizing inorganic/metallic nanomaterials have been developed to enhance drug delivery to target alveolar macrophages, where Mycobacterium tuberculosis resides. These nanomaterials have shown effectiveness against various strains of TB, offering benefits such as improved drug efficacy, minimized side effects, and sustained drug release at the infection site. This comprehensive review explores the applications of different metal nanoparticles, metal oxide nanoparticles, and metal-metal oxide hybrid nanoparticles in the management of TB, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. The synergistic effects of combining inorganic nanoparticles with conventional anti-TB drugs have demonstrated promising results in combating TB infections. Further research and development in this field hold great promise for overcoming the challenges faced in current TB therapy and improving patient outcomes.

Application of silicon-based nanomaterials for improving the performance of battery

This research discussed the improvement of using silicon-based nanomaterial in batteries compared to graphite batteries because not only in electric vehicles, but also mobile phone users are requiring for longer battery life and faster charging speed and phones cannot increase into an unacceptable weight. This research first introduces how lithium-ion batteries work and analyses the failure of lithium metallic battery: high cost and low security because of dendrites growth. Secondly, this paper discussed how mobile phone manufacturers improved their batteries by using silicon: Honors silicon carbon battery and Xiaomis silicon-oxygen anode battery. Both have increased the energy density and charging speed and lighter the weight at the same time. In general, silicon can improve battery performance through its high capacity for lithium-ion, and silicon can easily be found in a natural environment which will lead to lower manufacturing costs. As a result, this research can provide a new design approach for the structural design and application performance of nanomaterials in the field of battery applications.

Characterization of TiO2 nanoparticles for nanomaterial applications: Crystallite size, microstrain and phase analysis using multiple techniques

This study aimed to verify the suitability of TiO2 nanoparticles as nanomaterials in terms of crystallite size, microstrain and phase. The TiO2 nanoparticles were tested experimentally in suspensions of mono ethylene glycol and distilled water (MEG-DW) at ratios of 10:90, 25:75, and 40:60. The nanoparticles were dispersed in the base liquid via a two-step process, resulting in the formation of TiO2-3%/MEG-10, TiO2-3%/MEG-25, and TiO2-3%/MEG-40 nanofluids. The results revealed average crystallite sizes of approximately 20.10, 22.10, and 39.6 nm for the three nanofluid samples, as determined by the Scherrer equation, Williamson–Hall (W–H) plot, and TEM-ImageJ software. These results confirm that the TiO2 nanoparticles meet the nanomaterial criteria with a sub-100 nm size. The microstrain analysis yielded values of 0.000020, 0.000299, and 0.001386 for the three samples and further investigation confirmed the presence of rutile. The high-temperature stability of the rutile phase makes the TiO2 nanofluids suitable for use in industrial heating systems.

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

Sonodynamic therapy (SDT) has attracted significant attention in recent years as it is an innovative approach to tumor treatment. It involves the utilization of sound waves or ultrasound (US) to activate acoustic sensitizers, enabling targeted drug release for precise tumor treatment. This review aims to provide a comprehensive overview of SDT, encompassing its underlying principles and therapeutic mechanisms, the applications of nanomaterials, and potential synergies with combination therapies. The review begins by introducing the fundamental principle of SDT and delving into the intricate mechanisms through which it facilitates tumor treatment. A detailed analysis is presented, outlining how SDT effectively destroys tumor cells by modulating drug release mechanisms. Subsequently, this review explores the diverse range of nanomaterials utilized in SDT applications and highlights their specific contributions to enhancing treatment outcomes. Furthermore, the potential to combine SDT with other therapeutic modalities such as photothermal therapy (PTT) and chemotherapy is discussed. These combined approaches aim to synergistically improve therapeutic efficacy while mitigating side effects. In conclusion, SDT emerges as a promising frontier in tumor treatment that offers personalized and effective treatment options with the potential to revolutionize patient care. As research progresses, SDT is poised to play a pivotal role in shaping the future landscape of oncology by providing patients with a broader spectrum of efficacious and tailored treatment options.